Gene

KWMTBOMO15895

Annotation

PREDICTED:_dual_serine/threonine_and_tyrosine_protein_kinase-like_[Bombyx_mori]

Location

Bomo_Chr27(+):978531-980925      View in EpiBrowser

Full name

Dual serine/threonine and tyrosine protein kinase      

Alternative Name

Dusty protein kinase
Receptor-interacting serine/threonine-protein kinase 5

Location in the cell

Cytoplasmic   Reliability : 2.771

CDS

ATGAGGATCAGCTGCGATATCGTCGACGGCATCCGCTACCTGCACTCGCTGGGTCTGGTGCACCGCGACATCAAGACGAAGAACGTCCTCCTGGACGGGGCGGACCGCGCGGCGCTGTCGGACCTCGGCTTCTGCACGGCCGGCGCGCTCATGTCGGGCTCCGTGGTGGGCACGCCGGTGCACATGGCGCCCGAGCTGCTGGCCGGGGACTACCACGCCTCCGTCGACGTGTACGCTTTCGGGATCTTGTTCTGGTACGTGTGCGCTGGTGACATAAAGCTACCGTCAGCTTTCGAAACTTTCCAAAACAAGGAACAGCTTTGGAGTAAGGTTAAAAGAGGTCTGAGACCTGAACGTCTACCTCAGTTCTCGGACGAGTGCTGGGAGATCATGGAGTCGTGCTGGGCCTCCGAGCCCTCCCAGCGGGCGCTCCTCGGGGACGTGCAGAACAAGCTGGAGAGGATCTTGGAGCAGGCTCTAAAGGACGAAAAGTCTCCTGGCTACCTCGCCCCGGACGAGCCAGACCTTAACGACGACTAG

Protein

MRISCDIVDGIRYLHSLGLVHRDIKTKNVLLDGADRAALSDLGFCTAGALMSGSVVGTPVHMAPELLAGDYHASVDVYAFGILFWYVCAGDIKLPSAFETFQNKEQLWSKVKRGLRPERLPQFSDECWEIMESCWASEPSQRALLGDVQNKLERILEQALKDEKSPGYLAPDEPDLNDD

Description

Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
May act as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death (By similarity). Plays a role in the embryonic development.

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Keywords

ATP-binding   Cell junction   Cell membrane   Coiled coil   Complete proteome   Cytoplasm   Kinase   Membrane   Nucleotide-binding   Reference proteome   Transferase   Tyrosine-protein kinase   Alternative splicing   Developmental protein  

Feature

chain  Dual serine/threonine and tyrosine protein kinase
splice variant  In isoform 2.

Uniprot

A0A194PR80   A0A0N1IGG8   A0A2W1B383   A0A2H1W9T1   A0A2A4K4R5   A0A212FHW9   + More
A0A0T6AY16   A0A0L7R6A4   N6U6V5   A0A139WP41   A0A151XGN8   A0A151ING0   A0A026W067   A0A151I231   E9G2L0   A0A195F8R4   E2A026   A0A158ND34   F4X0G5   W4XY32   E2C1A0   A0A224YX58   A0A224YLQ7   B7P7E5   L7LY21   A0A069DN16   A0A232F999   A0A224YNP0   A0A0N8E2F9   A0A131XNM5   A0A131YBQ2   A0A0C9RJV3   A0A0C9QGB0   A0A131YVD8   T1JTX5   A0A1A6HAT5   A0A0P5JCT6   A0A3M0JE54   A0A0M8ZSU1   A0A1E1X3G5   H1A4G1   A0A0J7KZX5   A0A3S3PT07   A0A1E1XRS9   A0A023GDF7   A0A060WIK8   A0A293LJW0   A0A2U3Z5F0   A0A0P6GFZ8   A0A3R7MGE3   A0A0P5LEW9   A0A0N8CEF3   A0A0P5TVG1   A0A0P5TIH0   A0A087ZMX2   A0A0P5SF87   A0A0P5M8C7   A0A0P5YJ63   A0A0P6ADU7   A0A0P5Y2E2   A0A0P6JU25   A0A0P5QFK0   A0A0P5T3J6   A0A2A3EDW5   A0A293M158   K7FSS8   A0A226DLP2   K7FST1   F1PEI7   A0A2D4H9J4   A0A287B254   F1S361   K7FSS3   A0A3Q0GST0   A0A1Y1K4A8   A0A1Y1K584   A0A3N0YGD4   A0A1Z5KVH0   A0A091HIL8   A0A2U3ZZM0   A0A3Q7RNP7   A0A067RB43   A0A2Y9TK65   A0A212CQJ6   A0A2R5LI47   A0A164XGZ9   A0A2Y9TKH7   A0A3L7HK17   Q4VSN4   A0A093ELT1   A0A384CTG9   Q4VSN1-2   A0A2P4T4C5   Q4VSN1   A0A091K862   V5HLW5   A0A131XSW8   A0A091NLQ3   A0A384A693   M7B5Q0  

EC Number

2.7.12.1

Pubmed

26354079    28756777    22118469    23537049    18362917    19820115    + More
24508170    30249741    21292972    20798317    21347285    21719571    28797301    25576852    25233086    28648823    28049606    26830274    28503490    20360741    29209593    24755649    17381049    16341006    28004739    28528879    24845553    29704459    17123648    23862974    25765539    23624526   

EMBL

KQ459597    KPI95254.1    KQ460466    KPJ14600.1    KZ150391    PZC71049.1    + More
ODYU01007222    SOQ49810.1    NWSH01000148    PCG79059.1    AGBW02008451    OWR53333.1    LJIG01022577    KRT79835.1    KQ414646    KOC66405.1    APGK01047273    KB741077    KB632432    ENN74312.1    ERL95551.1    KQ971307    KYB29627.1    KQ982173    KYQ59380.1    KQ976933    KYN07003.1    KK107609    QOIP01000014    EZA48519.1    RLU15104.1    KQ976547    KYM80927.1    GL732530    EFX86277.1    KQ981744    KYN36439.1    GL435543    EFN73209.1    ADTU01012291    GL888498    EGI59957.1    AAGJ04000566    GL451914    EFN78262.1    GFPF01007398    MAA18544.1    GFPF01007400    MAA18546.1    ABJB010666035    ABJB010750526    DS651463    EEC02517.1    GACK01009280    JAA55754.1    GBGP01000278    JAC84917.1    NNAY01000604    OXU27421.1    GFPF01007399    MAA18545.1    GDIQ01068396    JAN26341.1    GEFH01000756    JAP67825.1    GEDV01012599    JAP75958.1    GBYB01013562    JAG83329.1    GBYB01012356    GBYB01013563    JAG82123.1    JAG83330.1    GEDV01006107    JAP82450.1    CAEY01000486    LZPO01037266    OBS75401.1    GDIQ01201949    JAK49776.1    QRBI01000149    RMB99252.1    KQ435896    KOX69266.1    GFAC01005368    JAT93820.1    ABQF01074534    LBMM01001760    KMQ95799.1    NCKU01000345    RWS15880.1    GFAA01001450    JAU01985.1    GBBM01003531    JAC31887.1    FR904557    CDQ66806.1    GFWV01009038    MAA33767.1    GDIQ01033662    JAN61075.1    QCYY01004352    ROT61111.1    GDIQ01170615    JAK81110.1    GDIP01139823    JAL63891.1    GDIP01121422    JAL82292.1    GDIP01125789    JAL77925.1    GDIP01140579    JAL63135.1    GDIQ01183010    JAK68715.1    GDIP01058741    JAM44974.1    GDIP01030694    JAM73021.1    GDIP01064948    JAM38767.1    GDIQ01008359    JAN86378.1    GDIQ01117866    JAL33860.1    GDIP01133027    JAL70687.1    KZ288287    PBC29366.1    GFWV01009039    MAA33768.1    AGCU01153103    AGCU01153104    AGCU01153105    AGCU01153106    AGCU01153107    AGCU01153108    AGCU01153109    AGCU01153110    AGCU01153111    AGCU01153112    LNIX01000017    OXA45764.1    AAEX03018251    AAEX03018252    IACK01003771    LAA68647.1    AEMK02000070    GEZM01095810    JAV55331.1    GEZM01095811    JAV55330.1    RJVU01042601    ROL45207.1    GFJQ02007945    JAV99024.1    KL536230    KFO94515.1    KK852812    KDR15870.1    MKHE01000014    OWK08202.1    GGLE01005050    MBY09176.1    LRGB01000996    KZS14223.1    RAZU01000200    RLQ66289.1    AY641093    KK376193    KFV46062.1    AY208855    AY429681    AY641096    BC067573    BC118677    PPHD01009339    POI31198.1    KK546586    KFP32526.1    GANP01009925    JAB74543.1    GEFM01006636    JAP69160.1    KL385747    KFP89854.1    KB548129    EMP30840.1   

Proteomes

UP000053268    UP000053240    UP000218220    UP000007151    UP000053825    UP000019118    + More
UP000030742    UP000007266    UP000075809    UP000078542    UP000053097    UP000279307    UP000078540    UP000000305    UP000078541    UP000000311    UP000005205    UP000007755    UP000007110    UP000008237    UP000001555    UP000215335    UP000015104    UP000092124    UP000269221    UP000053105    UP000007754    UP000036403    UP000285301    UP000193380    UP000245341    UP000283509    UP000005203    UP000242457    UP000007267    UP000198287    UP000002254    UP000008227    UP000189705    UP000245320    UP000286640    UP000027135    UP000248484    UP000076858    UP000273346    UP000261680    UP000000437    UP000261681    UP000031443   

PRIDE

B7P7E5    F1S361    Q4VSN4    Q4VSN1    V5HLW5   

Pfam

PF00069   Pkinase        + More
PF07714   Pkinase_Tyr
PF00400   WD40

Interpro

IPR008271   Ser/Thr_kinase_AS        + More
IPR011009   Kinase-like_dom_sf       
IPR000719   Prot_kinase_dom       
IPR017441   Protein_kinase_ATP_BS       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR007110   Ig-like_dom       
IPR017986   WD40_repeat_dom       
IPR001680   WD40_repeat       
IPR036179   Ig-like_dom_sf       
IPR015943   WD40/YVTN_repeat-like_dom_sf       

SUPFAM

SSF56112   SSF56112        + More
SSF48726   SSF48726       

Gene 3D

2.130.10.10    

ProteinModelPortal

A0A194PR80   A0A0N1IGG8   A0A2W1B383   A0A2H1W9T1   A0A2A4K4R5   A0A212FHW9   + More
A0A0T6AY16   A0A0L7R6A4   N6U6V5   A0A139WP41   A0A151XGN8   A0A151ING0   A0A026W067   A0A151I231   E9G2L0   A0A195F8R4   E2A026   A0A158ND34   F4X0G5   W4XY32   E2C1A0   A0A224YX58   A0A224YLQ7   B7P7E5   L7LY21   A0A069DN16   A0A232F999   A0A224YNP0   A0A0N8E2F9   A0A131XNM5   A0A131YBQ2   A0A0C9RJV3   A0A0C9QGB0   A0A131YVD8   T1JTX5   A0A1A6HAT5   A0A0P5JCT6   A0A3M0JE54   A0A0M8ZSU1   A0A1E1X3G5   H1A4G1   A0A0J7KZX5   A0A3S3PT07   A0A1E1XRS9   A0A023GDF7   A0A060WIK8   A0A293LJW0   A0A2U3Z5F0   A0A0P6GFZ8   A0A3R7MGE3   A0A0P5LEW9   A0A0N8CEF3   A0A0P5TVG1   A0A0P5TIH0   A0A087ZMX2   A0A0P5SF87   A0A0P5M8C7   A0A0P5YJ63   A0A0P6ADU7   A0A0P5Y2E2   A0A0P6JU25   A0A0P5QFK0   A0A0P5T3J6   A0A2A3EDW5   A0A293M158   K7FSS8   A0A226DLP2   K7FST1   F1PEI7   A0A2D4H9J4   A0A287B254   F1S361   K7FSS3   A0A3Q0GST0   A0A1Y1K4A8   A0A1Y1K584   A0A3N0YGD4   A0A1Z5KVH0   A0A091HIL8   A0A2U3ZZM0   A0A3Q7RNP7   A0A067RB43   A0A2Y9TK65   A0A212CQJ6   A0A2R5LI47   A0A164XGZ9   A0A2Y9TKH7   A0A3L7HK17   Q4VSN4   A0A093ELT1   A0A384CTG9   Q4VSN1-2   A0A2P4T4C5   Q4VSN1   A0A091K862   V5HLW5   A0A131XSW8   A0A091NLQ3   A0A384A693   M7B5Q0  

PDB

5O26     E-value=1.57968e-15,     Score=197

KEGG

101741067    K16288 dual serine/threonine and tyrosine protein kinase [EC:2.7.12.1] | (RefSeq) dual serine/threon

GO

GO:0004672   GO:0005524   GO:0004674   GO:0004709   GO:0016301   GO:0016323   GO:0005737   GO:0044344   GO:0043066   GO:0016324   GO:0070374   GO:0033674   GO:0045743   GO:0004713   GO:0004712   GO:0030054   GO:0048568   GO:0016021   GO:0006468   GO:0007016   GO:0005891   GO:0043565   GO:0003677   GO:0003707   GO:0006281   GO:0006259  

Subcellular location

Cytoplasm   Detected in basolateral and apical membranes of all tubular epithelia. Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane.   With evidence from 1 publications.
Cell membrane   Detected in basolateral and apical membranes of all tubular epithelia. Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane.   With evidence from 1 publications.
Apical cell membrane   Detected in basolateral and apical membranes of all tubular epithelia. Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane.   With evidence from 1 publications.
Basolateral cell membrane   Detected in basolateral and apical membranes of all tubular epithelia. Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane.   With evidence from 1 publications.
Cell junction   Detected in basolateral and apical membranes of all tubular epithelia. Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane.   With evidence from 1 publications.

Length:

179

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

4.48827

Exp number, first 60 AAs:

1.92463

Total prob of N-in:

0.22300

outside

1  -  179

 

 

Pi

43.857266

Theta

43.011215

Tajima's D

-0.431621

CLR

0.000008

CSRT

0.260886955652217

Interpretation

Uncertain