Gene

KWMTBOMO15739

Pre Gene Modal

BGIBMGA002325

Annotation

octopamine_receptor_[Bombyx_mori]

Location

Bomo_Chr26(+):8353209-8357142      View in EpiBrowser

Full name

Octopamine receptor beta-2R      

Location in the cell

PlasmaMembrane   Reliability : 4.95

CDS

ATGGATCGAGAAAACGTAACCCATCATGCAGTCAACGCGACTGTAAGCGCGACAATCAACGGGACGGCCGAAGAAGAGTATGACGTCACGCAGGGCGTGTTCTTCAAACTCCGGATGTCGGTGCTCCTGCTCATCGTTATCACGGCTGTGCTCGGGAACATGCTGGTCATCGTCAGTGTCATGAGGCACAGGAAACTCCGCGTCATAACCAACTACTTCGTCGTATCGTTGGCTTTCGCGGACATCCTCGTCGCGATGGTTGTGATGCCGTTCAACTTCAGCGTCCAGTTTTACCAGGGATGGGTCTTCGGGCCGATCATATGCGATCTTTGGAACTCATCAGACGTCTACTTTACGTCCACTTCTATACTGCACTTGTGCTGTATATCGGTTGACAGATACTATGCCATAGTAAAACCTTTGAAGTATCCAACGAAAATGACAAAAAAGGTGGCATTCATAATGCTGGCAGCGACGTGGTTAAGTCCGATCACGATATCTTACGTCCCGATTTTCATGGGATGGTATACGACGAACGATTACCTGCAAACAGCGTCGAGCGATCAGTGCGAATTCAAAGTGAACAAGCCATACGCAGTGATCTCAAGTTCTATATCATTCTGGATACCCTGTACGATCATGATATTCACTTACCTAGCGATTTTCAAGGAAGCGAATAGACAAGAGAAGGCTTTGCACGCTCGGGCTGGTAACGCTATGCTAATGCATCGACACTCAAGAGATGTGAGCGACAAAAATGGAGCTCTCCACATAAACGCGACGACACCGACCAAAGACAGGAATATCCTCAAAATGAAAAGGGAACACAAAGCCGCCCGAACTTTGGGAATTATCATGGGAGCATTTATTTTGTGCTGGTTGCCATTTTTTCTGTTTTACGTCTCGACTTCTTTGTGTGACACGTGCAAATGCCCCGACGTGGTCACGGTAATAATGTTCTGGACTGGCTATTTCAATTCCGCCCTTAATCCTATCATCTACGCGTATTTCAATAGGGATTTCCGTAATGCCTTCAAGAACACATTAGCGTGCGCTTTTTGTAGTTTCTGTAGACGCAATTCCTCAGATCTTGACGCGCTGGAGAGGCTCGACAGAAGGGGTTCCGCGCAATTACGCGTTCCTGTTGCTTCTAGGAGGGCATCAGATTTAGCGTCGCTTTGA

Protein

MDRENVTHHAVNATVSATINGTAEEEYDVTQGVFFKLRMSVLLLIVITAVLGNMLVIVSVMRHRKLRVITNYFVVSLAFADILVAMVVMPFNFSVQFYQGWVFGPIICDLWNSSDVYFTSTSILHLCCISVDRYYAIVKPLKYPTKMTKKVAFIMLAATWLSPITISYVPIFMGWYTTNDYLQTASSDQCEFKVNKPYAVISSSISFWIPCTIMIFTYLAIFKEANRQEKALHARAGNAMLMHRHSRDVSDKNGALHINATTPTKDRNILKMKREHKAARTLGIIMGAFILCWLPFFLFYVSTSLCDTCKCPDVVTVIMFWTGYFNSALNPIIYAYFNRDFRNAFKNTLACAFCSFCRRNSSDLDALERLDRRGSAQLRVPVASRRASDLASL

Description

Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. Also acts as a receptor for tyramine, but with much less potency. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (PubMed:15998303, PubMed:21186359). Essential for ovulation and fertilization (PubMed:25099506, PubMed:25353988). During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin-dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways (PubMed:25353988). Positively regulates synaptic growth; an action that is antagonized by Octbeta1R (PubMed:21186359, PubMed:22553037).

Similarity

Belongs to the G-protein coupled receptor 1 family.

Keywords

Cell membrane   G-protein coupled receptor   Glycoprotein   Membrane   Receptor   Transducer   Transmembrane   Transmembrane helix   Complete proteome   Reference proteome  

Feature

chain  Octopamine receptor beta-2R

Uniprot

D5MQ02   A0A2A4J6I0   A0A2H1W156   A0A0M5L056   G3M4F8   A0A194QIF7   + More
A0A0N1PEZ3   A0A212F1F1   D5JAN8   A0A067R5V7   A0A2J7PTR8   A0A1W4XHQ1   A0A2P8Z642   A0A3Q0IXL2   E0VX90   X2KWS2   A0A0K8SVR5   A0A1Z2RSH0   E2BJQ9   A0A1A9ZZ41   A0A3L8E294   A0A1A9VFV0   A0A1B0B2K8   A0A1B6FJN1   W8AYJ1   A0A1A9YSZ7   A0A182P804   A0A0J7KA71   F5HKI1   A0A182HTU2   E9IZU0   A0A151WUJ9   A0A1B6DUI6   A0A182XHK1   A0A1B6J0A5   W5JIB7   W0U9P0   A0A182VYP8   A0A1B6L9Y4   A0A023F4J9   A0A182RQ41   F4X5M0   A0A182XW86   A0A195FBV8   A0A182N715   A0A2A3EUB7   E2AS88   A0A154P9K2   T1I5H6   A0A195C9V3   K7INZ2   A0A182F973   A0A195BY94   A0A158NIU3   A0A151JSP6   A0A291L8J3   A0A0L0BYF4   A0A0A1WEQ6   A0A034VIK4   A0A0K8TYU8   T1PJE0   D6WZ37   A0A182K046   A0A1I8N820   A0A1W4UAS4   A0A182JGE1   A0A336KTN4   A0A1Y1JT10   B3P495   B4PPC0   A0A126GUT9   Q4LBB9   B4QS91   E1JIJ4   A0A3B0JJM4   B4JGS5   A0A310S995   A0A221LCB7   A0A3B0KA64   B4GPP5   I5AMZ4   A0A1I8PH50   B4HGV9   B4KCK0   N6SYP2   B4M5L1   B4NHZ4   A0A2H8TJT8   B3MST6   J9JW99   A0A2S2QUZ5   A0A0K8UTC3   A0A336MPC1   A0A1J1HTF2   A0A182LGA7   Q7PQX8   A0A1J1HPK6   A0A088AE16   A0A087T4K2  

Pubmed

19121390    22786641    26354079    22118469    20223248    24845553    + More
29403074    20566863    24646461    20798317    30249741    24495485    12364791    14747013    17210077    21282665    20920257    23761445    25474469    21719571    25244985    20075255    21347285    29018364    26108605    25830018    25348373    18054377    18025266    18362917    18316733    20068045    19820115    21843505    23604020    25315136    28004739    17994087    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    15998303    21186359    22553037    22303848    25099506    25353988    27717101    15632085    23537049    20966253   

EMBL

BABH01020758    AB470228    AB470229    BAJ06526.1    BAJ06527.1    NWSH01002763    + More
PCG67561.1    ODYU01005707    SOQ46821.1    KR057964    ALE20482.1    JN620367    AEO89318.1    KQ458761    KPJ05179.1    KQ461157    KPJ08080.1    AGBW02010893    OWR47568.1    GU237483    ADD91575.1    KK852941    KDR13533.1    NEVH01021226    PNF19714.1    PYGN01000178    PSN51957.1    DS235830    EEB17996.1    KJ152559    AHN85842.1    GBRD01008841    JAG56980.1    KX360126    ASA47149.1    GL448616    EFN84067.1    QOIP01000001    RLU26851.1    JXJN01007683    GECZ01030325    GECZ01019380    JAS39444.1    JAS50389.1    GAMC01015328    JAB91227.1    LBMM01010956    KMQ87121.1    AAAB01008859    EGK96733.1    APCN01000586    GL767232    EFZ13952.1    KQ982730    KYQ51516.1    GEDC01007966    JAS29332.1    GECU01015103    JAS92603.1    ADMH02001315    ETN63033.1    HF548210    CCO13923.1    GEBQ01019491    JAT20486.1    GBBI01002535    JAC16177.1    GL888730    EGI58225.1    KQ981677    KYN38115.1    KZ288187    PBC34729.1    GL442229    EFN63718.1    KQ434839    KZC08074.1    ACPB03016003    KQ978068    KYM97639.1    KQ976394    KYM93275.1    ADTU01017204    KQ978549    KYN30171.1    MF377526    ATI14906.1    JRES01001160    KNC25006.1    GBXI01016925    JAC97366.1    GAKP01016641    GAKP01016638    JAC42314.1    GDHF01032655    GDHF01012211    JAI19659.1    JAI40103.1    KA648230    AFP62859.1    BK005857    KQ971372    DAA64494.1    EFA10769.1    UFQS01001020    UFQT01001020    SSX08594.1    SSX28510.1    GEZM01101655    GEZM01101654    JAV52402.1    CH954181    EDV49340.1    CM000160    EDW97126.2    AE014297    ALI30563.1    AJ880689    BT053715    CAI56430.1    CM000364    EDX13187.1    ACZ94893.2    OUUW01000007    SPP82557.1    CH916369    EDV92679.1    KQ768897    OAD53031.1    KX578903    ASM90736.1    SPP82556.1    CH479186    EDW39128.1    CM000070    EIM52329.2    CH480815    EDW42430.1    CH933806    EDW14819.2    APGK01058926    KB741292    KB631995    ENN70343.1    ERL87783.1    CH940652    EDW58937.2    CH964272    EDW83644.2    GFXV01002436    MBW14241.1    CH902623    EDV30326.2    ABLF02038922    ABLF02038927    ABLF02038928    ABLF02038934    ABLF02038935    GGMS01012117    MBY81320.1    GDHF01022576    JAI29738.1    UFQS01001536    UFQT01001536    SSX11381.1    SSX30949.1    CVRI01000012    CRK89465.1    EAA08140.5    CRK89466.1    KK113376    KFM60041.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000027135    + More
UP000235965    UP000192223    UP000245037    UP000079169    UP000009046    UP000008237    UP000092445    UP000279307    UP000078200    UP000092460    UP000092443    UP000075885    UP000036403    UP000007062    UP000075840    UP000075809    UP000076407    UP000000673    UP000075920    UP000075900    UP000007755    UP000076408    UP000078541    UP000075884    UP000242457    UP000000311    UP000076502    UP000015103    UP000078542    UP000002358    UP000069272    UP000078540    UP000005205    UP000078492    UP000037069    UP000007266    UP000075881    UP000095301    UP000192221    UP000075880    UP000008711    UP000002282    UP000000803    UP000000304    UP000268350    UP000001070    UP000008744    UP000001819    UP000095300    UP000001292    UP000009192    UP000019118    UP000030742    UP000008792    UP000007798    UP000007801    UP000007819    UP000183832    UP000075882    UP000005203    UP000054359   

PRIDE

D5MQ02    Q4LBB9    E1JIJ4   

Pfam

PF00001   7tm_1

Interpro

IPR017452   GPCR_Rhodpsn_7TM        + More
IPR000276   GPCR_Rhodpsn       
IPR004827   bZIP       
IPR000929   Dopamine_rcpt       

ProteinModelPortal

D5MQ02   A0A2A4J6I0   A0A2H1W156   A0A0M5L056   G3M4F8   A0A194QIF7   + More
A0A0N1PEZ3   A0A212F1F1   D5JAN8   A0A067R5V7   A0A2J7PTR8   A0A1W4XHQ1   A0A2P8Z642   A0A3Q0IXL2   E0VX90   X2KWS2   A0A0K8SVR5   A0A1Z2RSH0   E2BJQ9   A0A1A9ZZ41   A0A3L8E294   A0A1A9VFV0   A0A1B0B2K8   A0A1B6FJN1   W8AYJ1   A0A1A9YSZ7   A0A182P804   A0A0J7KA71   F5HKI1   A0A182HTU2   E9IZU0   A0A151WUJ9   A0A1B6DUI6   A0A182XHK1   A0A1B6J0A5   W5JIB7   W0U9P0   A0A182VYP8   A0A1B6L9Y4   A0A023F4J9   A0A182RQ41   F4X5M0   A0A182XW86   A0A195FBV8   A0A182N715   A0A2A3EUB7   E2AS88   A0A154P9K2   T1I5H6   A0A195C9V3   K7INZ2   A0A182F973   A0A195BY94   A0A158NIU3   A0A151JSP6   A0A291L8J3   A0A0L0BYF4   A0A0A1WEQ6   A0A034VIK4   A0A0K8TYU8   T1PJE0   D6WZ37   A0A182K046   A0A1I8N820   A0A1W4UAS4   A0A182JGE1   A0A336KTN4   A0A1Y1JT10   B3P495   B4PPC0   A0A126GUT9   Q4LBB9   B4QS91   E1JIJ4   A0A3B0JJM4   B4JGS5   A0A310S995   A0A221LCB7   A0A3B0KA64   B4GPP5   I5AMZ4   A0A1I8PH50   B4HGV9   B4KCK0   N6SYP2   B4M5L1   B4NHZ4   A0A2H8TJT8   B3MST6   J9JW99   A0A2S2QUZ5   A0A0K8UTC3   A0A336MPC1   A0A1J1HTF2   A0A182LGA7   Q7PQX8   A0A1J1HPK6   A0A088AE16   A0A087T4K2  

PDB

3SN6     E-value=9.95781e-55,     Score=540

KEGG

100431169    K22790 octopamine receptor beta | (RefSeq) OAR2, BmOAR2.1, BmOAR2.2; octopamine receptor

GO

GO:0016021   GO:0004930   GO:0004989   GO:0005886   GO:0007189   GO:0071418   GO:0008226   GO:0071927   GO:0071928   GO:0004715   GO:0003700   GO:0030728   GO:0045887   GO:0007186   GO:0008227   GO:0005887   GO:0009566   GO:0004993   GO:0005215   GO:0006270   GO:0042555   GO:0003707   GO:0006281   GO:0006259  

Subcellular location

Cell membrane  

Length:

393

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

155.405

Exp number, first 60 AAs:

21.59164

Total prob of N-in:

0.02236

POSSIBLE N-term signal

sequence

outside

1  -  38

TMhelix

39  -  61

inside

62  -  67

TMhelix

68  -  90

outside

91  -  115

TMhelix

116  -  138

inside

139  -  150

TMhelix

151  -  173

outside

174  -  199

TMhelix

200  -  222

inside

223  -  277

TMhelix

278  -  300

outside

301  -  314

TMhelix

315  -  337

inside

338  -  393

 

 

Pi

41.929606

Theta

58.056681

Tajima's D

-1.303267

CLR

128.436588

CSRT

0.0875456227188641

Interpretation

Uncertain