Gene

KWMTBOMO15750

Pre Gene Modal

BGIBMGA002248

Annotation

PREDICTED:_octopamine_receptor_beta-1R_[Bombyx_mori]

Location

Bomo_Chr26(-):9011010-9012112      View in EpiBrowser

Full name

Octopamine receptor beta-1R       + More
Octopamine receptor beta-3R      

Location in the cell

PlasmaMembrane   Reliability : 4.951

CDS

ATGAAACTGGAAGTCGTATTCAGCCTTGAACTGGGCAACTTCACAGCGGACCTGCAAGATCTATCCACATCCATGTATCTAACGGACACTTACGTGAACAGGACGCTGGAAGTGAATTTGACGACCAATGACTTGGTGTACTCGAATCAGTTCGAAGACGATCCCCTAATTGTGTTTTTAATTATACTAAAATGCATGATAATGCTGTTCATAATATTGGCAGCGATATTTGGCAATCTGTTGGTGATAGTATCGGTGATGAGACACAGAAAATTGCGGGTCATAACGAACTATTTTGTCGTGTCGCTGGCTTTGGCTGATATGTTGGTCGCTATTTGGGCGATGTGCTTCAACTTCAGCGTGGAGATCACGAACGGGGAATGGTTATTTGGCTATTTCATGTGCGACGTTTGGAATTCGTTAGACGTGTACTTCTCGTCGGCGAGCATTCTTCATTTGTGCTGCATCAGTGTCGACCGATACTACGCAATCGTCCAGCCATTGGACTACCCGTTGATTATGACCACGGCCAAGCTCGGCATAATGTTGGCTGTAGTTTGGTGCAGTCCGGCATTGGTCTCGTTTCTACCGATCTTCATGGGTTGGTACACAACCGAGGATCATTTGGACTTCAGAAGACGCTACCCGAAAGTGTGCAGTTTCACAGTCAACAAAGTGTACGCAGTGATATCGAGCAGTATAAGTTTCTGGATTCCCGGTGTGATTATGTTGTTCATGTATTACAGGATTTATGTGGAAGCCGATAGACAGGAGAGAATGCTGTACAGGTAA

Protein

MKLEVVFSLELGNFTADLQDLSTSMYLTDTYVNRTLEVNLTTNDLVYSNQFEDDPLIVFLIILKCMIMLFIILAAIFGNLLVIVSVMRHRKLRVITNYFVVSLALADMLVAIWAMCFNFSVEITNGEWLFGYFMCDVWNSLDVYFSSASILHLCCISVDRYYAIVQPLDYPLIMTTAKLGIMLAVVWCSPALVSFLPIFMGWYTTEDHLDFRRRYPKVCSFTVNKVYAVISSSISFWIPGVIMLFMYYRIYVEADRQERMLYR

Description

Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (PubMed:15816867, PubMed:22553037). Negatively regulates synaptic growth by activating the inhibitory G protein Galphao and limiting cAMP production (PubMed:22553037). Antagonizes the action of Octbeta2R which stimulates synaptic growth (PubMed:22553037).
Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (By similarity). Probably also acts as a receptor for tyramine during ecdysone biosynthesis (PubMed:25605909). Required for the biosynthesis of the steroid hormone ecdysone which is necessary for metamorphosis (PubMed:25605909). Involved in activation of prothoracicotropic hormone and insulin-like peptide signaling which is required for the expression of ecdysone biosynthetic genes (PubMed:25605909).

Similarity

Belongs to the G-protein coupled receptor 1 family.

Keywords

Alternative splicing   Cell membrane   Complete proteome   G-protein coupled receptor   Glycoprotein   Membrane   Receptor   Reference proteome   Transducer   Transmembrane   Transmembrane helix  

Feature

chain  Octopamine receptor beta-1R
splice variant  In isoform B.

Uniprot

H9IYB5   A0A2H1W8D0   A0A2A4J6R9   A0A3S2M6T4   T2FFY0   A0A0N1IPC8   + More
H6V947   A0A0L7L9V2   A0A0L7L9J9   A0A139WBL3   A0A2R7W338   D6WZ39   N1NTW6   X2L2N9   T1HMS5   A0A2J7PYR1   A0A2H4T0P7   A0A067R718   N6TQ91   A0A1B6DVC9   A0A310SLL4   E2BB90   E0VA53   A0A087ZWL9   W0U8S1   E2ATC1   A0A151J0L6   A0A0J7KTY1   A0A0M9A9B9   A0A3L8DR92   A0A0C9QVS2   F4WII1   A0A0C9Q1P1   A0A026VXG0   A0A0L7R2G1   A0A158NZY3   E9J593   A0A1S3DGR0   A0A195BLI6   A0A154P6W6   A0A195F1Z2   A0A195CML9   A0A2H8TLG9   A0A1S3DBJ0   J9K3L5   A0A2S2QQC9   A0A1A9YSY0   A0A1A9ZZ24   A0A1A9VFW2   A0A1I8Q2X1   A0A1B0B2L8   A0A1B0FEL2   E0W0B9   A0A0R1E4D7   A0A0N8P1R6   Q9VCZ3-2   B4K9B5   E1JIT6   B4M0I5   A0A0P9A248   N1NTZ0   B4PMA9   B4JV44   B4R032   B4NJT1   Q9VCZ3   A0A0R1E4B6   B3P8N9   B4HEA3   B3LZZ4   A0A1W4W3K4   A0A0R3NFN9   G7H820   A0A221LCB0   A0A3B0JKB6   G2J627   B4GP31   D6WZ38   Q29BK0   A8E6P6   A0A026VTA1   A0A1Z2RSH0   X2KWS2   A0A0L0BYB7   E9IRG6   A0A1B0GLH6   A0A2J7PTR8   E2C5Q4   Q4LBB6-9   B4M5L3   X2KWM1   A0A067R5V7   A0A158NZY1   A0A3B0JJM1   A0A0L0BYA7   A0A1W4UBG5   B4JGS7   B3P498  

Pubmed

19121390    26354079    22504014    26227816    18362917    19820115    + More
18054377    18025266    18316733    20068045    21843505    23604020    24646461    24845553    23537049    20798317    20566863    30249741    21719571    24508170    21347285    21282665    17994087    17550304    15816867    15998303    10731132    12537572    22553037    22303848    12537568    12537573    12537574    16110336    17569856    17569867    15632085    27717101    23185243    26108605    25605909   

EMBL

BABH01020819    ODYU01006984    SOQ49320.1    NWSH01002989    PCG67140.1    RSAL01000019    + More
RVE52780.1    KF640249    AGV79326.1    KQ460620    KPJ13529.1    JN815182    AFA55165.1    JTDY01002081    KOB72154.1    KOB72153.1    KQ971372    KYB25290.1    KK854281    PTY14153.1    EFA10771.2    BK005858    DAA64495.1    KJ152558    AHN85841.1    ACPB03014337    NEVH01020342    PNF21440.1    KY352398    ATY68966.1    KK852660    KDR19125.1    APGK01059262    KB741292    KB632186    ENN70476.1    ERL89671.1    GEDC01007661    JAS29637.1    KQ764687    OAD54449.1    GL446948    EFN87040.1    DS235004    EEB10259.1    HF548209    CCO13922.1    GL442548    EFN63288.1    KQ980624    KYN15038.1    LBMM01003252    KMQ93751.1    KQ435721    KOX78519.1    QOIP01000005    RLU22816.1    GBYB01007839    JAG77606.1    GL888175    EGI66112.1    GBYB01007838    GBYB01009473    JAG77605.1    JAG79240.1    KK107816    EZA47549.1    KQ414666    KOC65065.1    ADTU01005126    GL768124    EFZ12018.1    KQ976440    KYM86550.1    KQ434829    KZC07669.1    KQ981856    KYN34595.1    KQ977580    KYN01722.1    GFXV01003045    MBW14850.1    ABLF02038092    ABLF02038101    ABLF02038102    ABLF02038105    GGMS01010734    MBY79937.1    JXJN01007683    CCAG010014863    DS235858    EEB19075.1    CM000160    KRK04060.1    CH902617    KPU80668.1    AJ617526    AJ880687    AJ880688    AE014297    AAF56012.1    CAE84925.1    CAI56428.1    CH933806    EDW15547.1    ACZ94986.1    CH940650    EDW68364.1    KPU80666.1    BK005856    DAA64493.1    EDW98014.1    CH916374    EDV91364.1    CM000364    EDX13938.1    CH964272    EDW85043.1    KRK04061.1    KRK04062.1    CH954182    EDV54134.1    CH480815    EDW43200.1    EDV44184.2    CM000070    KRS99707.1    BT132743    AES58502.1    KX578904    ASM90737.1    OUUW01000005    SPP80772.1    BT128884    AEO17899.1    CH479186    EDW38914.1    EFA10770.2    EAL26997.3    KRS99708.1    BT030838    ABV82220.1    KK107979    EZA47013.1    KX360126    ASA47149.1    KJ152559    AHN85842.1    JRES01001160    KNC25033.1    GL765144    EFZ16826.1    AJWK01035015    AJWK01035016    AJWK01035017    AJWK01035018    AJWK01035019    NEVH01021226    PNF19714.1    GL452786    EFN76724.1    AJ884591    AJ884592    AJ884593    AJ884594    BT029269    CAI56424.1    CH940652    EDW58939.2    KJ152560    AHN85843.1    KK852941    KDR13533.1    ADTU01005104    ADTU01005105    ADTU01005106    OUUW01000007    SPP82554.1    KNC25005.1    CH916369    EDV92681.1    CH954181    EDV49343.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000037510    UP000007266    + More
UP000015103    UP000235965    UP000027135    UP000019118    UP000030742    UP000008237    UP000009046    UP000005203    UP000000311    UP000078492    UP000036403    UP000053105    UP000279307    UP000007755    UP000053097    UP000053825    UP000005205    UP000079169    UP000078540    UP000076502    UP000078541    UP000078542    UP000007819    UP000092443    UP000092445    UP000078200    UP000095300    UP000092460    UP000092444    UP000002282    UP000007801    UP000000803    UP000009192    UP000008792    UP000001070    UP000000304    UP000007798    UP000008711    UP000001292    UP000192221    UP000001819    UP000268350    UP000008744    UP000037069    UP000092461   

PRIDE

H9IYB5    Q9VCZ3    G2J627    Q4LBB6   

Pfam

PF00001   7tm_1

Interpro

IPR000276   GPCR_Rhodpsn        + More
IPR017452   GPCR_Rhodpsn_7TM       
IPR002233   ADR_fam       

ProteinModelPortal

H9IYB5   A0A2H1W8D0   A0A2A4J6R9   A0A3S2M6T4   T2FFY0   A0A0N1IPC8   + More
H6V947   A0A0L7L9V2   A0A0L7L9J9   A0A139WBL3   A0A2R7W338   D6WZ39   N1NTW6   X2L2N9   T1HMS5   A0A2J7PYR1   A0A2H4T0P7   A0A067R718   N6TQ91   A0A1B6DVC9   A0A310SLL4   E2BB90   E0VA53   A0A087ZWL9   W0U8S1   E2ATC1   A0A151J0L6   A0A0J7KTY1   A0A0M9A9B9   A0A3L8DR92   A0A0C9QVS2   F4WII1   A0A0C9Q1P1   A0A026VXG0   A0A0L7R2G1   A0A158NZY3   E9J593   A0A1S3DGR0   A0A195BLI6   A0A154P6W6   A0A195F1Z2   A0A195CML9   A0A2H8TLG9   A0A1S3DBJ0   J9K3L5   A0A2S2QQC9   A0A1A9YSY0   A0A1A9ZZ24   A0A1A9VFW2   A0A1I8Q2X1   A0A1B0B2L8   A0A1B0FEL2   E0W0B9   A0A0R1E4D7   A0A0N8P1R6   Q9VCZ3-2   B4K9B5   E1JIT6   B4M0I5   A0A0P9A248   N1NTZ0   B4PMA9   B4JV44   B4R032   B4NJT1   Q9VCZ3   A0A0R1E4B6   B3P8N9   B4HEA3   B3LZZ4   A0A1W4W3K4   A0A0R3NFN9   G7H820   A0A221LCB0   A0A3B0JKB6   G2J627   B4GP31   D6WZ38   Q29BK0   A8E6P6   A0A026VTA1   A0A1Z2RSH0   X2KWS2   A0A0L0BYB7   E9IRG6   A0A1B0GLH6   A0A2J7PTR8   E2C5Q4   Q4LBB6-9   B4M5L3   X2KWM1   A0A067R5V7   A0A158NZY1   A0A3B0JJM1   A0A0L0BYA7   A0A1W4UBG5   B4JGS7   B3P498  

PDB

6IBL     E-value=8.58728e-40,     Score=409

KEGG

101746929    K22790 octopamine receptor beta | (RefSeq) octopamine receptor beta-1R

GO

GO:0004930   GO:0016021   GO:0004989   GO:0004715   GO:0004935   GO:0005886   GO:0045886   GO:0007189   GO:0007188   GO:0005887   GO:0008227   GO:0007186   GO:0005737   GO:0005215   GO:0006270   GO:0042555   GO:0003707   GO:0006281   GO:0006259  

Subcellular location

Cell membrane  

Length:

263

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

113.32138

Exp number, first 60 AAs:

3.53533

Total prob of N-in:

0.00368

outside

1  -  55

TMhelix

56  -  78

inside

79  -  98

TMhelix

99  -  121

outside

122  -  140

TMhelix

141  -  158

inside

159  -  178

TMhelix

179  -  201

outside

202  -  225

TMhelix

226  -  248

inside

249  -  263

 

 

Pi

193.510363

Theta

153.633244

Tajima's D

0.781141

CLR

0.604688

CSRT

0.592170391480426

Interpretation

Uncertain