Gene
KWMTBOMO15727
Pre Gene Modal
BGIBMGA002316
Annotation
PREDICTED:_octopamine_receptor_isoform_X1_[Bombyx_mori]
Full name
Probable G-protein coupled receptor No9
+ More
Octopamine receptor Oamb
Octopamine receptor Oamb
Alternative Name
Octopamine receptor in mushroom bodies
Location in the cell
PlasmaMembrane Reliability : 4.361
Sequence
CDS
ATGCGCTCGCTGAACGAGTCGGCCTGTGAGGCGTTGCTCGAGGACGTGCGCTGGGACGAGCCCACCAGCCTCGTGAGCCTCGCCGTGCTCGCGCTCATCGACGTACTCGTGATCGCCGGTAACTGTCTCGTTATCGCCGCTGTGCTCTGCTCGTCGAAGCTACGCAGCGTCACGAATCTGTTTATCGTGTCGCTAGCCGTCGCCGACTTGCTGGTGGGAGTCGCTGTACTGCCGTTCTCTGCGACGCGGGAAGTATTTGAGGTCTGGATCTTTGGCGACGTGTGGTGCTCAGTATGGCTAGCCGTGGACGTGTGGATGTGCACCGCCTCTATTCTCAATCTCTGCGCAATATCCCTGGACCGATACGTGGCTGTCACCCGTCCTGTCAGCTACCCGAGTATCATGAGCAGGAAGCGGGCTAAAGCATTAATAGCCGGTCTATGGGTGCTCTCTTTCGTAATTTGTTTCCCGCCGCTGGTAGGATGGAAGGATAAAAGGGATGATGACGGAACCCATAAAGAAGGCTGGGCTCCCAATCCTCCGTGCCAGTGGACCTGCGAGTTGACCAATGATGCTGGGTACGTTGTCTATTCAGCTTTGGGCTCCTTCTACATCCCGATGTTCGTGATGCTATTCTTCTATTGGAGGATCTACAAAGCTGCCGTTAGAACCACCAAGGCAATTAATCAAGGCTTTAGAACTACTAAAGGTAGAGGGCTGGGTAGTCGTTTCGATGACAACCGTCTCACGTTGCGAATACATCGCGGCAGAGGATCCAATCGTCCTCACGGCTCACCTCTGTCAGCTGCCTCGAATCACTCCACAAGCACATCGCTGAGCGCCTCGCCAGAACGACTTAGAAGGCACTCAAGCGCTCGCCGGGCCCACGAGAAAGTCAAAATATCCGTCTCTTATCCGTCAACGGAACAAATCTGTCCGGCCCACGAGAATTCTCGGTCGCCCAGCCGATCTCCTAGTCCTTCTCTGTACGCTGTTCATTACGAGAGAGACGGAAGGGAACTGACTGAGAGCAGACTCAGGGTCAGACCTTCGCATCATTTACATCCCGGACCGTTGTACGACGATTATGACGATAAGCCACGAACTCGACGCATGGGGAAGAGGAATATCAAAGCACAGGTGAAGCGCTTTAAGATGGAGACCAAAGCAGCAAAAACCCTGGGCATCATAGTCGGAGGCTTCGTGTTCTGCTGGCTGCCATTTTTCAGCGTCTACGTGGTCCGGGCGTTCTGTGGCGAATGCGTTACTCCCATAGTCTTCTCCGTACTATTCTGGCTGGGATACTGCAACTCTGCTATCAATCCACTCATTTATGCTCTGTTCTCCAAAGATTTTCGATTCGCATTCAAACGTATTATCTGCAAGTGCTTCTGCGGTGGCGGCGGAGCACGCCGGGAGTCTGATGAAGGTTCCGCGAGGCGTCCCAACCACAGACCAGTGCACTCACATTCTTTGGAGGAGCAGGAACCTAGTCAGACTACTCTAACTGCGGCAGAAAGGTGA
Protein
MRSLNESACEALLEDVRWDEPTSLVSLAVLALIDVLVIAGNCLVIAAVLCSSKLRSVTNLFIVSLAVADLLVGVAVLPFSATREVFEVWIFGDVWCSVWLAVDVWMCTASILNLCAISLDRYVAVTRPVSYPSIMSRKRAKALIAGLWVLSFVICFPPLVGWKDKRDDDGTHKEGWAPNPPCQWTCELTNDAGYVVYSALGSFYIPMFVMLFFYWRIYKAAVRTTKAINQGFRTTKGRGLGSRFDDNRLTLRIHRGRGSNRPHGSPLSAASNHSTSTSLSASPERLRRHSSARRAHEKVKISVSYPSTEQICPAHENSRSPSRSPSPSLYAVHYERDGRELTESRLRVRPSHHLHPGPLYDDYDDKPRTRRMGKRNIKAQVKRFKMETKAAKTLGIIVGGFVFCWLPFFSVYVVRAFCGECVTPIVFSVLFWLGYCNSAINPLIYALFSKDFRFAFKRIICKCFCGGGGARRESDEGSARRPNHRPVHSHSLEEQEPSQTTLTAAER
Summary
Description
Receptor for octopamine (OA) which is a neurotransmitter, neurohormone and neuromodulator in invertebrates (PubMed:9570796, PubMed:15816867). Stimulates intracellular accumulation of cAMP and Ca(2+) following ligand binding (PubMed:9570796, PubMed:15816867). Required for ovulation (PubMed:14623240, PubMed:19262750). Following activation on mature follicle cells by OA, induces activity of the metalloprotease Mmp2 which leads to breakdown of the posterior follicle wall, resulting in ovulation (PubMed:26473732). Ligand binding probably also leads to activation of CamKII which is also required for ovulation (PubMed:19262750). Modulates sleep/wake behavior by acting in neurons of the pars intercerebralis to promote wakefulness (PubMed:20223202). Plays a role in courtship conditioning where the courtship behavior of males rejected by already mated females is inhibited with further females (PubMed:23055498). Required in the mushroom body for appetitive olfactory learning (PubMed:23103875, PubMed:23345239). Specifically conveys the short-term reinforcing effects of sweet taste (PubMed:23103875, PubMed:25728694). In insulin-producing cells of the brain, plays a role in inhibiting transcription of insulin-like peptide Ilp3 (PubMed:24923784). Also plays a role in social behavior by modulating male agression (PubMed:24923784).
Similarity
Belongs to the G-protein coupled receptor 1 family.
Keywords
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Transducer
Transmembrane
Transmembrane helix
Alternative splicing
Behavior
Complete proteome
Reference proteome
Transcription
Transcription regulation
Feature
chain Probable G-protein coupled receptor No9
splice variant In isoform B.
splice variant In isoform B.
Uniprot
Q08JR9
A0A2W1BMU0
Q0GMY3
A0A212FB86
A0A2A4JPZ1
A0A2A4JRN5
+ More
A0A0N0P9Q7 G5DE89 A0A0N1IEY0 A0A2H1WYC2 H9IYI2 H9TN29 A0A1Y1M8N3 X2KSD8 A0A1W4X6F5 N1NV86 D6X0Y2 Q7YWB7 Q7PRZ8 A0A088AMT2 Q70TB0 A0A084VIY5 A0A0L7QR21 A0A2H4T0P1 A0A0N0BBE5 A0A310SJH9 A0A158NT67 E2BYN4 E2AUP4 A0A195EDS6 A0A3L8DL17 A0A232F1Z9 E0VUZ6 A0A151WEB8 A0A336M5F6 A0A195BDT8 A0A026X5N4 A0A195FHQ1 W8BDM0 A0A154PH52 A0A1B0CRD4 A0A2R7W521 U4U3I8 D7P7W8 Q93126 A0A2A3EEA8 T1IJG8 A0A1J1HS47 A0A1J1HNC6 V4A2Q6 A0A0C9R260 N6UP26 T1HBD1 A0A1W4VAE5 Q7JQF1 B4R1T7 A0A2J7PUF2 A0A3B0JLB2 A0A126GUW9 B4NFU1 A0A2P8XZ27 A0A3S0ZLT1 A0A0A1WGW8
A0A0N0P9Q7 G5DE89 A0A0N1IEY0 A0A2H1WYC2 H9IYI2 H9TN29 A0A1Y1M8N3 X2KSD8 A0A1W4X6F5 N1NV86 D6X0Y2 Q7YWB7 Q7PRZ8 A0A088AMT2 Q70TB0 A0A084VIY5 A0A0L7QR21 A0A2H4T0P1 A0A0N0BBE5 A0A310SJH9 A0A158NT67 E2BYN4 E2AUP4 A0A195EDS6 A0A3L8DL17 A0A232F1Z9 E0VUZ6 A0A151WEB8 A0A336M5F6 A0A195BDT8 A0A026X5N4 A0A195FHQ1 W8BDM0 A0A154PH52 A0A1B0CRD4 A0A2R7W521 U4U3I8 D7P7W8 Q93126 A0A2A3EEA8 T1IJG8 A0A1J1HS47 A0A1J1HNC6 V4A2Q6 A0A0C9R260 N6UP26 T1HBD1 A0A1W4VAE5 Q7JQF1 B4R1T7 A0A2J7PUF2 A0A3B0JLB2 A0A126GUW9 B4NFU1 A0A2P8XZ27 A0A3S0ZLT1 A0A0A1WGW8
Pubmed
17201769
28756777
16935223
22118469
26354079
19121390
+ More
28004739 24646461 18054377 18025266 18316733 20068045 21843505 23604020 18362917 19820115 15147753 12364791 12859685 24438588 21347285 20798317 30249741 28648823 20566863 24508170 24495485 23537049 20488921 8917082 23254933 9570796 15816867 10731132 12537572 14623240 19262750 20223202 23055498 23103875 23345239 24923784 25743690 25728694 26473732 17994087 12537568 12537573 12537574 16110336 17569856 17569867 29403074 25830018
28004739 24646461 18054377 18025266 18316733 20068045 21843505 23604020 18362917 19820115 15147753 12364791 12859685 24438588 21347285 20798317 30249741 28648823 20566863 24508170 24495485 23537049 20488921 8917082 23254933 9570796 15816867 10731132 12537572 14623240 19262750 20223202 23055498 23103875 23345239 24923784 25743690 25728694 26473732 17994087 12537568 12537573 12537574 16110336 17569856 17569867 29403074 25830018
EMBL
AB255163
BAF33393.1
KZ150018
PZC74934.1
DQ840514
ABI33825.1
+ More
AGBW02009366 OWR50990.1 NWSH01000816 PCG74071.1 PCG74072.1 KQ459199 KPJ02955.1 JN641302 AEQ33589.1 KQ460820 KPJ12098.1 ODYU01011998 SOQ58061.1 BABH01020669 BABH01020670 BABH01020671 JF502068 AFG22597.1 GEZM01037134 GEZM01037133 JAV82149.1 KJ152561 AHN85844.1 BK005859 DAA64496.1 KQ971372 EFA10678.2 AY333178 AAP93817.1 AAAB01008846 EAA06361.5 AJ547798 CAD67999.1 ATLV01013415 ATLV01013416 KE524855 KFB37929.1 KQ414785 KOC61009.1 KY352397 ATY68965.1 KQ436054 KOX67468.1 KQ760549 OAD59915.1 ADTU01000439 ADTU01000440 ADTU01000441 GL451499 EFN79188.1 GL442872 EFN62843.1 KQ979039 KYN23358.1 QOIP01000007 RLU21006.1 NNAY01001201 OXU24761.1 DS235797 EEB17202.1 KQ983238 KYQ46209.1 UFQT01000584 SSX25504.1 KQ976509 KYM82723.1 KK107019 EZA62769.1 KQ981606 KYN39534.1 GAMC01011474 GAMC01011473 GAMC01011472 JAB95083.1 KQ434902 KZC11173.1 AJWK01024638 AJWK01024639 AJWK01024640 AJWK01024641 AJWK01024642 AJWK01024643 KK854339 PTY14823.1 KB632063 ERL88449.1 GU074418 ADI56271.1 D78363 D78587 KZ288271 PBC29804.1 JH430285 CVRI01000010 CRK89025.1 CRK89026.1 KB202284 ESO90972.1 GBYB01010189 JAG79956.1 APGK01023893 APGK01023894 KB740523 ENN80487.1 ACPB03012893 AF065443 AJ007617 AJ007618 AE014297 BT010103 AAC17442.1 AAQ22572.1 CAB38025.1 CAB38026.1 CM000364 EDX12196.1 NEVH01021199 PNF19959.1 OUUW01000007 SPP83104.1 ALI30593.1 CH964251 EDW83158.2 PYGN01001139 PSN37259.1 RQTK01000376 RUS80725.1 GBXI01016557 JAC97734.1
AGBW02009366 OWR50990.1 NWSH01000816 PCG74071.1 PCG74072.1 KQ459199 KPJ02955.1 JN641302 AEQ33589.1 KQ460820 KPJ12098.1 ODYU01011998 SOQ58061.1 BABH01020669 BABH01020670 BABH01020671 JF502068 AFG22597.1 GEZM01037134 GEZM01037133 JAV82149.1 KJ152561 AHN85844.1 BK005859 DAA64496.1 KQ971372 EFA10678.2 AY333178 AAP93817.1 AAAB01008846 EAA06361.5 AJ547798 CAD67999.1 ATLV01013415 ATLV01013416 KE524855 KFB37929.1 KQ414785 KOC61009.1 KY352397 ATY68965.1 KQ436054 KOX67468.1 KQ760549 OAD59915.1 ADTU01000439 ADTU01000440 ADTU01000441 GL451499 EFN79188.1 GL442872 EFN62843.1 KQ979039 KYN23358.1 QOIP01000007 RLU21006.1 NNAY01001201 OXU24761.1 DS235797 EEB17202.1 KQ983238 KYQ46209.1 UFQT01000584 SSX25504.1 KQ976509 KYM82723.1 KK107019 EZA62769.1 KQ981606 KYN39534.1 GAMC01011474 GAMC01011473 GAMC01011472 JAB95083.1 KQ434902 KZC11173.1 AJWK01024638 AJWK01024639 AJWK01024640 AJWK01024641 AJWK01024642 AJWK01024643 KK854339 PTY14823.1 KB632063 ERL88449.1 GU074418 ADI56271.1 D78363 D78587 KZ288271 PBC29804.1 JH430285 CVRI01000010 CRK89025.1 CRK89026.1 KB202284 ESO90972.1 GBYB01010189 JAG79956.1 APGK01023893 APGK01023894 KB740523 ENN80487.1 ACPB03012893 AF065443 AJ007617 AJ007618 AE014297 BT010103 AAC17442.1 AAQ22572.1 CAB38025.1 CAB38026.1 CM000364 EDX12196.1 NEVH01021199 PNF19959.1 OUUW01000007 SPP83104.1 ALI30593.1 CH964251 EDW83158.2 PYGN01001139 PSN37259.1 RQTK01000376 RUS80725.1 GBXI01016557 JAC97734.1
Proteomes
UP000007151
UP000218220
UP000053268
UP000053240
UP000005204
UP000192223
+ More
UP000007266 UP000007062 UP000005203 UP000030765 UP000053825 UP000053105 UP000005205 UP000008237 UP000000311 UP000078492 UP000279307 UP000215335 UP000009046 UP000075809 UP000078540 UP000053097 UP000078541 UP000076502 UP000092461 UP000030742 UP000242457 UP000183832 UP000030746 UP000019118 UP000015103 UP000192221 UP000000803 UP000000304 UP000235965 UP000268350 UP000007798 UP000245037 UP000271974
UP000007266 UP000007062 UP000005203 UP000030765 UP000053825 UP000053105 UP000005205 UP000008237 UP000000311 UP000078492 UP000279307 UP000215335 UP000009046 UP000075809 UP000078540 UP000053097 UP000078541 UP000076502 UP000092461 UP000030742 UP000242457 UP000183832 UP000030746 UP000019118 UP000015103 UP000192221 UP000000803 UP000000304 UP000235965 UP000268350 UP000007798 UP000245037 UP000271974
Pfam
PF00001 7tm_1
Interpro
ProteinModelPortal
Q08JR9
A0A2W1BMU0
Q0GMY3
A0A212FB86
A0A2A4JPZ1
A0A2A4JRN5
+ More
A0A0N0P9Q7 G5DE89 A0A0N1IEY0 A0A2H1WYC2 H9IYI2 H9TN29 A0A1Y1M8N3 X2KSD8 A0A1W4X6F5 N1NV86 D6X0Y2 Q7YWB7 Q7PRZ8 A0A088AMT2 Q70TB0 A0A084VIY5 A0A0L7QR21 A0A2H4T0P1 A0A0N0BBE5 A0A310SJH9 A0A158NT67 E2BYN4 E2AUP4 A0A195EDS6 A0A3L8DL17 A0A232F1Z9 E0VUZ6 A0A151WEB8 A0A336M5F6 A0A195BDT8 A0A026X5N4 A0A195FHQ1 W8BDM0 A0A154PH52 A0A1B0CRD4 A0A2R7W521 U4U3I8 D7P7W8 Q93126 A0A2A3EEA8 T1IJG8 A0A1J1HS47 A0A1J1HNC6 V4A2Q6 A0A0C9R260 N6UP26 T1HBD1 A0A1W4VAE5 Q7JQF1 B4R1T7 A0A2J7PUF2 A0A3B0JLB2 A0A126GUW9 B4NFU1 A0A2P8XZ27 A0A3S0ZLT1 A0A0A1WGW8
A0A0N0P9Q7 G5DE89 A0A0N1IEY0 A0A2H1WYC2 H9IYI2 H9TN29 A0A1Y1M8N3 X2KSD8 A0A1W4X6F5 N1NV86 D6X0Y2 Q7YWB7 Q7PRZ8 A0A088AMT2 Q70TB0 A0A084VIY5 A0A0L7QR21 A0A2H4T0P1 A0A0N0BBE5 A0A310SJH9 A0A158NT67 E2BYN4 E2AUP4 A0A195EDS6 A0A3L8DL17 A0A232F1Z9 E0VUZ6 A0A151WEB8 A0A336M5F6 A0A195BDT8 A0A026X5N4 A0A195FHQ1 W8BDM0 A0A154PH52 A0A1B0CRD4 A0A2R7W521 U4U3I8 D7P7W8 Q93126 A0A2A3EEA8 T1IJG8 A0A1J1HS47 A0A1J1HNC6 V4A2Q6 A0A0C9R260 N6UP26 T1HBD1 A0A1W4VAE5 Q7JQF1 B4R1T7 A0A2J7PUF2 A0A3B0JLB2 A0A126GUW9 B4NFU1 A0A2P8XZ27 A0A3S0ZLT1 A0A0A1WGW8
PDB
6IBL
E-value=1.35423e-32,
Score=350
Ontologies
GO
GO:0005886
GO:0004935
GO:0016021
GO:0004930
GO:0007188
GO:0005887
GO:0071880
GO:0007268
GO:0007187
GO:0030594
GO:0004993
GO:0004989
GO:0030425
GO:0004715
GO:0016907
GO:0030728
GO:1904068
GO:1905050
GO:0042594
GO:0007612
GO:0010841
GO:0000122
GO:0006874
GO:0060279
GO:0008227
GO:0090328
GO:0007211
GO:0060278
GO:0008049
GO:0006979
GO:0051482
GO:0007186
GO:0005215
GO:0006270
GO:0042555
GO:0003707
GO:0006281
GO:0006259
Topology
Subcellular location
Cell membrane
Length:
507
Number of predicted TMHs:
7
Exp number of AAs in TMHs:
156.57788
Exp number, first 60 AAs:
24.8284
Total prob of N-in:
0.00257
POSSIBLE N-term signal
sequence
outside
1 - 24
TMhelix
25 - 47
inside
48 - 59
TMhelix
60 - 82
outside
83 - 96
TMhelix
97 - 119
inside
120 - 139
TMhelix
140 - 162
outside
163 - 192
TMhelix
193 - 215
inside
216 - 393
TMhelix
394 - 416
outside
417 - 425
TMhelix
426 - 448
inside
449 - 507
Population Genetic Test Statistics
Pi
203.157174
Theta
146.586347
Tajima's D
1.036084
CLR
0.027945
CSRT
0.668116594170291
Interpretation
Uncertain
