Silkworm Genome Informatics Database

Gene

KWMTBOMO15918

Pre Gene Modal

BGIBMGA013392

Annotation

PREDICTED:_inositol_1?4?5-trisphosphate_receptor_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr27(-):2049824-2122249 View in EpiBrowser

Full name

Inositol 1,4,5-trisphosphate receptor + More
Inositol 1,4,5-trisphosphate receptor type 2

Alternative Name

InsP3 receptor
IP3 receptor isoform 2
Type 2 inositol 1,4,5-trisphosphate receptor

Location in the cell

Nuclear Reliability : 2.099

CDS

ATGGGTGTCGTTGCATGGTGGGGGAGAGGAGAAGGCAAGAGGATGGGGGACAGCTTCTTGCACCTGGGGGACATTGTCTCCCTCTACGCGGAAGGGACTGTTGCGGGATTCCTCAGTACTTTAGGGTTGGTAGATGACAGGTGCGTGGTCTGTCCAGAGGCTGGCGACCTGACTGATCCACCCAAAAAGTTCCGAGATTGCCTGTTCAAAATATGTCCCATGAACCGGTACTCGGCTCAAAAGCAGTTCTGGAATACGGCCAAGCAGTCTGCGAACCCTAACGCGGACACCGGACTGCTGAAGAGGTTACACCATGCCGCTGAGATCGAGAAGAAGCAGAACGATTTGGAGAATAAGAAACTTCTGGGGACTGTCGTGCAGTACGGCAGCGTCATACAGCTGCTGCACGTCAAGTCTAACAAGTATCTTACGGTAAATAAGCGACTACCCGCATTGCTCGAGAAGAACGCGATGCGGGTTCATTTGGACGCTAACGGAAATGAGGGCTCCTGGTTTTACGTAATGCCTTTCTACAAATTGCGGTCGACTGGGGACAATGTGGTGGTCGGTGATAAAGTGATAATGAACCCGGTGAATGCGGGACAGCAAGTGTTGCACGTCTCTTCCAACCACGAGCTTCCGGACAACGCCGGCTGTATGGAGGTGAATGTAGTCAATTCCTCCACATCCTGGAAAGTCACCTTATTTCTCGAGCACAAAGAGAACCAGGAGGAGATATTGAAAGGTGGCGACGTGGTGAGGCTGTTCCATGCAGAGCAAGAGAAGTTCCTCACTATGGACGAGTACCAGAAACGGCAGCACGTGTTCCTGAGGACCACGGGTCGATCCAGCGCCACCGCCGCGACCAGCAGCAAAGCGCTGTGGGAGATTGAGGTGGTGCAGCACGACCCGTGCCGCGGCGGCGCTGGACACTGGAACTCCATCTTCAGGTTCAAGCACCTCGCCACCGGACACTACCTGGCGGCCGAGGCGTGCAACCGCCCACACGACGGGCCACTAGAAGCGGGCGAGCCGGCCTACCAGCTGGTCCCTGTCCCGCATTCATCGGAGATCGCAACACTTTTCGAACTGGACCCGACCACGATGACGCACTCTGACGCCCCCGTGCCGCAGAGTAGTTACGTTAGATTACAACATTTATGCACGCACACATGGGTCCACTCAACGTCGATACCAATTGACAAAGATGAAGAAAAACCGGTTATGTCAAAGGTGGGGTGCTCGTTGGTGAAAGAAGATAAGGAAGCGTTCGCCCTGATATCCGTGTCGCCGAGCGAGGTCCGGGATCTGGATTTCGCCAACGACGCCTGCAAGGTCCTCTCTGCGCTCTCCACCAAACTGCAGCAGGGCACCATAGAACCTAACGAGAGAAAAGCACTGACATGTCTGCTTCAGGACATAGTGTATTTCATAGCGGGCTTCGAAAACGAACCGAATAAGTCTGAAGCCTTGGACCTGGTCGTCGAGAACCCGCACAGAGACAGACAGAAGCTATTACGCGAACAATACATACTGAGACAGCTGTTCAAAATATTACAGGGTCCGTTCCAAGAGCCAGCCGACGGGGAGCCTTTCCTCAAGATCGAGGAGTTGAACGACACGCGCTACGCTCCATACAAGAACATCTTCCGGCTCTGCTACAGGATCCTGAGGCTCAGTCAGCAGGACTACAGGAAGAACCAGGAGTACATAGCGAAGCACTTCGGGTTCATGCAGAAGCAGATAGGGTACGACATCCTGGCTGAGGACACGATCACCGCCCTGTTGCACAACAATAGGAAGCTTCTGGAGAAACACATCACAGCATCCGAAATCGAGACCTTCGTAGGTCTCGTCCGGAAGAACATGCGCACCTGGCAGTCCCGGTTCCTGGACTACCTGAGCGACCTGTGCATCTCCAACAAGAAGGCTATTGCCGTCACGCAGGAGCTCATCTGCAAGAGCGTGCTCTGCGCCAACAACTCCGACATACTCATCGAGACCAGGCTGGTATCCATTAAATATAAAGAAAAAGGAAAGATGTCGGACCCCGATGAATCCAAGTGCAGCGTGGAGCAGAGAGTCATGCTGTTCTGGAACAACAAAAAGAATCAAAGATACCTGACGGACCTCGCGGCCGAGGCTCGCCTGGACCCCAACAGCGAGGCCGCCGCCATCCTGGACTACTATCGGCACCAGCTCGACCTGTTCTCGAACATGTGTCTCAACAGACAATACCTGGCGCTCAACACGCTGTCCCCACAGCTCCACATCGACCTCATATTGTTGTGCATGTCGAACTCGTCTCTGTCGTACGAGGTGCGCGCGTCGTTCTGCCGGCTGATGCTGCACCTGCACGCCGACCGCGACCCGCAGGAGCCGGTCACGCCCGTCAAGTACGCGCGCCTCTGGACCGAGGTCATCGACCGCATACACATCCACGATTACCAATGCGTGAAGGGGGGCCCGGACGCGAACAGAGAGAAGGTAAAGGAACAGTTCGCTCGCACGATACGTTTCGTCGAGAAGTACCTCTGCAACGTGGTCAGCAGGACCTGGTACTTCAGTGACCACGACCAGAACAAGTTGACCTTCGAAGTGGTAAAACTCGCCCGGGAACTCATTTACTTCGGATTTTACAGCTTCAGCGACCTACTCCGTTTGACGAAGACTCTGCTCAGCATCCTGGACTGCGTCACCGCCATGGATCTGCTCAACGAGACCAACGCTCTGTCCGGGGAGGTCGAATCCGAGGGCGGTGTACTCAGGAGCATAGGTGACATGGGAGCCGTTATGACTTCGATAACACTCGGATCTGTCGCTAGAAACCAAGTAGGAGGTACCGCGACAACCCCGGGAACGGGCACCGGGCTGCAGAGAAGCGCCTCCGCCCTGATGCTGGCCAGGGAACATCCCCTAGTCATGGACACGAAGCTCAAGATCATTGAGATATTGCAGTTCATCCTCGATGTAAGACTTGACTACCGCATCAGCTGTCTGCTGTCCATCTTCAAGAAGGAGTTCGAGCAGGCCGGGGATCAGCGTGCCGCCGACTCCCTGGGCCGGGCCGACGTGGAGGCCATAGGGCTGCAGGCCGAGGGCATCTTCAGCTGCCGGGACGGCTTAGACCTAGACGAATGCGGGGGACGCATGGTGTTACGCGTCCTCCTGCAGCTGTGCTCGCAGGGAGCCTCGGCGGCGCTCGTCTCCGGAGCCCTAGCGCTCCTGTTCCGACACTTCAGCCAAAGGCAGGAGGTTTTAGCTGCTTTCAAACAGGTCCAGCTCCTGGTTTCTGACGCTGATGTGGAATCGTACAAACAGATCAAAGCGGACTTGGACTTACTGCGGCAGAGCGTTGAGAAGTCCGAGCTCTGGGTCTTTAATAAGGGACGAGCTGTCTTACTCGATGAACTTGCCGGTGTGTGCCGCGCTTATGTTACCTTCTGCGTGTGTCCGTCGGGCGCGGTGGGGCCGGGCGGGGCGGTGCTCGAGCGTAACGCGTCGCTCGACAACGTTCTGGACACTTCGAGAACAGCCAAACACGACCACAACGAATATAAGAAGATTAAAGAGATCCTACAGCGCATGATCAAGTACTGCACGCACGGCAACAGCGGCGCCGGCGACTGCGGCCGCCCGCGCCGCCACGAGCAGCGCCTGCTGCGCAACATCGGCGTGCACAACATCGTGCTGGACTTGCTGCAGGTGCCGCACGACGAGGACGACGCAGCTATGGACGAGCTGCTGTCGCTAGCTCACGAGTTCCTCCAGCACTTCTGCCACGGAAACCAGCAGAACCAGACGATCCTCCACAAACATCTCGACTTGTTCCTCAACGCGGGAATCCGAGAGGCGCAGACGGTCTGCGCGATCTTCAAGGACAACGCGTCGCTGTGCGGGCACGAGGGCAACGAGAAGGTGGTGGCGCACTTCGTGCACTGCGTGGAGTCCCGCGGCAGGAAGCCCGACTACCTGCGCTTCCTGCAGACCATCGTCCACGCCGACAAGCAGTACATACGGAAGAGCCAGGACTTGGTCATGCAAGAGATGGTGAACGCCGGCGAGGATGTCTTGGTCTTCTACAATGACAAAGTTTCGTTCAATTACTTCATACAGATGATGAAACAGTACAAAGAGAAAGGGGAAATGCCCGAAGCTCTTACATACCACATCCAGCTCGTGAAGCTGCTGACGTGCTGCACTATGGGGAAGAACGTGTACACGGAGATCAAGTGCCACTCGCTGCTGCCGCTGGACGACATCGTGTCCGCCATCACCAACCCGCACTGCATCCCCGAGGTGAAAGAAGCGTACGTGGGCTTCCTGAACCACTGCTACATCGACACGGAGGTGGAGATGAAGGAGATCTACAGCAGCAACTACATGTGGGACCTGTTCGAGCGCTCCTTCCTCCAGGACATGCACGCCATCCTGCAGAGCGGCGCCGCCTGGTCGGACGTGCCGTCGTCGTCGCACAAGCCGTCCACCACCAGCACGCACCGCGCCTGGGTCAACTACGTCACCGACGTGCTCATGCACACCATATGCACGTTCTTCAACTCGCCCTTCAGCGACCAAAGCACAACCGTGCAGACCCGTCAGTCGATCTTCGTGAAGCTACTCCAGACGACGTTCAGTATATACCAGTGTCCGTGGCTCACGCCGCCGCAGAAGCTGAACGTGGAGAAGTGTATACGGACGCTCAGCGAGGTCGCGAAATCTCGCAGTATCGCGATCCCGCTGGAGCTCGAGGCTAAAATACAGACCGTGTTCGAGAAGGCTGCCGCGCTGTCCCGCCAGACCAGCAAGTGGCTGCAGGCCTCGAAGACTTCGAAACTTGAGAAGATGGCTTCGCAGTTGAACTTGCAGAACGATAGGTCGGTGATGGAGGGTCTACAGGAGATCGTGTCCCTACTGGAGGAACAGCTCCGGCCGCTGCTGCAGGCGGAGCAGTCGCTCCTGGTGGACATCCTGTACAAGCCGCACCTCCTGTTCACCAGCCCCGCCCAGCCCGACGCCAGCGGGATCTTTATATCACGATTAATACGTCACACCGAGAAGCTTCTAGAAGAAAAAGAAGAAAAACTGTGCGTGAAAGTCTTACGCACGTTGAGAGAGATGATGGCCGTGGACCCGGAATATGGCGAGAAGGGCAACCAACTGAGGAACAAGTTGCTGTCTCAATATTTCGTGAACCGCAAGTCCGAGCCGAAGGTGCAGCCCCCGCCGCCCCCCGCCCCCGCCACGCACGGGCCCGGCGCTAAAGTCTTGATGCGGACCGGCCAAACTCTGGCGCAAGTCCAAGCACACCTGGACAAGGAAGGCGCCTCTGACCTGGTCGTGGACCTCGTCATCAAAAGCACCAACCGCCCCGCCATATTCCTTGAGGCCATACAGCTGGGAATCGCTCTTCTAGAAGGGGGCAACCCTATAATACAGCAAAGCATTTACACTAAACTACAAAACGGAGAAATATCTCAAGCATTTTTGAAGGTGTTCTATGATAAAATGCGTGAAGCACAACAAGAGATCAGGTCGCTCGCGGCCAGCAGCACCACCGCCGCCGGCGCCGACAAGCAGCGGGCCCCGCACGCGGACGCCAAGAAGCCGCTTGAAAACGGGGTGAAGTCGAGTCCGGGGCCGCTGGTGGTGGGCGAGGAGATGGATGAGGAGGTGAACAGCGCGTGCGGCACCGCGGTGCACGCCTACTCCGACGTGCACACCATATCGCACGGTAGCACGGCGCTGGAAGAGATCATGTGCGAAAAGAAGCGGGAGTCCAGCAACTCGGACGTGCTGCCCCCCAAGGTGGCCGTCATGAAGCCCATACTCCGCTTCCTCCAGCTCTTGTGTGAAAACCACAACCCTGATCTACAGAACCTACTAAGAAACCAAAACAACAAATCGAACTACAACCTCGTGTCGGAGACGTTGATGTTCTTGGACTGCATCTGCGGCTCTACGACCGGCGGCCTCGGACTCCTCGGACTCTACATCAACGAGGGGAACGTCTCCCTTATCAACCAGACGTTGGAAACTCTTACTGAATACTGTCAAGGACCGTGTCACGAAAACCAGAATTGCATAGCGACGCACGAGAGCAACGGGCTGGACATCATCACGGCCCTGATCCTGAACGACATCAACCCGCTCGGCCGGACGCGCATGGACCTCGTGCTGGAGCTCAAGAACAACGCGTCCAAGCTGCTGCTCGCCATCATGGAGTCCAGGAACGACTCCGAGAACAACGCCGAGCGGATACTGTACAATATGAACCCCAAACAGCTGGTTGATGTTGCGTGCTCAGCCTTCCACCAGGAGCACGGCGCGGACTCGGACTCGGAGAGCGAGGACGACGCGCCCGTGCAGGCCGTCTCCCCCAAGGAAGTGGGCCACAACATCTACATACTGTGCCACCAGCTGGCGGCGCACAACAAGGAGCTGGCGGCGCTGGTGCGAGCCTCGCCCGCCGGCCCGCACGCGCTCGCGCTGCAGTACTACCGGACTCACACGGCGCAGATCGAGATCGTCCGCACGGACAGGAGCATGGAGCAGATCGTGTTCCCGATCCCGGAGATGTGCGAGTACCTGCCGGCCGACAGTAAGCACAGGGTGCTGCAGAGCGCCGAGCGCGACGACCAGGGCAGCAAGGTCGCGGACTTCTTCGCGAGGCTCGACCACCTCTTCCACGAAATGAAGTGGCAGAAGAAATTACGAGGACAACCTCTTCTGTTCTGGGTTTCATCTTACATGTCGCTGTGGAGTAACATATTGTTCAACTTCGCCGTTCTGATCAACGTCATCGTGGCCTTCTTCTACCCGTTTTCAGACGAGAACCCTCGTCTGGGCCAGCACGTGTCGCTGGCGGTGTGGGCGGCGAGTGGCGCGGCGGGCGCGCTGGTGGCGTGGGTGCCGCGGGGCGCGGGGGTGCGCGCGCTGCTCGCCTGCGCCATAGTGCGCGTGCTCTGCTCCGCCGGCCCCGAACCCACGCTCTGGGCGTTGGCTATGCTCACGATAATAGTAAAAGGTATCCATCTAGTCAGCATAATGGGTAACCAGGGTACGCTGTCCAAGTCGACGCGCAACGTCCTCACCGACCCTGAGCTCCTCTACCACACCGTCTACTTGTTGTTCTGCTTTCTCGGGATATGCTGCCACCCGTTCTTCTTTTCTGTCCTATTGCTGGACATCGTGTACCGAGAAGAGACGCTGCTTAACGTGATGCGGTCAGTGACTCGCAACGGGCGGTCCATCCTCCTGACGGCCGTGCTGGCGCTTGTCCTGGTCTACATGTTCTCCATCGTAGGCTACATGTTCTTCAGAGACCACTTCCTGGTCAACGTCGATCGGTTGGACGACGACGACGACCCCCGCTTCGAGGCCGACAGCTGCGGGCGCGACCCCGCCGACAAGTACCGAGGGGCGGGCGGGTGCCGCGCGGCGCCGCGCCTGGTGTTGGTGGGGGGCGAGCTGCGGGAGCGGAGCTGCGACTCGCTGCTCATGTGCATCGTCACCACGCTCAACCAGGGCCTGCGCAACGGGGGAGGCATCGGGGACATCCTGCGGGCGCCGGCCAGCTTCGAGCCGCTGTTCGTGGCGCGCGTGGTGTACGACCTGTTGTTCTTCTTCGTGGTGATCATCATAGTTCTCAACTTGATATTCGGCGTGATCATCGACACGTTCGCGGACCTGCGTAGCGAGAAGCAGCAAAAGGAATTAATACTTAAGAGCACCTGTTTTATATGTGGGTTGAACAGGTCAGCCTTTGACAATAAGACAGTGTCCTTCGAGGAACATATAAAGAGTGAGCATAACATGTGGCACTACCTGTACTTCATGGTGCTCGTGAGGGTCAAGGACCCCACAGAGTTCACCGGCCCCGAGAGTTACGTGCACTCTATGATAAAGTCCAACAACTTGGACTGGTTTCCGAGACTGCGGGCGCTGTCCCTGATGGGCGGCGTCGAGGGCGAGGGTGGGGAGCTGGAGCTGCGCGCGCTGCAGGCCCAGCTGGACCGCGCGCACCGCGCCGTGGCCACGCTCACCGAACTGCTCACCGACCTCAGGGACCAGATGACCGAGCAGCGGAAACAAAAGCAACGCATCGGCTTACTGAACTCGACCTCGGCGTACCTCCAGAACTTGCAATTGAACCTGCCACCGTGA

Protein

MGVVAWWGRGEGKRMGDSFLHLGDIVSLYAEGTVAGFLSTLGLVDDRCVVCPEAGDLTDPPKKFRDCLFKICPMNRYSAQKQFWNTAKQSANPNADTGLLKRLHHAAEIEKKQNDLENKKLLGTVVQYGSVIQLLHVKSNKYLTVNKRLPALLEKNAMRVHLDANGNEGSWFYVMPFYKLRSTGDNVVVGDKVIMNPVNAGQQVLHVSSNHELPDNAGCMEVNVVNSSTSWKVTLFLEHKENQEEILKGGDVVRLFHAEQEKFLTMDEYQKRQHVFLRTTGRSSATAATSSKALWEIEVVQHDPCRGGAGHWNSIFRFKHLATGHYLAAEACNRPHDGPLEAGEPAYQLVPVPHSSEIATLFELDPTTMTHSDAPVPQSSYVRLQHLCTHTWVHSTSIPIDKDEEKPVMSKVGCSLVKEDKEAFALISVSPSEVRDLDFANDACKVLSALSTKLQQGTIEPNERKALTCLLQDIVYFIAGFENEPNKSEALDLVVENPHRDRQKLLREQYILRQLFKILQGPFQEPADGEPFLKIEELNDTRYAPYKNIFRLCYRILRLSQQDYRKNQEYIAKHFGFMQKQIGYDILAEDTITALLHNNRKLLEKHITASEIETFVGLVRKNMRTWQSRFLDYLSDLCISNKKAIAVTQELICKSVLCANNSDILIETRLVSIKYKEKGKMSDPDESKCSVEQRVMLFWNNKKNQRYLTDLAAEARLDPNSEAAAILDYYRHQLDLFSNMCLNRQYLALNTLSPQLHIDLILLCMSNSSLSYEVRASFCRLMLHLHADRDPQEPVTPVKYARLWTEVIDRIHIHDYQCVKGGPDANREKVKEQFARTIRFVEKYLCNVVSRTWYFSDHDQNKLTFEVVKLARELIYFGFYSFSDLLRLTKTLLSILDCVTAMDLLNETNALSGEVESEGGVLRSIGDMGAVMTSITLGSVARNQVGGTATTPGTGTGLQRSASALMLAREHPLVMDTKLKIIEILQFILDVRLDYRISCLLSIFKKEFEQAGDQRAADSLGRADVEAIGLQAEGIFSCRDGLDLDECGGRMVLRVLLQLCSQGASAALVSGALALLFRHFSQRQEVLAAFKQVQLLVSDADVESYKQIKADLDLLRQSVEKSELWVFNKGRAVLLDELAGVCRAYVTFCVCPSGAVGPGGAVLERNASLDNVLDTSRTAKHDHNEYKKIKEILQRMIKYCTHGNSGAGDCGRPRRHEQRLLRNIGVHNIVLDLLQVPHDEDDAAMDELLSLAHEFLQHFCHGNQQNQTILHKHLDLFLNAGIREAQTVCAIFKDNASLCGHEGNEKVVAHFVHCVESRGRKPDYLRFLQTIVHADKQYIRKSQDLVMQEMVNAGEDVLVFYNDKVSFNYFIQMMKQYKEKGEMPEALTYHIQLVKLLTCCTMGKNVYTEIKCHSLLPLDDIVSAITNPHCIPEVKEAYVGFLNHCYIDTEVEMKEIYSSNYMWDLFERSFLQDMHAILQSGAAWSDVPSSSHKPSTTSTHRAWVNYVTDVLMHTICTFFNSPFSDQSTTVQTRQSIFVKLLQTTFSIYQCPWLTPPQKLNVEKCIRTLSEVAKSRSIAIPLELEAKIQTVFEKAAALSRQTSKWLQASKTSKLEKMASQLNLQNDRSVMEGLQEIVSLLEEQLRPLLQAEQSLLVDILYKPHLLFTSPAQPDASGIFISRLIRHTEKLLEEKEEKLCVKVLRTLREMMAVDPEYGEKGNQLRNKLLSQYFVNRKSEPKVQPPPPPAPATHGPGAKVLMRTGQTLAQVQAHLDKEGASDLVVDLVIKSTNRPAIFLEAIQLGIALLEGGNPIIQQSIYTKLQNGEISQAFLKVFYDKMREAQQEIRSLAASSTTAAGADKQRAPHADAKKPLENGVKSSPGPLVVGEEMDEEVNSACGTAVHAYSDVHTISHGSTALEEIMCEKKRESSNSDVLPPKVAVMKPILRFLQLLCENHNPDLQNLLRNQNNKSNYNLVSETLMFLDCICGSTTGGLGLLGLYINEGNVSLINQTLETLTEYCQGPCHENQNCIATHESNGLDIITALILNDINPLGRTRMDLVLELKNNASKLLLAIMESRNDSENNAERILYNMNPKQLVDVACSAFHQEHGADSDSESEDDAPVQAVSPKEVGHNIYILCHQLAAHNKELAALVRASPAGPHALALQYYRTHTAQIEIVRTDRSMEQIVFPIPEMCEYLPADSKHRVLQSAERDDQGSKVADFFARLDHLFHEMKWQKKLRGQPLLFWVSSYMSLWSNILFNFAVLINVIVAFFYPFSDENPRLGQHVSLAVWAASGAAGALVAWVPRGAGVRALLACAIVRVLCSAGPEPTLWALAMLTIIVKGIHLVSIMGNQGTLSKSTRNVLTDPELLYHTVYLLFCFLGICCHPFFFSVLLLDIVYREETLLNVMRSVTRNGRSILLTAVLALVLVYMFSIVGYMFFRDHFLVNVDRLDDDDDPRFEADSCGRDPADKYRGAGGCRAAPRLVLVGGELRERSCDSLLMCIVTTLNQGLRNGGGIGDILRAPASFEPLFVARVVYDLLFFFVVIIIVLNLIFGVIIDTFADLRSEKQQKELILKSTCFICGLNRSAFDNKTVSFEEHIKSEHNMWHYLYFMVLVRVKDPTEFTGPESYVHSMIKSNNLDWFPRLRALSLMGGVEGEGGELELRALQAQLDRAHRAVATLTELLTDLRDQMTEQRKQKQRIGLLNSTSAYLQNLQLNLPP

Description

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium (PubMed:1322910). Together with MCU, has a role in oxidative stress-induced ER-mitochondria calcium transfer (PubMed:28726639). May be involved in visual and olfactory transduction, and myoblast proliferation (PubMed:1322910). May be involved in ethanol tolerance (PubMed:29444420).
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity).

Subunit

Homotetramer.
Homotetramer. Interacts with CABP1 (PubMed:12032348). Interacts with BOK; regulates ITPR2 expression.

Similarity

Belongs to the InsP3 receptor family.

Keywords

Alternative splicing Calcium Calcium channel Calcium transport Complete proteome Developmental protein Endoplasmic reticulum Ion channel Ion transport Ligand-gated ion channel Membrane Olfaction Phosphoprotein Receptor Reference proteome Repeat Sensory transduction Transmembrane Transmembrane helix Transport Vision Polymorphism

Feature

chain Inositol 1,4,5-trisphosphate receptor
splice variant In isoform A.

Uniprot

H9JV29 A0A3S2PDM3 A0A212FL15 A0A0N1IGP3 A0A0N1PF50 A0A097P7A8 + More
A0A1B6EDM6 A0A1B6CLM5 A0A222AFM6 V9IA65 A0A1W4W984 A0A1W4WKF8 V9I9P7 V9I8A8 A0A1W4WJH4 A0A1W4WKP9 V9IAK4 A0A2A3ES56 A0A088A5K3 T1HK15 D6W7E2 A0A310SI82 A0A0L0CKU0 A0A2J7QR08 A0A0B4LGN1 B3P2E7 B4QWW9 P29993-2 P29993 B4PVB2 A0A1B0FD97 A0A147BQD7 A0A3B3QY67 A0A1W5A8G0 A0A3Q2EE34 A0A1W5AFB9 A0A1W5AFC4 A0A3Q1I0C3 A0A3B4WPP2 A0A3P8QSH9 A0A3Q3CHG1 A0A3B4EZY1 A0A1L8GPF1 A0A1L8GHJ0 A0A3P8SU81 A0A3Q1BXN9 Q91908 A0A3P9BR01 A0A3P8U0Q1 A0A1S3LB41 A0A3B5B4U3 A0A3Q1BHL7 A0A3B4UEJ4 A0A3Q4I9V8 A0A3Q3XN87 A0A2U9BG26 A0A3B4XIV1 A0A3Q3T285 H2TJZ1 A0A3Q3JRN7 A0A3Q3BBT2 A0A3B4E065 A0A096LQ05 A0A2U9BH53 A0A3B4CG39 A0A3P9JM70 A0A1S3P2Y3 A0A3Q4HW68 A0A1S3P2R8 A0A1A8EUD0 A0A1A7ZSM2 W5KHY9 A0A1S3P2N8 H2MBM2 F8W4B1 A0A3B4TQG1 A0A1S3P2X8 A0A2R8QHB5 A0A2R8QJM5 I3KSK9 A0A1S3P2Y1 A0A1S3P2R3 A0A1S3P2M9 A0A1S3P2X6 A0A1W5AGI2 A0A218UI34 A0A146VD63 M3YG40 A0A2Y9KZA0 Q6W3E4 M3W202 A0A3Q2H6V9 A0A1S2ZE43 R0JNL4 G1QZX2 A0A151MPL6 G1KLX9 P29995 H2NGU6 A0A3Q2H0L4

Pubmed

19121390 22118469 26354079 25330781 18362917 19820115 + More
26108605 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 17994087 1322910 10375644 1338312 28726639 29444420 17550304 29652888 29240929 27762356 8387895 25186727 21551351 17554307 25329095 23594743 17975172 19892987 22293439 1655411 12032348 23884412

EMBL

BABH01026287 BABH01026288 BABH01026289 BABH01026290 BABH01026291 RSAL01000085 + More
RVE48356.1 AGBW02007905 OWR54438.1 KQ459933 KPJ19289.1 KQ458883 KPJ04581.1 KM216387 AIU40167.1 GEDC01001277 JAS36021.1 GEDC01023107 JAS14191.1 KY290442 ASO75059.1 JR036746 AEY57366.1 JR036747 AEY57367.1 JR036743 AEY57363.1 JR036744 AEY57364.1 KZ288189 PBC34595.1 ACPB03006495 ACPB03006496 KQ971307 EFA11212.2 KQ767803 OAD53290.1 JRES01000249 KNC32983.1 NEVH01012081 PNF31015.1 AE014297 AHN57179.1 CH954181 EDV47897.1 CM000364 EDX11731.1 D90403 AJ238949 Z18535 CM000160 EDW95781.2 CCAG010014354 GEGO01002672 JAR92732.1 CM004472 OCT85738.1 CM004473 OCT83302.1 D14400 BAA03304.1 CP026248 AWP02975.1 AYCK01011154 AYCK01011155 AYCK01011156 AWP03365.1 HAEB01004223 SBQ50750.1 HADY01007284 SBP45769.1 BX957338 BX548005 AERX01006755 AERX01006756 AERX01006757 MUZQ01000306 OWK53070.1 GCES01071085 JAR15238.1 AEYP01089101 AEYP01089102 AEYP01089103 AEYP01089104 AEYP01089105 AEYP01089106 AEYP01089107 AEYP01089108 AEYP01089109 AEYP01089110 AY313846 AAQ82910.1 AANG04001751 KB743435 EOA98746.1 ADFV01029449 ADFV01029450 ADFV01029451 ADFV01029452 ADFV01029453 ADFV01029454 ADFV01029455 ADFV01029456 ADFV01029457 ADFV01029458 AKHW03005564 KYO26340.1 X61677 AF329470 ABGA01014346 ABGA01014347 ABGA01014348 ABGA01014349 ABGA01014350 ABGA01014351 ABGA01014352 ABGA01014353 ABGA01014354 ABGA01014355 NDHI03003395 PNJ67165.1

Proteomes

UP000005204 UP000283053 UP000007151 UP000053240 UP000053268 UP000192223 + More
UP000242457 UP000005203 UP000015103 UP000007266 UP000037069 UP000235965 UP000000803 UP000008711 UP000000304 UP000002282 UP000092444 UP000261540 UP000192224 UP000265020 UP000265040 UP000261360 UP000265100 UP000264840 UP000261460 UP000186698 UP000265080 UP000257160 UP000265160 UP000087266 UP000261400 UP000261420 UP000261580 UP000261620 UP000246464 UP000261640 UP000005226 UP000261600 UP000264800 UP000261440 UP000028760 UP000265200 UP000018467 UP000001038 UP000000437 UP000005207 UP000197619 UP000000715 UP000248482 UP000011712 UP000002281 UP000079721 UP000001073 UP000050525 UP000001646 UP000002494 UP000001595

PRIDE

H9JV29 P29993 Q6W3E4 P29995

Pfam

PF02815   MIR        + More
PF01365   RYDR_ITPR
PF08709   Ins145_P3_rec
PF00520   Ion_trans
PF08454   RIH_assoc
PF00089   Trypsin

Interpro

IPR000493   InsP3_rcpt        + More
IPR016093   MIR_motif
IPR005821   Ion_trans_dom
IPR035910   RyR/IP3R_RIH_dom_sf
IPR014821   Ins145_P3_rcpt
IPR000699   RIH_dom
IPR013662   RIH_assoc-dom
IPR036300   MIR_dom_sf
IPR001254   Trypsin_dom
IPR018114   TRYPSIN_HIS
IPR009003   Peptidase_S1_PA
IPR033116   TRYPSIN_SER
IPR016024   ARM-type_fold

SUPFAM

SSF100909   SSF100909        + More
SSF82109   SSF82109
SSF50494   SSF50494
SSF48371   SSF48371

CDD

cd00190 Tryp_SPc

ProteinModelPortal

H9JV29 A0A3S2PDM3 A0A212FL15 A0A0N1IGP3 A0A0N1PF50 A0A097P7A8 + More
A0A1B6EDM6 A0A1B6CLM5 A0A222AFM6 V9IA65 A0A1W4W984 A0A1W4WKF8 V9I9P7 V9I8A8 A0A1W4WJH4 A0A1W4WKP9 V9IAK4 A0A2A3ES56 A0A088A5K3 T1HK15 D6W7E2 A0A310SI82 A0A0L0CKU0 A0A2J7QR08 A0A0B4LGN1 B3P2E7 B4QWW9 P29993-2 P29993 B4PVB2 A0A1B0FD97 A0A147BQD7 A0A3B3QY67 A0A1W5A8G0 A0A3Q2EE34 A0A1W5AFB9 A0A1W5AFC4 A0A3Q1I0C3 A0A3B4WPP2 A0A3P8QSH9 A0A3Q3CHG1 A0A3B4EZY1 A0A1L8GPF1 A0A1L8GHJ0 A0A3P8SU81 A0A3Q1BXN9 Q91908 A0A3P9BR01 A0A3P8U0Q1 A0A1S3LB41 A0A3B5B4U3 A0A3Q1BHL7 A0A3B4UEJ4 A0A3Q4I9V8 A0A3Q3XN87 A0A2U9BG26 A0A3B4XIV1 A0A3Q3T285 H2TJZ1 A0A3Q3JRN7 A0A3Q3BBT2 A0A3B4E065 A0A096LQ05 A0A2U9BH53 A0A3B4CG39 A0A3P9JM70 A0A1S3P2Y3 A0A3Q4HW68 A0A1S3P2R8 A0A1A8EUD0 A0A1A7ZSM2 W5KHY9 A0A1S3P2N8 H2MBM2 F8W4B1 A0A3B4TQG1 A0A1S3P2X8 A0A2R8QHB5 A0A2R8QJM5 I3KSK9 A0A1S3P2Y1 A0A1S3P2R3 A0A1S3P2M9 A0A1S3P2X6 A0A1W5AGI2 A0A218UI34 A0A146VD63 M3YG40 A0A2Y9KZA0 Q6W3E4 M3W202 A0A3Q2H6V9 A0A1S2ZE43 R0JNL4 G1QZX2 A0A151MPL6 G1KLX9 P29995 H2NGU6 A0A3Q2H0L4

PDB

6MU1 E-value=0, Score=6993

KEGG

101741421 K04958 inositol 1,4,5-triphosphate receptor type 1 | (RefSeq) inositol 1,4,5-trisphosphate receptor

PATHWAY

04070    Phosphatidylinositol signaling system - Bombyx mori (domestic silkworm)
04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04745    Phototransduction - fly - Bombyx mori (domestic silkworm)

GO

GO:0016021 GO:0005783 GO:0070679 GO:0005220 GO:0004252 GO:0070588 GO:0051209 GO:0055089 GO:0005789 GO:0030322 GO:0042594 GO:0046000 GO:0051482 GO:0000280 GO:0007629 GO:0035071 GO:0009267 GO:0044295 GO:0006874 GO:0060259 GO:0030536 GO:0016319 GO:0005790 GO:0071361 GO:0050909 GO:0006979 GO:0007608 GO:0055088 GO:0007601 GO:0007591 GO:0006816 GO:0010888 GO:0016020 GO:0044325 GO:0071320 GO:0005634 GO:0005938 GO:0001666 GO:0033017 GO:0097110 GO:0005886 GO:0035091 GO:0043235 GO:0016529 GO:0005509 GO:0030667 GO:0030659 GO:0030424 GO:0071456 GO:0005737 GO:0043209 GO:0005262 GO:0005216 GO:0006811 GO:0000287 GO:0006281 GO:0006259 GO:0055085

Subcellular location

Endoplasmic reticulum membrane

Length:

2721

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

140.61187

Exp number, first 60 AAs:

0.30075

Total prob of N-in:

0.01375

outside

1 - 2252

TMhelix

2253 - 2275

inside

2276 - 2287

TMhelix

2288 - 2310

outside

2311 - 2329

TMhelix

2330 - 2352

inside

2353 - 2372

TMhelix

2373 - 2395

outside

2396 - 2417

TMhelix

2418 - 2440

inside

2441 - 2538

TMhelix

2539 - 2561

outside

2562 - 2721

Pi

243.894192

Theta

165.102653

Tajima's D

1.384527

CLR

0.134645

CSRT

0.755462226888656

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics