Silkworm Genome Informatics Database

Gene

KWMTBOMO15847 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000002

Annotation

PREDICTED:_uncharacterized_protein_LOC101745378_[Bombyx_mori]

Location

Bomo_Chr26(-):11379185-11385672 View in EpiBrowser

Full name

MICOS complex subunit MIC60

Alternative Name

Mitofilin

Location in the cell

Cytoplasmic Reliability : 1.282 Mitochondrial Reliability : 1.395

CDS

ATGTACAAATTTACGAATCATTTATCGAATGCTAAATTAGTTTTGGTAAGAAGACACATTGATGGGTCCTCAGCAGCACTGATAGTACTTCGTCAAAACTCATACTCCCAGGATCATGGTACACGACAGCAACCCCGCAAGTCACGCAAGCTCTTCTGGAGCACTGTCGGAGCGACTGTACTTACTGGAGCTGCTGTTGTTTATGCCAAACACAGTCCAGAGGCCCGAAACTGGTTAGAGTCAAATGTCCCTTGGGCCAATGACCTGGTAGCTCTCGTTTACCAGGAGAAGTCTTCACCGTGGAAGTTTACAGTGGACCGTTTCAACCAGGCCACCACGTCAATCAGCCACTTTGTGTTTGGAAAGGAAGGTGTTACGCCATTAGAGATAAAGTCGAGGTCACAGCAGGACATAGATGCAGATGCAGCAAAGAAGGCAACCAGCAAAGACTTCCAATTGCCTCCGCCCTCCCTTGAGCCCCTCTACGTGGAGGAGAAGAAGCTTGGAACACCGGATGTAGACACACCAGCTACGGTGGTGCAGACGGAGCGCTGCGAGCCCGCGCGCGCCCCGGCCGCCGCCGTGCCCGCCGAGCTGGTGCAGCTGGAGCGCGACATGATGGACAACACCAAGCTGGCCCTCGACAGCTACAAGCGCGCCTCCCAGCACTGCAAGCGCTACAACGACGCGCTCTACAAGATAGTGGAGTCCACCGTGGAGGAGCTGGACAAGAGGCACTTCTCGGCGCTGCAGGGCGCGCAGAGCGAGCGGGACGCGGCGCACGAGCAGGCCGCGGAGGCCGCCGCTCGCGCCAAGAGCGCCATCCAGCGGGTGGAGAGCGCGCTGGAGGCCGGGGCGCCGGTGCCGCCGCCCGCGGCCGCCGCCACCCGGCGCCACGCCGCCGCCTTCGGGGAGCAGCTGGCGGCCGCGGAGGCCGAGTACTGCCGGTGCCGGGACGAGGCGCTGCTGGCCGACCGCTACTGGGACAAGGTGGAGGCGGCCCGGTCTGCGTTCCGGGCGGAGCTGGCGGCGCTGTTCCCGGGCGCCGACCTCAGCGCGCGCTCCCTGCCCTCCGCGCACGTCGACCTGCTGCTCGTCTACACGCTCAAACAGATCCAGTTCCTGCAAAACCAGCTGGCGGAGCTGCAGACCGTGCGGGAGCAGAAGATCAACCGCGCCATTGAGTGTCACGACGAGAAGGCGCTCATCGAAGCTAAAGTGGAGGACCTAATCAAAGCGGAACGCGTCGAGAGGGAGAAGGAATTCCTCAAGAGGAGCCTGGCGCTGCAGGCCGAGGCCCACAGGAGCCTCCGGGAGCAGCTCAAGAAGCAGTTCGAGATACAGCAGGAGGTCCTGCAGGAGAAGGTCGCCAGCAAGGAGAAAGAGGTGATGTCCCGCCTGGCGCGCGCGCAGTCCGAGCGCCTGGAGCACGAGCGCGCGCAGCACAAGCGCGAGCTGGGCGCCGCCGCCGCGCGCCTCGCCGCCGTGCAGCACGCGCTCAAACAGCGGGCGGGCGCGGAGGAGGAGGCGCGGCGCAGCGCGGCGCTGTGGGCGGCGGCGGGCGGCGTGCTGGCCGCGCTGTCCGCGCCGCGCCGGGCGCCGCTGCGGGACCACGTGGCCGCCGTGCGCAGCGCCGGTAAGGACGACAAATTGGTGCAGAGCATCCTGCAGAGCATCTCGCGAGACGCGCTGGAGCACGGCGTGGCCACCGAGCAGGAGCTCCGGGACAGCTTCGACAGGATGGAAAAGACAGTACTGAAGGTGGCGCTGGTGGGGCGCGAGGGAGCCTCCCTGCCGGTGTACTTCCTGTCCTGGCTGCAGTCCAAGCTGCTGTTCTACAAGCTGTCGGAGCTTCCCGAGGAGGAGATGGAGGACAAGCCCGTGGACTACACCAAGCTGGACAACTTCGAGATCATGCAGCGGGCCAGATGGCAGCTGGAGCGCGGCGCGGTGGAGCGGGCGGCGCGGCTGGTGGGCGCGCTGCGGGGCGCGGGGCGGGCGGCGGGCGCGGCGTGGGCGGGGCCGGCGCGCGAGCACCTGGCCGTGCGTCAGGCCGCGCACGCGCTCATGGCGCACGCCGAGCTGTCCTCGCTGCTGCACGTGTAG

Protein

MYKFTNHLSNAKLVLVRRHIDGSSAALIVLRQNSYSQDHGTRQQPRKSRKLFWSTVGATVLTGAAVVYAKHSPEARNWLESNVPWANDLVALVYQEKSSPWKFTVDRFNQATTSISHFVFGKEGVTPLEIKSRSQQDIDADAAKKATSKDFQLPPPSLEPLYVEEKKLGTPDVDTPATVVQTERCEPARAPAAAVPAELVQLERDMMDNTKLALDSYKRASQHCKRYNDALYKIVESTVEELDKRHFSALQGAQSERDAAHEQAAEAAARAKSAIQRVESALEAGAPVPPPAAAATRRHAAAFGEQLAAAEAEYCRCRDEALLADRYWDKVEAARSAFRAELAALFPGADLSARSLPSAHVDLLLVYTLKQIQFLQNQLAELQTVREQKINRAIECHDEKALIEAKVEDLIKAERVEREKEFLKRSLALQAEAHRSLREQLKKQFEIQQEVLQEKVASKEKEVMSRLARAQSERLEHERAQHKRELGAAAARLAAVQHALKQRAGAEEEARRSAALWAAAGGVLAALSAPRRAPLRDHVAAVRSAGKDDKLVQSILQSISRDALEHGVATEQELRDSFDRMEKTVLKVALVGREGASLPVYFLSWLQSKLLFYKLSELPEEEMEDKPVDYTKLDNFEIMQRARWQLERGAVERAARLVGALRGAGRAAGAAWAGPAREHLAVRQAAHALMAHAELSSLLHV

Description

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

Subunit

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.

Similarity

Belongs to the MICOS complex subunit Mic60 family.

Uniprot

A0A212EMD7 A0A3S2PJ02 A0A2W1BHI2 A0A1E1WGW3 A0A194QDW5 B0XC15 + More
A0A195B5M7 A0A158P0P2 A0A151IF90 A0A0P4VUY0 A0A195EEM9 A0A151WKK5 A0A195F354 A0A182F6G5 A0A182XIC1

Pubmed

22118469 28756777 26354079 21347285 27129103

EMBL

AGBW02013848 OWR42660.1 RSAL01000019 RVE52792.1 KZ150122 PZC73165.1 + More
GDQN01004832 JAT86222.1 KQ459144 KPJ03614.1 DS232669 EDS44578.1 KQ976598 KYM79575.1 ADTU01001014 ADTU01001015 ADTU01001016 KQ977800 KYM99578.1 GDKW01000212 JAI56383.1 KQ979039 KYN23262.1 KQ983002 KYQ48413.1 KQ981855 KYN34893.1

Proteomes

UP000007151 UP000283053 UP000053268 UP000002320 UP000078540 UP000005205 + More
UP000078542 UP000078492 UP000075809 UP000078541 UP000069272 UP000076407

Pfam

PF09731   Mitofilin        + More
PF01918   Alba
PF00085   Thioredoxin

Interpro

IPR019133   Mt-IM_prot_Mitofilin        + More
IPR002775   DNA/RNA-bd_Alba-like
IPR036882   Alba-like_dom_sf
IPR013766   Thioredoxin_domain
IPR036249   Thioredoxin-like_sf
IPR011992   EF-hand-dom_pair
IPR013087   Znf_C2H2_type

SUPFAM

SSF52833   SSF52833        + More
SSF47473   SSF47473
SSF82704   SSF82704

Gene 3D

3.30.110.20

ProteinModelPortal

A0A212EMD7 A0A3S2PJ02 A0A2W1BHI2 A0A1E1WGW3 A0A194QDW5 B0XC15 + More
A0A195B5M7 A0A158P0P2 A0A151IF90 A0A0P4VUY0 A0A195EEM9 A0A151WKK5 A0A195F354 A0A182F6G5 A0A182XIC1

KEGG

101745378 K17785 mitofilin | (RefSeq) uncharacterized LOC101745378

GO

GO:0016021 GO:0005743 GO:0003676 GO:0045454

PANTHER

PTHR15415

Subcellular location

Mitochondrion inner membrane

Length:

701

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

15.38533

Exp number, first 60 AAs:

8.16454

Total prob of N-in:

0.81311

inside

1 - 50

TMhelix

51 - 69

outside

70 - 701

Pi

197.186506

Theta

161.94339

Tajima's D

0.654689

CLR

122.123812

CSRT

0.56237188140593

Interpretation

Uncertain

Source	Sequence	Identity	Evalue
28556443	FNQATTSISHFVFGK	100.00	2e-05
26822097	SIAIQAEAHR	100.00	2e-04
28467696	FNPFDITK	100.00	2e-04
28556443	APAAAVPAELVQLER	100.00	2e-04
28556443	QIQFLQNQLAELQTVR	100.00	0.002
28556443	LDNFEIMQR	100.00	0.002
28556443	LGTPDVDTPATVVQTER	100.00	0.002

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics