Gene

KWMTBOMO15781  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002346

Annotation

PREDICTED:_C-terminal-binding_protein_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr26(+):9943397-9965224      View in EpiBrowser

Full name

C-terminal-binding protein      

Alternative Name

dCtBP

Location in the cell

Cytoplasmic   Reliability : 1.091 Mitochondrial   Reliability : 1.556

CDS

ATGGACAAACGCAAGATGCTGCCAAAGAGAGCGCGCATGGATAGTATGCGGGGTCCTATTGCAAACGGACCCCTGCAATCAAGGCCACTCGTGGCCCTGCTGGACGGTCGGGATTGTACCGTCGAGATGCCGATCCTGAAAGACGTGGCGACGGTCGCCTTCTGCGACGCGCAGTCGACGTCCGAAATACACGAGAAGGTACTCAACGAAGCGGTCGGGGCCCTCATGTGGCACACCATTATACTAACCAAGGAGGACCTTGAGAAGTTCAAGGCGTTACGGATCATAGTACGCATCGGGTCAGGTGTCGATAATATCGACGTTAAAGCCGCCGGCGAATTAGGAATAGCGGTATGTAATGTTCCCGGGTACGGAGTCGAGGAGGTAGCCGACACCACGATGTGTCTCATATTGAATTTATATCGACGGACGTATTGGCTAGCCAATATGGTCAGAGAAGGAAAAAAATTTACAGGGCCGGAGCAGGTGCGCGAGGCGGCGGCGGGGTGCGCGCGCATCCGCGGCGACACGCTCGGCATCGTGGGGCTCGGCCGGATCGGCTCGGCCGTGGCGCTGCGGGCCAAGGCGTTCGGCTTCAATGTCATATTCTACGACCCCTACCTGCCTGACGGCATCGAGAAGTCGCTGGGCCTCACCAGGGTCTACACGCTACAGGACTTATTATTCCAGAGTGACTGTGTCTCACTGCACTGCAGCTTAAACGAGCACAATCACCACCTCATCAACGAGTTCACCATCAAACAGATGCGTCCAGGTGCGTTTCTGGTGAACACGGCGCGCGGCGGGCTCGTGGACGACGAGGGGCTCGCCGCCGCGCTCAAGCAGGGCCGCATCCGAGCCGCCGCGCTAGACGTGCACGAGAACGAACCCTTCAACGTCTTCCAGCAGGGTCCGCTGAAAGACGCTCCGAACCTGCTGTGCACGCCGCACGCGGCCTTCTACTCGGACGCGTCCGCACAGGAGCTGCGCGAGATGGCCGCCTCGGAGATCCGCCGCGCCATCGTCGGCCGCATCCCCGACTGTCTGCGGAACTGCGTCAATAAGGACTACTTCATGGCGGGAACGGGCGGCGTGGTGGGCGGAGTGGTGGGCGGCGTGGTGGGCGGCGTGGTGTCGGGGTCGGGCGGCGCGGGCGGCGCGTACGGCGAGGGCATCAACGGCGGGTACTACGGCGCCGCGCAGGCCGCGCACTCCACCACCGCCGTGCACGAGCCCGCCGCGCACGCCGCGCAGCCGCCGCCCGCGCAGCCCGCGCCGCAGCAGCAGCCGCCCATCACGCTGCCCATAAACACGACGGACCCGGCCAACCACCAGATCCCCAAGCAGGAGAGCTCGGACGTGCACTAG

Protein

MDKRKMLPKRARMDSMRGPIANGPLQSRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREAAAGCARIRGDTLGIVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIEKSLGLTRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDEGLAAALKQGRIRAAALDVHENEPFNVFQQGPLKDAPNLLCTPHAAFYSDASAQELREMAASEIRRAIVGRIPDCLRNCVNKDYFMAGTGGVVGGVVGGVVGGVVSGSGGAGGAYGEGINGGYYGAAQAAHSTTAVHEPAAHAAQPPPAQPAPQQQPPITLPINTTDPANHQIPKQESSDVH

Description

Corepressor targeting diverse transcription regulators. Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression.

Subunit

Homodimer. Interacts with hairy (h), knirps (kni), snail (sna), and Enhancer of split m-delta (HLHm-delta). Complex may be involved in transcriptional repression. Interacts also with adenovirus E1A protein.

Similarity

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Keywords

Alternative splicing   Complete proteome   Nucleus   Oxidoreductase   Reference proteome   Repressor   Transcription   Transcription regulation  

Feature

chain  C-terminal-binding protein
splice variant  In isoform A.

Uniprot

A0A3S2M7F4   A0A212ERH5   H9IYL2   A0A2H1W7H4   A0A222AJF1   S4P1X1   + More
A0A2W1BDW3   A0A194QC77   A0A1B6F6H4   A0A1B6DLE2   K7INJ3   A0A1B6LTR7   E2ADM8   A0A0N0U6Q9   A0A2J7PI32   V9I9U6   A0A067RB42   A0A0A9YD33   A0A087ZWM2   V9IC45   A0A026WZT5   A0A3L8DRR7   A0A151WRX6   A0A1Y1M9L8   A0A158NPF3   A0A224XC60   A0A310SG02   A0A069DUX2   A0A023F5Q7   A0A0P4VTC3   A0A154PLQ9   A0A0A9XCJ8   A0A0V0G9V3   E0W0A8   U4UHK9   A0A1B6DCA0   N6U4A8   A0A0C9RBU0   A0A1W4WUN9   A0A1B6EC23   A0A1W4X5D5   A0A0A9Y317   A0A0A9Y8M3   A0A0A9Y5K9   A0A1S3CWX9   A0A0A9Y744   A0A0A9Z857   A0A0A9Z291   A0A1S3CVK8   A0A1S3CVR8   V5GVC8   D6X2E0   A0A2A3E232   A0A195E543   A0A1W4WUM5   A0A1W4X5J2   A0A1B0GH93   A0A1I8N265   A0A1I8QDQ6   A0A1I8QDN8   A0A1I8N267   A0A0L0C742   A0A1A9XRG3   A0A1A9UFQ6   A0A1B0BVU9   A0A1A9ZA08   A0A1A9WS45   A0A1B0FIQ7   A0A0T6B5T9   A0A2S2QVF1   A0A1L8E0U4   A0A1L8E0P4   A0A1I8N289   U5ETF2   A0A1I8QDQ7   A0A195BA66   J9JJP6   B4N9Y3   Q299Q6   B4G5K5   A0A2S2NDF5   A0A2H8U079   A0A0Q9WYB4   B4K8I6   B4PPV3   B4HGC4   B3P196   A0A0A1WIH5   A0A1W4U824   A0A1W4UJ87   B4R1X7   O46036   A0A0K8VGV1   A0A0R1E2T5   A0A0A1WV51   W8AQ12   A0A0R1E2U6   A0A0M4EVQ0   B4JEW9   A0A0K8U655  

Pubmed

22118469    19121390    23622113    28756777    26354079    20075255    + More
20798317    24845553    25401762    24508170    30249741    28004739    21347285    26334808    25474469    27129103    20566863    23537049    26823975    18362917    19820115    25315136    26108605    17994087    15632085    17550304    25830018    9524128    9525852    10731132    12537572    12537569    24495485   

EMBL

RSAL01000019    RVE52754.1    AGBW02013027    OWR44069.1    BABH01020914    BABH01020915    + More
BABH01020916    ODYU01006824    SOQ49031.1    KY609804    ASO76495.1    GAIX01012280    JAA80280.1    KZ150129    PZC73078.1    KQ459193    KPJ03143.1    GECZ01024316    JAS45453.1    GEDC01010813    JAS26485.1    GEBQ01023355    GEBQ01012905    JAT16622.1    JAT27072.1    GL438820    EFN68390.1    KQ435721    KOX78528.1    NEVH01025129    PNF16000.1    JR037648    JR037649    AEY57892.1    AEY57893.1    KK852766    KDR16976.1    GBHO01016159    GBRD01012340    JAG27445.1    JAG53484.1    JR037650    JR037651    AEY57894.1    AEY57895.1    KK107063    EZA61256.1    QOIP01000005    RLU22863.1    KQ982807    KYQ50425.1    GEZM01036900    GEZM01036899    JAV82353.1    ADTU01022481    GFTR01006431    JAW09995.1    KQ768431    OAD53169.1    GBGD01001397    JAC87492.1    GBBI01002209    JAC16503.1    GDKW01000119    JAI56476.1    KQ434938    KZC12160.1    GBHO01028789    JAG14815.1    GECL01001439    JAP04685.1    DS235858    EEB19064.1    KB632204    ERL90101.1    GEDC01013975    JAS23323.1    APGK01043400    APGK01043401    APGK01043402    KB741014    ENN75461.1    GBYB01012614    GBYB01014044    GBYB01014052    JAG82381.1    JAG83811.1    JAG83819.1    GEDC01001810    JAS35488.1    GBHO01016152    JAG27452.1    GBHO01016156    GBRD01012339    GDHC01021047    JAG27448.1    JAG53485.1    JAP97581.1    GBHO01016155    GDHC01013700    JAG27449.1    JAQ04929.1    GBHO01016158    GBRD01012338    GDHC01000554    JAG27446.1    JAG53486.1    JAQ18075.1    GBHO01005609    GDHC01018275    JAG37995.1    JAQ00354.1    GBHO01005618    JAG37986.1    GALX01002834    JAB65632.1    KQ971371    EFA10253.2    KZ288438    PBC25748.1    KQ979608    KYN20305.1    AJWK01004097    AJWK01004098    AJWK01004099    AJWK01004100    AJWK01004101    JRES01000809    KNC28223.1    JXJN01021482    CCAG010023921    LJIG01009602    KRT82751.1    GGMS01011899    MBY81102.1    GFDF01001785    JAV12299.1    GFDF01001786    JAV12298.1    GANO01001948    JAB57923.1    KQ976542    KYM81120.1    ABLF02024982    CH964232    EDW81738.1    CM000070    EAL27645.2    CH479179    EDW24871.1    GGMR01002550    MBY15169.1    GFXV01008138    MBW19943.1    CH933806    KRG00991.1    EDW14385.1    CM000160    EDW97180.1    CH480815    EDW42372.1    CH954181    EDV49285.1    GBXI01015605    JAC98686.1    CM000364    EDX13129.1    AJ224690    AB011840    AE014297    AY060646    AY069170    GDHF01014569    JAI37745.1    KRK03563.1    GBXI01011776    GBXI01008114    JAD02516.1    JAD06178.1    GAMC01015686    GAMC01015685    GAMC01015684    GAMC01015683    JAB90870.1    KRK03565.1    CP012526    ALC47455.1    CH916369    EDV93250.1    GDHF01030278    GDHF01013710    JAI22036.1    JAI38604.1   

Proteomes

UP000283053    UP000007151    UP000005204    UP000053268    UP000002358    UP000000311    + More
UP000053105    UP000235965    UP000027135    UP000005203    UP000053097    UP000279307    UP000075809    UP000005205    UP000076502    UP000009046    UP000030742    UP000019118    UP000192223    UP000079169    UP000007266    UP000242457    UP000078492    UP000092461    UP000095301    UP000095300    UP000037069    UP000092443    UP000078200    UP000092460    UP000092445    UP000091820    UP000092444    UP000078540    UP000007819    UP000007798    UP000001819    UP000008744    UP000009192    UP000002282    UP000001292    UP000008711    UP000192221    UP000000304    UP000000803    UP000092553    UP000001070   

PRIDE

H9IYL2    O46036   

Pfam

PF00389   2-Hacid_dh        + More
PF02826   2-Hacid_dh_C

Interpro

IPR029753   D-isomer_DH_CS        + More
IPR029752   D-isomer_DH_CS1       
IPR036291   NAD(P)-bd_dom_sf       
IPR006139   D-isomer_2_OHA_DH_cat_dom       
IPR006140   D-isomer_DH_NAD-bd       

SUPFAM

SSF51735   SSF51735       

ProteinModelPortal

A0A3S2M7F4   A0A212ERH5   H9IYL2   A0A2H1W7H4   A0A222AJF1   S4P1X1   + More
A0A2W1BDW3   A0A194QC77   A0A1B6F6H4   A0A1B6DLE2   K7INJ3   A0A1B6LTR7   E2ADM8   A0A0N0U6Q9   A0A2J7PI32   V9I9U6   A0A067RB42   A0A0A9YD33   A0A087ZWM2   V9IC45   A0A026WZT5   A0A3L8DRR7   A0A151WRX6   A0A1Y1M9L8   A0A158NPF3   A0A224XC60   A0A310SG02   A0A069DUX2   A0A023F5Q7   A0A0P4VTC3   A0A154PLQ9   A0A0A9XCJ8   A0A0V0G9V3   E0W0A8   U4UHK9   A0A1B6DCA0   N6U4A8   A0A0C9RBU0   A0A1W4WUN9   A0A1B6EC23   A0A1W4X5D5   A0A0A9Y317   A0A0A9Y8M3   A0A0A9Y5K9   A0A1S3CWX9   A0A0A9Y744   A0A0A9Z857   A0A0A9Z291   A0A1S3CVK8   A0A1S3CVR8   V5GVC8   D6X2E0   A0A2A3E232   A0A195E543   A0A1W4WUM5   A0A1W4X5J2   A0A1B0GH93   A0A1I8N265   A0A1I8QDQ6   A0A1I8QDN8   A0A1I8N267   A0A0L0C742   A0A1A9XRG3   A0A1A9UFQ6   A0A1B0BVU9   A0A1A9ZA08   A0A1A9WS45   A0A1B0FIQ7   A0A0T6B5T9   A0A2S2QVF1   A0A1L8E0U4   A0A1L8E0P4   A0A1I8N289   U5ETF2   A0A1I8QDQ7   A0A195BA66   J9JJP6   B4N9Y3   Q299Q6   B4G5K5   A0A2S2NDF5   A0A2H8U079   A0A0Q9WYB4   B4K8I6   B4PPV3   B4HGC4   B3P196   A0A0A1WIH5   A0A1W4U824   A0A1W4UJ87   B4R1X7   O46036   A0A0K8VGV1   A0A0R1E2T5   A0A0A1WV51   W8AQ12   A0A0R1E2U6   A0A0M4EVQ0   B4JEW9   A0A0K8U655  

PDB

2HU2     E-value=2.30618e-160,     Score=1452

KEGG

101736219    K04496 C-terminal binding protein | (RefSeq) C-terminal-binding protein

PATHWAY

04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)
04330    Notch signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0016491   GO:0051287   GO:0016616   GO:0004617   GO:0090090   GO:0003713   GO:0000122   GO:0090263   GO:0006357   GO:0008134   GO:0042802   GO:0035220   GO:0003714   GO:0045944   GO:0042803   GO:0045892   GO:0070491   GO:0016360   GO:0022416   GO:0005634   GO:0043044   GO:0031010   GO:0008152   GO:0008270   GO:0005215   GO:0006270   GO:0042555   GO:0003707   GO:0006281   GO:0006259   GO:0055114  

Subcellular location

Nucleus  

Length:

455

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

11.74667

Exp number, first 60 AAs:

0.00013

Total prob of N-in:

0.41533

outside

1  -  455

 

 

Pi

211.368448

Theta

157.50617

Tajima's D

0.914076

CLR

0.444745

CSRT

0.63666816659167

Interpretation

Uncertain