Gene

KWMTBOMO15948

Pre Gene Modal

BGIBMGA013424

Annotation

hypothetical_protein_KGM_03254_[Danaus_plexippus]

Location

Bomo_Chr27(+):3506691-3507924      View in EpiBrowser

Full name

Rho GTPase-activating protein 190      

Alternative Name

Rho GTPase-activating protein of 190 kDa

Location in the cell

Extracellular   Reliability : 1.114 Nuclear   Reliability : 1.33

CDS

ATGTCGTTGTATGTTTGTAGAGTCGCCGACAACTCGAAACTGAACTCGATGGACAGCAAGAACCTGGCGATATGCTGGTGGCCGACCCTCCTCCCGGTGCAGTTCTCGGACATGGGCAGGTTCGAGATGACGAGGCCCTACCTCGAGGACATCGTCCAGACAATGATCGATCAGCACCCGTTTCTGTTTCGAGGGCAGGAGGCGTTTGTCATGGTGTGA

Protein

MSLYVCRVADNSKLNSMDSKNLAICWWPTLLPVQFSDMGRFEMTRPYLEDIVQTMIDQHPFLFRGQEAFVMV

Description

GTPase-activating protein (GAP) for RhoA/Rho1 that plays an essential role in the stability of dorsal branches of mushroom body (MB) neurons. The MB neurons are the center for olfactory learning and memory. Acts by converting RhoA/Rho1 to an inactive GDP-bound state, leading to repress the RhoA/Rho1-Drok-MRLC signaling pathway thereby maintaining axon branch stability.

Keywords

Alternative splicing   Coiled coil   Complete proteome   Developmental protein   GTPase activation   Phosphoprotein   Reference proteome   Repeat  

Feature

chain  Rho GTPase-activating protein 190
splice variant  In isoform 2.

Uniprot

A0A0N0PCX5   A0A194PVW5   A0A3S2TRZ6   A0A0L7LR77   H9JV61   A0A2A4JSL4   + More
A0A1Y1KQ67   A0A1W4XDQ3   A0A1Y1KQ68   A0A1Y1KTM3   A0A182J7I3   A0A1Y1KVX8   A0A1Y1KSX7   A0A182U865   A0A1S3DII1   A0A139WPB0   A0A139WPM0   D6W848   A0A139WPL6   A0A139WPB3   A0A1B6GH64   A0A1B6IEV2   A0A139WPT7   A0A1B6H8T2   A0A1B6K9C5   A0A1B6LPU4   A0A1B6D9I5   A0A1B6DTL1   A0A1B6C2R3   A0A182HMS3   A0A182PWH5   A0A182K6L6   A0A182N8J0   Q7Q4U2   A0A1B6CUS5   A0A182QWI7   A0A182XYA6   A0A182R261   A0A1J1HUZ3   A0A1J1HT50   W5JMC7   A0A1B0FY42   A0A2M4B8P1   A0A182FJM9   A0A2M4B923   A0A2M4A9K4   A0A182VVF3   A0A182M261   E0VLS6   A0A087ZTU0   A0A2A3EBP9   A0A0L7RBB4   A0A1I8PE60   A0A1I8PE53   A0A1I8PE48   E2C5J7   A0A1I8PE55   A0A1I8PEE1   A0A310SAT8   A0A1Y1KQ63   A0A232EWD7   A0A0T6B326   A0A0Q9WDF1   A0A0Q9WQX0   A0A0Q9WPF4   A0A0Q9WPQ1   B4MAZ2   A0A0Q9WE01   A0A0Q9WNN5   A0A0M3QZ95   A0A0R3NXW7   A0A026WFE0   A0A3B0J7L7   A0A3B0JBC8   A0A0R3P2Z7   A0A0R3P3J5   A0A0R3P485   A0A0R3P3N5   A0A3B0J6L2   B4H9W9   A0A3B0JWS2   A0A0R1EI73   B5DKM2   A0A0Q5TAE3   A0A0Q5T3Z0   M9PJQ3   A0A0R3NY69   A0A0R3NXX8   A0A1B0A2U6   A0A1B0FZZ7   A0A0C5KMR0   B4Q2I7   Q9VX32   A0A0Q5T3R5   A0A0R1EBJ3   A0A1A9URJ8   A0A0Q9XE92   A0A0Q9XSK8   A0A0Q5T6H5   M9PHY4  

Pubmed

26354079    26227816    19121390    28004739    18362917    19820115    + More
12364791    14747013    17210077    25244985    20920257    23761445    20566863    20798317    28648823    17994087    18057021    15632085    24508170    23185243    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    11672527    12537569    17227793    18327897   

EMBL

KQ460448    KPJ14685.1    KQ459590    KPI97467.1    RSAL01000012    RVE53521.1    + More
JTDY01000278    KOB77945.1    BABH01026464    NWSH01000653    PCG75001.1    GEZM01076910    JAV63559.1    GEZM01076914    JAV63552.1    GEZM01076909    JAV63560.1    GEZM01076912    JAV63556.1    GEZM01076915    JAV63551.1    KQ971307    KYB29839.1    KYB29836.1    EFA10998.2    KYB29837.1    KYB29838.1    GECZ01007981    JAS61788.1    GECU01022284    JAS85422.1    KYB29835.1    GECU01036667    JAS71039.1    GEBQ01031930    JAT08047.1    GEBQ01014443    JAT25534.1    GEDC01014951    JAS22347.1    GEDC01008319    JAS28979.1    GEDC01029497    JAS07801.1    APCN01004886    AAAB01008963    EAA12077.5    GEDC01020009    JAS17289.1    AXCN02002019    AXCN02002020    CVRI01000020    CRK91180.1    CRK91181.1    ADMH02000691    ETN65301.1    AJVK01005168    GGFJ01000229    MBW49370.1    GGFJ01000392    MBW49533.1    GGFK01004163    MBW37484.1    AXCM01004922    DS235281    EEB14332.1    KZ288291    PBC29203.1    KQ414617    KOC68212.1    GL452770    EFN76810.1    KQ778189    OAD52014.1    GEZM01076913    GEZM01076911    JAV63553.1    NNAY01001878    OXU22660.1    LJIG01016036    KRT81808.1    CH940655    KRF82668.1    KRF82672.1    KRF82665.1    KRF82669.1    KRF82670.1    KRF82667.1    EDW66401.2    KRF82666.1    KRF82671.1    CP012528    ALC49033.1    CH379063    KRT05922.1    KK107274    EZA53739.1    OUUW01000003    SPP77805.1    SPP77803.1    KRT05925.1    KRT05920.1    KRT05927.1    KRT05926.1    KRT05923.1    SPP77804.1    CH479232    EDW36626.1    SPP77806.1    CM000162    KRK06866.1    EDY72072.1    CH954180    KQS29998.1    KQS30001.1    KQS29997.1    AE014298    AGB95501.1    KRT05924.1    KRT05921.1    CCAG010006727    BT150459    AJP62081.1    EDX02628.1    KRK06860.1    AF387518    AY121666    KQS29994.1    KQS30002.1    KRK06863.1    KRK06864.1    CH933811    KRG06892.1    KRG06899.1    KQS30000.1    AGB95499.1   

Proteomes

UP000053240    UP000053268    UP000283053    UP000037510    UP000005204    UP000218220    + More
UP000192223    UP000075880    UP000075902    UP000079169    UP000007266    UP000075840    UP000075885    UP000075881    UP000075884    UP000007062    UP000075886    UP000076408    UP000075900    UP000183832    UP000000673    UP000092462    UP000069272    UP000075920    UP000075883    UP000009046    UP000005203    UP000242457    UP000053825    UP000095300    UP000008237    UP000215335    UP000008792    UP000092553    UP000001819    UP000053097    UP000268350    UP000008744    UP000002282    UP000008711    UP000000803    UP000092445    UP000092444    UP000078200    UP000009192   

PRIDE

H9JV61    Q9VX32    M9PHY4   

Pfam

PF00620   RhoGAP        + More
PF16512   RhoGAP-FF1
PF00071   Ras

Interpro

IPR008936   Rho_GTPase_activation_prot        + More
IPR000198   RhoGAP_dom       
IPR039007   pG1       
IPR039006   RhoGAP_pG2       
IPR002713   FF_domain       
IPR032835   RhoGAP-FF1       
IPR036517   FF_domain_sf       
IPR027417   P-loop_NTPase       
IPR001806   Small_GTPase       
IPR018247   EF_Hand_1_Ca_BS       

SUPFAM

SSF48350   SSF48350        + More
SSF52540   SSF52540       
SSF81698   SSF81698       

Gene 3D

1.10.555.10     1.10.10.440    

ProteinModelPortal

A0A0N0PCX5   A0A194PVW5   A0A3S2TRZ6   A0A0L7LR77   H9JV61   A0A2A4JSL4   + More
A0A1Y1KQ67   A0A1W4XDQ3   A0A1Y1KQ68   A0A1Y1KTM3   A0A182J7I3   A0A1Y1KVX8   A0A1Y1KSX7   A0A182U865   A0A1S3DII1   A0A139WPB0   A0A139WPM0   D6W848   A0A139WPL6   A0A139WPB3   A0A1B6GH64   A0A1B6IEV2   A0A139WPT7   A0A1B6H8T2   A0A1B6K9C5   A0A1B6LPU4   A0A1B6D9I5   A0A1B6DTL1   A0A1B6C2R3   A0A182HMS3   A0A182PWH5   A0A182K6L6   A0A182N8J0   Q7Q4U2   A0A1B6CUS5   A0A182QWI7   A0A182XYA6   A0A182R261   A0A1J1HUZ3   A0A1J1HT50   W5JMC7   A0A1B0FY42   A0A2M4B8P1   A0A182FJM9   A0A2M4B923   A0A2M4A9K4   A0A182VVF3   A0A182M261   E0VLS6   A0A087ZTU0   A0A2A3EBP9   A0A0L7RBB4   A0A1I8PE60   A0A1I8PE53   A0A1I8PE48   E2C5J7   A0A1I8PE55   A0A1I8PEE1   A0A310SAT8   A0A1Y1KQ63   A0A232EWD7   A0A0T6B326   A0A0Q9WDF1   A0A0Q9WQX0   A0A0Q9WPF4   A0A0Q9WPQ1   B4MAZ2   A0A0Q9WE01   A0A0Q9WNN5   A0A0M3QZ95   A0A0R3NXW7   A0A026WFE0   A0A3B0J7L7   A0A3B0JBC8   A0A0R3P2Z7   A0A0R3P3J5   A0A0R3P485   A0A0R3P3N5   A0A3B0J6L2   B4H9W9   A0A3B0JWS2   A0A0R1EI73   B5DKM2   A0A0Q5TAE3   A0A0Q5T3Z0   M9PJQ3   A0A0R3NY69   A0A0R3NXX8   A0A1B0A2U6   A0A1B0FZZ7   A0A0C5KMR0   B4Q2I7   Q9VX32   A0A0Q5T3R5   A0A0R1EBJ3   A0A1A9URJ8   A0A0Q9XE92   A0A0Q9XSK8   A0A0Q5T6H5   M9PHY4  

PDB

5IRC     E-value=1.05336e-08,     Score=136

KEGG

101742582    K13709 Rho GTPase-activating protein 5 | (RefSeq) rho GTPase-activating protein 190

GO

GO:0007165   GO:0005525   GO:0003924   GO:0045792   GO:0030215   GO:0050770   GO:0005829   GO:0016319   GO:0007415   GO:0007266   GO:0005096   GO:0007264   GO:0006811   GO:0005220   GO:0005783   GO:0006816   GO:0000287   GO:0006281   GO:0006259  

Length:

72

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.29046

Exp number, first 60 AAs:

0.29046

Total prob of N-in:

0.42934

outside

1  -  72

 

 

Pi

291.687347

Theta

203.601477

Tajima's D

1.339455

CLR

0.043805

CSRT

0.747862606869657

Interpretation

Uncertain