Gene

KWMTBOMO15877  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013369

Annotation

PREDICTED:_vinculin_[Bombyx_mori]

Location

Bomo_Chr27(+):590762-616996      View in EpiBrowser

Full name

Vinculin      

Location in the cell

Cytoplasmic   Reliability : 2.856

CDS

ATGCCTGTGTTCCACACGAAAATTATCGAAAGCATTCTAGAGCCAGTCGCTCAGCAGGTGTCTCGACTGGTCATCCTCCATGAAGAAGCAGAAGATGGCAACGCTATGCCGGACTTGGCTCGTCCTGTGCAGGCCGTCTCTCTTGCCGTCAACAACCTCGTCAAGGTTGGCCACGAGACCATAGAGTCATCAGACGATGCGATCCTGCGGCACGACATGCCGGGAGCCTTGCACCGCGTGGAGACGGCAGCCACCCTGCTGCAGCAGGCCTCTGATATGCTCAGAGCTGATCCGTATTCGGGGCCCGCTAGGAAGAAGCTGATCGAAGGGTCCCGCGGTATCCTGCAGGGTACATCGGCGTTGCTCCTCTGTTTCGATGAGTCTGAAGTCAGAAAGATTGTCAAAGAATGCAAGAAGGTTCTAGATTACCTCGGAGTTGCCGAGGTGATAGACACGATGGAGGACTTGGTTCAGTTCCTGAGGGACATCTCGCCGGCGCTCTCCAGGGCGGCCAGAGAGGTGGCGGCCCGCGCTTCGGAGCTGACCCATCCCCCTCACGCCGAGATCCTCACGCAGTGCCTGGAGAGCGTCAAGCAGCTCGCGCCCGTGCTCATCTGCTCCATGAAGATATACATACACATCCTCACCGAGGGCGGCAAGGGCATGGAAGAAGCGGCCGAGAACAGGAACTACCTGGCGCAGAGGATGGCGGATGAGATCCACGAGATCATCAGGGTTCTACAGCTGACGTCGTACGTGGAGGACGGCGGCGAGAAGGACAACATCACCGTGCTTAAAGCTCTCCAAAGTCAGATATACACCAAGATAGGCGCTGCACACGAGTTTTTGAATGACGCGGCGGCGCTGCGCAACAGCTCCGGCGAGCGAGCCCTGCGCTCCGTGCTCACGTCGGCCCAGCGCGCCGCCGAGCACCTGCCGCCCGCGCCCGCCGACGCAGTCGCCGCACGCGTCCGGTGA

Protein

MPVFHTKIIESILEPVAQQVSRLVILHEEAEDGNAMPDLARPVQAVSLAVNNLVKVGHETIESSDDAILRHDMPGALHRVETAATLLQQASDMLRADPYSGPARKKLIEGSRGILQGTSALLLCFDESEVRKIVKECKKVLDYLGVAEVIDTMEDLVQFLRDISPALSRAAREVAARASELTHPPHAEILTQCLESVKQLAPVLICSMKIYIHILTEGGKGMEEAAENRNYLAQRMADEIHEIIRVLQLTSYVEDGGEKDNITVLKALQSQIYTKIGAAHEFLNDAAALRNSSGERALRSVLTSAQRAAEHLPPAPADAVAARVR

Description

Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane.

Subunit

Exhibits self-association properties.

Similarity

Belongs to the vinculin/alpha-catenin family.

Keywords

Actin-binding   Cell adhesion   Cell junction   Cell membrane   Complete proteome   Cytoplasm   Cytoskeleton   Membrane   Phosphoprotein   Reference proteome   Repeat  

Feature

chain  Vinculin

Uniprot

A0A1E1W0V8   H9JV06   A0A0N0PCQ9   A0A194PP83   A0A3S2TTN0   A0A212FNK3   + More
A0A1I8PZF7   A0A0M4FA38   T1PGN4   A0A1Y1KTI0   A0A1A9WVM6   B4NQ05   A0A1A9YMG2   A0A1A9UW50   A0A1B0G8P6   A0A1A9ZKT4   B4L5U0   B4M7C8   A0A3B0JTC8   Q29JL3   T1J8S2   B4Q189   A0A1B6HF25   A0A158NN08   B4JJ77   A0A2J7RNG9   B3P8Y8   A0A151WUQ8   A0A195EWY0   A0A034VPM4   A0A0K8VFK9   X2JAB9   O46037   B3MYS8   A0A195C5N0   A0A026WMK2   A0A1B6G3E0   A0A0A1XKI0   T1HKY3   A0A151JBF5   W8BFM7   A0A3L8DJC6   E2ACE9   A0A1B6ERX3   A0A1L8E3V2   A0A1B0CGY0   Q24584   E2BTN6   A0A069DWV1   A0A2M4A655   A0A2M4BCB1   A0A2M3Z6A1   A0A0A9W3G4   B4I9S2   A0A182FG03   A0A0J7KY03   A0A0A9WQ53   A0A0A9VYZ0   W5JGR3   A0A1W4VS88   A0A1Q3FB41   A0A182NHR3   A0A182PQA9   A0A182X3L7   Q7QJI4   A0A182I3F2   A0A182KRH3   A0A336MF54   A0A131XPW9   A0A1B6CKP3   A0A336MYC4   B0X394   V5GV37   A0A084WNF9   A0A023EWN7   A0A182IJR2   A0A336M9K2   A0A0P4WR17   A0A182JNC5   A0A182WJ44   A0A182Q5G7   Q178I1   A0A182VMB9   A0A131YDG3   V5IK57   A0A131YF27   A0A224Z5F6   A0A0P4WJ01   A0A1E1XF93   A0A0P4W6D5   B7Q5X7   A0A2D3E2W8   U5EZL2   A0A0N7ZCC0   A0A139WG82   A0A226CXN2   A0A1J1HT91   A0A087UMP9   A0A2R5LHL7  

Pubmed

19121390    26354079    22118469    25315136    28004739    17994087    + More
15632085    23185243    17550304    21347285    25348373    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    9280281    10731137    12537569    17372656    24508170    25830018    24495485    30249741    20798317    26334808    25401762    20920257    23761445    12364791    14747013    17210077    20966253    28049606    24438588    24945155    17510324    26830274    25765539    28797301    28503490    18362917    19820115   

EMBL

GDQN01010424    JAT80630.1    BABH01037485    BABH01037486    BABH01037487    KQ460466    + More
KPJ14608.1    KQ459597    KPI95246.1    RSAL01000002    RVE54937.1    AGBW02005352    OWR55289.1    CP012528    ALC49537.1    KA647023    AFP61652.1    GEZM01075901    JAV63888.1    CH964291    EDW86230.1    CCAG010000299    CH933811    EDW06549.1    CH940653    EDW62695.1    OUUW01000003    SPP78720.1    CH379063    EAL32288.2    KRT05813.1    JH431963    CM000162    EDX01396.2    GECU01034507    JAS73199.1    ADTU01020808    ADTU01020809    CH916370    EDV99629.1    NEVH01002541    PNF42368.1    CH954183    EDV45593.1    KQ982721    KYQ51650.1    KQ981940    KYN32733.1    GAKP01015203    GAKP01015202    JAC43750.1    GDHF01014667    GDHF01004794    JAI37647.1    JAI47520.1    AE014298    AHN59284.1    AHN59285.1    AL009193    AY128501    CH902632    EDV32772.1    KQ978231    KYM96152.1    KK107152    EZA57138.1    GECZ01012946    JAS56823.1    GBXI01014012    GBXI01012659    GBXI01003214    GBXI01002835    JAD00280.1    JAD01633.1    JAD11078.1    JAD11457.1    ACPB03014658    ACPB03014659    KQ979147    KYN22447.1    GAMC01009048    GAMC01009047    JAB97507.1    QOIP01000007    RLU20520.1    GL438494    EFN68888.1    GECZ01029034    GECZ01018276    GECZ01016277    GECZ01014322    GECZ01013789    GECZ01013540    GECZ01000202    JAS40735.1    JAS51493.1    JAS53492.1    JAS55447.1    JAS55980.1    JAS56229.1    JAS69567.1    GFDF01000780    JAV13304.1    AJWK01011708    X96601    CAA65421.1    GL450467    EFN80951.1    GBGD01000346    JAC88543.1    GGFK01002938    MBW36259.1    GGFJ01001548    MBW50689.1    GGFM01003306    MBW24057.1    GBHO01044200    GBHO01044199    JAF99403.1    JAF99404.1    CH480825    EDW43953.1    LBMM01002163    KMQ95196.1    GBHO01044197    GBHO01036614    JAF99406.1    JAG06990.1    GBHO01044201    GBHO01000457    JAF99402.1    JAG43147.1    ADMH02001234    ETN63552.1    GFDL01010278    JAV24767.1    AAAB01008807    EAA04738.1    APCN01000207    UFQS01000750    UFQT01000750    SSX06610.1    SSX26957.1    GEFH01000970    JAP67611.1    GEDC01023355    GEDC01006906    JAS13943.1    JAS30392.1    UFQT01001504    SSX30858.1    DS232311    EDS39596.1    GALX01000467    JAB67999.1    ATLV01024599    KE525352    KFB51753.1    GAPW01000126    JAC13472.1    SSX06609.1    SSX26956.1    GDRN01069570    JAI64022.1    AXCN02000376    CH477363    EAT42601.1    GEDV01012035    JAP76522.1    GANP01000267    JAB84201.1    GEDV01012036    JAP76521.1    GFPF01013309    MAA24455.1    GDRN01069569    JAI64023.1    GFAC01001251    JAT97937.1    GDRN01069573    JAI64020.1    ABJB010224227    ABJB010232067    ABJB010363238    ABJB010536428    ABJB010621932    ABJB010691707    ABJB010992157    DS863867    EEC14249.1    MF140475    ATU31740.1    GANO01000589    JAB59282.1    GDRN01069568    JAI64024.1    KQ971346    KYB26983.1    LNIX01000061    OXA37247.1    CVRI01000020    CRK91221.1    KK120598    KFM78638.1    GGLE01004888    MBY09014.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000283053    UP000007151    UP000095300    + More
UP000092553    UP000095301    UP000091820    UP000007798    UP000092443    UP000078200    UP000092444    UP000092445    UP000009192    UP000008792    UP000268350    UP000001819    UP000002282    UP000005205    UP000001070    UP000235965    UP000008711    UP000075809    UP000078541    UP000000803    UP000007801    UP000078542    UP000053097    UP000015103    UP000078492    UP000279307    UP000000311    UP000092461    UP000008237    UP000001292    UP000069272    UP000036403    UP000000673    UP000192221    UP000075884    UP000075885    UP000076407    UP000007062    UP000075840    UP000075882    UP000002320    UP000030765    UP000075880    UP000075881    UP000075920    UP000075886    UP000008820    UP000075903    UP000001555    UP000007266    UP000198287    UP000183832    UP000054359   

PRIDE

H9JV06    X2JAB9    O46037    Q24584    V5IK57    B7Q5X7    + More

Pfam

PF01044   Vinculin

Interpro

IPR036723   Alpha-catenin/vinculin-like_sf        + More
IPR017997   Vinculin       
IPR006077   Vinculin/catenin       
IPR000633   Vinculin_CS       
IPR003323   OTU_dom       
IPR038765   Papain-like_cys_pep_sf       

SUPFAM

SSF47220   SSF47220        + More
SSF54001   SSF54001       

ProteinModelPortal

A0A1E1W0V8   H9JV06   A0A0N0PCQ9   A0A194PP83   A0A3S2TTN0   A0A212FNK3   + More
A0A1I8PZF7   A0A0M4FA38   T1PGN4   A0A1Y1KTI0   A0A1A9WVM6   B4NQ05   A0A1A9YMG2   A0A1A9UW50   A0A1B0G8P6   A0A1A9ZKT4   B4L5U0   B4M7C8   A0A3B0JTC8   Q29JL3   T1J8S2   B4Q189   A0A1B6HF25   A0A158NN08   B4JJ77   A0A2J7RNG9   B3P8Y8   A0A151WUQ8   A0A195EWY0   A0A034VPM4   A0A0K8VFK9   X2JAB9   O46037   B3MYS8   A0A195C5N0   A0A026WMK2   A0A1B6G3E0   A0A0A1XKI0   T1HKY3   A0A151JBF5   W8BFM7   A0A3L8DJC6   E2ACE9   A0A1B6ERX3   A0A1L8E3V2   A0A1B0CGY0   Q24584   E2BTN6   A0A069DWV1   A0A2M4A655   A0A2M4BCB1   A0A2M3Z6A1   A0A0A9W3G4   B4I9S2   A0A182FG03   A0A0J7KY03   A0A0A9WQ53   A0A0A9VYZ0   W5JGR3   A0A1W4VS88   A0A1Q3FB41   A0A182NHR3   A0A182PQA9   A0A182X3L7   Q7QJI4   A0A182I3F2   A0A182KRH3   A0A336MF54   A0A131XPW9   A0A1B6CKP3   A0A336MYC4   B0X394   V5GV37   A0A084WNF9   A0A023EWN7   A0A182IJR2   A0A336M9K2   A0A0P4WR17   A0A182JNC5   A0A182WJ44   A0A182Q5G7   Q178I1   A0A182VMB9   A0A131YDG3   V5IK57   A0A131YF27   A0A224Z5F6   A0A0P4WJ01   A0A1E1XF93   A0A0P4W6D5   B7Q5X7   A0A2D3E2W8   U5EZL2   A0A0N7ZCC0   A0A139WG82   A0A226CXN2   A0A1J1HT91   A0A087UMP9   A0A2R5LHL7  

PDB

1ST6     E-value=1.32346e-76,     Score=728

KEGG

101736001    K05700 vinculin | (RefSeq) vinculin

GO

GO:0051015   GO:0007155   GO:0015629   GO:0005198   GO:0098592   GO:0005737   GO:0003779   GO:0005925   GO:0007016   GO:0016021   GO:0004965   GO:0005891   GO:0043565   GO:0003677   GO:0003707   GO:0006281   GO:0006259  

PANTHER

PTHR46180  

Subcellular location

Cytoplasm   Cytoplasmic face of adhesion plaques.   With evidence from 2 publications.
Cytoskeleton   Cytoplasmic face of adhesion plaques.   With evidence from 2 publications.
Cell junction   Cytoplasmic face of adhesion plaques.   With evidence from 2 publications.
Adherens junction   Cytoplasmic face of adhesion plaques.   With evidence from 2 publications.
Cell membrane   Cytoplasmic face of adhesion plaques.   With evidence from 2 publications.

Length:

325

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00188

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01452

outside

1  -  325

 

 

Pi

235.406224

Theta

169.549791

Tajima's D

1.348912

CLR

0.304006

CSRT

0.75691215439228

Interpretation

Uncertain