Gene

KWMTBOMO15808

Pre Gene Modal

BGIBMGA000016

Annotation

neuropeptide_receptor_A4_[Bombyx_mori]

Location

Bomo_Chr26(-):10598036-10608209      View in EpiBrowser

Full name

Neuropeptide F receptor      

Location in the cell

PlasmaMembrane   Reliability : 4.996

CDS

ATGCTTACTGATGTTAGGGGGCTTGACCCCAGCGTGAACCTCACGTTGAATGCTTCAGCGAAACAGCTTATTGAGGCTTCAAAAGGCATCCAAGACCCAAACATACTCCTGGAGAAGTTTTCTCAGAATCGAAAAGTCGACGATCCAACGAGATCCTTACTGATAGCGTTTTACATCATCCTGGTCGTGATCGGAGCTGTGGGGAATGCACTCGTCATATTATCTGTGGTGCGAAAGCCGGTCATGAGAACAGCAAGGAACATGTTCATCGTCAATTTAGCCGTGTCCGATGCCCTGGTCTGCGTGGTCGGAACCCCGCTGACTCTTATGGAACTCCTGACCAAGCATTGGCCGTTACCGGACTGGCCAAGTTTGTGCAAGGCGTGTGGCGCGATCCAAGCTATATCGATCTTCGTGTCCACTATATCCATAACTGCCATTGCCCTTGATCGATATCAGTTGATCGTCTACCCCACCAAGCCTGGCGTTCAAACAATAGGAGCGCTTGTCACTATGTTCTTCATCTGGGTAACAGCATTCATCCTTGCTTCACCCCTCTACATCTTCCGGAGCCTCAAAACGCACAAACTCGGCATCGCCGGTATCAGCTCTCTAAGTTTCTGCATAGAAGACTGGCCTATCACTGACGGTAGAGCTATCTATTCTCTCCTAAGCCTGATCTTTCAATACCTTCTACCGGTTCTGGTCGTCGTGATGGCCCACATTCAGATACATAGAAGACTGCGAGGCCGAAGAAGGACCACGAGGAAAACGCCAGCAATATTAATAGCCATAGCAGTTACATACGTCATAAGCTGGCTACCACTTAATGTATTTAATCTGGTGGCTGACTTCAGTTCGGCGCCATTTAAAGACGAGAAGACTATGACGGTTACTTATGCTGTCTGCCACATGTTTGGCATGTCGAGTGCCGTTTCAAATCCTTTACTCTACGGATGGTTAAATGATAATTTCCGAAAGGAATTCGAAGAGATCCTGACGAAGTGCTGCTGCAGGAAGAAGCCTTTAGTTAACGGCACGAGGACTACTAATCGGAGGATGGAGACGGAATTGACTGCGCTGGCACAGTTGGAGCATACCGTGACCGGGAACACCAAGACGTCGCAGTGCTCCCAGGTTTTCTGA

Protein

MLTDVRGLDPSVNLTLNASAKQLIEASKGIQDPNILLEKFSQNRKVDDPTRSLLIAFYIILVVIGAVGNALVILSVVRKPVMRTARNMFIVNLAVSDALVCVVGTPLTLMELLTKHWPLPDWPSLCKACGAIQAISIFVSTISITAIALDRYQLIVYPTKPGVQTIGALVTMFFIWVTAFILASPLYIFRSLKTHKLGIAGISSLSFCIEDWPITDGRAIYSLLSLIFQYLLPVLVVVMAHIQIHRRLRGRRRTTRKTPAILIAIAVTYVISWLPLNVFNLVADFSSAPFKDEKTMTVTYAVCHMFGMSSAVSNPLLYGWLNDNFRKEFEEILTKCCCRKKPLVNGTRTTNRRMETELTALAQLEHTVTGNTKTSQCSQVF

Description

Receptor for NPF. Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to diverse stressful stimuli (chemical stress and noxious heat) through attenuation of TRP channel-induced neuronal excitation. NPF neural signaling system plays a physiological role in acute modulation of alcohol sensitivity in adults, rather than a general response to intoxication by sedative agents. Activation and inhibition of the NPF system reduces and enhances ethanol preference, respectively. Sexual experience, the NPF system activity and ethanol consumption are all linked; sexual deprivation is a major contributor to enhanced ethanol preference.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Keywords

Alternative splicing   Behavior   Complete proteome   Disulfide bond   G-protein coupled receptor   Membrane   Neuropeptide   Receptor   Reference proteome   Stress response   Transducer   Transmembrane   Transmembrane helix  

Feature

chain  Neuropeptide F receptor
splice variant  In isoform 2 and isoform 6.

Uniprot

B3XXL6   A0A2A4J983   A0A0S1YD64   A0A2A4J9L8   A0A2W1BYM3   A0A194QDU4   + More
A0A1E1W5R9   H9IRZ6   A0A212F140   A0A1E1WB26   A0A0N1IES3   A0A1W4XJH0   A0A2P8YDJ1   A0A067RKH6   A0A2J7QXK0   A0A1S4FQV5   B0WJ64   U5N0V1   A0A182H7A0   A0A1A9VIV6   A0A182GCN7   A0A1B0ERV5   Q16SC4   A0A3R7PJV0   B4G380   A0A1A9ZT02   A0A0R3NHE1   B4JYG2   Q297Y5   A0A0R3NMC1   A0A0R3NH99   A0A182XIY4   A0A182VIA4   A0A345AH67   A0A139WBY5   A0A182YGI2   A0A182L7I2   Q7PQN7   A0A182I7X3   A0A182RYI7   A0A182VSB6   A0A182P5Y9   A0A3B0JCV9   A0A182QAR7   A0A1I8NTF3   A0A182N5N3   A0A1A9W5L1   A0A182F6P1   B4MBR2   W5JC27   A0A1I8M4L5   A0A1I8M4K9   A0A1B0B4V9   A0A084VL74   A0A1A9YQ48   B4KB11   A0A1W4V450   A0A0R3NNU4   B4NHE1   E9GG50   A0A0M4F4U0   A0A0Q9VZP6   E9GBE9   A0A0P6CD76   A0A0Q9X5N6   A0A2P6LJY7   A0A0P6C9L9   A0A0P6HFJ0   T1IW42   A0A1D2N3W3   B3NYL4   E0VA32   A0A0P4Z0P0   W8C5G8   Q9VNM1-6   Q9VNM1   A0A0N7ZMC1   B4QXP8   Q9VNM1-4   A0A0B4K601   A0A0P5CAX0   A0A0P5YB18   A0A0P5WDL7   A0A0P5I5Y2   A0A0P5ZX39   A0A0P5MX59   A0A0N8DQ53   A0A164RXS6   A0A0P5MQL8   A0A0P6FUI5   A0A0P5WCS6   A0A0P5CZ61   A0A0R1E416   A0A0N8D8A5   B4PVM0   A0A0P4YK79   T1KR44  

Pubmed

18725956    28756777    26354079    19121390    22118469    29403074    + More
24845553    24130914    26483478    17510324    17994087    15632085    18362917    19820115    25244985    20966253    12364791    14747013    15626509    17210077    20920257    23761445    25315136    24438588    18057021    21292972    27289101    20566863    24495485    11897397    10731132    12537572    15677721    19837040    20164335    22422983    12537568    12537573    12537574    16110336    17569856    17569867    17550304   

EMBL

AB330424    BAG68402.1    NWSH01002516    PCG68094.1    KT031001    ALM88299.1    + More
PCG68093.1    KZ149905    PZC78337.1    KQ459144    KPJ03642.1    GDQN01008744    JAT82310.1    BABH01035606    AGBW02010970    OWR47452.1    GDQN01006862    JAT84192.1    KQ461188    KPJ07299.1    PYGN01000679    PSN42328.1    KK852623    KDR19960.1    NEVH01009379    PNF33311.1    DS231956    EDS28954.1    KC439539    AGX85007.1    JXUM01115799    JXUM01115800    JXUM01115801    KQ565916    KXJ70537.1    JXUM01054483    KQ561822    KXJ77427.1    CCAG010011761    CH477676    EAT37369.2    QCYY01002621    ROT68912.1    CH479179    EDW24275.1    CM000070    KRT00420.1    CH916377    EDV90724.1    EAL28070.3    KRT00421.1    KRT00423.1    MF175146    AXF35701.1    KQ971372    KYB25447.1    AY579078    AAAB01008880    AAT81602.1    EAA08566.3    APCN01002570    OUUW01000005    SPP80217.1    AXCN02001159    CH940656    EDW58533.2    ADMH02001637    ETN61661.1    JXJN01008559    ATLV01014424    KE524972    KFB38718.1    CH933806    EDW14689.1    KRG01147.1    KRT00422.1    CH964272    EDW84617.2    GL732543    EFX81337.1    CP012526    ALC46837.1    KRF78332.1    GL732538    EFX83169.1    GDIP01003024    JAN00692.1    KRG01146.1    MWRG01000011    PRD38886.1    GDIP01006624    LRGB01002860    JAM97091.1    KZS05899.1    GDIQ01019765    JAN74972.1    JH431607    LJIJ01000243    ODM99959.1    CH954181    EDV47995.1    DS235004    EEB10238.1    GDIP01219684    JAJ03718.1    GAMC01001762    JAC04794.1    AF364400    DQ666847    DQ666848    DQ666849    DQ666850    DQ666851    AE014297    AY071152    BT044552    AAF51909.3    AAK50050.1    AAL48774.1    ABH01175.1    GDIP01231369    JAI92032.1    CM000364    EDX11834.1    AFH06266.1    GDIP01202513    GDIP01201262    GDIP01173725    GDIP01123317    GDIP01095034    JAJ49677.1    GDIP01166693    GDIP01160573    GDIP01085406    GDIP01062604    GDIP01061044    JAM42671.1    GDIP01087610    JAM16105.1    GDIQ01217536    JAK34189.1    GDIP01235972    GDIP01208272    GDIP01200012    GDIP01155090    GDIP01121780    GDIP01038158    JAM65557.1    GDIQ01158311    JAK93414.1    GDIP01011823    JAM91892.1    LRGB01002121    KZS09045.1    GDIQ01160112    JAK91613.1    GDIQ01042849    JAN51888.1    GDIP01088852    JAM14863.1    GDIP01206670    GDIP01204670    GDIP01167620    GDIP01113120    GDIP01070803    JAJ55782.1    CM000160    KRK03990.1    KRK03991.1    KRK03992.1    GDIP01059007    JAM44708.1    EDW97829.1    GDIP01228480    JAI94921.1    CAEY01000383   

Proteomes

UP000218220    UP000053268    UP000005204    UP000007151    UP000053240    UP000192223    + More
UP000245037    UP000027135    UP000235965    UP000002320    UP000069940    UP000249989    UP000078200    UP000092444    UP000008820    UP000283509    UP000008744    UP000092445    UP000001819    UP000001070    UP000076407    UP000075903    UP000007266    UP000076408    UP000075882    UP000007062    UP000075840    UP000075900    UP000075920    UP000075885    UP000268350    UP000075886    UP000095300    UP000075884    UP000091820    UP000069272    UP000008792    UP000000673    UP000095301    UP000092460    UP000030765    UP000092443    UP000009192    UP000192221    UP000007798    UP000000305    UP000092553    UP000076858    UP000094527    UP000008711    UP000009046    UP000000803    UP000000304    UP000002282    UP000015104   

PRIDE

B3XXL6    H9IRZ6    Q9VNM1   

Pfam

PF00001   7tm_1

Interpro

IPR000276   GPCR_Rhodpsn        + More
IPR000611   NPY_rcpt       
IPR017452   GPCR_Rhodpsn_7TM       

ProteinModelPortal

B3XXL6   A0A2A4J983   A0A0S1YD64   A0A2A4J9L8   A0A2W1BYM3   A0A194QDU4   + More
A0A1E1W5R9   H9IRZ6   A0A212F140   A0A1E1WB26   A0A0N1IES3   A0A1W4XJH0   A0A2P8YDJ1   A0A067RKH6   A0A2J7QXK0   A0A1S4FQV5   B0WJ64   U5N0V1   A0A182H7A0   A0A1A9VIV6   A0A182GCN7   A0A1B0ERV5   Q16SC4   A0A3R7PJV0   B4G380   A0A1A9ZT02   A0A0R3NHE1   B4JYG2   Q297Y5   A0A0R3NMC1   A0A0R3NH99   A0A182XIY4   A0A182VIA4   A0A345AH67   A0A139WBY5   A0A182YGI2   A0A182L7I2   Q7PQN7   A0A182I7X3   A0A182RYI7   A0A182VSB6   A0A182P5Y9   A0A3B0JCV9   A0A182QAR7   A0A1I8NTF3   A0A182N5N3   A0A1A9W5L1   A0A182F6P1   B4MBR2   W5JC27   A0A1I8M4L5   A0A1I8M4K9   A0A1B0B4V9   A0A084VL74   A0A1A9YQ48   B4KB11   A0A1W4V450   A0A0R3NNU4   B4NHE1   E9GG50   A0A0M4F4U0   A0A0Q9VZP6   E9GBE9   A0A0P6CD76   A0A0Q9X5N6   A0A2P6LJY7   A0A0P6C9L9   A0A0P6HFJ0   T1IW42   A0A1D2N3W3   B3NYL4   E0VA32   A0A0P4Z0P0   W8C5G8   Q9VNM1-6   Q9VNM1   A0A0N7ZMC1   B4QXP8   Q9VNM1-4   A0A0B4K601   A0A0P5CAX0   A0A0P5YB18   A0A0P5WDL7   A0A0P5I5Y2   A0A0P5ZX39   A0A0P5MX59   A0A0N8DQ53   A0A164RXS6   A0A0P5MQL8   A0A0P6FUI5   A0A0P5WCS6   A0A0P5CZ61   A0A0R1E416   A0A0N8D8A5   B4PVM0   A0A0P4YK79   T1KR44  

PDB

5ZBQ     E-value=4.68799e-29,     Score=318

KEGG

100187563    K04209 neuropeptide F receptor | (RefSeq) NGR-A4, BNGR-A4; neuropeptide receptor A4

GO

GO:0016021   GO:0004983   GO:0004930   GO:0050254   GO:0007218   GO:0042263   GO:0007186   GO:0030513   GO:0005887   GO:0007194   GO:1990834   GO:0004995   GO:0008188   GO:0030536   GO:0007217   GO:0038002   GO:0042048   GO:0005215   GO:0006270   GO:0042555   GO:0003707   GO:0006281   GO:0006259  

Subcellular location

Membrane  

Length:

381

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

155.24053

Exp number, first 60 AAs:

6.96999

Total prob of N-in:

0.00011

outside

1  -  53

TMhelix

54  -  76

inside

77  -  87

TMhelix

88  -  110

outside

111  -  129

TMhelix

130  -  149

inside

150  -  165

TMhelix

166  -  188

outside

189  -  218

TMhelix

219  -  241

inside

242  -  260

TMhelix

261  -  283

outside

284  -  297

TMhelix

298  -  320

inside

321  -  381

 

 

Pi

180.47584

Theta

174.573911

Tajima's D

0.302787

CLR

18.80785

CSRT

0.454427278636068

Interpretation

Uncertain