Gene
KWMTBOMO15711
Pre Gene Modal
BGIBMGA002262
Annotation
PREDICTED:_ubiquitin_thioesterase_trabid_[Bombyx_mori]
Full name
Ubiquitin thioesterase trabid
Location in the cell
Nuclear Reliability : 3.423
Sequence
CDS
ATGAGTGAAGAGGCGAAGAATGATGCGTCAAGAAAGAGTGCATCACAGTCTGTGGGGATTGATTGTGCTTCAGGCCCAGGGGCTGAGGCGATCACACAGGATGCCGCCACTACCATTTCCCAAATTGGACAGATGACAACAAGTTCAGCGCCACCGTGCGAGAATTCGAAATGGAGCTGTGAGATGTGTACTTACGAAAATTTTCCTCTCTCACGAAAGTGTACAATGTGTAGATCACCGAAGCCACTACTGGGCGAAGACATATTCAGATTACAGGACGGCGCCAGCGCTCTTCCATCACAGGAAACGTGTGGAGCGGAAGCCGTAGCAGATAGACTGAAACCCCTCAGGATATCATCGCCTCAAGGTCACACTAGTGCCTCTACTCTTGTTAAATGGTCATGTCCTACGTGCACGTACGAGAATTGGCCGAAGTCGATAAAGTGTGCGATGTGCGGCTACGGCAACCCTAATCCGGCCCACTCGCCCCCGTGCGACCCCAGGCTCCCGAGACCCCCAGGTGTAAACGAAATATGTAACAATCAAACCGCGTCTCTGCACGACGTAGACGGCAGCACGAGGAGATCGAAGCGGCGCGCCAGCAACATCGACTGGATATGGCTGCAGGCCTGTCTCGGCGTAGTGGAAGGTGAATCTCGAAGGGTCGAGACATATCTGTCGAGTGGAGGCGATCCGGCCCGGGCCCTCACTCACGCCGAAGTTCAACTTCTCAATCGAGCTTCCGCCTTCGACGCTGGATACACGCTCGTACACTTAGCGATCAGATTTCAAAGACAAGAAATTTTATCAACATTACTGTCACGGATATCGGGCGGCGGACCCGGACTGAAACGATCTCCCTCTTATATAGCGCCGGACCTGGCGTCAGCGATACGTCGGCACATAGCGGGGTGCTTAAGGCAGAAAAAAGGAAATTTTCCATGTCGATACATCAACGAGTTCTGTACCTTCTCGTTGCCTGCTGATATCGAAGAGTTACCGGCTGCGATACAAGAGCAGCTATTCTCCGAGTTACTGGACAGAGAAGCACAACAGACTTTAGAAGCGGATCCTCCACTCATAAACTGGAGCTTGGAGTTCACCGTTAACCTTGGGTCCCGGCTGTACGCCCTCTGGAACCGCTCGGCCGGCGACTGCCTGCCCGACGCCGTGTGCCAGGCCGCCTACGGGGTGTTCGACAGGAACAACGCGCTCCGGACCGCGCTGGCGGACTCGCTGCACCAAGCCCACAGGAGTTTCTACGAGCGTTGGCAGGCGTGGGAGCGAATGCAGGCGTCGCTGTTACATTACGCGCCCGAGGAGGGGCAGCTGAGGGCGGAGTGGAGCAGGATATTAGCGTCCGCCGCCCGACCCGGCACGCCGCTGCACCAGATCCATGTGTTCGTCCTCGCGCACGTGATGCGTCGTCCGATCATCGTGTACGGGGTCAACGTTGTGAATTCCTTCCGGGGGGAGGCCTTAGGATTTGCACGGTTTCAAGGTATATACTTACCGCTACTGTGGGACCCCCAGTTTTGTTCTAAATCGCCTTTATGCCTCGGATACACTCGCGGACATTTCTCCGCGCTAGTGCCCATAGAGCCTTATTCGCATAGGCATACGTATATTTGTCGGGAACAACAAGATGACAATGAAGATATGATATACCTGCCGCTAACGGATTCAGAAGGGAAATTATTGCCTGTACATTTTCTGACTTGCGATGAGATGTCGGAAGCGGAGAGCGTGGTCCGTCGCTGGGTGGTGTGGCGCGAGACGTCGGGCGGGCTGGCGGCGGCGCGGAGGCCCTCGCTGGCGCCCTCGCTGCTGCAGGCACAGATGCTGGAGGAGTGGCTCAACCACTACCGCAGGCTCGCACAACAAACGAGAGGTCCATTTCCACCGCGACTCCAAGCCGCGGCAGCGGAATACTCAAGCGATCCCGATACAGATGAAGAATGA
Protein
MSEEAKNDASRKSASQSVGIDCASGPGAEAITQDAATTISQIGQMTTSSAPPCENSKWSCEMCTYENFPLSRKCTMCRSPKPLLGEDIFRLQDGASALPSQETCGAEAVADRLKPLRISSPQGHTSASTLVKWSCPTCTYENWPKSIKCAMCGYGNPNPAHSPPCDPRLPRPPGVNEICNNQTASLHDVDGSTRRSKRRASNIDWIWLQACLGVVEGESRRVETYLSSGGDPARALTHAEVQLLNRASAFDAGYTLVHLAIRFQRQEILSTLLSRISGGGPGLKRSPSYIAPDLASAIRRHIAGCLRQKKGNFPCRYINEFCTFSLPADIEELPAAIQEQLFSELLDREAQQTLEADPPLINWSLEFTVNLGSRLYALWNRSAGDCLPDAVCQAAYGVFDRNNALRTALADSLHQAHRSFYERWQAWERMQASLLHYAPEEGQLRAEWSRILASAARPGTPLHQIHVFVLAHVMRRPIIVYGVNVVNSFRGEALGFARFQGIYLPLLWDPQFCSKSPLCLGYTRGHFSALVPIEPYSHRHTYICREQQDDNEDMIYLPLTDSEGKLLPVHFLTCDEMSEAESVVRRWVVWRETSGGLAAARRPSLAPSLLQAQMLEEWLNHYRRLAQQTRGPFPPRLQAAAAEYSSDPDTDEE
Summary
Description
Positive regulator of the Wnt signaling pathway. Specifically cleaves 'Lys-63'-linked ubiquitin chains. May act by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription (By similarity). Required for an efficient wg response, but not for other signaling responses, in the eye.
Catalytic Activity
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Subunit
Interacts with Apc.
Similarity
Belongs to the peptidase C64 family.
Keywords
Complete proteome
Hydrolase
Metal-binding
Phosphoprotein
Protease
Reference proteome
Repeat
Thiol protease
Ubl conjugation pathway
Wnt signaling pathway
Zinc
Zinc-finger
Feature
chain Ubiquitin thioesterase trabid
Uniprot
A0A212FEC0
A0A0N0PBS4
A0A1Y1NH75
A0A1Y1NIR5
A0A0T6BGD5
A0A1B6IZ83
+ More
A0A1W4WF83 D6WZW4 A0A026W364 A0A1L8DM50 A0A2R7WDH7 A0A195F3D3 F4WII2 E9J592 A0A151X4B3 A0A195CLW2 A0A151J121 E2ATC0 A0A023F2H3 A0A069DVY9 A0A0J7L995 A0A310S6A1 A0A0L7R2G4 K7INK9 A0A0K8UGR9 A0A232EU55 A0A034VM41 Q29B13 B4GZ81 A0A0N0U6P9 A0A154PL03 A0A2A3E1Y3 V9IK19 A0A087ZWL7 W8BU92 A0A1W4VZZ2 A0A1I8N6P1 Q9VH90 B4PVD0 B4HJV2 B3NZM2 A0A224X9B6 A0A0A1WVC1 A0A2P8YJ28 A0A1A9XG38 A0A3B0K1V9 A0A0L0CJC3 B3MX66 A0A1A9UJS1 A0A1A9Z9J7 E2BB89 B4N9H3 A0A0M5J6Q2 B4KCW0 A0A1B0BEF9 A0A1Q3FAP9 A0A067QZ02 B4JS28 B4MBI0 A0A1Q3FAX6 A0A1S4F0N0 A0A336MV22 Q17J95 E0VTH8 A0A023EVV4 A0A2J7PJC5 A0A2J7PJA6 U5EKR7 A0A182GXG7 A0A2M4AS32 A0A2M4ARY8 T1HNE8 A0A2M4BFG2 A0A182MA02 A0A0Q9X365 W5JFR8 A0A182F9A5 A0A084WNM3 A0A1B0GK75 A0A182TV76 A0A182UZI3 A0A182WV08 A0A182SGQ8 A0A182I8N3 A0A182LAJ1 A0A182IKJ9 A0A182XX44 Q7QFT5 A0A182W151 A0A182RVY5 A0A182P2N9 A0A182NFZ0 A0A182QNK9 A0A182K2P8 A0A2H8TR10
A0A1W4WF83 D6WZW4 A0A026W364 A0A1L8DM50 A0A2R7WDH7 A0A195F3D3 F4WII2 E9J592 A0A151X4B3 A0A195CLW2 A0A151J121 E2ATC0 A0A023F2H3 A0A069DVY9 A0A0J7L995 A0A310S6A1 A0A0L7R2G4 K7INK9 A0A0K8UGR9 A0A232EU55 A0A034VM41 Q29B13 B4GZ81 A0A0N0U6P9 A0A154PL03 A0A2A3E1Y3 V9IK19 A0A087ZWL7 W8BU92 A0A1W4VZZ2 A0A1I8N6P1 Q9VH90 B4PVD0 B4HJV2 B3NZM2 A0A224X9B6 A0A0A1WVC1 A0A2P8YJ28 A0A1A9XG38 A0A3B0K1V9 A0A0L0CJC3 B3MX66 A0A1A9UJS1 A0A1A9Z9J7 E2BB89 B4N9H3 A0A0M5J6Q2 B4KCW0 A0A1B0BEF9 A0A1Q3FAP9 A0A067QZ02 B4JS28 B4MBI0 A0A1Q3FAX6 A0A1S4F0N0 A0A336MV22 Q17J95 E0VTH8 A0A023EVV4 A0A2J7PJC5 A0A2J7PJA6 U5EKR7 A0A182GXG7 A0A2M4AS32 A0A2M4ARY8 T1HNE8 A0A2M4BFG2 A0A182MA02 A0A0Q9X365 W5JFR8 A0A182F9A5 A0A084WNM3 A0A1B0GK75 A0A182TV76 A0A182UZI3 A0A182WV08 A0A182SGQ8 A0A182I8N3 A0A182LAJ1 A0A182IKJ9 A0A182XX44 Q7QFT5 A0A182W151 A0A182RVY5 A0A182P2N9 A0A182NFZ0 A0A182QNK9 A0A182K2P8 A0A2H8TR10
EC Number
3.4.19.12
Pubmed
22118469
26354079
28004739
18362917
19820115
24508170
+ More
30249741 21719571 21282665 20798317 25474469 26334808 20075255 28648823 25348373 15632085 17994087 23185243 24495485 25315136 10731132 12537572 12537569 18281465 18327897 17550304 25830018 29403074 26108605 18057021 24845553 17510324 20566863 24945155 26483478 20920257 23761445 24438588 20966253 25244985 12364791 14747013 17210077
30249741 21719571 21282665 20798317 25474469 26334808 20075255 28648823 25348373 15632085 17994087 23185243 24495485 25315136 10731132 12537572 12537569 18281465 18327897 17550304 25830018 29403074 26108605 18057021 24845553 17510324 20566863 24945155 26483478 20920257 23761445 24438588 20966253 25244985 12364791 14747013 17210077
EMBL
AGBW02008963
OWR52070.1
KQ460820
KPJ12112.1
GEZM01005674
JAV95995.1
+ More
GEZM01005673 JAV95996.1 LJIG01000544 KRT86396.1 GECU01015448 JAS92258.1 KQ971372 EFA09636.1 KK107512 QOIP01000001 EZA49479.1 RLU26285.1 GFDF01006546 JAV07538.1 KK854606 PTY17301.1 KQ981856 KYN34594.1 GL888175 EGI66113.1 GL768124 EFZ12011.1 KQ982557 KYQ55110.1 KQ977580 KYN01721.1 KQ980624 KYN15037.1 GL442548 EFN63287.1 GBBI01003212 JAC15500.1 GBGD01000814 JAC88075.1 LBMM01000214 KMR04462.1 KQ768431 OAD53174.1 KQ414666 KOC65067.1 GDHF01026566 GDHF01012806 GDHF01011989 GDHF01011806 GDHF01008260 GDHF01008141 GDHF01000996 JAI25748.1 JAI39508.1 JAI40325.1 JAI40508.1 JAI44054.1 JAI44173.1 JAI51318.1 NNAY01002170 OXU21882.1 GAKP01015793 GAKP01015791 GAKP01015790 GAKP01015788 JAC43162.1 CM000070 EAL27186.2 KRS99819.1 KRS99820.1 KRS99821.1 CH479198 EDW28099.1 KQ435721 KOX78521.1 KQ434938 KZC12154.1 KZ288438 PBC25743.1 JR049041 AEY60841.1 GAMC01009684 GAMC01009683 GAMC01009682 GAMC01009680 JAB96871.1 AE014297 AY058438 AY069258 CM000160 EDW96703.1 KRK03308.1 KRK03309.1 KRK03310.1 CH480815 EDW42836.1 CH954181 EDV49732.1 GFTR01007479 JAW08947.1 GBXI01011268 JAD03024.1 PYGN01000562 PSN44204.1 OUUW01000013 SPP88247.1 JRES01000409 KNC31579.1 CH902629 EDV35289.1 KPU75521.1 KPU75522.1 GL446948 EFN87039.1 CH964232 EDW81649.1 KRF99505.1 CP012526 ALC45818.1 CH933806 EDW16982.1 KRG02429.1 KRG02430.1 JXJN01012890 GFDL01010467 JAV24578.1 KK853179 KDR10208.1 CH916373 EDV94568.1 CH940656 EDW58451.1 GFDL01010366 JAV24679.1 UFQT01002833 SSX34116.1 CH477234 EAT46711.1 DS235766 EEB16684.1 GAPW01000377 JAC13221.1 NEVH01024949 PNF16423.1 PNF16425.1 GANO01001703 JAB58168.1 JXUM01095178 JXUM01095179 JXUM01095180 KQ564177 KXJ72619.1 GGFK01010263 MBW43584.1 GGFK01010223 MBW43544.1 ACPB03007651 GGFJ01002649 MBW51790.1 AXCM01000081 KRG02428.1 ADMH02001636 ETN61664.1 ATLV01024634 KE525354 KFB51817.1 AJWK01028428 APCN01003090 AAAB01008844 EAA06001.5 AXCN02000343 GFXV01004829 MBW16634.1
GEZM01005673 JAV95996.1 LJIG01000544 KRT86396.1 GECU01015448 JAS92258.1 KQ971372 EFA09636.1 KK107512 QOIP01000001 EZA49479.1 RLU26285.1 GFDF01006546 JAV07538.1 KK854606 PTY17301.1 KQ981856 KYN34594.1 GL888175 EGI66113.1 GL768124 EFZ12011.1 KQ982557 KYQ55110.1 KQ977580 KYN01721.1 KQ980624 KYN15037.1 GL442548 EFN63287.1 GBBI01003212 JAC15500.1 GBGD01000814 JAC88075.1 LBMM01000214 KMR04462.1 KQ768431 OAD53174.1 KQ414666 KOC65067.1 GDHF01026566 GDHF01012806 GDHF01011989 GDHF01011806 GDHF01008260 GDHF01008141 GDHF01000996 JAI25748.1 JAI39508.1 JAI40325.1 JAI40508.1 JAI44054.1 JAI44173.1 JAI51318.1 NNAY01002170 OXU21882.1 GAKP01015793 GAKP01015791 GAKP01015790 GAKP01015788 JAC43162.1 CM000070 EAL27186.2 KRS99819.1 KRS99820.1 KRS99821.1 CH479198 EDW28099.1 KQ435721 KOX78521.1 KQ434938 KZC12154.1 KZ288438 PBC25743.1 JR049041 AEY60841.1 GAMC01009684 GAMC01009683 GAMC01009682 GAMC01009680 JAB96871.1 AE014297 AY058438 AY069258 CM000160 EDW96703.1 KRK03308.1 KRK03309.1 KRK03310.1 CH480815 EDW42836.1 CH954181 EDV49732.1 GFTR01007479 JAW08947.1 GBXI01011268 JAD03024.1 PYGN01000562 PSN44204.1 OUUW01000013 SPP88247.1 JRES01000409 KNC31579.1 CH902629 EDV35289.1 KPU75521.1 KPU75522.1 GL446948 EFN87039.1 CH964232 EDW81649.1 KRF99505.1 CP012526 ALC45818.1 CH933806 EDW16982.1 KRG02429.1 KRG02430.1 JXJN01012890 GFDL01010467 JAV24578.1 KK853179 KDR10208.1 CH916373 EDV94568.1 CH940656 EDW58451.1 GFDL01010366 JAV24679.1 UFQT01002833 SSX34116.1 CH477234 EAT46711.1 DS235766 EEB16684.1 GAPW01000377 JAC13221.1 NEVH01024949 PNF16423.1 PNF16425.1 GANO01001703 JAB58168.1 JXUM01095178 JXUM01095179 JXUM01095180 KQ564177 KXJ72619.1 GGFK01010263 MBW43584.1 GGFK01010223 MBW43544.1 ACPB03007651 GGFJ01002649 MBW51790.1 AXCM01000081 KRG02428.1 ADMH02001636 ETN61664.1 ATLV01024634 KE525354 KFB51817.1 AJWK01028428 APCN01003090 AAAB01008844 EAA06001.5 AXCN02000343 GFXV01004829 MBW16634.1
Proteomes
UP000007151
UP000053240
UP000192223
UP000007266
UP000053097
UP000279307
+ More
UP000078541 UP000007755 UP000075809 UP000078542 UP000078492 UP000000311 UP000036403 UP000053825 UP000002358 UP000215335 UP000001819 UP000008744 UP000053105 UP000076502 UP000242457 UP000005203 UP000192221 UP000095301 UP000000803 UP000002282 UP000001292 UP000008711 UP000245037 UP000092443 UP000268350 UP000037069 UP000007801 UP000078200 UP000092445 UP000008237 UP000007798 UP000092553 UP000009192 UP000092460 UP000027135 UP000001070 UP000008792 UP000008820 UP000009046 UP000235965 UP000069940 UP000249989 UP000015103 UP000075883 UP000000673 UP000069272 UP000030765 UP000092461 UP000075902 UP000075903 UP000076407 UP000075901 UP000075840 UP000075882 UP000075880 UP000076408 UP000007062 UP000075920 UP000075900 UP000075885 UP000075884 UP000075886 UP000075881
UP000078541 UP000007755 UP000075809 UP000078542 UP000078492 UP000000311 UP000036403 UP000053825 UP000002358 UP000215335 UP000001819 UP000008744 UP000053105 UP000076502 UP000242457 UP000005203 UP000192221 UP000095301 UP000000803 UP000002282 UP000001292 UP000008711 UP000245037 UP000092443 UP000268350 UP000037069 UP000007801 UP000078200 UP000092445 UP000008237 UP000007798 UP000092553 UP000009192 UP000092460 UP000027135 UP000001070 UP000008792 UP000008820 UP000009046 UP000235965 UP000069940 UP000249989 UP000015103 UP000075883 UP000000673 UP000069272 UP000030765 UP000092461 UP000075902 UP000075903 UP000076407 UP000075901 UP000075840 UP000075882 UP000075880 UP000076408 UP000007062 UP000075920 UP000075900 UP000075885 UP000075884 UP000075886 UP000075881
PRIDE
SUPFAM
SSF90209
SSF90209
ProteinModelPortal
A0A212FEC0
A0A0N0PBS4
A0A1Y1NH75
A0A1Y1NIR5
A0A0T6BGD5
A0A1B6IZ83
+ More
A0A1W4WF83 D6WZW4 A0A026W364 A0A1L8DM50 A0A2R7WDH7 A0A195F3D3 F4WII2 E9J592 A0A151X4B3 A0A195CLW2 A0A151J121 E2ATC0 A0A023F2H3 A0A069DVY9 A0A0J7L995 A0A310S6A1 A0A0L7R2G4 K7INK9 A0A0K8UGR9 A0A232EU55 A0A034VM41 Q29B13 B4GZ81 A0A0N0U6P9 A0A154PL03 A0A2A3E1Y3 V9IK19 A0A087ZWL7 W8BU92 A0A1W4VZZ2 A0A1I8N6P1 Q9VH90 B4PVD0 B4HJV2 B3NZM2 A0A224X9B6 A0A0A1WVC1 A0A2P8YJ28 A0A1A9XG38 A0A3B0K1V9 A0A0L0CJC3 B3MX66 A0A1A9UJS1 A0A1A9Z9J7 E2BB89 B4N9H3 A0A0M5J6Q2 B4KCW0 A0A1B0BEF9 A0A1Q3FAP9 A0A067QZ02 B4JS28 B4MBI0 A0A1Q3FAX6 A0A1S4F0N0 A0A336MV22 Q17J95 E0VTH8 A0A023EVV4 A0A2J7PJC5 A0A2J7PJA6 U5EKR7 A0A182GXG7 A0A2M4AS32 A0A2M4ARY8 T1HNE8 A0A2M4BFG2 A0A182MA02 A0A0Q9X365 W5JFR8 A0A182F9A5 A0A084WNM3 A0A1B0GK75 A0A182TV76 A0A182UZI3 A0A182WV08 A0A182SGQ8 A0A182I8N3 A0A182LAJ1 A0A182IKJ9 A0A182XX44 Q7QFT5 A0A182W151 A0A182RVY5 A0A182P2N9 A0A182NFZ0 A0A182QNK9 A0A182K2P8 A0A2H8TR10
A0A1W4WF83 D6WZW4 A0A026W364 A0A1L8DM50 A0A2R7WDH7 A0A195F3D3 F4WII2 E9J592 A0A151X4B3 A0A195CLW2 A0A151J121 E2ATC0 A0A023F2H3 A0A069DVY9 A0A0J7L995 A0A310S6A1 A0A0L7R2G4 K7INK9 A0A0K8UGR9 A0A232EU55 A0A034VM41 Q29B13 B4GZ81 A0A0N0U6P9 A0A154PL03 A0A2A3E1Y3 V9IK19 A0A087ZWL7 W8BU92 A0A1W4VZZ2 A0A1I8N6P1 Q9VH90 B4PVD0 B4HJV2 B3NZM2 A0A224X9B6 A0A0A1WVC1 A0A2P8YJ28 A0A1A9XG38 A0A3B0K1V9 A0A0L0CJC3 B3MX66 A0A1A9UJS1 A0A1A9Z9J7 E2BB89 B4N9H3 A0A0M5J6Q2 B4KCW0 A0A1B0BEF9 A0A1Q3FAP9 A0A067QZ02 B4JS28 B4MBI0 A0A1Q3FAX6 A0A1S4F0N0 A0A336MV22 Q17J95 E0VTH8 A0A023EVV4 A0A2J7PJC5 A0A2J7PJA6 U5EKR7 A0A182GXG7 A0A2M4AS32 A0A2M4ARY8 T1HNE8 A0A2M4BFG2 A0A182MA02 A0A0Q9X365 W5JFR8 A0A182F9A5 A0A084WNM3 A0A1B0GK75 A0A182TV76 A0A182UZI3 A0A182WV08 A0A182SGQ8 A0A182I8N3 A0A182LAJ1 A0A182IKJ9 A0A182XX44 Q7QFT5 A0A182W151 A0A182RVY5 A0A182P2N9 A0A182NFZ0 A0A182QNK9 A0A182K2P8 A0A2H8TR10
PDB
3ZRH
E-value=2.58303e-124,
Score=1142
Ontologies
GO
Topology
Length:
653
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.0085
Exp number, first 60 AAs:
0.00023
Total prob of N-in:
0.00074
outside
1 - 653
Population Genetic Test Statistics
Pi
271.50842
Theta
172.162748
Tajima's D
1.871704
CLR
0.071128
CSRT
0.863506824658767
Interpretation
Uncertain
