Gene

KWMTBOMO15849  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000062

Annotation

fumarylacetoacetase_[Bombyx_mori]

Location

Bomo_Chr26(+):11392413-11397877      View in EpiBrowser

Full name

Fumarylacetoacetate hydrolase domain-containing protein 2       + More
MICOS complex subunit MIC60      

Alternative Name

Mitofilin

Location in the cell

Cytoplasmic   Reliability : 1.496 Nuclear   Reliability : 1.03

CDS

ATGAAGTTAGTTCAGTTTTCATACAAAGATAGTCCAAAAAATATACGTGTGGGCTACCTGGAAGGAGATGATATTGTAGATATTAATAAGGCGGACTCCAGTTTGCCGACCACTTTGCTCCAAATACTCAGGAATGGAGACTTAGAAAAAGTGAAGAAGTTGAAATCAACAAAACCAGCAACTATACCACTATCATCAGTCACTCTAACTGCACCCATACATGGTGTAGATAAAATCCTCTGTATCGGCTTGAACTACAAGGATCACTGCCAAGAGCAGAATCTCACCCCACCTCCTGTGCCGATGGTGTTCAGTAAATTTTCAAGCACCATCATTGGACCTGATCAGCCTGTTAGGATCAGAACTGATGTTACTAAGAAGGTGGACTGGGAGGTGGAGCTGTGCGTGGTGGTGGGGCGCGAGGCCAGCTGCGTGCGCGAGGAGGACGCGCTGCAGCACGTGGCCGGGTACACCGTCGCGCAGGACATCAGCGCCAGGGACTGGCAGAAAGAGAAGAACATGGGGCAGTTCCTGCTAGGGAAGTCCATGGACACGTTCTGTCCGCTGGGCCCGTGCGTGCTGACGAGCGACGAGGTGGGCGCGGCCGTGGAGCTGCGCGTGTCCTGCTCGCTCAACGGGGTCCTCAAGCAGAGCAGCAGCACGGCGCAGCTAGTGCACTCCATCCCGAGCCTGCTGCACAGGATCTCCTCCGTGATGACCCTGGTCCCCGGCGACCTGATCCTGACGGGCACCCCGGGGGGCGTGGGCATGTACCGGCAGCCCCCGGAGTACCTGCAGCCCGGGGACGTGCTCACCAGCGAGATCGAGAAGATCGGCGCCTTCGACGTTCGCATCGAGAAGTTTTAG

Protein

MKLVQFSYKDSPKNIRVGYLEGDDIVDINKADSSLPTTLLQILRNGDLEKVKKLKSTKPATIPLSSVTLTAPIHGVDKILCIGLNYKDHCQEQNLTPPPVPMVFSKFSSTIIGPDQPVRIRTDVTKKVDWEVELCVVVGREASCVREEDALQHVAGYTVAQDISARDWQKEKNMGQFLLGKSMDTFCPLGPCVLTSDEVGAAVELRVSCSLNGVLKQSSSTAQLVHSIPSLLHRISSVMTLVPGDLILTGTPGGVGMYRQPPEYLQPGDVLTSEIEKIGAFDVRIEKF

Description

May have hydrolase activity.
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

Cofactor

Ca(2+)
Mg(2+)

Subunit

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.

Similarity

Belongs to the FAH family.
Belongs to the MICOS complex subunit Mic60 family.

Keywords

Calcium   Hydrolase   Magnesium   Metal-binding  

Feature

chain  Fumarylacetoacetate hydrolase domain-containing protein 2

Uniprot

Q2F601   H9IS36   Q2F600   S4PCS0   A0A3S2NJT7   A0A2H1VFY1   + More
A0A2H1VWM9   A0A2A4K945   A0A0L7L322   A0A2W1BQW5   A0A2A4JGP7   H9IUY8   A0A2H1V0L4   A0A2A4K9I9   I4DP61   A0A194QDS5   A0A1B6CPP5   J3JX48   A0A1Y1NGL8   A0A1B6IE47   A0A1B6GRW8   A0A2J7QJJ6   A0A067R380   N6TM24   A0A023ERA0   D6WZV5   Q17N03   E0VV30   A0A182KBL7   A0A182MXL1   A0A1B6DMP2   B0XIL6   K1QP24   A0A0B6ZZ25   A0A1B0CS49   A0A182HN30   A0A182WX74   Q5TMH4   A0A182VNE1   A0A1B6LC38   A0A182PDB0   A0A0K8TM05   E2AQK2   Q6GLT8   A0A026WDZ7   A0A182LNV2   A0A1L8E2L4   A0A1L8E2P0   A0A182U545   K7IP22   A0A1Y1NGR3   A0A2P8XJY1   A0A1B6CY00   V9KVI1   W5JD71   U4UIB3   A0A1L8E9V2   A0A182MSH9   A0A2M4AM47   A0A2M4AMK1   A0A2M4BTK7   F2U773   A0A210PYB4   A0A0B8RYW5   A0A336L0T5   A0A182WEL4   A0A084WQ20   A0A2D4P1P8   A0A0J7NXS4   A0A1Q3FKJ5   A0A336KQN9   T1DGH7   A0A1U7Q9F0   A0A182QB46   G3H030   A0A2M4AMS7   A0A2M4BTR5   A0A2M4BTY1   A0A1I8PWU6   I3NDW8   A0A182FBE3   A0A3L7HEG4   A0A1L8H1M1   E2BP43   F4W975   A0A182YNI4   A0A0R4J094   D6WZV6   A0A1Q3FIU4   L8Y998   A0A250YF70   A0A1Q3FKS1   A0A2M3ZAH2   G1TPZ3   A0A1S3FGH8   V4AI08   A0A0A9XLH6   A0A286XAZ9   A0A1U7TLE7  

EC Number

3.-.-.-

Pubmed

19121390    23622113    26227816    28756777    22651552    26354079    + More
22516182    28004739    24845553    23537049    24945155    18362917    19820115    17510324    20566863    22992520    12364791    14747013    17210077    26369729    20798317    24508170    20966253    20075255    29403074    24402279    20920257    23761445    28812685    25476704    24438588    21804562    29704459    27762356    21719571    25244985    19468303    21183079    23806337    23576753    23385571    28087693    21993624    23254933    25401762   

EMBL

DQ311271    ABD36216.1    BABH01035686    DQ311272    ABD36217.1    GAIX01004016    + More
JAA88544.1    RSAL01000019    RVE52794.1    ODYU01002352    SOQ39735.1    ODYU01004895    SOQ45239.1    NWSH01000019    PCG80727.1    JTDY01003234    KOB69908.1    KZ149928    PZC77479.1    NWSH01001435    PCG71237.1    BABH01000070    ODYU01000131    SOQ34390.1    PCG80729.1    AK403436    BAM19701.1    KQ459144    KPJ03612.1    GEDC01021841    JAS15457.1    BT127816    AEE62778.1    GEZM01002881    JAV97093.1    GECU01022497    JAS85209.1    GECZ01004610    JAS65159.1    NEVH01013553    PNF28760.1    KK852941    KDR13529.1    APGK01058790    APGK01058791    APGK01058792    APGK01058793    KB741292    ENN70305.1    GAPW01002414    JAC11184.1    KQ971372    EFA10483.2    CH477202    EAT48142.1    DS235802    EEB17236.1    GEDC01010386    JAS26912.1    DS233329    EDS29440.1    JH816002    EKC38637.1    HACG01026090    CEK72955.1    AJWK01025642    APCN01001831    AAAB01008986    EAL38923.3    GEBQ01018730    JAT21247.1    GDAI01002214    JAI15389.1    GL441777    EFN64270.1    BC074365    KK107293    EZA53254.1    GFDF01001104    JAV12980.1    GFDF01001103    JAV12981.1    GEZM01002880    JAV97094.1    PYGN01001893    PSN32303.1    GEDC01018994    JAS18304.1    JW870532    AFP03050.1    ADMH02001501    ETN62292.1    KB632334    ERL92767.1    GFDG01003417    JAV15382.1    AXCM01002192    GGFK01008523    MBW41844.1    GGFK01008656    MBW41977.1    GGFJ01007264    MBW56405.1    GL832963    EGD83290.1    NEDP02005386    OWF41480.1    GBSH01001032    JAG67993.1    UFQS01000773    UFQT01000773    SSX06780.1    SSX27125.1    ATLV01025159    KE525370    KFB52314.1    IACN01043830    LAB51914.1    LBMM01000919    KMQ97215.1    GFDL01007013    JAV28032.1    SSX06779.1    SSX27124.1    GAMD01002771    JAA98819.1    AXCN02001066    JH000086    EGW04973.1    GGFK01008587    MBW41908.1    GGFJ01007263    MBW56404.1    GGFJ01007260    MBW56401.1    AGTP01102139    RAZU01000234    RLQ64354.1    CM004470    OCT89956.1    GL449529    EFN82540.1    GL888002    EGI69257.1    AL731831    EFA10484.1    GFDL01007642    JAV27403.1    KB365080    ELV11525.1    GFFW01002505    JAV42283.1    GFDL01006969    JAV28076.1    GGFM01004724    MBW25475.1    AAGW02007409    KB201977    ESO93041.1    GBHO01022780    GBHO01022778    GBRD01006623    GBRD01006622    JAG20824.1    JAG20826.1    JAG59198.1    AAKN02027871   

Proteomes

UP000005204    UP000283053    UP000218220    UP000037510    UP000053268    UP000235965    + More
UP000027135    UP000019118    UP000007266    UP000008820    UP000009046    UP000075881    UP000075884    UP000002320    UP000005408    UP000092461    UP000075840    UP000076407    UP000007062    UP000075903    UP000075885    UP000000311    UP000053097    UP000075882    UP000075902    UP000002358    UP000245037    UP000000673    UP000030742    UP000075883    UP000007799    UP000242188    UP000075920    UP000030765    UP000036403    UP000189706    UP000075886    UP000001075    UP000095300    UP000005215    UP000069272    UP000273346    UP000186698    UP000008237    UP000007755    UP000076408    UP000000589    UP000011518    UP000001811    UP000081671    UP000030746    UP000005447    UP000189704   

PRIDE

Q2F601    H9IS36    Q2F600    H9IUY8    Q6GLT8    G3H030    + More
A0A0R4J094   

Pfam

PF01557   FAA_hydrolase        + More
PF00232   Glyco_hydro_1
PF15247   SLBP_RNA_bind
PF09731   Mitofilin
PF09495   DUF2462

Interpro

IPR036663   Fumarylacetoacetase_C_sf        + More
IPR011234   Fumarylacetoacetase-like_C       
IPR001360   Glyco_hydro_1       
IPR017853   Glycoside_hydrolase_SF       
IPR029344   SLBP_RNA_bind       
IPR038294   SLBP_RNA_bind_sf       
IPR019133   Mt-IM_prot_Mitofilin       
IPR019034   UPF0390       

SUPFAM

SSF56529   SSF56529        + More
SSF51445   SSF51445       

Gene 3D

3.90.850.10     1.10.8.1120    

ProteinModelPortal

Q2F601   H9IS36   Q2F600   S4PCS0   A0A3S2NJT7   A0A2H1VFY1   + More
A0A2H1VWM9   A0A2A4K945   A0A0L7L322   A0A2W1BQW5   A0A2A4JGP7   H9IUY8   A0A2H1V0L4   A0A2A4K9I9   I4DP61   A0A194QDS5   A0A1B6CPP5   J3JX48   A0A1Y1NGL8   A0A1B6IE47   A0A1B6GRW8   A0A2J7QJJ6   A0A067R380   N6TM24   A0A023ERA0   D6WZV5   Q17N03   E0VV30   A0A182KBL7   A0A182MXL1   A0A1B6DMP2   B0XIL6   K1QP24   A0A0B6ZZ25   A0A1B0CS49   A0A182HN30   A0A182WX74   Q5TMH4   A0A182VNE1   A0A1B6LC38   A0A182PDB0   A0A0K8TM05   E2AQK2   Q6GLT8   A0A026WDZ7   A0A182LNV2   A0A1L8E2L4   A0A1L8E2P0   A0A182U545   K7IP22   A0A1Y1NGR3   A0A2P8XJY1   A0A1B6CY00   V9KVI1   W5JD71   U4UIB3   A0A1L8E9V2   A0A182MSH9   A0A2M4AM47   A0A2M4AMK1   A0A2M4BTK7   F2U773   A0A210PYB4   A0A0B8RYW5   A0A336L0T5   A0A182WEL4   A0A084WQ20   A0A2D4P1P8   A0A0J7NXS4   A0A1Q3FKJ5   A0A336KQN9   T1DGH7   A0A1U7Q9F0   A0A182QB46   G3H030   A0A2M4AMS7   A0A2M4BTR5   A0A2M4BTY1   A0A1I8PWU6   I3NDW8   A0A182FBE3   A0A3L7HEG4   A0A1L8H1M1   E2BP43   F4W975   A0A182YNI4   A0A0R4J094   D6WZV6   A0A1Q3FIU4   L8Y998   A0A250YF70   A0A1Q3FKS1   A0A2M3ZAH2   G1TPZ3   A0A1S3FGH8   V4AI08   A0A0A9XLH6   A0A286XAZ9   A0A1U7TLE7  

PDB

6IYM     E-value=7.15621e-42,     Score=427

KEGG

692880    no KO assigned | (RefSeq) Faah; fumarylacetoacetate hydrolase

GO

GO:0016787   GO:0003824   GO:0004553   GO:0005975   GO:0003723   GO:0016853   GO:0008704   GO:0018800   GO:0046872   GO:0005743   GO:0016021   GO:0008152   GO:0005840   GO:0006412   GO:0005215   GO:0006270   GO:0042555   GO:0003707   GO:0006281   GO:0006259  

PANTHER

PTHR10353  

Subcellular location

Mitochondrion inner membrane  

Length:

288

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0618

Exp number, first 60 AAs:

0.0009

Total prob of N-in:

0.04666

outside

1  -  288

 

 

Pi

221.312781

Theta

171.429055

Tajima's D

0.853341

CLR

0.071765

CSRT

0.618069096545173

Interpretation

Uncertain