Gene

KWMTBOMO15777

Pre Gene Modal

BGIBMGA002343

Annotation

PREDICTED:_protein_TRC8_homolog_[Amyelois_transitella]

Location

Bomo_Chr26(+):9735957-9754496      View in EpiBrowser

Full name

Protein TRC8 homolog      

Location in the cell

PlasmaMembrane   Reliability : 4.906

CDS

ATGTCGCTGAGGTTGAAGGCCCTGGCACTAGTGGAGGTGCTACTGAGGGTGCCACCGTTGTTTGTGGTGGATGAGTTCCTTAAGATCAGCCTAGGGCTGCCCGTGTCCAGCGAGGAAGTGCCAGTATTGAGCAATGTCACAGTGGACCACGTCGATATATTGGAGCCAGATGTGAATTACTACGATGCTAACTTCTATAATGCATTTTTCGTCACTTTTTTCAAGTTCCTCGTTTGCTGTTCAGGATGTTTATCGTCACTCTGCATTTTCGTGCTATACGCGAAGCACCTCATCATCGTATACCTTTACCTCACGTCGCTGGGCATCGTGTTCGTGTCGTACTGGACCAATGTATCCGCAATCAAACAGATACAAGCTCTCGCACAGCTAGCCACCTCGCCTCACCACTCGTCCAGCATCCTCGAAGACATTCTAAACTTAAACCTTAAAAATCTGTTCGATCTCGACGGACCCGGCGTTTTGGTGGTACAGAATTTCGCGATACAGTTCGCTCTCTCGATCGTGTTCAGGAACGTTCACTTGGGGCCCCGAGTGCCTCTAATACAAAAGCTACTGCCGGTCAGTTTCATGGCCCCCTCGTTTTTGGCCATGCTACCGATGCCGCCAAATCTCCTGCACCATTCACCAGTATTTTCGTCGTTACTACCACTTCTCCTTGTCAAATTTGTATTGTGGTCGTCGACTTACACCATCATTCACGTTATCTACGCCGGCTACCAGCACGGTAGATTGTTTGTTAGCAATTACGGTCTGTCGGCGTTAGTCGAAACTGAGTGGATGCGACTTAACGTCCCCTGCGTTTTGAGGGTTTTCTGGGTGCTGCGAGTCGCCGAGCACGCCATTCTCCTGCTCATGGATAACTACGATGAAGACACAGAGGAAGGTGTCCGAATATCTACGCTGCTTGCTGTGCAATCGCTCGCTTCAATGGCCAAATCCTTACTGGTGACGGGCTGTGAAACCATCACCGCAGTATTAGGAATGACATCAGTGATCTCATTTTTCTGCCATTACATTGGAAACTTCTTCCAGTGGATTCTGTTGACCGACGAGGAAGAAGACAAAAGTATCGGAACCGTATCGGCGATTCTGTTTTACATTTTAGCACTCCAAACTGGTCTAACTTCTCTACATCCAGAGAAGAGATTCATTCGTTTGTGCAAGAACGTCTGCTTGTTGTTCACGGCTCTATTGCATTTCCTACACAACATAGTCAATCCGATGTTGATGTCGTTGAGTGCTTCGCACAATCCGAGCATTCACCGGCACGTCAGGGCTCTGGGCGTATGCGCGTTCCTGATAATCTTCCCCATATCGCTACTAGTGTATTTGTGGTCTCAACACAACGTGTCCACTTGGCTATTAGCGGTCACCGCCTTCAGCATAGAAGTGATAGTCAAAGTGGTCGTTAGTCTCATGATATACTCCTTATTCCTGATCGACGCCTACAGGAGCACGTTCTGGGAGCAGTTGGACGACTACGTGTATTACATACGCGCTTTCGGTAACACGATCGAATTCTGTTTCGGCATTTTCTTGTTCTTCAACGGGGCCTGGATCCTGCTGTTCGAATCGGGCGGGGCGATCCGCGCCGTCATGATGTGCATACACGCGTACTTCAACATATGGTGCGAAGCGAGAGCCGGCTGGTCCGTGTTCATGAAGCGTCGCACCGCGGTGAACAAGATCAACTCGCTCAAGGAGGCCTCGTACACTCAACTCAGCAATCTGGACGACGTGTGCGCGATCTGCTACCAGGAGATGCACTCGGCGAAGATAACGCGCTGCAACCATTTCTTCCACGGCGTCTGCTTGAGGAAGTGGCTGTACGTGCAGGACCGGTGTCCGCTGTGCCACGATATCCTGTACAAGATCGACAACGATGCGAACAAAGACTCGAACTCTGACGCCGAGGCGGAGGAAAACAGAAACAACCAGAACCATGTGTTGGAAGAGGGGGCGGACCTACTGCTCGGGGATGGCGTGAGGTGGCTCCGCCAGAACTAA

Protein

MSLRLKALALVEVLLRVPPLFVVDEFLKISLGLPVSSEEVPVLSNVTVDHVDILEPDVNYYDANFYNAFFVTFFKFLVCCSGCLSSLCIFVLYAKHLIIVYLYLTSLGIVFVSYWTNVSAIKQIQALAQLATSPHHSSSILEDILNLNLKNLFDLDGPGVLVVQNFAIQFALSIVFRNVHLGPRVPLIQKLLPVSFMAPSFLAMLPMPPNLLHHSPVFSSLLPLLLVKFVLWSSTYTIIHVIYAGYQHGRLFVSNYGLSALVETEWMRLNVPCVLRVFWVLRVAEHAILLLMDNYDEDTEEGVRISTLLAVQSLASMAKSLLVTGCETITAVLGMTSVISFFCHYIGNFFQWILLTDEEEDKSIGTVSAILFYILALQTGLTSLHPEKRFIRLCKNVCLLFTALLHFLHNIVNPMLMSLSASHNPSIHRHVRALGVCAFLIIFPISLLVYLWSQHNVSTWLLAVTAFSIEVIVKVVVSLMIYSLFLIDAYRSTFWEQLDDYVYYIRAFGNTIEFCFGIFLFFNGAWILLFESGGAIRAVMMCIHAYFNIWCEARAGWSVFMKRRTAVNKINSLKEASYTQLSNLDDVCAICYQEMHSAKITRCNHFFHGVCLRKWLYVQDRCPLCHDILYKIDNDANKDSNSDAEAEENRNNQNHVLEEGADLLLGDGVRWLRQN

Description

Plays a role in growth inhibition that is dependent upon COP9 signalosome subunits CSN5 and CSN6. May modulate signalosome levels or compartmentalization. Probably functions in the same or a related pathway to VHL during early midline development.

Subunit

Interacts with VHL. Interacts with the MPN domain of CSN5. Interacts with EIF3F and EIF3H.

Keywords

Alternative splicing   Complete proteome   Endoplasmic reticulum   Membrane   Metal-binding   Reference proteome   Transmembrane   Transmembrane helix   Zinc   Zinc-finger  

Feature

chain  Protein TRC8 homolog
splice variant  In isoform A.

Uniprot

A0A1E1WEI4   A0A2W1BCV9   A0A2A4JAX4   A0A212EPD9   A0A0L7L6B6   A0A0N1PGU2   + More
A0A194QC80   A0A2H1WR06   A0A2P8XWF4   A0A2J7QDT6   A0A067RD47   A0A1B6J967   A0A1B6FRI9   T1HPT5   A0A224X8X4   A0A0V0GBM5   A0A023F250   A0A1Y1KFH2   A0A1W4WFB8   A0A151I6J7   A0A195BAK0   A0A195FLD7   A0A158NUQ2   A0A151IU11   A0A0A9X4Q2   V9II24   A0A088AFC8   A0A2R7X392   A0A146MDQ1   A0A026WTD5   E0VTX2   E2BP75   A0A151WRZ5   A0A069DW46   A0A1B6C141   F4WRB9   E9IPC8   A0A023EW45   V5GN12   B0WR55   Q175Q2   A0A1S4FE16   A0A1Q3F656   A0A0M8ZYT8   U5ETF7   A0A1L8DSR7   A0A1L8DSL4   D6WZZ4   A0A0L7QKX9   A0A1Q3F5Z3   A0A1Q3F649   A0A1B0GIM9   A0A154PSW2   A0A084VEM7   E2A3B8   A0A182ISV7   A0A2M4CZ81   A0A182NCH8   A0A182JWT1   A0A2M4BE54   A0A182RRR5   A0A2M4CN21   A0A182P3Z6   A0A2M4ACG4   A0A2M4AC99   A0A182YG46   W5J262   A0A0K8TSH6   A0A2M4CZY1   A0A182W117   A0A182F8I1   A0A2M4BE01   A0A2M4ACJ9   A0A2M4ACI8   A0A182I966   A0A182WVI7   A0A2M3Z1P7   Q7QAJ7   A0A182ULT0   A0A2M3ZGC4   A0A182MDU5   B4HZA3   N6U422   A0A1W4U5G6   A0A3B0KGS1   A0A1Q3F617   A0A1W4UIT4   A0A3B0K9W1   A0A0Q9X5X5   B4PQ28   A0A1Q3F623   A0A1Q3F5S7   Q7KRW1-2   A4V3L3   B4KCJ2   A0A2H8TR43   Q29BW4   A0A1L8DSB7  

Pubmed

28756777    22118469    26227816    26354079    29403074    24845553    + More
25474469    28004739    21347285    25401762    26823975    24508170    30249741    20566863    20798317    26334808    21719571    21282665    24945155    17510324    18362917    19820115    24438588    25244985    20920257    23761445    26369729    12364791    14747013    17210077    17994087    23537049    17550304    12032852    10731132    12537572    12537569    15735686    20068067    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    15632085   

EMBL

GDQN01005689    JAT85365.1    KZ150129    PZC73082.1    NWSH01002164    PCG69009.1    + More
AGBW02013496    OWR43327.1    JTDY01002679    KOB70950.1    KQ461188    KPJ07326.1    KQ459193    KPJ03148.1    ODYU01010376    SOQ55447.1    PYGN01001244    PSN36337.1    NEVH01015814    PNF26750.1    KK852714    KDR17883.1    GECU01012037    JAS95669.1    GECZ01017038    JAS52731.1    ACPB03017188    GFTR01007641    JAW08785.1    GECL01001357    JAP04767.1    GBBI01003055    JAC15657.1    GEZM01085119    JAV60209.1    KQ978473    KYM93724.1    KQ976532    KYM81576.1    KQ981512    KYN40804.1    ADTU01026668    KQ980975    KYN10878.1    GBHO01029811    JAG13793.1    JR048538    AEY60695.1    KK856662    PTY26216.1    GDHC01001753    JAQ16876.1    KK107109    QOIP01000008    EZA59325.1    RLU19872.1    DS235774    EEB16828.1    GL449553    EFN82495.1    KQ982806    KYQ50445.1    GBGD01001007    JAC87882.1    GEDC01030309    JAS06989.1    GL888284    EGI63336.1    GL764483    EFZ17575.1    GAPW01000236    JAC13362.1    GALX01002977    JAB65489.1    DS232051    EDS33161.1    CH477397    EAT41798.1    GFDL01012003    JAV23042.1    KQ435821    KOX72383.1    GANO01002798    JAB57073.1    GFDF01004719    JAV09365.1    GFDF01004720    JAV09364.1    KQ971372    EFA10501.1    KQ414940    KOC59240.1    GFDL01012065    JAV22980.1    GFDL01012005    JAV23040.1    AJWK01015109    KQ435180    KZC15006.1    ATLV01012284    ATLV01012285    KE524778    KFB36421.1    GL436364    EFN72062.1    GGFL01006333    MBW70511.1    GGFJ01002100    MBW51241.1    GGFL01002497    MBW66675.1    GGFK01005091    MBW38412.1    GGFK01005086    MBW38407.1    ADMH02002206    ETN57821.1    GDAI01000517    JAI17086.1    GGFL01006240    MBW70418.1    GGFJ01002082    MBW51223.1    GGFK01005186    MBW38507.1    GGFK01005149    MBW38470.1    APCN01003211    GGFM01001698    MBW22449.1    AAAB01008888    EAA08783.5    GGFM01006790    MBW27541.1    AXCM01000041    AXCM01000042    CH480819    EDW53360.1    APGK01050349    APGK01050350    KB741169    KB632203    ENN73337.1    ERL90066.1    OUUW01000007    SPP82868.1    GFDL01012034    JAV23011.1    SPP82869.1    CH933806    KRG01210.1    CM000160    EDW98297.1    GFDL01012035    JAV23010.1    GFDL01012124    JAV22921.1    AF387786    AE014297    AY069375    AY122250    BT001260    AAL57300.1    AAM52762.1    AAN71016.1    AAS65223.1    AAN14174.1    AGB96450.1    EDW14811.1    GFXV01004664    MBW16469.1    CM000070    EAL26882.1    GFDF01004721    JAV09363.1   

Proteomes

UP000218220    UP000007151    UP000037510    UP000053240    UP000053268    UP000245037    + More
UP000235965    UP000027135    UP000015103    UP000192223    UP000078542    UP000078540    UP000078541    UP000005205    UP000078492    UP000005203    UP000053097    UP000279307    UP000009046    UP000008237    UP000075809    UP000007755    UP000002320    UP000008820    UP000053105    UP000007266    UP000053825    UP000092461    UP000076502    UP000030765    UP000000311    UP000075880    UP000075884    UP000075881    UP000075900    UP000075885    UP000076408    UP000000673    UP000075920    UP000069272    UP000075840    UP000076407    UP000007062    UP000075903    UP000075883    UP000001292    UP000019118    UP000030742    UP000192221    UP000268350    UP000009192    UP000002282    UP000000803    UP000001819   

PRIDE

Q7KRW1    A4V3L3   

Pfam

PF13705   TRC8_N        + More
PF13639   zf-RING_2

Interpro

IPR025754   TRC8_N_dom        + More
IPR013083   Znf_RING/FYVE/PHD       
IPR001841   Znf_RING       
IPR011016   Znf_RING-CH       

Gene 3D

3.30.40.10    

ProteinModelPortal

A0A1E1WEI4   A0A2W1BCV9   A0A2A4JAX4   A0A212EPD9   A0A0L7L6B6   A0A0N1PGU2   + More
A0A194QC80   A0A2H1WR06   A0A2P8XWF4   A0A2J7QDT6   A0A067RD47   A0A1B6J967   A0A1B6FRI9   T1HPT5   A0A224X8X4   A0A0V0GBM5   A0A023F250   A0A1Y1KFH2   A0A1W4WFB8   A0A151I6J7   A0A195BAK0   A0A195FLD7   A0A158NUQ2   A0A151IU11   A0A0A9X4Q2   V9II24   A0A088AFC8   A0A2R7X392   A0A146MDQ1   A0A026WTD5   E0VTX2   E2BP75   A0A151WRZ5   A0A069DW46   A0A1B6C141   F4WRB9   E9IPC8   A0A023EW45   V5GN12   B0WR55   Q175Q2   A0A1S4FE16   A0A1Q3F656   A0A0M8ZYT8   U5ETF7   A0A1L8DSR7   A0A1L8DSL4   D6WZZ4   A0A0L7QKX9   A0A1Q3F5Z3   A0A1Q3F649   A0A1B0GIM9   A0A154PSW2   A0A084VEM7   E2A3B8   A0A182ISV7   A0A2M4CZ81   A0A182NCH8   A0A182JWT1   A0A2M4BE54   A0A182RRR5   A0A2M4CN21   A0A182P3Z6   A0A2M4ACG4   A0A2M4AC99   A0A182YG46   W5J262   A0A0K8TSH6   A0A2M4CZY1   A0A182W117   A0A182F8I1   A0A2M4BE01   A0A2M4ACJ9   A0A2M4ACI8   A0A182I966   A0A182WVI7   A0A2M3Z1P7   Q7QAJ7   A0A182ULT0   A0A2M3ZGC4   A0A182MDU5   B4HZA3   N6U422   A0A1W4U5G6   A0A3B0KGS1   A0A1Q3F617   A0A1W4UIT4   A0A3B0K9W1   A0A0Q9X5X5   B4PQ28   A0A1Q3F623   A0A1Q3F5S7   Q7KRW1-2   A4V3L3   B4KCJ2   A0A2H8TR43   Q29BW4   A0A1L8DSB7  

PDB

4LAD     E-value=1.42725e-06,     Score=127

KEGG

101742140    K15703 E3 ubiquitin-protein ligase RNF139 [EC:2.3.2.27] | (RefSeq) protein TRC8 homolog

GO

GO:0016021   GO:0016874   GO:0008270   GO:0005783   GO:0061630   GO:0036503   GO:0012505   GO:0007418   GO:0045926   GO:0004842   GO:0016567   GO:0005789   GO:0005515   GO:0006468   GO:0005215   GO:0006270   GO:0042555   GO:0003707   GO:0006281   GO:0006259  

Subcellular location

Endoplasmic reticulum membrane  

Length:

675

Number of predicted TMHs:

10

Exp number of AAs in TMHs:

244.35998

Exp number, first 60 AAs:

1.8387

Total prob of N-in:

0.20062

inside

1  -  70

TMhelix

71  -  93

outside

94  -  96

TMhelix

97  -  119

inside

120  -  184

TMhelix

185  -  207

outside

208  -  221

TMhelix

222  -  244

inside

245  -  330

TMhelix

331  -  353

outside

354  -  362

TMhelix

363  -  385

inside

386  -  396

TMhelix

397  -  416

outside

417  -  430

TMhelix

431  -  453

inside

454  -  459

TMhelix

460  -  482

outside

483  -  507

TMhelix

508  -  530

inside

531  -  675

 

 

Pi

246.500697

Theta

217.634947

Tajima's D

0.104996

CLR

0.942697

CSRT

0.39638018099095

Interpretation

Uncertain