SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO15911  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA013413
Annotation
GL12416_[Drosophila_persimilis]
Location
Bomo_Chr27(+):1902040-1904233      View in EpiBrowser
Full name
Tubulin alpha chain       + More
Tubulin alpha-1 chain      
Location in the cell
Cytoplasmic   Reliability : 3.645
 

Sequence

CDS
ATGCGTGAGTGCATCTCTGTACACGTTGGCCAAGCCGGAGTCCAGATCGGTAATGCCTGCTGGGAGCTTTACTGCCTGGAGCACGGCATCCAGCCTGATGGCCAGATGCCCACAGACAAGACCATCGGGGGTGGAGACGATTCTTTCAACACTTTCTTCAGCGAGACCGGAGCTGGCAAGCACGTACCCCGTGCTGTCTTCGTCGATCTTGAACCTACTGTTGTTGATGAGGTCCGCACTGGCACATACAGACAGTTGTTTCATCCAGAACAACTTATTACTGGTAAGGAAGATGCGGCCAACAACTATGCCCGTGGTCACTACACCATTGGAAAGGAAATCGTAGATTTGGTTTTGGACAGAATCCGCAAGCTCGCTGACCAGTGTACCGGTCTGCAAGGATTCCTGATCTTCCACTCCTTCGGTGGAGGTACCGGCTCTGGGTTCACTTCCTTATTGATGGAGCGTCTCTCCGTTGACTACGGCAAGAAGTCTAAACTGGAGTTCGCCATCTACCCCGCGCCTCAGGTTTCCACTGCCGTCGTCGAGCCCTACAACTCTATCCTCACCACCCACACAACCCTTGAGCACTCTGACTGTGCTTTCATGGTCGACAATGAAGCCATCTATGACATCTGCCGCCGTAATCTCGACATTGAGCGCCCAACCTACACCAACCTGAATCGTCTCATCGGACAGATTGTCTCCTCGATCACTGCTTCTTTGAGATTCGACGGCGCTCTGAATGTGGACCTCACCGAGTTCCAGACTAACTTGGTGCCTTACCCCCGTATCCACTTCCCACTGGTCACGTACGCGCCAGTCATCTCTGCCGAGAAGGCCTACCATGAACAGCTTTCCGTCGCCGAGATCACAAACGCATGCTTCGAGCCCGCCAACCAGATGGTGAAATGCGACCCCCGTCATGGCAAGTACATGGCTTGCTGTATGCTGTACCGTGGTGACGTCGTACCCAAGGATGTGAACGCGGCCATCGCTACCATCAAAACCAAGCGTACTATCCAATTCGTCGACTGGTGTCCAACCGGTTTCAAGGTCGGTATCAACTACCAGCCACCCACCGTGGTGCCCGGAGGCGACTTGGCCAAGGTTCAACGTGCCGTCTGCATGTTGTCCAACACCACCGCCATCGCCGAAGCTTGGGCTCGCCTTGACCACAAGTTCGACCTCATGTACGCCAAGCGTGCTTTCGTGCACTGGTACGTCGGTGAGGGTATGGAGGAGGGAGAGTTCTCCGAAGCCCGTGAGGACCTGGCTGCCCTCGAGAAGGATTACGAAGAAGTCGGCATGGACTCCGCTGAAGGCGAGGGTGAGGGAGCCGAAGAGTACTAA
Protein
MRECISVHVGQAGVQIGNACWELYCLEHGIQPDGQMPTDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGMDSAEGEGEGAEEY

Summary

Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Subunit
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with Ote (PubMed:22751930).
Similarity
Belongs to the tubulin family.
Keywords
Acetylation   Complete proteome   Cytoplasm   Cytoskeleton   GTP-binding   Microtubule   Nucleotide-binding   Reference proteome  
Feature
chain  Tubulin alpha-1 chain
Uniprot
B4GMN3   A0A2A3ECI2   U5KIT6   A0A221SMS6   I4DM73   I4DIF5   + More
H9JV50   A0A3G1T187   A0A2Z4N443   A0A0N0BGY9   A0A3L8DTU0   A7XW51   A7XW55   A0A2H1WYZ0   A7XW49   A7XW44   A0A2H4WW89   C4NFK7   A0A310SJM0   A0A2P8XUI7   F4WDI4   A0A182KKE9   Q964U9   A0A212EJZ3   A0A0P6JKY5   B0XE76   Q16JS3   E0VSM7   A0A023ETJ9   A0A0N1IP51   A0A182IR52   R4FNL0   A0A088AKL6   A0A0K8TTW1   A0A069DUT9   V9I891   A0A1Y1M5C8   A0A1L8E538   A0A0C4USD5   V5GIX6   R9W3D8   A0A151I0Y5   A0A1Q3FAK3   K7IX45   A0A161MFA4   V9IE59   G3FP83   A0A088A436   A0A0T6AZS7   A0A2M3ZF39   A0A2M4A014   A7UIK9   W5J7G0   A0A1W4VLS5   B4LZC9   B4QYZ8   W8BQW7   B4KDS3   A0A1A9Y408   A0A3B0JUV0   I6T3B1   A0A0K8VM53   A0A1A9VVT4   F4X8P4   I6T3B6   A0A1B0BSN7   A0A1I8JVA8   Q294S5   I6TYJ7   A0A034WN15   B4PS19   A0A2A3EL84   A0A0M4F580   A0A182YSD1   A0A220D6C6   A0A1I8Q721   B3LYC5   B4NKL9   A0A0L0BWD3   B4I4N6   B4JHW4   B3P2S7   A0A0A1XPI7   A0A1L8EI06   A0A1A9Z3N0   A0A1A9WRU7   A0A2J7QX75   A0A182PRV6   D3TQG7   T1PH24   Q1HR53   A0A182J1K8   A0A1B2AS19   Q7PUE2   A0A182HAM9   P06603   A0A182WUL0   A0A0L7LGW1   A0A182RW73   A0A182N2N9  
Pubmed
17994087    22651552    19121390    30249741    19442669    29403074    + More
21719571    20966253    11489310    22118469    17510324    20566863    24945155    26483478    26354079    26369729    26334808    28004739    25692689    23777660    20075255    18754809    20920257    23761445    24495485    15632085    25348373    17550304    25244985    28746411    26108605    25830018    20353571    25315136    17204158    27470169    12364791    14747013    17210077    3095837    10731132    12537572    22751930    26227816   
EMBL
CH479185    EDW38107.1    KZ288285    PBC29447.1    JX970946    AGR86105.1    + More
KX668534    ASN77690.1    AK402391    BAM19013.1    AK401073    BAM17695.1    BABH01026259    MG846905    AXY94757.1    MG132200    AWX63638.1    KQ435768    KOX75272.1    QOIP01000004    RLU23319.1    EU100017    ABU94678.1    EU100018    ABU94679.1    ODYU01012101    SOQ58217.1    EU100016    ABU94677.1    EU100015    ABU94676.1    KY514092    AUD12123.1    FJ550360    NWSH01001800    ACR07789.1    PCG70095.1    KQ760551    OAD59858.1    PYGN01001324    PSN35673.1    GL888087    EGI67764.1    AF272829    AAK58683.1    AGBW02014365    OWR41785.1    GDIQ01051546    GDIQ01051545    GDIQ01050155    GDIQ01050154    GDIQ01048651    GDIQ01048650    GDIQ01047206    GDIQ01003930    JAN90807.1    DS234244    DS232809    EDS33374.1    EDS45909.1    CH477994    EAT34538.1    DS235751    EEB16383.1    JXUM01090583    GAPW01001408    GAPW01001407    KQ563850    JAC12191.1    KXJ73172.1    KQ460772    KPJ12503.1    GAHY01000548    JAA76962.1    GDAI01000027    JAI17576.1    GBGD01001437    JAC87452.1    JR036023    JR036024    AEY56866.1    AEY56867.1    GEZM01042508    JAV79810.1    GFDF01000308    JAV13776.1    KJ534554    AIY54295.1    GALX01004467    JAB63999.1    KC149906    AGN90966.1    KQ976601    KYM79439.1    GFDL01010431    JAV24614.1    AAZX01000600    AAZX01006238    GEMB01003839    JAR99415.1    JR041162    AEY59375.1    JF751032    AEO51765.1    LJIG01022464    KRT80443.1    GGFM01006381    MBW27132.1    GGFK01000667    MBW33988.1    EU073050    KU521361    ABU24274.1    ANS71241.1    ADMH02002115    ETN58805.1    CH940650    EDW68164.1    CM000364    EDX11938.1    GAMC01014636    JAB91919.1    CH933806    EDW14920.1    OUUW01000008    SPP84172.1    JQ866747    AFM80098.1    GDHF01012343    JAI39971.1    GL888932    EGI57313.1    JQ866752    AFM80103.1    JXJN01019798    CM000070    EAL28889.1    JQ866758    AFM80109.1    GAKP01003387    JAC55565.1    CM000160    EDW96419.1    KZ288219    PBC32254.1    CP012526    ALC46657.1    KY558640    ARQ84036.1    CH902617    EDV41788.1    CH964272    EDW85191.1    JRES01001243    KNC24340.1    CH480821    EDW55179.1    CH916369    EDV92872.1    CH954181    EDV48099.1    GBXI01001517    JAD12775.1    GFDG01000514    JAV18285.1    NEVH01020936    NEVH01009388    PNF20592.1    PNF33185.1    CCAG010010324    EZ423669    ADD19945.1    KA647435    AFP62064.1    DQ440241    CH477400    ABF18274.1    EAT41733.1    AXCP01002644    KX228233    PYGN01000366    ANY30847.1    PSN47598.1    AAAB01008987    EAA01685.6    EAL38636.4    JXUM01123000    KQ566666    KXJ69929.1    M14643    AE014297    BT012506    JTDY01001171    KOB74667.1   
Proteomes
UP000008744    UP000242457    UP000005204    UP000053105    UP000279307    UP000218220    + More
UP000245037    UP000007755    UP000075882    UP000007151    UP000002320    UP000008820    UP000009046    UP000069940    UP000249989    UP000053240    UP000075880    UP000005203    UP000078540    UP000002358    UP000000673    UP000192221    UP000008792    UP000000304    UP000009192    UP000092443    UP000268350    UP000078200    UP000092460    UP000075903    UP000001819    UP000002282    UP000092553    UP000076408    UP000095300    UP000007801    UP000007798    UP000037069    UP000001292    UP000001070    UP000008711    UP000092445    UP000091820    UP000235965    UP000075885    UP000092444    UP000095301    UP000007062    UP000000803    UP000076407    UP000037510    UP000075900    UP000075884   
PRIDE
H9JV50    E0VSM7    A0A088A436    Q1HR53    P06603   
Pfam
PF00091   Tubulin        + More
PF00005   ABC_tran
PF03953   Tubulin_C
PF00664   ABC_membrane
Interpro
IPR023123   Tubulin_C        + More
IPR017871   ABC_transporter_CS       
IPR003439   ABC_transporter-like       
IPR000217   Tubulin       
IPR018316   Tubulin/FtsZ_2-layer-sand-dom       
IPR036640   ABC1_TM_sf       
IPR027417   P-loop_NTPase       
IPR036525   Tubulin/FtsZ_GTPase_sf       
IPR011527   ABC1_TM_dom       
IPR003593   AAA+_ATPase       
IPR002452   Alpha_tubulin       
IPR017975   Tubulin_CS       
IPR003008   Tubulin_FtsZ_GTPase       
IPR008280   Tub_FtsZ_C       
IPR037103   Tubulin/FtsZ_C_sf       
IPR000719   Prot_kinase_dom       
IPR011009   Kinase-like_dom_sf       
SUPFAM
SSF52540   SSF52540        + More
SSF90123   SSF90123       
SSF55307   SSF55307       
SSF52490   SSF52490       
SSF56112   SSF56112       
Gene 3D
1.10.287.600     1.20.1560.10     3.30.1330.20     3.40.50.1440    
ProteinModelPortal
B4GMN3   A0A2A3ECI2   U5KIT6   A0A221SMS6   I4DM73   I4DIF5   + More
H9JV50   A0A3G1T187   A0A2Z4N443   A0A0N0BGY9   A0A3L8DTU0   A7XW51   A7XW55   A0A2H1WYZ0   A7XW49   A7XW44   A0A2H4WW89   C4NFK7   A0A310SJM0   A0A2P8XUI7   F4WDI4   A0A182KKE9   Q964U9   A0A212EJZ3   A0A0P6JKY5   B0XE76   Q16JS3   E0VSM7   A0A023ETJ9   A0A0N1IP51   A0A182IR52   R4FNL0   A0A088AKL6   A0A0K8TTW1   A0A069DUT9   V9I891   A0A1Y1M5C8   A0A1L8E538   A0A0C4USD5   V5GIX6   R9W3D8   A0A151I0Y5   A0A1Q3FAK3   K7IX45   A0A161MFA4   V9IE59   G3FP83   A0A088A436   A0A0T6AZS7   A0A2M3ZF39   A0A2M4A014   A7UIK9   W5J7G0   A0A1W4VLS5   B4LZC9   B4QYZ8   W8BQW7   B4KDS3   A0A1A9Y408   A0A3B0JUV0   I6T3B1   A0A0K8VM53   A0A1A9VVT4   F4X8P4   I6T3B6   A0A1B0BSN7   A0A1I8JVA8   Q294S5   I6TYJ7   A0A034WN15   B4PS19   A0A2A3EL84   A0A0M4F580   A0A182YSD1   A0A220D6C6   A0A1I8Q721   B3LYC5   B4NKL9   A0A0L0BWD3   B4I4N6   B4JHW4   B3P2S7   A0A0A1XPI7   A0A1L8EI06   A0A1A9Z3N0   A0A1A9WRU7   A0A2J7QX75   A0A182PRV6   D3TQG7   T1PH24   Q1HR53   A0A182J1K8   A0A1B2AS19   Q7PUE2   A0A182HAM9   P06603   A0A182WUL0   A0A0L7LGW1   A0A182RW73   A0A182N2N9  
PDB
5KX5     E-value=0,     Score=2320

Ontologies

KEGG
692428    K07374 tubulin alpha | (RefSeq) Tua1, bmtua1; alpha-tubulin
PATHWAY
04145    Phagosome - Bombyx mori (domestic silkworm)
GO
GO:0005525   GO:0042626   GO:0005874   GO:0007017   GO:0005524   GO:0005200   GO:0016021   GO:0005737   GO:0003924   GO:0019730   GO:0005813   GO:0048471   GO:0000235   GO:0032418   GO:0000226   GO:0000278   GO:0005634   GO:0005819   GO:0004672   GO:0003676   GO:0000287   GO:0006281   GO:0006259  
PANTHER
PTHR11588  

Topology

Subcellular location
  
Length:
450
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
1.89626
Exp number, first 60 AAs:
0.00431
Total prob of N-in:
0.08731
outside
1  -  450
 
 

Population Genetic Test Statistics

Pi
76.824391
Theta
149.438348
Tajima's D
-1.313251
CLR
2759.583078
CSRT
0.0820958952052397
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
Peptides ×
Source Sequence Identity Evalue
28556443 LADQCTGLQGFLIFH 100.00 2e-11
28556443 LADQCTGLQGFLIFHSF 100.00 2e-11
28556443 LIGQIVSSITA 100.00 8e-11
28556443 AYHEQLSVAEITNACFEPANQMVK 100.00 2e-10
28556443 AYHEQLSVAEITNACFEPANQMVK 100.00 2e-10
28556443 AYHEQLSVAEITNACFEPANQMVK 100.00 2e-10
28556443 AYHEQLSVAEITNACFEPANQMVK 100.00 2e-10
28556443 AVFVDLEPTVVDEVR 100.00 2e-10
28556443 AVFVDLEPTVVDEVR 100.00 2e-10
26822097 IHFPIVTYAPVISAEK 95.83 4e-10
26280517 AGSIWINTYEHVTTQTPFGGFK 95.83 4e-10
28467696 AYGVPDIDVFQTVDIWEKK 95.83 4e-10
28467696 RAEVNTFNATNR 100.00 7e-10
28556443 AIYPAPQVSTAVVEPYNSILTTH 100.00 4e-09
28556443 AFVHWYVGEGMEEGEFSEAR 100.00 4e-09
28556443 AFVHWYVGEGMEEGEFSEAR 100.00 4e-09
28556443 VGINYQPPTVVPGGDLAK 100.00 4e-09
28556443 VGINYQPPTVVPGGDLAK 100.00 4e-09
26280517 AFSGYIGEDK 100.00 5e-09
28467696 AFVDEIVPVPVPQKR 100.00 5e-09
28556443 AFVHWYVGEGMEEGEFSEAR 100.00 5e-09
28556443 AFVHWYVGEGMEEGEFSEAR 100.00 5e-09
28556443 AFVHWYVGEGMEEGEFSEAR 100.00 5e-09
28556443 DVNAAIATIKTK 100.00 5e-09
28556443 WLDSNQLADKEEYEHK 100.00 5e-09
26280517 VGFIIPVEGTTDQFVVGVER 95.24 1e-08
28556443 EIVDLVLDR 100.00 1e-08
28556443 EIVDLVLDR 100.00 1e-08
26822097 DVNAAIATIK 100.00 2e-08
26280517 SAISGGYGTMVFTKEPMVNIDMK 100.00 2e-08
28467696 TIGETFISSCDVDQDVVR 100.00 2e-08
21761556 YLTVAAIFR 100.00 2e-08
28556443 TIGGGDDSFNTFFSETGAGK 100.00 2e-08
28556443 TIGGGDDSFNTFFSETGAGK 100.00 2e-08
28556443 TIGGGDDSFNTF 100.00 2e-08
28556443 SFGGGTGSGFTSLLMER 100.00 2e-08
21761556 TIGGGDDSFNTFFSETGAGK 100.00 6e-07
28556443 VGINYQPPTVVPGGDLAK 100.00 6e-07
28556443 VGINYQPPTVVPGGDLAK 100.00 6e-07
28556443 VGINYQPPTVVPGGDLAK 100.00 6e-07
28556443 VGINYQPPTVVPGGDLAK 100.00 6e-07
28556443 VGINYQPPTVVPGGDLAK 100.00 6e-07
28556443 VGINYQPPTVVPGGDLAK 100.00 6e-07
28556443 TTAIAEAWAR 100.00 6e-07
28556443 TTAIAEAWAR 100.00 6e-07
28556443 GDVVPKDVNAAIATIK 100.00 1e-06
28556443 VGINYQPPTVVPGGDLAKVQR 100.00 5e-06
28556443 VGINYQPPTVVPGGDLAKVQR 100.00 5e-06
28556443 AVCMLSNTTAIAEAWAR 100.00 6e-06
28556443 AVCMLSNTTAIAEAWAR 100.00 6e-06
28556443 AIYPAPQVSTAVVEPYNSILTTH 100.00 6e-06
28556443 AIYPAPQVSTAVVEPYNSILTTH 100.00 6e-06
26822097 ISVDYGK 100.00 2e-05
26280517 RANNTEYGIASGVFTR 100.00 2e-05
25044914 RTIDIIAAK 100.00 2e-05
28467696 RTIFGEKDEIVAEK 100.00 2e-05
28556443 LADQCTGLQGFLIFH 100.00 3e-05
28556443 LADQCTGLQGFLIFH 100.00 3e-05
28556443 LADQCTGLQGFLIFH 100.00 3e-05
28556443 LADQCTGLQGF 100.00 3e-05
28556443 IHFPLVTYAPVISAEK 100.00 3e-05
28556443 VDLEPTVVDEVR 100.00 5e-05
21761556 VGINYQPPTVVPGGDLAK 100.00 9e-05
28556443 IHFPLVTYAPVISAEK 100.00 9e-05
28556443 IHFPLVTYAPVISAEK 100.00 9e-05
28556443 IHFPLVTYAPVISAEK 100.00 9e-05
28556443 IHFPLVTYAPVISAEK 100.00 9e-05
28556443 IHFPLVTYAPVISAEK 100.00 9e-05
28556443 IHFPLVTYAPVISAEK 100.00 9e-05
28556443 IHFPLVTYAPVISAEK 100.00 9e-05
28556443 IHFPLVTYAPVISAEK 100.00 9e-05
28556443 IHFPLVTYAPVISAEK 100.00 9e-05
28556443 IHFPLVTYAPVISAEK 100.00 9e-05
28556443 IHFPLVTYAPVISAEK 100.00 9e-05
28556443 IHFPLVTYAPVISA 100.00 9e-05
28556443 IHFPLVTYAPVISA 100.00 9e-05
26822097 VGINYQPPTVVPGGDIAK 100.00 1e-04
26280517 QFDHDAFIGEDQAK 100.00 1e-04
25044914 TIQAIEADFNVR 100.00 1e-04
24093152 TIPYWNNVIVPQIK 100.00 1e-04
28467696 TIQFEPSTTVYDACR 100.00 1e-04
28556443 TIQFVDWCPTGFK 100.00 1e-04
28556443 TIQFVDWCPTGFK 100.00 1e-04
28556443 TIGGGDDSFNTFFSETGAGK 100.00 1e-04
28556443 TIGGGDDSFNTFFSETGAGK 100.00 1e-04
28556443 LSVDYGK 100.00 3e-04
28556443 NLDIERPTYTNLNR 100.00 5e-04
28556443 MLSNTTAIAEAWAR 100.00 5e-04
28556443 MLSNTTAIAEAWAR 100.00 5e-04
28556443 LSVDYGK 100.00 0.002
28556443 LIGQIVSSITASLR 100.00 0.002
28556443 IHFPLVTYAPVISA 100.00 0.002
28556443 IHFPLVTYAPVISA 100.00 0.002
28556443 IHFPLVTYAPVISA 100.00 0.002
28556443 IHFPLVTYAP 100.00 0.002
28556443 HSFGGGTGSGFTSLLMER 100.00 0.002
28556443 EDLAALEK 100.00 0.002
28556443 AVFVDLEPTVVDEVR 100.00 0.005
28556443 AVFVDLEPTVVDEVR 100.00 0.005
28556443 AVFVDLEPTVVDEVR 100.00 0.005
28556443 AVFVDLEPTVVDEVR 100.00 0.005
28556443 AVFVDLEPTVVDEVR 100.00 0.005
28556443 AVFVDLEPTVVDEVR 100.00 0.005
28556443 AVFVDLEPTVVDEVR 100.00 0.005
28556443 AVFVDLEPTVVDEVR 100.00 0.005
28556443 AVFVDLEPTVVDEVR 100.00 0.005
28556443 AVCMLSNTTAIAEAWAR 100.00 0.005
28556443 AVCMLSNTTAIAEAWAR 100.00 0.005
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