Gene

KWMTBOMO15689

Pre Gene Modal

BGIBMGA002275

Annotation

dopamine_receptor-1_[Bombyx_mori]

Location

Bomo_Chr26(-):6536378-6575264      View in EpiBrowser

Full name

Dopamine receptor 1      

Alternative Name

Dopamine 1-like receptor 1

Location in the cell

PlasmaMembrane   Reliability : 4.988

CDS

ATGGAGTTCGCCTCCACCTTAGCTACGAATGTGGAGTTCCTGCTTAACGACACGACGGTGGAGTATGAAGACAACGATCCAGATGCCGTCACGCTACTCTCCATATTACTTGTTGGTATATTCTTATCACTGCTCATATTTCTGAGTGTGGCTGGGAATATTCTGGTCTGCATAGCTATCTACACAGACCGGGGCCTGCGGAGGATCGGGAATCTGTTCCTGGCATCCTTGGCGATAGCTGACATGTTGGTTGCTGCTGCCGTTATGACATTTGCTGGAGTCAATGATTTATTAGGGTATTGGGTATTCGGCGAGCAATTTTGCGATACATGGGTGGCGTGCGACGTCATGTGCTCAACTGCTTCCATATTGAATCTGTGTGCGATCTCACTAGATCGATACATTCACATCAAAGATCCGCTAAGATACGGCCGCTGGGTGACGCGTCGTGTTGCGATCACGACAATCGCAATGATATGGCTATTAGCTGCCCTAGTTAGCTTTCTGCCAATTTCTCTGGGACTTCACCGACCCGACGAGGAGGCTTTAGCGACACAAAGACCCCCTAAGTACCCGACCTGCGCGTTAGTGCTCACACCGACGTACGCGGTCGTTTCAAGCTGTATATCATTTATACTGCCTTGCATTGTGATGATCAGTATTTACTGCCGGCTCTACTGCTACGCCCAGAAACACGTCAAATCGATTCGGGCGGTAACCCGAACGGTTCAAATGCCGGACAATAGAACCAAATCGGTCCGGACCCGCGTCCACACGCACGTTCACTCGTCACCGTACCACGTGTCCGACCACAAGGCTGCCATCACGGTGGGCATCATCATGGGCGTCTTCCTCCTCTGCTGGGTTCCGTTCTTCTGCGTGAATATCGTCGCTGCTTTCTGCAAGACCTGCATCCCTGAGGTTACTGGAGTACATAGACGTCTACAACGTAAATGCTGCTACCCACCTAGAGAGTTCTAA

Protein

MEFASTLATNVEFLLNDTTVEYEDNDPDAVTLLSILLVGIFLSLLIFLSVAGNILVCIAIYTDRGLRRIGNLFLASLAIADMLVAAAVMTFAGVNDLLGYWVFGEQFCDTWVACDVMCSTASILNLCAISLDRYIHIKDPLRYGRWVTRRVAITTIAMIWLLAALVSFLPISLGLHRPDEEALATQRPPKYPTCALVLTPTYAVVSSCISFILPCIVMISIYCRLYCYAQKHVKSIRAVTRTVQMPDNRTKSVRTRVHTHVHSSPYHVSDHKAAITVGIIMGVFLLCWVPFFCVNIVAAFCKTCIPEVTGVHRRLQRKCCYPPREF

Description

Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, Dop1R1 expression levels are reduced; sleep may have a role in restoring dopamine homeostasis.

Miscellaneous

Potency of neurotransmitter agonists in stimulating cAMP production and the lack of stimulation by other transmitters and metabolites suggests this is a D1-like receptor. Low homology to vertebrate D1 receptors suggests this may be a progenitor of the D1 receptor subfamily.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Disulfide bond   G-protein coupled receptor   Glycoprotein   Lipoprotein   Membrane   Palmitate   Phosphoprotein   Polymorphism   Receptor   Reference proteome   Signal   Transducer   Transmembrane   Transmembrane helix  

Feature

chain  Dopamine receptor 1
splice variant  In isoform C.

Uniprot

A9ZLX6   A0A2W1BCZ2   A0A0K0QVU3   G9FIE3   A0A194QI65   A0A0N1PHN8   + More
A0A212EWQ1   N1NTX2   D6X2C4   B4R0G6   A0A1W4URH6   B4HF43   A0A0L0BR86   B3P0M9   A0A0B4K6H0   P41596   A0A3B0KNB2   A0A0B4KHI2   B4PTB2   A0A126GUU2   I5ANU3   B4N9I8   A0A2P8YCS4   B3LYB5   B4M048   A0A1B0B2Q4   A0A1A9YST9   B4KDV5   P41596-3   A0A1A9VG05   A0A1I8MJ91   P41596-2   A0A1A9ZYZ2   Q7Q7P1   A0A1Z2RSH3   B4G4U7   A0A084W7U2   A0A0U1ZZX3   A0A0C9S1R7   H6D5H1   Q17E57   A0A1J1ILW3   A0A2A3ECL1   A0A2J7PUW3   O44198   A0A088AFE3   A9NJ55   A0A0M4F308   A0A3L8DZP5   A0A1S4EIA6   A0A195E4H8   A0A154PGY0   A0A195BEZ8   A0A151WQW0   A0A195FFN8   A0A1J1IRL7   A0A0J7L2S9   A0A026WC04   A0A2R7W0S5   I2FKE9   K7INX8   E9ICA7   A0A2S2R5V5   A0A232FJJ9   A0A2S2N7W3   A0A2H8TQS6   E0VTL3   A0A1D2NMV5   J9K2E2   A0A1B0FEI1   E9G2Y8   A0A1Y1LG14   A0A0A8J2D2   A0A1I8PSI5   A0A0N0BDA3   A0A1S4GMA7   K9MSS8   A0A0P5YZI9   A0A0P4YA30   A0A1Z5LF95   A0A0P5XH57   B7P6V6   A0A023FH63   L7MG46   L7MGJ2   A0A1E1X3Q1   A0A2P6KWR7   H9B3Y5   A0A1B3P5W3   A0A131YQC5   A0A0P5DCD5   A0A2R5L3W1   A0A0P5QF22   A0A061QFZ7   A0A0P4Z7R0   A0A087TFH8   A0A131XDL1  

Pubmed

18353107    28756777    26179416    26354079    22118469    18054377    + More
18025266    18316733    20068045    21843505    23604020    18362917    19820115    17994087    26108605    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    7953290    8630055    7720859    12711555    17634358    18674913    17550304    15632085    29403074    25315136    12364791    24438588    25873872    22292096    17510324    9422342    30249741    24508170    20075255    21282665    28648823    20566863    27289101    21292972    28004739    28528879    25576852    28503490    22403662    26830274    28049606   

EMBL

AB162715    AB362162    BAF98647.1    BAG14260.1    KZ150270    PZC71684.1    + More
KP784317    RSAL01000087    AKR18178.1    RVE48225.1    JN117928    AEU17117.1    KQ458761    KPJ05207.1    KQ459993    KPJ18572.1    AGBW02011944    OWR45877.1    BK005863    DAA64500.1    KQ971371    EFA10743.2    CM000364    EDX12981.1    CH480815    EDW42217.1    JRES01001482    KNC22547.1    CH954181    EDV48855.1    AE014297    AFH06410.1    X77234    BT030444    BT150144    U22106    OUUW01000013    SPP88079.1    AGB95944.1    CM000160    EDW97611.2    ALI30568.1    CM000070    EIM52628.2    CH964232    EDW81664.2    PYGN01000699    PSN42062.1    CH902617    EDV44019.2    CH940650    EDW68298.2    JXJN01007687    CH933806    EDW14952.2    AAAB01008952    EAA10574.3    KX360128    ASA47151.1    CH479179    EDW24613.1    ATLV01021298    ATLV01021299    KE525316    KFB46286.1    KP780182    AKD41292.1    GBYB01014731    JAG84498.1    JN043502    AFB73766.1    CH477285    EAT44745.2    CVRI01000055    CRL01152.1    KZ288287    PBC29430.1    NEVH01021192    PNF20110.1    Y13429    CAA73841.1    DQ645628    ABG29734.1    CP012526    ALC45545.1    QOIP01000002    RLU25877.1    KQ979685    KYN19807.1    KQ434902    KZC11072.1    KQ976509    KYM82740.1    KQ982815    KYQ50244.1    KQ981606    KYN39515.1    CRL01161.1    LBMM01001069    KMQ96983.1    KK107323    EZA52589.1    KK854224    PTY13312.1    AB720739    BAM15634.1    GL762231    EFZ21779.1    GGMS01016234    MBY85437.1    NNAY01000127    OXU30720.1    GGMR01000611    MBY13230.1    GFXV01004544    MBW16349.1    DS235767    EEB16740.1    LJIJ01000002    ODN06613.1    ABLF02030575    ABLF02030583    ABLF02030585    CCAG010001986    GL732530    EFX86123.1    GEZM01056721    JAV72599.1    LC012537    BAQ00365.1    KQ435879    KOX69872.1    JQ901712    AFX71574.1    GDIP01064329    GDIQ01016098    LRGB01000512    JAM39386.1    JAN78639.1    KZS18574.1    GDIP01231363    JAI92038.1    GFJQ02001296    JAW05674.1    GDIP01072179    JAM31536.1    ABJB010003390    DS648196    EEC02328.1    GBBK01004499    JAC19983.1    GACK01002074    JAA62960.1    GACK01002087    JAA62947.1    GFAC01005527    JAT93661.1    MWRG01004155    PRD30775.1    JN974914    AFC88983.1    KU712060    AOG12990.1    GEDV01008261    JAP80296.1    GDIP01159686    JAJ63716.1    GGLE01000021    MBY04147.1    GDIQ01136327    GDIP01103420    JAL15399.1    JAM00295.1    GBFC01000016    JAC59322.1    GDIP01216858    JAJ06544.1    KK114977    KFM63867.1    GEFH01004109    JAP64472.1   

Proteomes

UP000283053    UP000053268    UP000053240    UP000007151    UP000007266    UP000000304    + More
UP000192221    UP000001292    UP000037069    UP000008711    UP000000803    UP000268350    UP000002282    UP000001819    UP000007798    UP000245037    UP000007801    UP000008792    UP000092460    UP000092443    UP000009192    UP000078200    UP000095301    UP000092445    UP000007062    UP000008744    UP000030765    UP000008820    UP000183832    UP000242457    UP000235965    UP000005203    UP000092553    UP000279307    UP000079169    UP000078492    UP000076502    UP000078540    UP000075809    UP000078541    UP000036403    UP000053097    UP000002358    UP000215335    UP000009046    UP000094527    UP000007819    UP000092444    UP000000305    UP000095300    UP000053105    UP000076858    UP000001555    UP000054359   

PRIDE

A9ZLX6    P41596   

Pfam

PF00001   7tm_1

Interpro

IPR000276   GPCR_Rhodpsn        + More
IPR017452   GPCR_Rhodpsn_7TM       
IPR000929   Dopamine_rcpt       

ProteinModelPortal

A9ZLX6   A0A2W1BCZ2   A0A0K0QVU3   G9FIE3   A0A194QI65   A0A0N1PHN8   + More
A0A212EWQ1   N1NTX2   D6X2C4   B4R0G6   A0A1W4URH6   B4HF43   A0A0L0BR86   B3P0M9   A0A0B4K6H0   P41596   A0A3B0KNB2   A0A0B4KHI2   B4PTB2   A0A126GUU2   I5ANU3   B4N9I8   A0A2P8YCS4   B3LYB5   B4M048   A0A1B0B2Q4   A0A1A9YST9   B4KDV5   P41596-3   A0A1A9VG05   A0A1I8MJ91   P41596-2   A0A1A9ZYZ2   Q7Q7P1   A0A1Z2RSH3   B4G4U7   A0A084W7U2   A0A0U1ZZX3   A0A0C9S1R7   H6D5H1   Q17E57   A0A1J1ILW3   A0A2A3ECL1   A0A2J7PUW3   O44198   A0A088AFE3   A9NJ55   A0A0M4F308   A0A3L8DZP5   A0A1S4EIA6   A0A195E4H8   A0A154PGY0   A0A195BEZ8   A0A151WQW0   A0A195FFN8   A0A1J1IRL7   A0A0J7L2S9   A0A026WC04   A0A2R7W0S5   I2FKE9   K7INX8   E9ICA7   A0A2S2R5V5   A0A232FJJ9   A0A2S2N7W3   A0A2H8TQS6   E0VTL3   A0A1D2NMV5   J9K2E2   A0A1B0FEI1   E9G2Y8   A0A1Y1LG14   A0A0A8J2D2   A0A1I8PSI5   A0A0N0BDA3   A0A1S4GMA7   K9MSS8   A0A0P5YZI9   A0A0P4YA30   A0A1Z5LF95   A0A0P5XH57   B7P6V6   A0A023FH63   L7MG46   L7MGJ2   A0A1E1X3Q1   A0A2P6KWR7   H9B3Y5   A0A1B3P5W3   A0A131YQC5   A0A0P5DCD5   A0A2R5L3W1   A0A0P5QF22   A0A061QFZ7   A0A0P4Z7R0   A0A087TFH8   A0A131XDL1  

PDB

6IBL     E-value=5.33911e-47,     Score=472

KEGG

100141434    K04144 dopamine receptor D1 | (RefSeq) Dopr1; dopamine receptor-1

PATHWAY

04080    Neuroactive ligand-receptor interaction - Bombyx mori (domestic silkworm)

GO

GO:0004930   GO:0016021   GO:0005886   GO:0035240   GO:0007191   GO:0001588   GO:0001965   GO:0098793   GO:0071329   GO:0008355   GO:0008306   GO:0008542   GO:1990834   GO:0042594   GO:0090328   GO:0005887   GO:0004952   GO:0040040   GO:0009744   GO:0099509   GO:0007613   GO:0043052   GO:0007612   GO:0007212   GO:0004993   GO:0030594   GO:0030425   GO:0007187   GO:0007268   GO:0004715   GO:0007186   GO:0004983   GO:0005634   GO:0006270   GO:0042555   GO:0003707   GO:0006281   GO:0006259  

Subcellular location

Cell membrane  

Length:

326

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

136.76539

Exp number, first 60 AAs:

24.07116

Total prob of N-in:

0.00031

POSSIBLE N-term signal

sequence

outside

1  -  28

TMhelix

29  -  51

inside

52  -  71

TMhelix

72  -  94

outside

95  -  108

TMhelix

109  -  131

inside

132  -  150

TMhelix

151  -  173

outside

174  -  200

TMhelix

201  -  223

inside

224  -  276

TMhelix

277  -  299

outside

300  -  326

 

 

Pi

269.218957

Theta

183.322833

Tajima's D

1.553649

CLR

0.093793

CSRT

0.802109894505275

Interpretation

Uncertain