Gene

KWMTBOMO15987  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005727

Annotation

PREDICTED:_pyrroline-5-carboxylate_reductase-like_isoform_X1_[Papilio_xuthus]

Location

Bomo_Chr27(-):5193739-5203782      View in EpiBrowser

Full name

Pyrroline-5-carboxylate reductase      

Location in the cell

Mitochondrial   Reliability : 1.937

CDS

ATGCTGAAATTACCATTAATAGAAGCTATGAAGATCGGATTTATAGGCGGCGGCAGGCTTGCGTTTGCTTTGGCGAACGGCTTTATTTCGGCGGGTCTGGCAAAACCCGACGAAATCACAGCTAGCTGTCATCCTTCCGATGTTGCCAGCGCCAAAGCTTTTCAGGGCTTGGGAGCTACAGCGTTATTTGAAAATATATCCGTGGTGGAGAGGTCTGAAGTGGTGATAGTATCTGTCAAGCCCGATGTCGTGGTACCCGCTCTTAAAGAGATAAAAAACCTGCCTTCGGCGAAGAATAAACTCTTCATTTCCGTTGCCATGGGAATTACTATCGCTACAGTCGAATCGAATTTGCCTTCTGAGGCTCGTGTGATTCGTGTAATGCCAAACACTCCGGCGTTAGTGAAAGAAGGCGCAGCTGCCTTTAGTCGTGGTACTAAAGCCACAGCGGAAGACGCACAACTGACGTCACAGCTCTTCAAGGCGGTGGGTACCTGCGATGAGGTACCAGAGTACCAAATGGACGCTATAACCGCCCTTAGTGGAAGTGGACCCGCTTACGTTTACATGCTAATAGAATCTCTAGCTGATGGTGGAGTTCGTTGTGGCTTACCTCGCGACCTCGCACTTCGCCTGGCCGCCCAAACCACCCTGGGTTCCGCAGCCATGGTCAAAACTGGTGATCATCCAGCCATGTTGAAAGACAATGTCACCAGTCCCGCAGGGTCTACCGCTGAGGGAACATATCACTTGGAGAAAAACGGTTTCCGTTCTGCCATAATCGGTGCAGTGTCTGCGGCAGTAGATAGATGTAAGATTGTAAAAAAACAATTGAACGATTAG

Protein

MLKLPLIEAMKIGFIGGGRLAFALANGFISAGLAKPDEITASCHPSDVASAKAFQGLGATALFENISVVERSEVVIVSVKPDVVVPALKEIKNLPSAKNKLFISVAMGITIATVESNLPSEARVIRVMPNTPALVKEGAAAFSRGTKATAEDAQLTSQLFKAVGTCDEVPEYQMDAITALSGSGPAYVYMLIESLADGGVRCGLPRDLALRLAAQTTLGSAAMVKTGDHPAMLKDNVTSPAGSTAEGTYHLEKNGFRSAIIGAVSAAVDRCKIVKKQLND

Catalytic Activity

L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH

Similarity

Belongs to the pyrroline-5-carboxylate reductase family.

Feature

chain  Pyrroline-5-carboxylate reductase

Uniprot

H9J885   A0A0N1PJ82   A0A194Q6L9   A0A2A4KA00   A0A2W1BFW2   A0A2A4KAD6   + More
A0A2H1VGZ2   A0A212EIV7   D6WHI9   A0A1B6KM20   A0A1B6I3B3   J9WM64   A0A1J1HJ17   A0A1A9WNS5   A0A1L8E2K6   J3JUU5   G9FQ76   A0A1A9UEM6   A0A1B0C6T3   A0A1A9X9X1   A0A1A9YUI0   U5EUM2   A0A1L8EFP3   B4JTU7   A0A1S4FFD3   Q173T1   Q2KQA0   Q29A90   A0A1B6E9L7   A0A1L8EBY5   A0A0L0C7U0   A0A182N1U1   A0A182GUZ7   A0A182J885   E0VU70   A0A182R2B9   A0A0K8U985   A0A034WHX1   A0A0C9RP24   A0A182U1W0   B3LVQ0   A0A3B0K4U7   A0A182VAQ4   A0A182KNJ5   Q7PPH9   A0A182HQR1   A0A146KKA3   N6U3D7   A0A0A9WR31   A0A1I8PIX4   A0A182WM59   Q9VEJ3   A0A182FLD0   A0A2M3Z7E7   A0A2M3Z7F8   B3P3D2   B4PKF1   A0A0M5JCD7   A0A1Y1KTM8   A0A1W4V516   Q0QHK5   W5JE89   B4QVP6   B4LY47   B4IBG7   A0A2M4AQV9   B4K7N1   T1PG15   A0A3L8DJ27   A0A2M4BWS7   B4G2L5   K7J149   A0A232FIG1   B4N8G5   A0A0P4VK41   A0A224XHV6   A0A0A1XKR3   A0A0K8VNU6   W8AYB1   A0A2S2QXU0   B0VZ26   A0A195F9T8   A0A034WGW1   C4WS23   E1ZX14   A0A1Q3FNK1   A0A0L7QQL9   A0A0J7L134   A0A182S9T1   A0A170YTU3   A0A0C9QTC7   A0A2H8TXC9   T1HIQ9   A0A154PFY4   A0A158NP73   F4WF31   A0A0L7LI33   A0A195DYH3  

EC Number

1.5.1.2

Pubmed

19121390    26354079    28756777    22118469    18362917    19820115    + More
22972362    22516182    17994087    17510324    15804581    15632085    26108605    26483478    20566863    25348373    20966253    12364791    14747013    17210077    26823975    23537049    25401762    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    28004739    20920257    23761445    25315136    30249741    20075255    28648823    27129103    25830018    24495485    20798317    21347285    21719571    26227816   

EMBL

BABH01038495    KQ459890    KPJ19552.1    KQ459460    KPJ00650.1    NWSH01000025    + More
PCG80613.1    KZ150219    PZC72117.1    PCG80612.1    ODYU01002517    SOQ40113.1    AGBW02014566    OWR41400.1    KQ971321    EFA00672.1    GEBQ01027510    JAT12467.1    GECU01026341    GECU01003200    JAS81365.1    JAT04507.1    JX462668    AFS17324.1    CVRI01000006    CRK88005.1    GFDF01001170    JAV12914.1    BT127010    AEE61972.1    JN187430    AET80386.2    JXJN01026961    CCAG010011557    GANO01002260    JAB57611.1    GFDG01001291    JAV17508.1    CH916374    EDV91526.1    CH477417    EAT41304.1    AY623403    AAV31912.1    CM000070    EAL27460.2    GEDC01003386    GEDC01002744    JAS33912.1    JAS34554.1    GFDG01002531    JAV16268.1    JRES01000789    KNC28326.1    JXUM01019405    KQ560541    KXJ81941.1    DS235780    EEB16926.1    GDHF01029161    JAI23153.1    GAKP01005579    JAC53373.1    GBYB01010185    JAG79952.1    CH902617    EDV43674.2    OUUW01000005    SPP80646.1    AAAB01008948    EAA10379.5    APCN01004681    GDHC01021616    JAP97012.1    APGK01041389    KB740993    ENN76080.1    GBHO01033370    GBHO01033362    JAG10234.1    JAG10242.1    AE014297    AY071558    BT010232    AAF55428.1    AAL49180.1    AAQ23550.1    GGFM01003691    MBW24442.1    GGFM01003690    MBW24441.1    CH954181    EDV48712.1    CM000160    EDW95790.1    CP012526    ALC46294.1    GEZM01074059    JAV64684.1    DQ374014    ABG77992.1    ADMH02001638    ETN61658.1    CM000364    EDX12559.1    CH940650    EDW67935.1    CH480827    EDW44725.1    GGFK01009667    MBW42988.1    CH933806    EDW15375.1    KA647701    AFP62330.1    QOIP01000007    RLU20434.1    GGFJ01008323    MBW57464.1    CH479179    EDW24060.1    NNAY01000180    OXU30248.1    CH964232    EDW81416.1    GDKW01001932    JAI54663.1    GFTR01004359    JAW12067.1    GBXI01003154    JAD11138.1    GDHF01011750    JAI40564.1    GAMC01016717    GAMC01016716    JAB89838.1    GGMS01013373    MBY82576.1    DS231813    EDS25746.1    KQ981727    KYN36814.1    GAKP01005577    JAC53375.1    ABLF02032883    ABLF02032887    ABLF02045861    AK340016    BAH70693.1    GL434948    EFN74284.1    GFDL01005963    JAV29082.1    KQ414786    KOC60923.1    LBMM01001448    KMQ96293.1    GEMB01002968    JAS00235.1    GBYB01006964    JAG76731.1    GFXV01007091    MBW18896.1    ACPB03009651    KQ434896    KZC10751.1    ADTU01022267    ADTU01022268    GL888115    EGI67082.1    JTDY01001021    KOB75112.1    KQ980066    KYN17928.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000007151    UP000007266    + More
UP000183832    UP000091820    UP000078200    UP000092460    UP000092443    UP000092444    UP000001070    UP000008820    UP000001819    UP000037069    UP000075884    UP000069940    UP000249989    UP000075880    UP000009046    UP000075900    UP000075902    UP000007801    UP000268350    UP000075903    UP000075882    UP000007062    UP000075840    UP000019118    UP000095300    UP000075920    UP000000803    UP000069272    UP000008711    UP000002282    UP000092553    UP000192221    UP000000673    UP000000304    UP000008792    UP000001292    UP000009192    UP000095301    UP000279307    UP000008744    UP000002358    UP000215335    UP000007798    UP000002320    UP000078541    UP000007819    UP000000311    UP000053825    UP000036403    UP000075901    UP000015103    UP000076502    UP000005205    UP000007755    UP000037510    UP000078492   

PRIDE

H9J885    Q9VEJ3   

Pfam

PF14748   P5CR_dimer        + More
PF03807   F420_oxidored

Interpro

IPR029036   P5CR_dimer        + More
IPR008927   6-PGluconate_DH-like_C_sf       
IPR036291   NAD(P)-bd_dom_sf       
IPR028939   P5C_Rdtase_cat_N       
IPR000304   Pyrroline-COOH_reductase       
IPR033379   Acid_Pase_AS       

SUPFAM

SSF51735   SSF51735        + More
SSF48179   SSF48179       

ProteinModelPortal

H9J885   A0A0N1PJ82   A0A194Q6L9   A0A2A4KA00   A0A2W1BFW2   A0A2A4KAD6   + More
A0A2H1VGZ2   A0A212EIV7   D6WHI9   A0A1B6KM20   A0A1B6I3B3   J9WM64   A0A1J1HJ17   A0A1A9WNS5   A0A1L8E2K6   J3JUU5   G9FQ76   A0A1A9UEM6   A0A1B0C6T3   A0A1A9X9X1   A0A1A9YUI0   U5EUM2   A0A1L8EFP3   B4JTU7   A0A1S4FFD3   Q173T1   Q2KQA0   Q29A90   A0A1B6E9L7   A0A1L8EBY5   A0A0L0C7U0   A0A182N1U1   A0A182GUZ7   A0A182J885   E0VU70   A0A182R2B9   A0A0K8U985   A0A034WHX1   A0A0C9RP24   A0A182U1W0   B3LVQ0   A0A3B0K4U7   A0A182VAQ4   A0A182KNJ5   Q7PPH9   A0A182HQR1   A0A146KKA3   N6U3D7   A0A0A9WR31   A0A1I8PIX4   A0A182WM59   Q9VEJ3   A0A182FLD0   A0A2M3Z7E7   A0A2M3Z7F8   B3P3D2   B4PKF1   A0A0M5JCD7   A0A1Y1KTM8   A0A1W4V516   Q0QHK5   W5JE89   B4QVP6   B4LY47   B4IBG7   A0A2M4AQV9   B4K7N1   T1PG15   A0A3L8DJ27   A0A2M4BWS7   B4G2L5   K7J149   A0A232FIG1   B4N8G5   A0A0P4VK41   A0A224XHV6   A0A0A1XKR3   A0A0K8VNU6   W8AYB1   A0A2S2QXU0   B0VZ26   A0A195F9T8   A0A034WGW1   C4WS23   E1ZX14   A0A1Q3FNK1   A0A0L7QQL9   A0A0J7L134   A0A182S9T1   A0A170YTU3   A0A0C9QTC7   A0A2H8TXC9   T1HIQ9   A0A154PFY4   A0A158NP73   F4WF31   A0A0L7LI33   A0A195DYH3  

PDB

5UAX     E-value=7.6763e-47,     Score=470

KEGG

101739225    K00286 pyrroline-5-carboxylate reductase [EC:1.5.1.2] | (RefSeq) pyrroline-5-carboxylate reductase

PATHWAY

00330    Arginine and proline metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)

GO

GO:0006561   GO:0004735   GO:0055129   GO:0016021   GO:0055114   GO:0016311   GO:0016791   GO:0004725   GO:0007166   GO:0016020   GO:0000287   GO:0006281   GO:0006259  

Length:

280

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.66149

Exp number, first 60 AAs:

3.39842

Total prob of N-in:

0.14528

outside

1  -  280

 

 

Pi

219.513481

Theta

151.788989

Tajima's D

1.438328

CLR

0.164585

CSRT

0.769561521923904

Interpretation

Uncertain