SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO15930  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA013416
Annotation
PREDICTED:_filamin-A_isoform_X1_[Papilio_xuthus]
Full name
Filamin-A      
Alternative Name
Actin-binding protein 280
Filamin-1
Filamin1
Location in the cell
Cytoplasmic   Reliability : 2.54
 

Sequence

CDS
ATGGCTTTTATGAGTGGCCTTTGGAATTCCCTCGTTGGCCTCAACGAAAAAGAAGTTTCCTGGCAAGATATAAGCCAGTTCTATTTGGACACGACGAAGAAATATTTCTCTGTATCTGAGGTCGATAAAGAGGAATCGCCAACAGTTTACGCAGAGACACACAAAATATCCTTCAACAAAAGCGCTTTTGGATACACGTTCACTCCACTCAACTTTGTGACGATCTATCACATTGATTCCAGAAAAGCCGAAGTAAAGATGCCCAGCGGCCACATTGACCAGCCCGTCATTGAAGATAACCGCGATGGTACCGTCAGCATCAAATACGACCCTCGCGAGGAAGGCGTTCACGAGCTCTACGTCAAATATAACGGAGAACACGTTCAAGGCTCCCCGTACAAGTTCCACGTGGACTCCATTTCCTCGGGCTACGTAACCGCCTACGGTCCCGGTCTGATCAATGGCGTTAGTGGAGAGCCGAGCCAGTTCACCATCAGCACGAAGGGCGCCGGTGCCGGTGGACTGTCTATGGCCGTTGAGGGTCCTAGCAAAGCTGAGATAACTTGCCACGACAACAAGGATGGCACCGTCTCCGTGTCCTATCTGCCCACCGCTCCTGGGGAATACAAGATCTCGGTCAGGTTCGGCGACAAACACATCAAGGGTTCACCGTTCGTGGCCAAGGTGACCGGCGAGGGCCGAAAGAGGAATCAAATCTCTGTCGGGAGCTGCAGCGAGGTCACACTACCCGGTAAAGTCAATGACGATGACATTCGCAGTCTCAACGCTTCCATCCAGGCTCCTTCCGGCCTTGAGGAGCCGTGCTTCCTCAAACGGTTGCCGTCTGGGAACATCGGCATCAGCTTCACTCCTCGCGAGGCCGGCCAGCACATCGTCTCCGTCAAGAAAATGGGCGTCCACATTCAGAACTCTCCTTTCAACATCACCGTCCACGAGCAAGAAGTCGGTGACGCTAAGAAAGTTAAGGTCTCCGGAACCGCTCTGAAGGAAGGCAAGACTCAGTGCGAGAACACGTTCTCCGTGGACACCAGGAACGCTGGCTACGGCGGTCTCTCTCTCTCCATCGAAGGTCCCAGTAAAGCGGAAATCCAGTGCGCTGACAGCAAGGATGGCGTGCTGGCGATCAGCTACAAGCCCACAGAGCCGGGATACTACATCGTCAACCTTAAATTCGCTGATCACCATGTCGAGGGATCTCCCTTCACCGTCAAGGTGACCGGTGAAGGCAGCAACAGACAGCGCGAGAAGATTCAGAGGCATCGCGACTCTGCCCCCCTCACCGAAGTGGGCACCAACTGCAAGCTGACCTTCAAAATGCCTGGTATCACATCATTCGACCTGGCCGCCACCGTGACCAGCCCTGGGGGAGTCTCCGAAGACGCTGAAATCCAGGAGGTCGAAGACGGCCTGTACTCCGTCCACTTCGTGCCCAAGGAACTCGGCGTTCACACCGTCTCTGTAAAATACAGGGAAATCCATATTCCCGGATCTCCGTTCCAGTTTACCGTGGGTCCTCTACGGGACTCCGGTGCTCACTTGGTGAAGGCCGGCGGTGGAGGTCTGGAGCGAGGAGAAGCTGGCAGATTCAATGAGTTCAACGTTTGGACCCGTGAGGCTGGCGCCGGACAGCTGGCCATCTCCCTGGAGGGGCCCAGCAAGGCCGAGATCGACTTCAAGGACAGGAAGGACGGATCCTGCGACGTGTCCTACAAGGTCGACGAACCTGGCGAATACCGTATTGGTTTGAAGTTCAACGAGCAGCACATCCCTGATTCGCCCTTCAAGGTCTACATCTCGCCGGCCGCCGGAGACGCTTATCTCCTCGAAGTGGCCCAGTTCCCGGACTCGGCTCAAGTGGATAAGCCAACCCAGTTTTACATTAGGATGAACGGCGCCAAGGGCAACCTGAACGGGACGGTCATTTCGCCATCGGGCAAGACCGACGATTGCTTCATCCAGAACATCGATGGCGACCAGTACTCGGTGAGGTTCATGCCAAGGGAGAACGGAGTCCACAACATCAACGTGAAGTTCAACGGCGTTCACATACCTGCTTCGCCTTTGAGGATTAAGGTCGGCAAGGATGACGCTGATCCGGCTGCGGTTCACGCTCACGGACCCGGTCTGGGAACAGTCAAAACTGGTGCCAAAACTGACCTTATTATTGACACCTGTAACGCTGGAGCTGGCATCCTCGCCGTCACCGTGGACGGACCTTCCAGAGTCTCCATGGACTGCACCGAAGTCGAAGAGGGTTATAAGGTCCGCTACACTCCTCTATCTCCAGGCTTCTATTACATGAGCATCAAGTATAACGGAGCTCACATCGTCGGATCTCCCTTCAAAATCGAAGCTACTGGTGGTAATCTGGCTGAGATCGGTGCCCAGGAGACCTCGTCGGTGACAGTCGAAACCGTCCAAAAGGTGTCGAAGGCTGCCCAGAAGCAGGGTCCGGTGTTACCGCACTTCAAGTCCGACGCCACCAAGGTCACGAGCAAGGGAATGGGCCTGAAGAAGGCCTACCTCAACAAGCACAATCAGTTTACAGTTCACGCCGGAGACGCTGGTACCAATATCCTGTACGTCGGCATCTACGGACCCAAAGGTCCTTGCGACGAAGTCCAGTTGAAGCACAAGGGCAAGAACAACTACGAGTGCTGGTACGTCGTCAGAGACAGGGGAGACTACATTGTGATCGTGAAGTGGGGGGATGACCACATTCCCGGATCCCCTTACAAAGTTGAGGTTTAA
Protein
MAFMSGLWNSLVGLNEKEVSWQDISQFYLDTTKKYFSVSEVDKEESPTVYAETHKISFNKSAFGYTFTPLNFVTIYHIDSRKAEVKMPSGHIDQPVIEDNRDGTVSIKYDPREEGVHELYVKYNGEHVQGSPYKFHVDSISSGYVTAYGPGLINGVSGEPSQFTISTKGAGAGGLSMAVEGPSKAEITCHDNKDGTVSVSYLPTAPGEYKISVRFGDKHIKGSPFVAKVTGEGRKRNQISVGSCSEVTLPGKVNDDDIRSLNASIQAPSGLEEPCFLKRLPSGNIGISFTPREAGQHIVSVKKMGVHIQNSPFNITVHEQEVGDAKKVKVSGTALKEGKTQCENTFSVDTRNAGYGGLSLSIEGPSKAEIQCADSKDGVLAISYKPTEPGYYIVNLKFADHHVEGSPFTVKVTGEGSNRQREKIQRHRDSAPLTEVGTNCKLTFKMPGITSFDLAATVTSPGGVSEDAEIQEVEDGLYSVHFVPKELGVHTVSVKYREIHIPGSPFQFTVGPLRDSGAHLVKAGGGGLERGEAGRFNEFNVWTREAGAGQLAISLEGPSKAEIDFKDRKDGSCDVSYKVDEPGEYRIGLKFNEQHIPDSPFKVYISPAAGDAYLLEVAQFPDSAQVDKPTQFYIRMNGAKGNLNGTVISPSGKTDDCFIQNIDGDQYSVRFMPRENGVHNINVKFNGVHIPASPLRIKVGKDDADPAAVHAHGPGLGTVKTGAKTDLIIDTCNAGAGILAVTVDGPSRVSMDCTEVEEGYKVRYTPLSPGFYYMSIKYNGAHIVGSPFKIEATGGNLAEIGAQETSSVTVETVQKVSKAAQKQGPVLPHFKSDATKVTSKGMGLKKAYLNKHNQFTVHAGDAGTNILYVGIYGPKGPCDEVQLKHKGKNNYECWYVVRDRGDYIVIVKWGDDHIPGSPYKVEV

Summary

Description
Involved in the germline ring canal formation. May tether actin microfilament within the ovarian ring canal to the cell membrane. Contributes to actin microfilaments organization.
Subunit
Interacts with Ten-m.
Similarity
Belongs to the filamin family.
Keywords
Actin-binding   Alternative splicing   Cell membrane   Complete proteome   Cytoplasm   Cytoskeleton   Membrane   Reference proteome   Repeat  
Feature
chain  Filamin-A
splice variant  In isoform 2.
EMBL
NWSH01002475    PCG68223.1    KQ459572    KPI99576.1    RSAL01000085    RVE48358.1    + More
JXUM01021857    JXUM01021858    JXUM01034814    KQ561037    KQ560613    KXJ79937.1    KXJ81622.1    AXCM01000316    AXCN02001182    AAAB01008898    DS231831    EDS31280.1    GL447043    EFN86968.1    LJIG01016074    KRT81692.1    AJWK01015716    APGK01047281    APGK01047282    KB741077    ENN74328.1    GFDF01000123    JAV13961.1    NEVH01002143    PNF42561.1    KQ971307    EFA11221.2    EGK97146.1    GGFL01001599    MBW65777.1    KYB29723.1    GGFJ01000071    MBW49212.1    GGFJ01000041    MBW49182.1    GGFL01016221    MBW80399.1    GGFK01000748    MBW34069.1    GGFK01000859    MBW34180.1    GEDC01027918    JAS09380.1    KB632432    ERL95534.1    EAA09206.6    GEZM01103001    JAV51630.1    GEZM01103002    JAV51629.1    ADMH02001534    ETN62143.1    EGK97147.1    KK107182    EZA55995.1    APCN01005778    AAZX01000594    GFDL01016019    JAV19026.1    GFDL01016020    JAV19025.1    GFDL01016016    JAV19029.1    GFDL01016017    JAV19028.1    GFDL01003692    JAV31353.1    GFDL01007489    JAV27556.1    GFDL01003690    JAV31355.1    GFDL01016018    JAV19027.1    GFDL01003691    JAV31354.1    CH933806    KRG01192.1    GFDL01003689    JAV31356.1    BT099681    ACV44467.1    AE014297    BT133034    ACL83525.1    AEX93120.1    CH940652    KRF78716.1    PCG68224.1    CH902617    KPU79595.1    CM000160    KRK03447.1    KQ976691    KYM77983.1    CH964232    KRF99510.1    ADTU01023670    ADTU01023671    ADTU01023672    ADTU01023673    GL437497    EFN70346.1    KQ981965    KYN31786.1    KQ979608    KYN20409.1    KQ982944    KYQ48951.1    KQ759918    OAD61981.1    KQ977574    KYN01827.1    GEDC01018034    JAS19264.1    QOIP01000003    RLU25083.1    AAN13735.2    BT099680    ACV44466.1    KRK03449.1    CP012526    ALC46484.1    GFXV01001327    MBW13132.1    GEDC01004756    JAS32542.1    LJIJ01000129    ODN02004.1    CM000070    KRS99791.1    JRES01001300    KNC23810.1    KRG01193.1    AY094964    AAM11317.1    BT024206    ABC86268.1    AH010162    AF183179    AF183180    AF183181    AAG43431.1    AF188360    AF188361    AF174492    AF183182    KRF78719.1    KRF78720.1    KRG01197.1    KQ435711    KOX79459.1    KRG01195.1    KRG01196.1   
Pfam
PF00630   Filamin        + More
PF00307   CH
Interpro
IPR014756   Ig_E-set        + More
IPR017868   Filamin/ABP280_repeat-like       
IPR001298   Filamin/ABP280_rpt       
IPR013783   Ig-like_fold       
IPR036872   CH_dom_sf       
IPR001589   Actinin_actin-bd_CS       
IPR001715   CH-domain       
IPR029874   FLNB       
SUPFAM
SSF81296   SSF81296        + More
SSF47576   SSF47576       
Gene 3D
PDB
2J3S     E-value=4.51874e-85,     Score=805

Ontologies

Topology

Subcellular location
Cytoplasm  
Cytoskeleton  
Cell membrane  
Length:
923
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.14226
Exp number, first 60 AAs:
0.0131
Total prob of N-in:
0.00697
outside
1  -  923
 
 

Population Genetic Test Statistics

Pi
207.599042
Theta
151.22395
Tajima's D
1.18286
CLR
0.302516
CSRT
0.708214589270536
Interpretation
Uncertain
Peptides ×
Source Sequence Identity Evalue
28467696 AEISDVANAIIDGADCVMISGETAK 96.15 2e-11
28467696 MPRPPPPTMPESMR 100.00 1e-08
28467696 VGIVSPGVPMEIVINK 95.45 1e-07
26822097 AVFVDIEPTVVDEVR 100.00 2e-06
28467696 TDAGCEEIVR 100.00 2e-06
28556443 EIHIPGSPFQFTVGPLR 100.00 9e-06
28556443 YNGEHVQGSPYK 100.00 9e-06
28556443 EAGAGQLAISLEGPSK 100.00 9e-06
28556443 EIHIPGSPFQFTVGPLR 100.00 0.001
28556443 GAGAGGLSMAVEGPSK 100.00 0.001
28467696 FADGIAEIGIAPIDPVQIGTVEVNNPAIK 100.00 0.003
28556443 DSAPLTEVGTNCK 100.00 0.005
28556443 EIHIPGSPFQFTVGPLR 100.00 0.008
25044914 WGAQAFDNMIIVPPGSGIVHQVNIEYIAR 100.00 0.014
28556443 SGSIPCDFVADILR 100.00 0.028
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