Gene

KWMTBOMO15868  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA013349

Annotation

PREDICTED:_adapter_molecule_Crk_[Papilio_machaon]

Location

Bomo_Chr27(-):359844-370601      View in EpiBrowser

Full name

Adapter molecule Crk      

Location in the cell

Cytoplasmic   Reliability : 1.429 Peroxisomal   Reliability : 1.108

CDS

ATGGCGAATTCCGGAATGGGGGGTTCCTTCGACCCCAATGACATGAGCAGCTGGTACTTTCACGGCATGACGCGGAAAGAAGCTACAGATCTGCTCCTTAATGAGACTGAGAGTGGCGTGTTTCTGGTCAGGGATTCGAAGTCCATTGTTGGAAACTACGTTCTTTGCGTCAAAGAAGCAGGTCGGGTGTCGAACTATATAATCGATCGCATCGTTTCACCCGACGGCTCGGTGCTCTTCCGCATCGGAGACCAGGTGTTCGTGGACATGGCGGCGCTGTTGTCGTTCTACCGCGTCCACTACTTGGACACGACGGCGCTGGTGAGGCCCTACGCGAGGACGGCCATCGCTCACCAGCCTCCGCAGCAGAACCAGACCCTAGAGATAGTTATCGCGAAGTTCGATTTCGCTGGCAACGACGCAGACGACCTCCCGTTCCGGCGCGGCGAGAAGCTGGCGGTGGTGAGTCGCGACGAGGAGCAGTGGTGGACCGCGCGCAACGTGCACGGCCGCACCGGCTCCATCCCCGTGCCCTACGTGCAGAGGATGGCGGACATGTCTGCGGAGTCCCTGGAGGCCCCGGCCCCGCCCGTCAACAAGAACTCCCACCTCACCAACATGGAGCGCAAGCTGCCCGCCCTGGCGCGCGTGCGGCAGGCCCGGGTGCCCAACGCCTACGACAAGACGGCCCTCAAACTTGAGGAAGGAGACATCATTAAGGTCACAAAGATCAACATCAACGGGCAGTGGGTCGGGGAACTGAACGGCCGGACCGGACACTTCCCCTTCACATACGTCGAGTTCCTGGACGAGAACACGCCCAGCTAG

Protein

MANSGMGGSFDPNDMSSWYFHGMTRKEATDLLLNETESGVFLVRDSKSIVGNYVLCVKEAGRVSNYIIDRIVSPDGSVLFRIGDQVFVDMAALLSFYRVHYLDTTALVRPYARTAIAHQPPQQNQTLEIVIAKFDFAGNDADDLPFRRGEKLAVVSRDEEQWWTARNVHGRTGSIPVPYVQRMADMSAESLEAPAPPVNKNSHLTNMERKLPALARVRQARVPNAYDKTALKLEEGDIIKVTKININGQWVGELNGRTGHFPFTYVEFLDENTPS

Description

Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development.

Similarity

Belongs to the CRK family.

Keywords

Complete proteome   Developmental protein   Reference proteome   Repeat   SH2 domain   SH3 domain  

Feature

chain  Adapter molecule Crk

Uniprot

H9JUY6   A0A2A4J7D4   A0A0N0PCV4   A0A194PVT4   A0A1Y1MAE5   A0A0A9WED1   + More
A0A1S4EKH5   A0A224XI25   A0A1B0CLT4   A0A1B6KTB1   A0A1B6D8E3   A0A0P4VQ02   Q7QG48   A0A023F5B5   A0A1L8DLM6   A0A0V0G7J0   A0A069DR22   A0A336KM49   T1I0P2   A0A2J7QYR6   A0A0P4ZQ04   T1JIX5   A0A1B6IWS6   A0A1B6G2X3   Q9XYM0   A0A0J9S0Q9   B4IL88   B4PVZ1   A0A2H8TUB2   F4WKU4   A0A151WV37   A0A0T6BG36   A0A2A3EDF2   A0A2S2PN28   A0A182PA74   E9J1P7   A0A3L8DAF9   B3P9V1   J9JYW1   A0A0J7KK00   A0A182KGM0   B4NHJ7   A0A3S4QUX1   B0W5R9   A0A182RGE0   A0A1I8P005   A0A182R117   E0VNA4   K7IWQ3   A0A0M9ABN6   A0A1E1X7T4   E2AJ57   A0A182M0X9   A0A0J9US85   A0A084VPI1   B4JZT2   A0A154PK49   A0A1W4WXR1   A0A232EY17   D6W7Z9   Q29CU6   B4H853   A0A182IPR7   A0A0R1EC50   A0A3B0K4C6   Q0IF64   A0A1S4J6E9   E2C5L7   B4MF31   A0A1W4VY38   U5EZD7   A0A1J1HTR5   B4L789   A0A195CN46   A0A182GSA0   A0A0M3QYR4   A0A224Z7A0   A0A131YRY2   A0A0K8TKN9   A0A2R5LMG8   B3MZ90   A0A0Q9XFT5   A0A158P3Y0   A0A131XES9   A0A182L5K4   H9XVM6   A0A1B0G637   D3TQG1   A0A1A9UL38   A0A1A9ZD07   A0A0L0BQC7   A0A1A9XCS7   A0A1B0AUT2   L7M1T1   A0A151JVS7   A0A310SMC9   A0A195BKT6   A0A0L7R8N7   V5GM20   A0A026WWK6  

Pubmed

19121390    26354079    28004739    25401762    26823975    27129103    + More
12364791    25474469    26334808    10072777    10731132    12537572    22936249    17994087    17550304    21719571    21282665    30249741    20566863    20075255    28503490    20798317    24438588    28648823    18362917    19820115    15632085    17510324    18057021    20479145    26483478    28797301    26830274    26369729    21347285    28049606    20966253    12537568    12537573    12537574    16110336    17569856    17569867    20353571    26108605    25576852    24508170   

EMBL

BABH01037460    NWSH01002557    PCG67995.1    KQ460466    KPJ14615.1    KQ459597    + More
KPI95240.1    GEZM01037757    JAV81958.1    GBHO01040387    GBHO01040385    GBHO01040384    GBHO01040383    GBHO01040382    GBHO01014703    GBRD01003779    GDHC01010176    JAG03217.1    JAG03219.1    JAG03220.1    JAG03221.1    JAG03222.1    JAG28901.1    JAG62042.1    JAQ08453.1    GFTR01004291    JAW12135.1    AJWK01017609    GEBQ01025302    GEBQ01011037    JAT14675.1    JAT28940.1    GEDC01015366    JAS21932.1    GDKW01002713    JAI53882.1    AAAB01008839    EAA05910.3    GBBI01002414    JAC16298.1    GFDF01006715    JAV07369.1    GECL01002049    JAP04075.1    GBGD01002564    JAC86325.1    UFQS01000668    UFQT01000668    SSX05974.1    SSX26331.1    ACPB03016929    NEVH01009083    PNF33725.1    GDIP01214002    GDIP01152781    GDIP01115860    JAJ09400.1    AFFK01016682    GECU01031934    GECU01016312    GECU01014205    JAS75772.1    JAS91394.1    JAS93501.1    GECZ01012997    JAS56772.1    AF112976    AE014135    BT012456    CM002916    KMZ07168.1    CH480867    EDW53719.1    CM000161    EDW99296.1    GFXV01006058    MBW17863.1    GL888206    EGI65186.1    KQ982708    KYQ51792.1    LJIG01000734    KRT86206.1    KZ288288    PBC29322.1    GGMR01018165    MBY30784.1    GL767674    EFZ13209.1    QOIP01000011    RLU17132.1    CH954184    EDV45264.1    ABLF02034895    ABLF02034902    LBMM01006501    KMQ90561.1    CH964272    EDW83566.2    NCKU01003150    RWS08075.1    DS231844    EDS35722.1    AXCN02000858    DS235335    EEB14860.1    AAZX01007094    KQ435689    KOX81245.1    GFAC01003904    JAT95284.1    GL439967    EFN66497.1    AXCM01000440    KMZ07166.1    ATLV01015007    KE524999    KFB39875.1    CH916380    EDV90948.1    KQ434931    KZC11834.1    NNAY01001690    OXU23215.1    KQ971307    EFA11162.1    CH475405    EAL29244.2    CH479221    EDW34853.1    KRK04802.1    OUUW01000017    SPP89054.1    CH477394    EAT41873.1    GL452770    EFN76830.1    CM000831    CH940665    ACY70513.1    EDW71132.1    GANO01000982    JAB58889.1    CVRI01000021    CRK91464.1    CH933813    EDW10883.2    KQ977513    KYN02171.1    JXUM01005913    JXUM01084232    JXUM01084233    KQ560204    KXJ83839.1    CP012527    ALC48069.1    GFPF01011106    MAA22252.1    GEDV01007327    JAP81230.1    GDAI01002912    JAI14691.1    GGLE01006575    MBY10701.1    CH902633    EDV33695.2    KRG07213.1    ADTU01008610    GEFH01004420    JAP64161.1    AFH06771.1    CCAG010001717    EZ423663    ADD19939.1    JRES01001537    KNC22188.1    JXJN01003723    GACK01007966    JAA57068.1    KQ981701    KYN37490.1    KQ763581    OAD54928.1    KQ976453    KYM85335.1    KQ414631    KOC67235.1    GALX01005814    JAB62652.1    KK107078    EZA60460.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000079169    UP000092461    + More
UP000007062    UP000015103    UP000235965    UP000000803    UP000001292    UP000002282    UP000007755    UP000075809    UP000242457    UP000075885    UP000279307    UP000008711    UP000007819    UP000036403    UP000075881    UP000007798    UP000285301    UP000002320    UP000075900    UP000095300    UP000075886    UP000009046    UP000002358    UP000053105    UP000000311    UP000075883    UP000030765    UP000001070    UP000076502    UP000192223    UP000215335    UP000007266    UP000001819    UP000008744    UP000075880    UP000268350    UP000008820    UP000008237    UP000008792    UP000192221    UP000183832    UP000009192    UP000078542    UP000069940    UP000249989    UP000092553    UP000007801    UP000005205    UP000075882    UP000092444    UP000078200    UP000092445    UP000037069    UP000092443    UP000092460    UP000078541    UP000078540    UP000053825    UP000053097   

PRIDE

H9JUY6    Q9XYM0    H9XVM6   

Pfam

PF00017   SH2        + More
PF07653   SH3_2
PF00018   SH3_1

Interpro

IPR036028   SH3-like_dom_sf        + More
IPR036860   SH2_dom_sf       
IPR001452   SH3_domain       
IPR000980   SH2       
IPR035458   CRK_SH3_C       
IPR035457   CRK_SH3_N       

SUPFAM

SSF55550   SSF55550        + More
SSF50044   SSF50044       

Gene 3D

3.30.505.10    

CDD

cd11759  SH3_CRK_C
cd11758  SH3_CRK_N

ProteinModelPortal

H9JUY6   A0A2A4J7D4   A0A0N0PCV4   A0A194PVT4   A0A1Y1MAE5   A0A0A9WED1   + More
A0A1S4EKH5   A0A224XI25   A0A1B0CLT4   A0A1B6KTB1   A0A1B6D8E3   A0A0P4VQ02   Q7QG48   A0A023F5B5   A0A1L8DLM6   A0A0V0G7J0   A0A069DR22   A0A336KM49   T1I0P2   A0A2J7QYR6   A0A0P4ZQ04   T1JIX5   A0A1B6IWS6   A0A1B6G2X3   Q9XYM0   A0A0J9S0Q9   B4IL88   B4PVZ1   A0A2H8TUB2   F4WKU4   A0A151WV37   A0A0T6BG36   A0A2A3EDF2   A0A2S2PN28   A0A182PA74   E9J1P7   A0A3L8DAF9   B3P9V1   J9JYW1   A0A0J7KK00   A0A182KGM0   B4NHJ7   A0A3S4QUX1   B0W5R9   A0A182RGE0   A0A1I8P005   A0A182R117   E0VNA4   K7IWQ3   A0A0M9ABN6   A0A1E1X7T4   E2AJ57   A0A182M0X9   A0A0J9US85   A0A084VPI1   B4JZT2   A0A154PK49   A0A1W4WXR1   A0A232EY17   D6W7Z9   Q29CU6   B4H853   A0A182IPR7   A0A0R1EC50   A0A3B0K4C6   Q0IF64   A0A1S4J6E9   E2C5L7   B4MF31   A0A1W4VY38   U5EZD7   A0A1J1HTR5   B4L789   A0A195CN46   A0A182GSA0   A0A0M3QYR4   A0A224Z7A0   A0A131YRY2   A0A0K8TKN9   A0A2R5LMG8   B3MZ90   A0A0Q9XFT5   A0A158P3Y0   A0A131XES9   A0A182L5K4   H9XVM6   A0A1B0G637   D3TQG1   A0A1A9UL38   A0A1A9ZD07   A0A0L0BQC7   A0A1A9XCS7   A0A1B0AUT2   L7M1T1   A0A151JVS7   A0A310SMC9   A0A195BKT6   A0A0L7R8N7   V5GM20   A0A026WWK6  

PDB

2EYZ     E-value=5.09874e-62,     Score=601

KEGG

101745959    K04438 proto-oncogene C-crk | (RefSeq) adapter molecule Crk

GO

GO:0007298   GO:0006911   GO:0046330   GO:0048013   GO:0043087   GO:0032956   GO:0030971   GO:0046529   GO:0007520   GO:0048010   GO:0005515   GO:0043401   GO:0003700   GO:0005634   GO:0008270   GO:0043565   GO:0003677   GO:0003707   GO:0006281   GO:0006259  

Length:

275

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02499

Exp number, first 60 AAs:

0.00018

Total prob of N-in:

0.00986

outside

1  -  275

 

 

Pi

297.087263

Theta

156.893377

Tajima's D

-1.208355

CLR

0.130696

CSRT

0.106194690265487

Interpretation

Uncertain