Gene

KWMTBOMO15917

Pre Gene Modal

BGIBMGA013393

Annotation

trypsin-like_serine_protease_precursor?_partial_[Alabama_argillacea]

Location

Bomo_Chr27(-):2032094-2044029      View in EpiBrowser

Full name

Trypsin CFT-1      

Location in the cell

Extracellular   Reliability : 3.186

CDS

ATGATACCAACATCTAGGGCGCAGTGTTTTTATAACTTCACAAACACAATGTTGTGTGCGGTGGTCATTTTGTCGTTAATTCTGTGCTCACAAGCAAGAGATCTGAGTCTCGAATTTGAAACGATAGCAGCCGTCCCGCTTCCGCTGAGCTCCGGATCTGATACTCGCATTATTGGGGGCTCGCCTACCACAATCGAAAGATATCCCTACACAGTTCAGGTTTTATACAACGGTCAATTGTCGTGCGGAGGCTCGCTGATCACCAAGAGGCACGTGCTGAGCGCGGGACACTGCTTTATAGACACTAACGGCAACGTGGCTAGTCCCACATTGTTCAGCATTCGCTCCGGAAGCAGTGTTCTATACTCTGGGGGAAGTATTCACTCCGTGTCTATGATCATCGTCCACGAGCGGTACAACGTCCCGATCAGAGACAACGATATCGCTGTACTGGTATTGTCTTCTCCTGTGACCCTGAGCGCGAGCGTGGCGCAAGCTTGTATACCGGTGCAGTGGGCGGAAGTACCTGATAATTCCTCGGTTATTCACGTGGGTTGGGGCAGGACTAATGTGAACGTAGCTCAAGCTTCTTCAGTCCTCAACGAGGTTGAGGTCCGGATAGTCAACAGGGATGTCTGCCGGACTCGGTACGAGTTTCTGGAGAGCGTGACCGGGGATCCCTTCCCAGTCACCGTAAACATGATCTGCGCGGGACTGCTCGATATCGGAGGCAAGGACGCTTGTCAAGGTGACAGCGGCGGTCCCCTGATATACAACAACATCGTGGTGGGGCTGACCTCGTGGGGCTACGGGTGTGCGGAGCCCATGTTCCCGGGCGTCAGCGCCAGAGTCTCAAGCTACACTAACTGGATTAACAACACGGTGACGCGGTATAGCGGCGGGGCTGCGCTGGCGGGCGGGGGCTCCGCGACGCTCCTGGCGGCGATATTGTCTTTAATTGTGACCACCTATCATTAG

Protein

MIPTSRAQCFYNFTNTMLCAVVILSLILCSQARDLSLEFETIAAVPLPLSSGSDTRIIGGSPTTIERYPYTVQVLYNGQLSCGGSLITKRHVLSAGHCFIDTNGNVASPTLFSIRSGSSVLYSGGSIHSVSMIIVHERYNVPIRDNDIAVLVLSSPVTLSASVAQACIPVQWAEVPDNSSVIHVGWGRTNVNVAQASSVLNEVEVRIVNRDVCRTRYEFLESVTGDPFPVTVNMICAGLLDIGGKDACQGDSGGPLIYNNIVVGLTSWGYGCAEPMFPGVSARVSSYTNWINNTVTRYSGGAALAGGGSATLLAAILSLIVTTYH

Catalytic Activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Similarity

Belongs to the peptidase S1 family.

Keywords

Direct protein sequencing   Disulfide bond   Hydrolase   Protease   Secreted   Serine protease   Signal   Zymogen  

Feature

propeptide  Activation peptide
chain  Trypsin CFT-1

Uniprot

A0A089Q9M3   A0A089QFN5   A0A0N0PA32   A0A1E1W9P7   A0A1E1WH25   A0A2A4J5B8   + More
A0A212FL72   A0A2A4JRB9   A0A0N1IGP3   I6TMX2   A0A3S2M0M1   T1QDH4   A0A0M5KXX2   T1QDH1   I3UIJ0   I6TEW4   A0A2A4JCA8   A0A2W1C1W9   A0A2H1VG89   B1NLD9   H9JM38   I7D523   A0A2H1V951   Q56IB0   Q56IB2   A0A2W1BTM0   A0A194QJ28   E7D014   C9W8I2   I7DEJ5   A0A089RSX5   A0A2H1WEE4   A0A2H1WTV1   S5PZA0   A0A2A4JUT0   Q9NB91   A0A194PVB6   A0A2W1BUQ8   Q56IB1   A0A2H1VGQ2   C9W8J1   A0A212EW56   A0A089QDB3   Q9NB92   A0A0L7KYH0   A0A194PNR3   A0A0M4M544   A0A2A4JTP3   B6CME9   A0A194PQQ5   Q4L1K1   A0A212EJA7   A0A1E1WAD4   A0A2H1VGP3   A0A0M4MT18   A0A2W1BJP2   B6D1Q8   S5PVP1   E7D012   A0A0N1PGP3   A0A2H1W3L1   I7DHM0   A0A2H1V654   V9LL27   P35042   A0A194QD45   A0A2A4JT25   E2IGY7   Q27540   C9W8I6   A0A1E1WDA8   A0A194QD40   A0A0N1PHJ0   A0A0L7L163   A0A194PP33   T1QDI0   Q6R560   Q9U4I4   A0A194PQQ0   A0A3S2TNU2   A0A194QDC5   A5CG75   Q4L1L0   A0A2W1BE44   A0A194QET8   A0A2W1BP62   I3UII6   I7CHH2   Q9U4I5   B1NLE4   A0A0N1I947   I6TRT9   A0A2A4JSY0   O18435   A0A2A4K747   A0A3S2P336   A0A194PNR6  

EC Number

3.4.21.4

Pubmed

26354079    22118469    23955944    22432944    28756777    18314941    + More
19121390    22824002    16469064    20824821    23606528    11267903    26227816    18760362    15979001    19133073    8294037    8353523    7550246    15944081    10989289    18634789    9404008   

EMBL

KM083778    AIR09759.1    KM083785    AIR09766.1    KQ458883    KPJ04582.1    + More
GDQN01007351    JAT83703.1    GDQN01004848    JAT86206.1    NWSH01003106    PCG66936.1    AGBW02007905    OWR54439.1    NWSH01000830    PCG73960.1    KQ459933    KPJ19289.1    JQ904128    AFM77758.1    RSAL01000085    RVE48354.1    JQ429436    AFW03961.1    KR024669    ALE15211.1    JQ429437    AFW03962.1    JN315764    AFK64828.1    JQ904129    AFM77759.1    NWSH01002022    PCG69396.1    KZ149911    PZC78103.1    ODYU01002419    SOQ39873.1    EF600054    ABU98619.1    BABH01005843    JN793545    AFO68325.1    ODYU01001303    SOQ37326.1    AY953064    AY953068    AAX62037.1    AAX63384.1    AY953065    AAX62038.1    KZ150010    PZC75083.1    KQ459167    KPJ03461.1    HM990184    ADT80832.1    FJ205428    ACR15995.1    JN793549    AFO68329.1    KM083776    AIR09757.1    ODYU01007983    SOQ51222.1    ODYU01011017    SOQ56495.1    KC175565    AGR92347.1    NWSH01000631    PCG75152.1    AF261971    AF261990    AAF74733.1    KQ459597    KPI95070.1    PZC78101.1    AY953066    AAX62039.1    ODYU01002467    SOQ39997.1    FJ205440    ACR16004.1    AGBW02012089    OWR45697.1    KM083787    AIR09768.1    AF261970    AAF74732.1    JTDY01004416    KOB68185.1    KPI95066.1    KR024672    ALE15214.1    PCG75146.1    EU325549    ACB54939.1    KPI95074.1    AY587164    AAT95356.1    AGBW02014494    OWR41582.1    GDQN01007155    JAT83899.1    SOQ39998.1    KR024671    ALE15213.1    PZC75088.1    EU673451    ACI45414.1    KC175562    AGR92345.1    HM990182    ADT80830.1    KQ460409    KPJ14943.1    ODYU01006115    SOQ47675.1    JN793547    AFO68327.1    ODYU01000875    SOQ36297.1    JQ340915    AFP74111.1    L04749    KPJ03463.1    NWSH01000723    PCG74613.1    HM535626    ADK66277.1    U12917    AAA84423.1    FJ205433    ACR15999.2    GDQN01010607    GDQN01006137    JAT80447.1    JAT84917.1    KPJ03458.1    KQ460226    KPJ16473.1    JTDY01003642    KOB69233.1    KPI95067.1    JQ429438    AFW03963.1    AY513650    AAR98919.1    AF173498    AAF24228.1    KPI95069.1    RSAL01000038    RVE51123.1    KPJ03462.1    AM690450    CAM84320.1    AY587155    AAT95347.1    KZ150104    PZC73442.1    KPJ03460.1    PZC75087.1    JN315760    AFK64824.1    JN793546    AFO68326.1    AF173497    AAF24227.1    EF600059    ABU98624.1    KPJ16474.1    JQ904126    AFM77756.1    PCG75147.1    Y12270    CAA72949.1    NWSH01000106    PCG79472.1    RVE51121.1    KPI95071.1   

Proteomes

UP000053268    UP000218220    UP000007151    UP000053240    UP000283053    UP000005204    + More
UP000037510   

PRIDE

H9JM38    P35042   

Pfam

PF00089   Trypsin        + More
PF01365   RYDR_ITPR
PF02815   MIR
PF00520   Ion_trans
PF08709   Ins145_P3_rec
PF08454   RIH_assoc

Interpro

IPR033116   TRYPSIN_SER        + More
IPR009003   Peptidase_S1_PA       
IPR001314   Peptidase_S1A       
IPR018114   TRYPSIN_HIS       
IPR001254   Trypsin_dom       
IPR013662   RIH_assoc-dom       
IPR000699   RIH_dom       
IPR014821   Ins145_P3_rcpt       
IPR036300   MIR_dom_sf       
IPR035910   RyR/IP3R_RIH_dom_sf       
IPR005821   Ion_trans_dom       
IPR000493   InsP3_rcpt       
IPR016093   MIR_motif       
IPR012224   Pept_S1A_FX       

SUPFAM

SSF50494   SSF50494        + More
SSF82109   SSF82109       
SSF100909   SSF100909       

CDD

cd00190  Tryp_SPc

ProteinModelPortal

A0A089Q9M3   A0A089QFN5   A0A0N0PA32   A0A1E1W9P7   A0A1E1WH25   A0A2A4J5B8   + More
A0A212FL72   A0A2A4JRB9   A0A0N1IGP3   I6TMX2   A0A3S2M0M1   T1QDH4   A0A0M5KXX2   T1QDH1   I3UIJ0   I6TEW4   A0A2A4JCA8   A0A2W1C1W9   A0A2H1VG89   B1NLD9   H9JM38   I7D523   A0A2H1V951   Q56IB0   Q56IB2   A0A2W1BTM0   A0A194QJ28   E7D014   C9W8I2   I7DEJ5   A0A089RSX5   A0A2H1WEE4   A0A2H1WTV1   S5PZA0   A0A2A4JUT0   Q9NB91   A0A194PVB6   A0A2W1BUQ8   Q56IB1   A0A2H1VGQ2   C9W8J1   A0A212EW56   A0A089QDB3   Q9NB92   A0A0L7KYH0   A0A194PNR3   A0A0M4M544   A0A2A4JTP3   B6CME9   A0A194PQQ5   Q4L1K1   A0A212EJA7   A0A1E1WAD4   A0A2H1VGP3   A0A0M4MT18   A0A2W1BJP2   B6D1Q8   S5PVP1   E7D012   A0A0N1PGP3   A0A2H1W3L1   I7DHM0   A0A2H1V654   V9LL27   P35042   A0A194QD45   A0A2A4JT25   E2IGY7   Q27540   C9W8I6   A0A1E1WDA8   A0A194QD40   A0A0N1PHJ0   A0A0L7L163   A0A194PP33   T1QDI0   Q6R560   Q9U4I4   A0A194PQQ0   A0A3S2TNU2   A0A194QDC5   A5CG75   Q4L1L0   A0A2W1BE44   A0A194QET8   A0A2W1BP62   I3UII6   I7CHH2   Q9U4I5   B1NLE4   A0A0N1I947   I6TRT9   A0A2A4JSY0   O18435   A0A2A4K747   A0A3S2P336   A0A194PNR6  

PDB

5XWL     E-value=4.23827e-33,     Score=352

KEGG

101738380    no KO assigned | (RefSeq) trypsin CFT-1-like

GO

GO:0004252   GO:0005220   GO:0070679   GO:0005783   GO:0016021   GO:0008236   GO:0005509   GO:0007596   GO:0005615   GO:0006508   GO:0006468   GO:0004674   GO:0005525   GO:0004672   GO:0003676   GO:0000287   GO:0006281   GO:0006259  

Subcellular location

  

SignalP

Position:   1 - 32,         Likelihood:  0.662706

 

 

Length:

325

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

43.45382

Exp number, first 60 AAs:

18.40536

Total prob of N-in:

0.45569

POSSIBLE N-term signal

sequence

outside

1  -  9

TMhelix

10  -  29

inside

30  -  299

TMhelix

300  -  322

outside

323  -  325

 

 

Pi

223.85841

Theta

162.484659

Tajima's D

1.074904

CLR

0.021606

CSRT

0.684065796710165

Interpretation

Uncertain