Silkworm Genome Informatics Database

Gene

KWMTBOMO15842

Pre Gene Modal

BGIBMGA000060

Annotation

PREDICTED:_cGMP-specific_3'?5'-cyclic_phosphodiesterase-like_[Bombyx_mori]

Location

Bomo_Chr26(+):11340753-11357332 View in EpiBrowser

Full name

Phosphodiesterase + More
cGMP-specific 3',5'-cyclic phosphodiesterase

Alternative Name

DmPDE5/6

Location in the cell

Cytoplasmic Reliability : 2.164

CDS

ATGAGGTCGCGGTCGCCGAGCAGCTCGGCGCAGAGGCAGCTGGATGAGGCGGATCTATTCATGGACCTCATCAAGGACGTCGCCAACGAACTGGATATAGATGTCTTGTGTCACAAGATCCTGGTAAACGTGTGTTTGCTGACGTCAGCAGACCGAGGAAGTCTATTCCTAGCGAAGGGCGTGCCTCCAAACCGGTACCTACAGGCGAAACTCTTCGATGTCACACGAGATACAGAACTGAACGATGCGCTTCGGACGGCCAGGACACAAGAGATCAAAATCCGGTTCGGTGTGGGAGTGGCGGGACTCGCAGCTCAGACCAAAAACCATATCAACATCAGGAATGCATACGCCGATCCCAGGTTCAACAGCGAGATCGACGCTCGGACTGGCTACAAGACGGAGCTCATCCTGTGCATGCCGATCTGCAACTACGAGGGCGACGTGGTCGGCGTCGCACAGATCATCAACAAGACTGATGGCTCGAAAGAATTCTCGTCCAGAGACGTCGAAGTGTTCAGGCGATACCTCACATTCTGCGGTATAGGCATCCAGAACGCTCAGCTCTTTGAGTCCTCGGTACTCGAATACAAGAGGAACCAGATCCTCCTTGCTCTGGCGCGGAGCATCTTCGAAGAGCAGAGCAATTTGGAGTGCTTGGTTACCAAGATCATGACAGAAGCCAGGGATCTGCTCAAGTGCGAGCGATGTGCTGTCTTCATACTCGACACCGACCATTGTGAATCTAGTCACCTGGAGCGCATCGTGCAGCGGCCGGGCGGCGCGGCGGGGGGCGGGGCGCGGCGCGGGGGGCTGGCGGCCCTGCCCCCGCCGGCGCCCACCCGCTTCCACACGGTGTTCGAGCTGGGCGCGCCGCGGCGCCCGCACGACGCGCTGCCCGCCATCGCACTCGCGGTGGCCCGCTCAAACAAATCACTAAACATATCAGACGTGGAGCAATGGTTGCGCGACAATAACATGTCCGCCGGGGAGAACTCGGCCGGCGTGCGGACCCTGCTGTGCATGCCCATCGTCAATGCCAATAAAGATGTCATCGGAGTGGCGCAACTCATCAACAAGGAAAACGGTTCGCAGTTCACGGAGGGCGACGTGTCGATATTCGAAGCGTTCGCTATATTCTGTGGACTTGGCATACACAACACGCAGATGTATGAGAACGCCTGCAAGCTGATGGCCAAACAAAAGGTGGCGCTGGAGTGCCTGTCGTACCACGCGACGGCGTCGGCCGAGGACACCAGCAAGCTGTGCCAGGACGAGATCCCCTCCGCAGAGACCTACAACTTGTACAGCTTCCAGTTTCACGACTTCGACCTGACCGACGAGGACACGTGCCGCGCGACGCTGCGCATGTTCCTGCAGTGCGAGCTGGTGGAGAAGTTCCACATCCCGTACGACGTCCTCTGCCGCTGGATACTAAGCGTCAAGAAGAATTACAGACCTGTGAAGTACCACAACTGGCGACACGCCCTCAACGTCGCACAGACTATGTTCGCGATGCTCAAGACGGGCAAGATGGAGCGCTTCATGTCCGACCTGGAGATCCTGGGGCTGCTGGTCGCCTGTCTGTGCCACGACCTGGACCACAGGGGCACCAACAACGCCTTCCAGACCAAGACGGAGAGCCCCCTGGCCATCCTGTACTCCACCTCCACCATGGAGCACCACCACTTTGACCAATGCGTCATGATACTGAACAGCGAAAGTAATAACATATTTCAGGCGCTGTCCCCGCGCGACTACAAGGACGTGATGCACGTGGTGGAGACGGCCATCCTGTCCACCGACCTGGCCATGTACTTCAAGAAGAAGTCCAAGTTCCTGGAGCTGGTCGACAACGGGGAGTTCGACTGGCAAGCGCAGGAGAAGAAGGAGTTGCTGTGCGGCATGATGATGACGGCGTGCGACGTGTCGGCCATCGCCAAGCCGTGGGAGGTGCAGCATCGCATCGCCAAGCTCGTCGCCGACGAGTTCTTCGACCAGGGAGACCTCGAGAAGCTGCAGCTCAACCAGCAACCCATCGCCATGATGGACAGAGAGAAGAAGGACGAGCTGCCGCAGATGCAGGTGGGCTTCATCGACACGATCTGCCTGCCGCTGTACAAGGTGCTCTCCGACACCTTCCCCTGGATGACGCCGCTGCGCACCGGCACGGCTGACAACCGCCGCCGCTGGCAGGACCTCGCCGAGAAGGTGGACATGGGGCTCACCTGGATCGACCACGACACCATCGACAAGCCCGTCGAGGAGTTCACCGCACTGAACGAGCCGCTCGCGGACGTGGAGCTGACGGTGACGACGCTGAACTGCGCGGCCGGCCCCCCCGCCAAGCCGCTCAAGACTCCCTTCCACTCGCTGCGGAGGGGGAGGGCGCCCCCCGCGCCCCGCCCCGCGCGCACCAAGCTCACCAGCTTGTTTCAGGTCGCTCTACTCCGCTCCAAGCTCCCATCGAGAAGACAGAGACAGAGAGAGGGAGAAGGAGAGGGAAGTAGAGAGAGAGGAGAAGGTGGTGCAGAAGGCGACGGTGGTGTGGGACGGGCGGAGCACGGCGCTGGCCCCGCCGGGACCGCACGCGCGGGCGCGGCCGCGGCGGCTGTGCCACGTGTTGTGACGACTGAGTCTTAA

Protein

MRSRSPSSSAQRQLDEADLFMDLIKDVANELDIDVLCHKILVNVCLLTSADRGSLFLAKGVPPNRYLQAKLFDVTRDTELNDALRTARTQEIKIRFGVGVAGLAAQTKNHINIRNAYADPRFNSEIDARTGYKTELILCMPICNYEGDVVGVAQIINKTDGSKEFSSRDVEVFRRYLTFCGIGIQNAQLFESSVLEYKRNQILLALARSIFEEQSNLECLVTKIMTEARDLLKCERCAVFILDTDHCESSHLERIVQRPGGAAGGGARRGGLAALPPPAPTRFHTVFELGAPRRPHDALPAIALAVARSNKSLNISDVEQWLRDNNMSAGENSAGVRTLLCMPIVNANKDVIGVAQLINKENGSQFTEGDVSIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASAEDTSKLCQDEIPSAETYNLYSFQFHDFDLTDEDTCRATLRMFLQCELVEKFHIPYDVLCRWILSVKKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMSDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYSTSTMEHHHFDQCVMILNSESNNIFQALSPRDYKDVMHVVETAILSTDLAMYFKKKSKFLELVDNGEFDWQAQEKKELLCGMMMTACDVSAIAKPWEVQHRIAKLVADEFFDQGDLEKLQLNQQPIAMMDREKKDELPQMQVGFIDTICLPLYKVLSDTFPWMTPLRTGTADNRRRWQDLAEKVDMGLTWIDHDTIDKPVEEFTALNEPLADVELTVTTLNCAAGPPAKPLKTPFHSLRRGRAPPAPRPARTKLTSLFQVALLRSKLPSRRQRQREGEGEGSRERGEGGAEGDGGVGRAEHGAGPAGTARAGAAAAAVPRVVTTES

Description

Has a role regulating cGMP transport in Malpighian tubule principal cells.
Hydrolyzes the second messager cGMP, which is a key regulator of many important physiological processes (PubMed:15673286). Has cAMP phosphodiesterase activity in vitro but not in vivo (PubMed:15673286). Has a role regulating cGMP transport in Malpighian tubule principal cells (PubMed:16232123).

Catalytic Activity

3',5'-cyclic GMP + H2O = GMP + H(+)

Cofactor

a divalent metal cation

Biophysicochemical Properties

37 uM for cGMP

Subunit

Interacts with PrBP.

Similarity

Belongs to the cyclic nucleotide phosphodiesterase family.

Keywords

Cell membrane cGMP Complete proteome Hydrolase Lipoprotein Membrane Metal-binding Methylation Prenylation Reference proteome Repeat

Feature

chain cGMP-specific 3',5'-cyclic phosphodiesterase
propeptide Removed in mature form

Uniprot

A0A2W1BTH9 A0A212EMF2 A0A194QDX0 A0A2H1VAG1 H9IS34 B4K9L4 + More
A0A0M4F2T2 B4JXX2 A0A1W4V598 A0A0K8W2Z8 B4PSS5 A0A0A1WJY6 B4LVU6 A0A0B4KFZ3 A0A0B4LH87 B4QZU1 Q9VFI9 A0A034VKQ6 A0A1I8P6W0 A0A088ADF4 A0A1I8MS12 A0A3B0JKC8 Q298P4 A0A3B0K9Q0 B4NAL6 A0A310SS13 A0A151WMH2 A0A158NVJ1 F4WLE6 E2BNK0 B3P3K2 A0A154PRS7 E2AIP9 A0A1B0B4W7 A0A3L8DKH9 A0A2A3EEB7 A0A195D4A4 A0A0L7RJ81 A0A0C9RFF7 A0A1A9WNF2 A0A195BPH2 B3LVW5 A0A182JMR5 A0A0N0BF29 A0A182VJ89 A0A023F441 A0A182L7I4 E9IWT3 A0A1Y1MPH6 A0A182U165 A0A026X3X8 A0A182XIY1 A0A1B0G0J3 A0A2M4CPN9 A0A2M4CR21 A0A2M4BAP0 A0A0A9XI48 A0A146L047 A0A182YGH8 Q7QB99 A0A232FHB1 A0A1S4G790 A0A182F6N8 E0VBQ2 A0A1A9YQ37 A0A084W396 A0A1W4XLF3 A0A1W4XLS2 A0A1W4XWW8 N6UF09 D6X0V1 A0A182N5N0 T1HTV2 J9K083 A0A2S2P4H8 A0A2H8TYG0 A0A1Q3FUQ5 A0A1Q3FUQ9 A0A182P8X7 A0A034VLH8 A0A0L0C9R3 A0A1J1HZW5 A0A3B0KGL2 A0A182Q798 A0A182I7X6 A0A1W4XVW3 A0A226E6T2 A0A1D2MK92 A0A1S3GXM6 A0A1S3GY79 A0A1S3H0C2 A0A1S3GXN1 A0A1Y1ML52 A0A1S3GZG0 A0A1S3GXZ0 A0A1S3GZG7 A0A1S3GY84 Q3SBD3

EC Number

3.1.4.-
3.1.4.35

Pubmed

28756777 22118469 26354079 19121390 17994087 25830018 + More
10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 12537569 15673286 16232123 18503409 25348373 25315136 15632085 21347285 21719571 20798317 30249741 25474469 20966253 21282665 28004739 24508170 25401762 26823975 25244985 12364791 28648823 17510324 20566863 24438588 23537049 18362917 19820115 26108605 27289101 16236790

EMBL

KZ149905 PZC78368.1 AGBW02013848 OWR42658.1 KQ459144 KPJ03619.1 + More
ODYU01001512 SOQ37828.1 BABH01035679 BABH01035680 CH933806 EDW16674.1 CP012526 ALC45432.1 CH916377 EDV90534.1 GDHF01012587 GDHF01006761 JAI39727.1 JAI45553.1 CM000160 EDW97571.1 GBXI01014948 GBXI01014157 JAC99343.1 JAD00135.1 CH940650 EDW67551.1 AE014297 AGB95947.1 AHN57326.1 CM000364 EDX12939.1 AY058470 AAL13699.1 GAKP01016552 JAC42400.1 OUUW01000007 SPP82797.1 CM000070 SPP82799.1 CH964232 EDW80830.1 KQ760549 OAD59892.1 KQ982944 KYQ49046.1 ADTU01027217 GL888207 EGI65109.1 GL449414 EFN82779.1 CH954181 EDV48890.1 KQ435092 KZC14616.1 GL439853 EFN66686.1 JXJN01008561 QOIP01000007 RLU20955.1 KZ288271 PBC29814.1 KQ976870 KYN07718.1 KQ414581 KOC71027.1 GBYB01011847 JAG81614.1 KQ976433 KYM87352.1 CH902617 EDV41498.1 KQ435812 KOX72731.1 GBBI01002476 JAC16236.1 GL766597 EFZ14970.1 GEZM01030958 JAV85137.1 KK107019 EZA62798.1 CCAG010011760 GGFL01003116 MBW67294.1 GGFL01003160 MBW67338.1 GGFJ01000949 MBW50090.1 GBHO01023980 GBHO01023975 GBHO01023974 JAG19624.1 JAG19629.1 JAG19630.1 GDHC01016646 JAQ01983.1 AAAB01008880 EAA08620.5 NNAY01000222 OXU29910.1 AAZO01000777 DS235035 EEB10808.1 ATLV01019871 KE525281 KFB44690.1 APGK01029573 APGK01029574 KB740735 KB631809 ENN79211.1 ERL86302.1 KQ971372 EFA09545.1 ACPB03014254 ACPB03014255 ACPB03014256 ACPB03014257 ABLF02027366 ABLF02027370 ABLF02027372 ABLF02034192 ABLF02034195 ABLF02050337 GGMR01011633 MBY24252.1 GFXV01007530 MBW19335.1 GFDL01003863 JAV31182.1 GFDL01003862 JAV31183.1 GAKP01016549 JAC42403.1 JRES01000718 KNC28992.1 CVRI01000023 CRK92094.1 SPP82798.1 AXCN02001159 LNIX01000006 OXA53169.1 LJIJ01000987 ODM93439.1 GEZM01030959 JAV85135.1 AAGJ04128901 DQ073640 AAZ22857.1

Proteomes

UP000007151 UP000053268 UP000005204 UP000009192 UP000092553 UP000001070 + More
UP000192221 UP000002282 UP000008792 UP000000803 UP000000304 UP000095300 UP000005203 UP000095301 UP000268350 UP000001819 UP000007798 UP000075809 UP000005205 UP000007755 UP000008237 UP000008711 UP000076502 UP000000311 UP000092460 UP000279307 UP000242457 UP000078542 UP000053825 UP000091820 UP000078540 UP000007801 UP000075880 UP000053105 UP000075903 UP000075882 UP000075902 UP000053097 UP000076407 UP000092444 UP000076408 UP000007062 UP000215335 UP000069272 UP000009046 UP000092443 UP000030765 UP000192223 UP000019118 UP000030742 UP000007266 UP000075884 UP000015103 UP000007819 UP000075885 UP000037069 UP000183832 UP000075886 UP000198287 UP000094527 UP000085678 UP000007110

PRIDE

H9IS34 B4JXX2 B4PSS5 Q9VFI9 B3LVW5

Pfam

PF00233 PDEase_I + More
PF01590 GAF

Interpro

IPR023174   PDEase_CS        + More
IPR023088   PDEase
IPR003018   GAF
IPR029016   GAF-like_dom_sf
IPR002073   PDEase_catalytic_dom
IPR036971   PDEase_catalytic_dom_sf
IPR003607   HD/PDEase_dom

Gene 3D

1.10.1300.10 3.30.450.40

CDD

cd00077 HDc

ProteinModelPortal

A0A2W1BTH9 A0A212EMF2 A0A194QDX0 A0A2H1VAG1 H9IS34 B4K9L4 + More
A0A0M4F2T2 B4JXX2 A0A1W4V598 A0A0K8W2Z8 B4PSS5 A0A0A1WJY6 B4LVU6 A0A0B4KFZ3 A0A0B4LH87 B4QZU1 Q9VFI9 A0A034VKQ6 A0A1I8P6W0 A0A088ADF4 A0A1I8MS12 A0A3B0JKC8 Q298P4 A0A3B0K9Q0 B4NAL6 A0A310SS13 A0A151WMH2 A0A158NVJ1 F4WLE6 E2BNK0 B3P3K2 A0A154PRS7 E2AIP9 A0A1B0B4W7 A0A3L8DKH9 A0A2A3EEB7 A0A195D4A4 A0A0L7RJ81 A0A0C9RFF7 A0A1A9WNF2 A0A195BPH2 B3LVW5 A0A182JMR5 A0A0N0BF29 A0A182VJ89 A0A023F441 A0A182L7I4 E9IWT3 A0A1Y1MPH6 A0A182U165 A0A026X3X8 A0A182XIY1 A0A1B0G0J3 A0A2M4CPN9 A0A2M4CR21 A0A2M4BAP0 A0A0A9XI48 A0A146L047 A0A182YGH8 Q7QB99 A0A232FHB1 A0A1S4G790 A0A182F6N8 E0VBQ2 A0A1A9YQ37 A0A084W396 A0A1W4XLF3 A0A1W4XLS2 A0A1W4XWW8 N6UF09 D6X0V1 A0A182N5N0 T1HTV2 J9K083 A0A2S2P4H8 A0A2H8TYG0 A0A1Q3FUQ5 A0A1Q3FUQ9 A0A182P8X7 A0A034VLH8 A0A0L0C9R3 A0A1J1HZW5 A0A3B0KGL2 A0A182Q798 A0A182I7X6 A0A1W4XVW3 A0A226E6T2 A0A1D2MK92 A0A1S3GXM6 A0A1S3GY79 A0A1S3H0C2 A0A1S3GXN1 A0A1Y1ML52 A0A1S3GZG0 A0A1S3GXZ0 A0A1S3GZG7 A0A1S3GY84 Q3SBD3

PDB

3BJC E-value=3.00642e-179, Score=1617

KEGG

101745078 K13763 cGMP-specific 3',5'-cyclic phosphodiesterase, invertebrate [EC:3.1.4.35] | (RefSeq) cGMP-spec

PATHWAY

00230 Purine metabolism - Bombyx mori (domestic silkworm)
01100 Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004114 GO:0007165 GO:0046872 GO:0046068 GO:0005886 GO:0047555 GO:0016020 GO:0032240 GO:0016324 GO:0016787 GO:0005737 GO:0005634 GO:0016021 GO:0005515 GO:0008081 GO:0005215 GO:0006270 GO:0042555 GO:0003707 GO:0006281 GO:0006259

Subcellular location

Cell membrane

Length:

880

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01981

Exp number, first 60 AAs:

0.00356

Total prob of N-in:

0.00078

outside

1 - 880

Pi

184.908116

Theta

152.213568

Tajima's D

0.47032

CLR

0.214926

CSRT

0.510374481275936

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics