Gene

KWMTBOMO15969

Pre Gene Modal

BGIBMGA005724

Annotation

PREDICTED:_growth/differentiation_factor_8_[Bombyx_mori]

Location

Bomo_Chr27(+):4268582-4276260      View in EpiBrowser

Full name

Growth/differentiation factor 8      

Alternative Name

Myostatin

Location in the cell

Nuclear   Reliability : 3.127

CDS

ATGGATGAATGTATACTTTGGCGTATACAATGGGATCTGCACACACAGAAGAAACTAAATACATTCCAAATTCATGAATTTTATTCTTGCATCCAAGACCTAAGAGAGATGCTACACATAATGCGGCATAGCGTATTCAAGGGCCTGAAGGTCATAGACTTCCGCCTCAGCAACAAGGTCTTACAGAACGAACTCGACGAGGCGGTCCTAAACCTTCACGTCCAGGAGCTAGACAACAGAAACACCACCTTCGACCCCGAAGAGTTGTTCACGCTAAACCTTCAAGTGAGCAGGGTGACGCGAAACAGTCAGGGTGGGAAGGCGTCGGTACTGTACTCTGAAAATTCGGTTACGATGACAAGAAGAGATTTGAAATTAGGGAAGTGGTTGAAAGTGAACGTGACGACGATGGTGGAGGAGTTCTGTAGGCTGCCCAGGGAGAGTTTAGCTATAGTTGCGAGAGTACAAGACTCGAGCGATCGGATTGGACTAGTCGTACCACATCCGAGCTCGGAATCAAATCATGCATTGATGCCATATATAGAAGTAAGTCTCAAGGACAACACGCATAAGCGCACACGGCGTACCGTCGTCATGGACTGCACGGAGAGCACCAAGGAAGTCCGCTGCTGCCGCTATCCCCTCGTCGTGAACTTCGAAGAGTTCGGCTGGGATTGGATAATAGCTCCGAAATTTTACAACGCTAACTATTGCAGCGGGGAATGTCCGTACAGCTTCCTGCAGAAGTACCCTCACACGCATCTGATACATCTATCCTCGCCCCAGGGCAGCGTGGGCCCGTGTTGCGCGCCGAGGCGGATGACCAGCATCTCGATGTTGTATTTCGACCACAACTCCAACATAATATATGGGACGATCCCCGGCATGGTTGTCGAGAGCTGTGGTTGCTCATAG

Protein

MDECILWRIQWDLHTQKKLNTFQIHEFYSCIQDLREMLHIMRHSVFKGLKVIDFRLSNKVLQNELDEAVLNLHVQELDNRNTTFDPEELFTLNLQVSRVTRNSQGGKASVLYSENSVTMTRRDLKLGKWLKVNVTTMVEEFCRLPRESLAIVARVQDSSDRIGLVVPHPSSESNHALMPYIEVSLKDNTHKRTRRTVVMDCTESTKEVRCCRYPLVVNFEEFGWDWIIAPKFYNANYCSGECPYSFLQKYPHTHLIHLSSPQGSVGPCCAPRRMTSISMLYFDHNSNIIYGTIPGMVVESCGCS

Description

Acts specifically as a negative regulator of skeletal muscle growth.

Subunit

Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
Homodimer; disulfide-linked.

Similarity

Belongs to the TGF-beta family.

Keywords

Cleavage on pair of basic residues   Cytokine   Disulfide bond   Glycoprotein   Growth factor   Heparin-binding   Secreted   Signal   Complete proteome   Reference proteome   Disease mutation  

Feature

chain  Growth/differentiation factor 8

Uniprot

H9J882   A0A220QT59   A0A0N1INF5   A0A3S2LTJ6   A0A0N1PI39   A0A212EJ50   + More
A0A0L7LJN4   A0A160PBD6   A0A2P8XX66   A0A2J7PJQ9   T1HD40   A0A2K8JWJ5   A0A2P6KNU8   A0A1B6I2N8   A0A087SWE6   A0A2R7X1G0   A0A293MJA7   A0A1Z5L5B6   A0A0A9WQV7   F6K8I2   G9CGV6   Q5ICE6   Q5USV9   A5YU17   Q19BJ5   O18830   Q5USV8   Q6T5B8   G5DE32   F8R0Y9   A0A091NQL3   Q5USW0   Q5USV6   B0G0U6   G9C674   Q5USV7   D3VWC5   A0A146LTT2   A0A093FZY4   A0A2P4SJA6   Q06BS3   O42220   A0A2K6TJS1   A0A091UXG0   F8R0Z1   A0A093QFN0   A0A091E8A7   H0ZKS5   A0A093QUJ5   A0A091KHY6   A0A091QDP6   G8HY01   Q8AVB2   A0A3M0L5X5   A0A3L8SGJ9   A0A218UNU5   A0A091GMQ5   A0A091K9F0   A0A093FDT0   A0A091P474   O42221   A0A093L850   A0A087QXT3   A0A091I502   A0A2I0TSM6   A0A091UKZ6   A0A093FC63   A0A0A0ARZ4   A0A091SSX8   R0KAD8   A0A093IT04   A0A093NQL2   A0A091W2S8   U3JP74   A0A0M4FGG4   A0A226NRZ5   Q8UWD7   A0A1V4K700   G2HE13   A0A1D5QIC1   L5LNU0   Q8UWD8   A0A1U7RCX6   G1KCN0   F8R0Z4   L8HXR9   B5B580   C6KEF7   O18836   Q5RZV4   Q5USW1   D3XQM7   A0A0C5GDU2   A0A2K5S9X7  

Pubmed

19121390    26354079    22118469    26227816    27140602    29403074    + More
28528879    25401762    15522803    16751773    9356471    26823975    15566475    20360741    30282656    24621616    21484476    17431167    22751099    9314496    11451380   

EMBL

BABH01038199    KY328718    ASK12086.1    KQ458565    KPJ05810.1    RSAL01000012    + More
RVE53510.1    KQ459933    KPJ19280.1    AGBW02014530    OWR41509.1    JTDY01000820    KOB75763.1    LC128665    BAU88601.1    PYGN01001216    PSN36596.1    NEVH01024946    PNF16576.1    ACPB03011111    KY031036    ATU82787.1    MWRG01007889    PRD28002.1    GECU01026505    JAS81201.1    KK112252    KFM57185.1    KK856367    PTY25614.1    GFWV01021039    MAA45767.1    GFJQ02004364    JAW02606.1    GBHO01036376    GBHO01036374    JAG07228.1    JAG07230.1    HM559219    AEB33874.1    JF312048    AEV40924.1    AH014549    AAW29941.1    AY629305    EF588017    EF588018    EF588019    EF588020    EF588021    EF588022    EF588023    EF588024    EF588025    EF588026    EF588027    EF588028    EF588029    EF588030    EF588031    EF588032    EF588033    EF588034    EF588035    EF591039    GU183368    GQ246166    HM559220    ABQ58833.1    ABQ81812.1    ACZ58362.1    ADD12957.1    AEB33875.1    DQ530260    MH025940    AM992883    ABF81405.1    AWH13061.1    CAQ52585.1    AF019622    AY629306    AY436347    DQ167575    JN639006    AEP84103.1    HM462259    AEH58031.1    KL389729    KFP91194.1    AY629304    AY629308    EU372977    ABY74330.1    HQ889747    AEV40897.1    AY629307    GQ246167    ADD12958.1    GDHC01008467    JAQ10162.1    KL215154    KFV63470.1    PPHD01043126    POI24194.1    DQ912835    GU075927    ABI96987.1    ACY68209.1    AF019621    AY448007    AF346599    KK406064    KFQ82268.1    HM462261    AEH58033.1    KL672248    KFW85190.1    KK717875    KFO52887.1    ABQF01009979    KL434768    KFW92558.1    KK742157    KFP39103.1    KK697103    KFQ25014.1    JN662463    AEQ61832.1    AF407340    QRBI01000096    RMC18390.1    QUSF01000024    RLW01010.1    MUZQ01000206    OWK55326.1    KL447623    KFO75362.1    KK548179    KFP32981.1    KK623585    KFV52409.1    KK668157    KFQ02777.1    AF019625    KK599757    KFW05411.1    KL225995    KFM06037.1    KL218241    KFP03292.1    KZ507445    PKU36814.1    KL409708    KFQ91321.1    KK387111    KFV51819.1    KL872975    KGL97339.1    KK485172    KFQ61754.1    KB742542    EOB07276.1    KK568482    KFW05855.1    KL224653    KFW62447.1    KK734599    KFR09759.1    AGTO01000456    KR006339    ALC79915.1    AWGT02001246    OXB70676.1    AF440864    LSYS01004331    OPJ80161.1    AK304977    BAK61971.1    JSUE03009315    KB109900    ELK27712.1    AF440863    HM462266    AEH58036.1    JH882948    ELR47832.1    EU926669    EU926670    JN642607    ACG70209.1    ACG70210.1    AEO20321.1    GQ184147    JQ711180    ACS70961.1    AFN44374.1    AF019761    AF019620    AF320998    AB076403    AY160688    AY850105    BC134563    AY794986    AY629303    GU377303    ADC54262.1    KP057613    AJP07997.1   

Proteomes

UP000005204    UP000053268    UP000283053    UP000053240    UP000007151    UP000037510    + More
UP000245037    UP000235965    UP000015103    UP000054359    UP000002356    UP000291000    UP000053875    UP000000539    UP000233220    UP000053258    UP000052976    UP000007754    UP000269221    UP000276834    UP000197619    UP000053760    UP000001645    UP000053286    UP000054308    UP000053283    UP000053858    UP000054081    UP000053605    UP000016665    UP000198419    UP000190648    UP000006718    UP000189706    UP000001646    UP000009136    UP000233040   

PRIDE

H9J882    Q5USW0    Q5USV7    O42220    Q8AVB2    O42221    + More
Q8UWD7    Q8UWD8    Q5USW1   

Pfam

PF00019   TGF_beta        + More
PF00688   TGFb_propeptide

Interpro

IPR001839   TGF-b_C        + More
IPR029034   Cystine-knot_cytokine       
IPR015615   TGF-beta-rel       
IPR017948   TGFb_CS       
IPR009057   Homeobox-like_sf       
IPR001111   TGF-b_propeptide       

SUPFAM

SSF57501   SSF57501        + More
SSF46689   SSF46689       

Gene 3D

2.10.90.10    

ProteinModelPortal

H9J882   A0A220QT59   A0A0N1INF5   A0A3S2LTJ6   A0A0N1PI39   A0A212EJ50   + More
A0A0L7LJN4   A0A160PBD6   A0A2P8XX66   A0A2J7PJQ9   T1HD40   A0A2K8JWJ5   A0A2P6KNU8   A0A1B6I2N8   A0A087SWE6   A0A2R7X1G0   A0A293MJA7   A0A1Z5L5B6   A0A0A9WQV7   F6K8I2   G9CGV6   Q5ICE6   Q5USV9   A5YU17   Q19BJ5   O18830   Q5USV8   Q6T5B8   G5DE32   F8R0Y9   A0A091NQL3   Q5USW0   Q5USV6   B0G0U6   G9C674   Q5USV7   D3VWC5   A0A146LTT2   A0A093FZY4   A0A2P4SJA6   Q06BS3   O42220   A0A2K6TJS1   A0A091UXG0   F8R0Z1   A0A093QFN0   A0A091E8A7   H0ZKS5   A0A093QUJ5   A0A091KHY6   A0A091QDP6   G8HY01   Q8AVB2   A0A3M0L5X5   A0A3L8SGJ9   A0A218UNU5   A0A091GMQ5   A0A091K9F0   A0A093FDT0   A0A091P474   O42221   A0A093L850   A0A087QXT3   A0A091I502   A0A2I0TSM6   A0A091UKZ6   A0A093FC63   A0A0A0ARZ4   A0A091SSX8   R0KAD8   A0A093IT04   A0A093NQL2   A0A091W2S8   U3JP74   A0A0M4FGG4   A0A226NRZ5   Q8UWD7   A0A1V4K700   G2HE13   A0A1D5QIC1   L5LNU0   Q8UWD8   A0A1U7RCX6   G1KCN0   F8R0Z4   L8HXR9   B5B580   C6KEF7   O18836   Q5RZV4   Q5USW1   D3XQM7   A0A0C5GDU2   A0A2K5S9X7  

PDB

5NXS     E-value=2.61383e-54,     Score=535

KEGG

101742737    K05497 growth differentiation factor 8 | (RefSeq) growth/differentiation factor 8

GO

GO:0005576   GO:0008083   GO:0016021   GO:0005615   GO:0042802   GO:0014839   GO:0010592   GO:0010759   GO:0005125   GO:0008201   GO:0048632   GO:0045662   GO:0071549   GO:0046716   GO:0046627   GO:0042803   GO:0007179   GO:0033673   GO:0051898   GO:0005623   GO:0045893   GO:1902725   GO:1902723   GO:0033002   GO:2000818   GO:0009792   GO:0048468   GO:0007519   GO:0005160   GO:0010862   GO:0042981   GO:0060395   GO:0045595   GO:0040008   GO:0043408   GO:0048147   GO:0016020   GO:0006810   GO:0005783   GO:0006816   GO:0000287   GO:0006281   GO:0006259  

PANTHER

PTHR11848  

Subcellular location

Secreted  

Length:

304

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02321

Exp number, first 60 AAs:

0

Total prob of N-in:

0.03451

outside

1  -  304

 

 

Pi

282.905712

Theta

159.306391

Tajima's D

1.431822

CLR

1113.010985

CSRT

0.767461626918654

Interpretation

Uncertain