Gene

KWMTBOMO15692

Pre Gene Modal

BGIBMGA002273

Annotation

PREDICTED:_wolframin_isoform_X4_[Bombyx_mori]

Location

Bomo_Chr26(-):6728356-6742729      View in EpiBrowser

Full name

Wolframin      

Location in the cell

PlasmaMembrane   Reliability : 4.671

CDS

ATGCCCGGGGGACGCAAACGGTGGAATTTACATGATGGACCTCAAGGGTCACTACGTCGACTTAGGAATCAGTTAGCTGAGGATGGTTGTGCTGAATCTCAAGTGGTACTGGCTAAACAGCTCTTGGAAGAAAAATGTGAGCTTGAGGCTGACAAGATATCAAATTTCAAACAGGCTTTAGAATGGCTCATATGCGCAACGGAACAAGCACACCCGGAAGCAAGGAGGCTTTTAAGAAGGTGTATCCGTAGCGGCGTCATAGATGAGGACAGCGCAGCGATAGTACGTGCCAAGTCTTGTCTGGCGGCTAGCAGACAGGAGACAGTCGCTAGGAAAGCGGCTAGAGATCTATTTGCCAGTTTGTCGAATGGTGAACAATACATAACAACGGTTCAACTCGAACGTCGGATAAGAGAGATTTGCAATACGACGTTACGGAAGACAGCGGCCGAAGACAGCGATTCTCCTGACGACGATAACTCAGAAGCGGCAAATGCGCTAGACGATGCCGCACAAGCATTAGAACCATCTGACCTACAAGCTGGCGATCACATAAACAGTAATGGAACGCTGCGTACCTCACATGACCTCGAAGAAGATGTACCTGACAGATGTTCGAATGAAGAGATACGTAACTTGACAGTTGACAATCTAGTATCGGCAGCGGTCGATTATTGTCAGGGCGAACTGCCTCTAGTCAGCTATGAATTGACCTTAACGGACCCTAGCGTTAAGTCTCTCGATCACATTCCATTGCTTCAACAAGCCTTTCTACATCCAATAGTTTTCTTACAAGTTTTATATCTCAAACTACTCTATTACTTTGGTTCGTTTTCGTTTAGATTATCCAACATAGAGCTGTCTTTAGTTCTAATAGCGTATCTATTCGTTAGTGCCGATAGTTTGTATCATTTAGTTCCGCTAGTCCTTTACTACGTCAGTTTCGTCGCCATGGTGATTTGCACGTTCAAAATGTTGCATGCGAAACGACAGTTTATCGATTTTCGTAAGTGGTCCGGTCTCTTCTTGAGGTACAGCGACGGTAATTTGCAACCAGACGAGTCTGAGAATTTGTTTGTACGCAACAATCTGGGTCCGTTCATTCAGTTCTTTGTGGCGTTGTTTGTGAATTTATTTTTATATCCCTTTATAGCAACACAATGGGTTCCGTTTTCTGAGCTCTGCGTGTTGTCCTTCTTTCTGATGTTCCTTACACTGTGTTCATTTGGAGCTAACGGGAACCCTTATCCGGACGTTTTAGCTCTAATTTCATTCGCCATTAACGTGCTGGCCAAATACCCCTACGAGAAGGATACAGTTGTACATCAGGGGTGGAGATTTTTAGATTTTCACATATCGAATTATCCGTCTTATGTCCTCGGGAATAGCATAGAGTTTTGTTTGAACGGTCGAATGTTCTTTTCGTTGTTGATACCGGTCATTTTGGTGTTGATGGCGCGCAGAAGCGATTGGCAGGGTTTTTTTAAACAAACGCTACCACATTGCGTGACTTTAAGCTGGTTGCAGATGTTCATAATGTCTTCACATGGCTGTACCACGTACGGATTGATTAGGGGGACATTGGCGTTAGTGTGTTCATTCCTATTTCTTCCATTAATCGGAGTGATGACCGTGACCTTGCCATTATTCGCGTTTCTGCAGTACATTACGTTGCCAAGGATTATTTATACGGCGACCATGGTGTTGAGCTTTGGCCTAAGTTTGGGCTTTACTTGTTTGCTGGCAAAGTCTGAAGCAACGAAGCGATTTGTCACTCCGTTTCAGCTCGTATTCGGTACATTAGCCATTATATACTTTGGGAACCAGTTCGTTTTGAACATACGCGATGACGGTCTCCCGTCAGGCCTTATCGAACTATTGGCCGATGAGAAGCCGAGCATAAAGAACCTTCTAAAAAACGAATTCCTTAGCGAATACGAAGACAACAATTACCACATAAATTGGGACGATTATTACACTCACTGTAACAATCCATCTTGGACTGATTATAATATAGCCGCAACTCAAATCAAGTGTTCGGTACTAGAGGGCGCGAACGTCAACTGGGAAGGTTATGTCAAAGATGTCAGTTTATTAAACGTCAAAAATAAATGGAGGGACTTTGCGTATTGGTTGCCGGGTTTCTTGCAAGAGTACTTTAAGTGCTATTACGGCGAGGAGTATTCGAATGTGTGTCGAGGCTCGGACGGTGTTCAGTCTGTGGCGGAATGCGAATTCGTTAGCAGTGTTGCCAGGCAAAGCGGAAAGAGTTGCCATCTTGATAACTTGAATGAATACACGTATGAAGTGAAATTAATGATGGAAGCCAGTGGCGGTATTTTGAAGCGCCACGCGGAAATCGTCATACACTTTGGTCATTATTTTACGAATTTTACACGTTTACTGCGATCGGACGACAAGATACGTTTTAAAGGGACGCTTTCGAACGAAAACCGACCTTATAACATTGGCGCTAAGGACTTGACTATAAGGGGCTACGAAATTAACTGTTTGGAATGCAAAGAGGCGCGCGGCTCTGTGACTCTGAAGACGTCGTCCGCATCGAAATTCTCTGAGCTGTTTAAAACAATTGTGAATGATTGCGTTGTATCGACAAAGTATATTTTGAATTTCATGTTGAATCCTATAATTGTTTTCAAATAA

Protein

MPGGRKRWNLHDGPQGSLRRLRNQLAEDGCAESQVVLAKQLLEEKCELEADKISNFKQALEWLICATEQAHPEARRLLRRCIRSGVIDEDSAAIVRAKSCLAASRQETVARKAARDLFASLSNGEQYITTVQLERRIREICNTTLRKTAAEDSDSPDDDNSEAANALDDAAQALEPSDLQAGDHINSNGTLRTSHDLEEDVPDRCSNEEIRNLTVDNLVSAAVDYCQGELPLVSYELTLTDPSVKSLDHIPLLQQAFLHPIVFLQVLYLKLLYYFGSFSFRLSNIELSLVLIAYLFVSADSLYHLVPLVLYYVSFVAMVICTFKMLHAKRQFIDFRKWSGLFLRYSDGNLQPDESENLFVRNNLGPFIQFFVALFVNLFLYPFIATQWVPFSELCVLSFFLMFLTLCSFGANGNPYPDVLALISFAINVLAKYPYEKDTVVHQGWRFLDFHISNYPSYVLGNSIEFCLNGRMFFSLLIPVILVLMARRSDWQGFFKQTLPHCVTLSWLQMFIMSSHGCTTYGLIRGTLALVCSFLFLPLIGVMTVTLPLFAFLQYITLPRIIYTATMVLSFGLSLGFTCLLAKSEATKRFVTPFQLVFGTLAIIYFGNQFVLNIRDDGLPSGLIELLADEKPSIKNLLKNEFLSEYEDNNYHINWDDYYTHCNNPSWTDYNIAATQIKCSVLEGANVNWEGYVKDVSLLNVKNKWRDFAYWLPGFLQEYFKCYYGEEYSNVCRGSDGVQSVAECEFVSSVARQSGKSCHLDNLNEYTYEVKLMMEASGGILKRHAEIVIHFGHYFTNFTRLLRSDDKIRFKGTLSNENRPYNIGAKDLTIRGYEINCLECKEARGSVTLKTSSASKFSELFKTIVNDCVVSTKYILNFMLNPIIVFK

Description

Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (By similarity). In neurons and glial cells, has a role in maintaining neuronal function and integrity during aging (PubMed:29357349).

Keywords

Alternative splicing   Complete proteome   Endoplasmic reticulum   Glycoprotein   Membrane   Mitochondrion   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Wolframin
splice variant  In isoform C.

Uniprot

H9IYE0   A0A2W1BD50   A0A2H1VKQ0   A0A194QF89   A0A0N1I708   A0A1E1WGH4   + More
A0A212F968   A0A0L7LDZ0   D6X0P3   A0A0L7QL14   A0A088AFE1   A0A0T6AW23   A0A1Y1LW29   E2A2Z7   A0A158NXQ4   F4X4B3   A0A2J7PI79   A0A0N0BD29   A0A1Y1LXD6   A0A067R4P7   A0A195BSD6   A0A2A3ED75   A0A3L8DZL1   A0A195E4H1   A0A151WR02   A0A195FHM7   B0X167   A0A151I6F5   A0A154PSY5   A0A026W9B5   E9ICB1   A0A1Q3F2T7   Q171Y3   A0A182GCP4   A0A182G1I2   A0A0N8ES65   A0A1S4FGN5   A0A336M988   E2BH31   A0A1Y1LZD7   A0A0C9QKN0   A0A0L0C7H6   A0A1I8Q0D4   K7J8R9   A0A1I8MVQ3   T1P809   A0A182Q5F5   A0A182JCT5   A0A1A9ZLD1   A0A1A9YIX8   A0A182RI24   Q7QA69   A0A182UNT3   A0A1B0C0Y0   A0A182HVN9   A0A182K4W4   A0A182KZS0   A0A232EZB0   A0A2M4BDH5   A0A182XF68   A0A2M4BCX6   A0A182UB07   A0A1A9VZX8   A0A182FAF5   A0A182Y907   U5EYL1   A0A182T659   A0A182NCV0   A0A2M4AMS2   A0A336MAJ0   A0A182W385   A0A182M7N0   W5JSX2   A0A0A1X9P0   A0A0K8U828   A0A034WSW1   A0A1A9VQX9   A0A182PLH1   Q8IMZ9-2   A0A0R1E4B4   B3P8L4   W8BU78   U4TXE6   Q8IMZ9   B4PMD5   N6TMB5   B4R0P1   A0A084VDJ9   A0A1W4VL02   B4HER8   B3M366   B4NBR7   A0A0M5J5I5   B4JRZ8   B4M642   A0A1B0GMR6   N6UKG0   A0A3B0KUZ2  

Pubmed

19121390    28756777    26354079    22118469    26227816    18362917    + More
19820115    28004739    20798317    21347285    21719571    24845553    30249741    24508170    21282665    17510324    26483478    26999592    26108605    20075255    25315136    12364791    14747013    17210077    20966253    28648823    25244985    20920257    23761445    25830018    25348373    10731132    12537572    12537569    29357349    17994087    17550304    24495485    23537049    24438588   

EMBL

BABH01020573    BABH01020574    BABH01020575    BABH01020576    KZ150122    PZC73169.1    + More
ODYU01003100    SOQ41429.1    KQ459144    KPJ03610.1    KQ461111    KPJ08944.1    GDQN01004996    JAT86058.1    AGBW02009638    OWR50271.1    JTDY01001491    KOB73743.1    KQ971371    EFA10125.2    KQ414940    KOC59221.1    LJIG01022687    KRT79249.1    GEZM01045539    JAV77759.1    GL436239    EFN72205.1    ADTU01000477    GL888633    EGI58709.1    NEVH01025129    PNF16038.1    KQ435879    KOX69868.1    GEZM01045537    JAV77761.1    KK852895    KDR14192.1    KQ976423    KYM88917.1    KZ288287    PBC29434.1    QOIP01000002    RLU25786.1    KQ979685    KYN19802.1    KQ982815    KYQ50238.1    KQ981606    KYN39509.1    DS232254    EDS38516.1    KQ978476    KYM93679.1    KQ435180    KZC15012.1    KK107323    EZA52583.1    GL762231    EFZ21806.1    GFDL01013237    JAV21808.1    CH477443    EAT40803.1    JXUM01054530    KQ561824    KXJ77421.1    JXUM01023445    JXUM01023446    KQ560661    KXJ81387.1    GDUN01000330    JAN95589.1    UFQT01000564    SSX25353.1    GL448268    EFN84952.1    GEZM01045538    JAV77760.1    GBYB01002846    GBYB01004109    GBYB01004254    JAG72613.1    JAG73876.1    JAG74021.1    JRES01000809    KNC28230.1    KA644771    AFP59400.1    AXCN02001206    AAAB01008898    EAA09198.5    JXJN01023809    APCN01005808    NNAY01001520    OXU23705.1    GGFJ01001717    MBW50858.1    GGFJ01001716    MBW50857.1    GANO01001938    JAB57933.1    GGFK01008775    MBW42096.1    UFQT01000793    SSX27276.1    AXCM01000104    ADMH02000180    ETN67462.1    GBXI01008183    GBXI01006273    JAD06109.1    JAD08019.1    GDHF01029794    JAI22520.1    GAKP01002084    JAC56868.1    AE014297    AY119144    AAM51004.1    CM000160    KRK04091.1    CH954182    EDV54109.1    GAMC01009699    JAB96856.1    KB631805    ERL86279.1    EDW98040.1    APGK01029501    KB740735    ENN79168.1    CM000364    EDX13964.1    ATLV01011556    KE524695    KFB36043.1    CH480815    EDW43229.1    CH902617    EDV42466.1    CH964232    EDW81231.1    CP012526    ALC47781.1    CH916373    EDV94538.1    CH940652    EDW59118.1    AJVK01026430    AJVK01026431    AJVK01026432    ENN79167.1    OUUW01000013    SPP87768.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000007151    UP000037510    UP000007266    + More
UP000053825    UP000005203    UP000000311    UP000005205    UP000007755    UP000235965    UP000053105    UP000027135    UP000078540    UP000242457    UP000279307    UP000078492    UP000075809    UP000078541    UP000002320    UP000078542    UP000076502    UP000053097    UP000008820    UP000069940    UP000249989    UP000008237    UP000037069    UP000095300    UP000002358    UP000095301    UP000075886    UP000075880    UP000092445    UP000092443    UP000075900    UP000007062    UP000075903    UP000092460    UP000075840    UP000075881    UP000075882    UP000215335    UP000076407    UP000075902    UP000091820    UP000069272    UP000076408    UP000075901    UP000075884    UP000075920    UP000075883    UP000000673    UP000078200    UP000075885    UP000000803    UP000002282    UP000008711    UP000030742    UP000019118    UP000000304    UP000030765    UP000192221    UP000001292    UP000007801    UP000007798    UP000092553    UP000001070    UP000008792    UP000092462    UP000268350   

PRIDE

H9IYE0    Q8IMZ9   

Pfam

PF05510   Sarcoglycan_2

Interpro

IPR026209   Wolframin_fam        + More
IPR011990   TPR-like_helical_dom_sf       
IPR008908   Sarcoglycan_alpha/epsilon       
IPR015919   Cadherin-like_sf       

SUPFAM

SSF49313   SSF49313       

Gene 3D

1.25.40.10    

ProteinModelPortal

H9IYE0   A0A2W1BD50   A0A2H1VKQ0   A0A194QF89   A0A0N1I708   A0A1E1WGH4   + More
A0A212F968   A0A0L7LDZ0   D6X0P3   A0A0L7QL14   A0A088AFE1   A0A0T6AW23   A0A1Y1LW29   E2A2Z7   A0A158NXQ4   F4X4B3   A0A2J7PI79   A0A0N0BD29   A0A1Y1LXD6   A0A067R4P7   A0A195BSD6   A0A2A3ED75   A0A3L8DZL1   A0A195E4H1   A0A151WR02   A0A195FHM7   B0X167   A0A151I6F5   A0A154PSY5   A0A026W9B5   E9ICB1   A0A1Q3F2T7   Q171Y3   A0A182GCP4   A0A182G1I2   A0A0N8ES65   A0A1S4FGN5   A0A336M988   E2BH31   A0A1Y1LZD7   A0A0C9QKN0   A0A0L0C7H6   A0A1I8Q0D4   K7J8R9   A0A1I8MVQ3   T1P809   A0A182Q5F5   A0A182JCT5   A0A1A9ZLD1   A0A1A9YIX8   A0A182RI24   Q7QA69   A0A182UNT3   A0A1B0C0Y0   A0A182HVN9   A0A182K4W4   A0A182KZS0   A0A232EZB0   A0A2M4BDH5   A0A182XF68   A0A2M4BCX6   A0A182UB07   A0A1A9VZX8   A0A182FAF5   A0A182Y907   U5EYL1   A0A182T659   A0A182NCV0   A0A2M4AMS2   A0A336MAJ0   A0A182W385   A0A182M7N0   W5JSX2   A0A0A1X9P0   A0A0K8U828   A0A034WSW1   A0A1A9VQX9   A0A182PLH1   Q8IMZ9-2   A0A0R1E4B4   B3P8L4   W8BU78   U4TXE6   Q8IMZ9   B4PMD5   N6TMB5   B4R0P1   A0A084VDJ9   A0A1W4VL02   B4HER8   B3M366   B4NBR7   A0A0M5J5I5   B4JRZ8   B4M642   A0A1B0GMR6   N6UKG0   A0A3B0KUZ2  

KEGG

101737669    K14020 wolfamin | (RefSeq) wolframin

PATHWAY

04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0016874   GO:0016012   GO:0005509   GO:0008344   GO:0005739   GO:0001306   GO:0036474   GO:0005783   GO:0010629  

PANTHER

PTHR13098  

Subcellular location

Membrane  
Endoplasmic reticulum  
Mitochondrion  

Length:

887

Number of predicted TMHs:

8

Exp number of AAs in TMHs:

197.47948

Exp number, first 60 AAs:

0

Total prob of N-in:

0.11506

outside

1  -  260

TMhelix

261  -  280

inside

281  -  300

TMhelix

301  -  323

outside

324  -  366

TMhelix

367  -  389

inside

390  -  393

TMhelix

394  -  416

outside

417  -  463

TMhelix

464  -  486

inside

487  -  528

TMhelix

529  -  551

outside

552  -  560

TMhelix

561  -  583

inside

584  -  589

TMhelix

590  -  612

outside

613  -  887

 

 

Pi

380.067306

Theta

177.634021

Tajima's D

1.340145

CLR

0.291344

CSRT

0.745862706864657

Interpretation

Uncertain