Gene

KWMTBOMO15997

Pre Gene Modal

BGIBMGA004611

Annotation

PREDICTED:_dual_specificity_tyrosine-phosphorylation-regulated_kinase_2-like_[Bombyx_mori]

Location

Bomo_Chr27(-):5660006-5661086      View in EpiBrowser

Full name

Putative dual specificity tyrosine-phosphorylation-regulated kinase 3 homolog       + More
Dual specificity tyrosine-phosphorylation-regulated kinase 2      

Location in the cell

Mitochondrial   Reliability : 1.515 Nuclear   Reliability : 1.341

CDS

ATGCCTCTGGGGAGCGCGCACGCGTTCGGGCTCGCGTTGCTCCGGGACGGGGCACTGCCGCCGCTGGAGCCTGGCCCGCCCGCACCGCCGGCAGCCAACGCGCAACCGCCCGACAAGCGACCGACGGCCGCCGCCGCCAGTCCCGAGCAGGTCATGAAGCTCTATATGAACAAACTCACGCCTTACGAGCACCGTGAAATATTCGACTATCCTCAAGTGTACTTCATAGGTGCGAACGCGAAGAAGCGCCCCGGCCTAGTCGGGTTCCCAAACAATTGCGAGTATGACAACGAGCAGGGCTCGTATATCCACATCCCCCACGACCACATAGCCTACAGATACGAAGTGCTGAAAGTCATCGGCAAAGGTAGCTTCGGGCAAGTGGTGAAAGCGTTCGATCATAAGAAACGCGAACACGTTGCCCTCAAGATGGTCCGCAACGAAAAGCGGTTTCACAGACAAGCACAGGAGGAGATCCGTATACTGGAGCACCTCCGCGAGCAAGACAAGGACAACACGATGAACGTCATCCACATGTTCGACTCGTTCACATTCAGGAATCACACGTGCATCACTTTCGAGCTACTCTCGATCAACTTGTACGAGTTGATAAAGAAGAACAAGTTCCAAGGTTTCTCTCTGCAGTTGGTGCGTAAGTTCTCGCATAGTCTTCTGCAGTGTCTGCACGCTCTAAACAAGAACCGCATCATCCACTGCGACATGAAGCCAGAGAACGTGCTGCTCAAGCAACAGGGACGATCTGGTATCAAGGTCAGTATGCTTAAAATGATTATAACCGGTTGTGTAAAAATGATACTACTATCTATAAAATACCGAGTAATAATCAAACCAATTGCAGTCCTTATGCATATTTCGAAATTTTCATTATTAGTGTTCCATTAG

Protein

MPLGSAHAFGLALLRDGALPPLEPGPPAPPAANAQPPDKRPTAAAASPEQVMKLYMNKLTPYEHREIFDYPQVYFIGANAKKRPGLVGFPNNCEYDNEQGSYIHIPHDHIAYRYEVLKVIGKGSFGQVVKAFDHKKREHVALKMVRNEKRFHRQAQEEIRILEHLREQDKDNTMNVIHMFDSFTFRNHTCITFELLSINLYELIKKNKFQGFSLQLVRKFSHSLLQCLHALNKNRIIHCDMKPENVLLKQQGRSGIKVSMLKMIITGCVKMILLSIKYRVIIKPIAVLMHISKFSLLVFH

Description

Serine/threonine-protein kinase involved in the control of mitotic transition and the regulation of cellular growth and/or development.

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Cofactor

Mg(2+)
Mn(2+)

Subunit

Interacts with MDM2.

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

Keywords

ATP-binding   Complete proteome   Kinase   Nucleotide-binding   Phosphoprotein   Reference proteome   Transferase   Tyrosine-protein kinase   Apoptosis   Cytoplasm   Magnesium   Manganese   Nucleus   Ubl conjugation  

Feature

chain  Putative dual specificity tyrosine-phosphorylation-regulated kinase 3 homolog

Uniprot

H9J521   A0A2A4J084   A0A2W1BNM3   A0A2H1WZK8   A0A222AJ63   A0A194Q549   + More
A0A0N0PBK1   V5I7X1   A0A1Y1L2W6   A0A2J7PXY8   A0A2P8XTB8   A0A0T6B1H5   D6W776   E9IBY7   F4X1P3   A0A151WNG7   K7J5L1   E2ACJ1   A0A1B6CMA4   A0A232F437   A0A151IW63   A0A195BEK7   A0A195C9L9   E2BBP0   A0A2R5LMB7   A0A293LS30   A0A158NQU4   A0A195F5I2   A0A2A3ETQ0   T1JLC7   A0A088ALP9   A0A0M9A182   A0A1B6LKS8   E0W1C0   A0A1B6HJ39   A0A3L8DTD2   L7LW76   L7LT75   A0A131XUL6   A0A1A9UMB8   A0A1A9ZM30   A0A0P4WDQ9   A0A310S6M1   A0A087SVP6   N6T9F7   A0A099YYF6   A0A093JLF6   B4PW56   A0A0L0BL59   A0A0C9R8B8   A0A1A9WQC1   B3P9N5   A0A0J9S1A8   A0A1I8M0W0   P83102   B4IKS4   A0A0J9S1C0   T1PLQ1   U3KJU8   A0A091QHR0   A0A1A9YKB5   A0A1B0BID7   B4NHG7   W8C7X9   A0A2Y9E3X7   M1EJV5   A0A1V9X078   A0A212DF93   A0A2K6G6Z1   L8HRY6   A0A2K5SCX2   A0A3B0KXV9   F1RYI2   A0A3P8Y962   W5Q8S2   A0A3Q7SPL6   A0A286ZM94   H0XS18   A0A1B0FDU3   E1BG90   A0A1U7RM61   A0A3B4UQW6   T0MIS9   A0A3P8YBD9   U6DY67   A0A2K6SL42   M3Z5N1   A0A2K6SL48   A0A2U3X3H9   M3WEG8   Q5ZIU3   U3DTS3   A0A091EQ34   E2R3D8   A0A2P4SVP3   B4JZR2  

EC Number

2.7.12.1

Pubmed

19121390    28756777    26354079    28004739    29403074    18362917    + More
19820115    21282665    21719571    20075255    20798317    28648823    21347285    20566863    30249741    25576852    29652888    23537049    17994087    17550304    26108605    22936249    25315136    10731132    12537572    12537569    18327897    24495485    23236062    28327890    29294181    22751099    25069045    20809919    19393038    23149746    17975172    15642098    25243066    16341006   

EMBL

BABH01025857    NWSH01004019    PCG65567.1    KZ150055    PZC74330.1    ODYU01012242    + More
SOQ58447.1    KY609556    ASO76420.1    KQ459460    KPJ00663.1    KQ460891    KPJ10844.1    GALX01005695    JAB62771.1    GEZM01066361    JAV67924.1    NEVH01020852    PNF21201.1    PYGN01001379    PSN35261.1    LJIG01016290    KRT81044.1    KQ971307    EFA11400.2    GL762138    EFZ21916.1    GL888544    EGI59634.1    KQ982907    KYQ49383.1    GL438528    EFN68857.1    GEDC01022783    JAS14515.1    NNAY01001002    OXU25534.1    KQ980874    KYN12044.1    KQ976500    KYM83008.1    KQ978068    KYM97410.1    GL447128    EFN86917.1    GGLE01006544    MBY10670.1    GFWV01004910    MAA29640.1    ADTU01023607    ADTU01023608    ADTU01023609    ADTU01023610    KQ981810    KYN35437.1    KZ288189    PBC34586.1    JH430326    KQ435794    KOX73803.1    GEBQ01015687    JAT24290.1    DS235867    EEB19426.1    GECU01033019    JAS74687.1    QOIP01000004    RLU23705.1    GACK01008989    JAA56045.1    GACK01009743    JAA55291.1    GEFM01006450    GEGO01001631    JAP69346.1    JAR93773.1    GDRN01097294    JAI59149.1    KQ767803    OAD53297.1    KK112173    KFM56935.1    APGK01039173    KB740967    KB632399    ENN76889.1    ERL94622.1    KL886538    KGL73933.1    KL206175    KFV79604.1    CM000161    EDW99361.1    KRK05016.1    JRES01001702    KNC20801.1    GBYB01004258    GBYB01004260    JAG74025.1    JAG74027.1    CH954184    EDV45198.1    CM002916    KMZ07417.1    AE014135    AY118401    AF103941    CH480855    EDW52664.1    KMZ07418.1    KMZ07419.1    KMZ07420.1    KA648975    AFP63604.1    AGTO01020282    KK698728    KFQ25976.1    JXJN01014918    JXJN01014919    CH964272    EDW83536.2    GAMC01007776    JAB98779.1    JP009043    AER97640.1    MNPL01031106    OQR66796.1    MKHE01000003    OWK16927.1    JH883377    ELR46631.1    OUUW01000017    SPP88918.1    AEMK02000033    AMGL01081100    AAQR03139938    AAQR03139939    CCAG010003810    KB017114    EQB78420.1    HAAF01015576    CCP87396.1    AEYP01031577    AANG04003655    AJ720691    CAG32350.1    GAMT01003581    GAMS01006677    GAMR01007047    GAMQ01006234    JAB08280.1    JAB16459.1    JAB26885.1    JAB35617.1    KK718745    KFO58439.1    AAEX03007035    AAEX03007036    PPHD01020415    POI28195.1    CH916380    EDV90928.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000235965    UP000245037    + More
UP000007266    UP000007755    UP000075809    UP000002358    UP000000311    UP000215335    UP000078492    UP000078540    UP000078542    UP000008237    UP000005205    UP000078541    UP000242457    UP000005203    UP000053105    UP000009046    UP000279307    UP000078200    UP000092445    UP000054359    UP000019118    UP000030742    UP000053641    UP000053584    UP000002282    UP000037069    UP000091820    UP000008711    UP000095301    UP000000803    UP000001292    UP000016665    UP000092443    UP000092460    UP000007798    UP000248480    UP000192247    UP000233160    UP000233040    UP000268350    UP000008227    UP000265140    UP000002356    UP000286640    UP000005225    UP000092444    UP000009136    UP000189705    UP000261420    UP000233220    UP000000715    UP000245340    UP000011712    UP000000539    UP000008225    UP000052976    UP000002254    UP000001070   

PRIDE

H9J521    P83102    F1RYI2    Q5ZIU3   

Pfam

PF00069   Pkinase

Interpro

IPR000719   Prot_kinase_dom        + More
IPR017441   Protein_kinase_ATP_BS       
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       

SUPFAM

SSF56112   SSF56112       

ProteinModelPortal

H9J521   A0A2A4J084   A0A2W1BNM3   A0A2H1WZK8   A0A222AJ63   A0A194Q549   + More
A0A0N0PBK1   V5I7X1   A0A1Y1L2W6   A0A2J7PXY8   A0A2P8XTB8   A0A0T6B1H5   D6W776   E9IBY7   F4X1P3   A0A151WNG7   K7J5L1   E2ACJ1   A0A1B6CMA4   A0A232F437   A0A151IW63   A0A195BEK7   A0A195C9L9   E2BBP0   A0A2R5LMB7   A0A293LS30   A0A158NQU4   A0A195F5I2   A0A2A3ETQ0   T1JLC7   A0A088ALP9   A0A0M9A182   A0A1B6LKS8   E0W1C0   A0A1B6HJ39   A0A3L8DTD2   L7LW76   L7LT75   A0A131XUL6   A0A1A9UMB8   A0A1A9ZM30   A0A0P4WDQ9   A0A310S6M1   A0A087SVP6   N6T9F7   A0A099YYF6   A0A093JLF6   B4PW56   A0A0L0BL59   A0A0C9R8B8   A0A1A9WQC1   B3P9N5   A0A0J9S1A8   A0A1I8M0W0   P83102   B4IKS4   A0A0J9S1C0   T1PLQ1   U3KJU8   A0A091QHR0   A0A1A9YKB5   A0A1B0BID7   B4NHG7   W8C7X9   A0A2Y9E3X7   M1EJV5   A0A1V9X078   A0A212DF93   A0A2K6G6Z1   L8HRY6   A0A2K5SCX2   A0A3B0KXV9   F1RYI2   A0A3P8Y962   W5Q8S2   A0A3Q7SPL6   A0A286ZM94   H0XS18   A0A1B0FDU3   E1BG90   A0A1U7RM61   A0A3B4UQW6   T0MIS9   A0A3P8YBD9   U6DY67   A0A2K6SL42   M3Z5N1   A0A2K6SL48   A0A2U3X3H9   M3WEG8   Q5ZIU3   U3DTS3   A0A091EQ34   E2R3D8   A0A2P4SVP3   B4JZR2  

PDB

5ZTN     E-value=7.40634e-103,     Score=954

KEGG

101736919    K18669 dual specificity tyrosine-phosphorylation-regulated kinase 2/3/4 [EC:2.7.12.1] | (RefSeq) dua

GO

GO:0004674   GO:0005524   GO:0004672   GO:0004712   GO:0004713   GO:1990904   GO:0007224   GO:0042771   GO:0005829   GO:0045725   GO:0070885   GO:0000287   GO:0000151   GO:0005654   GO:0030145   GO:0016301   GO:0005634   GO:0005737   GO:0006468   GO:0008270   GO:0016887   GO:0007166   GO:0016020   GO:0006281   GO:0006259  

Subcellular location

Cytoplasm  
Nucleus  

Length:

300

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.11674

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01142

outside

1  -  300

 

 

Pi

215.768392

Theta

231.606095

Tajima's D

-0.197796

CLR

465.869401

CSRT

0.313684315784211

Interpretation

Uncertain