Gene

KWMTBOMO15687

Pre Gene Modal

BGIBMGA002277

Annotation

PREDICTED:_dopamine_receptor_1_[Papilio_polytes]

Location

Bomo_Chr26(-):6524447-6525674      View in EpiBrowser

Full name

Dopamine receptor 1      

Alternative Name

Dopamine 1-like receptor 1

Location in the cell

Extracellular   Reliability : 1.741 PlasmaMembrane   Reliability : 1.802

CDS

ATGAGCATTCCTTTTCCAGATCTAGCCTTCAAGATATTGACGTGGCTGGGATACTCCAACTCGGCGTTCAACCCTATTATCTACTCGATATTCAACACGGAATTCAGGGAGGCCTTCAAGAAAATCCTCACCTCGAGGTATCCACCTTGTTGCGGCTATCAAACGGTCAGAGCGAACACGCCGACGAGAAACGACAACTTCGTCACAGATTACGGAACTAAGACATTAGTGGTACGCCGAAGCGGCTCCTTAGGTCTTTCAGGAGTAGACCCCACCCCTAGATCCTCAGCGGAATCGGTAAGACCACTACGGGAATACCACATCTGA

Protein

MSIPFPDLAFKILTWLGYSNSAFNPIIYSIFNTEFREAFKKILTSRYPPCCGYQTVRANTPTRNDNFVTDYGTKTLVVRRSGSLGLSGVDPTPRSSAESVRPLREYHI

Description

Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, Dop1R1 expression levels are reduced; sleep may have a role in restoring dopamine homeostasis.

Miscellaneous

Potency of neurotransmitter agonists in stimulating cAMP production and the lack of stimulation by other transmitters and metabolites suggests this is a D1-like receptor. Low homology to vertebrate D1 receptors suggests this may be a progenitor of the D1 receptor subfamily.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Disulfide bond   G-protein coupled receptor   Glycoprotein   Lipoprotein   Membrane   Palmitate   Phosphoprotein   Polymorphism   Receptor   Reference proteome   Signal   Transducer   Transmembrane   Transmembrane helix  

Feature

chain  Dopamine receptor 1
splice variant  In isoform C.

Uniprot

H9IYE4   A9ZLX6   A0A0K0QVU3   A0A0N1PHN8   A0A194QI65   A0A2W1BCZ2   + More
A0A212EWQ1   U4TY40   N6UC11   N1NTX2   D6X2C4   A9NJ55   A0A1W4URH6   B4R0G6   A0A3B0KNB2   A0A0M4F308   A0A1Z2RSH3   B4K025   B4G4U7   I5ANU3   P41596-3   B4HF43   B4N9I8   B3P0M9   P41596-2   A0A0B4K6H0   P41596   B3LYB5   B4M048   T1ICS3   B4KDV5   A0A0B4KHI2   B4PTB2   A0A126GUU2   A0A1I8PSI5   A0A1I8MJ91   A0A0L0BR86   A0A067RC96   A0A2P8YCS4   A0A226DLA0   A0A1A9VG05   A0A1B0FEI1   A0A1A9YST9   A0A1B0B2Q4   A0A1A9ZYZ2   A0A1D2NMV5   A0A2S2N7W3   K7INX8   A0A232FJJ9   A0A2R7W0S5   A0A0C9S1R7   E2A2Z0   E2BH27   A0A0B5H6U8   F4X4A8   A0A158NXC2   A0A0L7QKS6   A0A151WQW0   A0A026WC04   A0A154PGY0   O44198   E9ICA7   A0A2A3ECL1   A0A3L8DZP5  

Pubmed

19121390    18353107    26179416    26354079    28756777    22118469    + More
23537049    18054377    18025266    18316733    20068045    21843505    23604020    18362917    19820115    17994087    15632085    7953290    10731132    12537572    8630055    7720859    12711555    17634358    18674913    12537568    12537573    12537574    16110336    17569856    17569867    17550304    25315136    26108605    24845553    29403074    27289101    20075255    28648823    20798317    21719571    21347285    24508170    9422342    21282665    30249741   

EMBL

BABH01020548    AB162715    AB362162    BAF98647.1    BAG14260.1    KP784317    + More
RSAL01000087    AKR18178.1    RVE48225.1    KQ459993    KPJ18572.1    KQ458761    KPJ05207.1    KZ150270    PZC71684.1    AGBW02011944    OWR45877.1    KB631642    ERL84903.1    APGK01029541    KB740735    ENN79190.1    BK005863    DAA64500.1    KQ971371    EFA10743.2    DQ645628    ABG29734.1    CM000364    EDX12981.1    OUUW01000013    SPP88079.1    CP012526    ALC45545.1    KX360128    ASA47151.1    CH916384    EDV91627.1    CH479179    EDW24613.1    CM000070    EIM52628.2    X77234    AE014297    BT030444    BT150144    U22106    CH480815    EDW42217.1    CH964232    EDW81664.2    CH954181    EDV48855.1    AFH06410.1    CH902617    EDV44019.2    CH940650    EDW68298.2    ACPB03020246    CH933806    EDW14952.2    AGB95944.1    CM000160    EDW97611.2    ALI30568.1    JRES01001482    KNC22547.1    KK852731    KDR17488.1    PYGN01000699    PSN42062.1    LNIX01000017    OXA45614.1    CCAG010001986    JXJN01007687    LJIJ01000002    ODN06613.1    GGMR01000611    MBY13230.1    NNAY01000127    OXU30720.1    KK854224    PTY13312.1    GBYB01014731    JAG84498.1    GL436239    EFN72198.1    GL448268    EFN84948.1    KP233833    AJF39157.1    GL888633    EGI58704.1    ADTU01000452    KQ414940    KOC59217.1    KQ982815    KYQ50244.1    KK107323    EZA52589.1    KQ434902    KZC11072.1    Y13429    CAA73841.1    GL762231    EFZ21779.1    KZ288287    PBC29430.1    QOIP01000002    RLU25877.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000053268    UP000007151    UP000030742    + More
UP000019118    UP000007266    UP000192221    UP000000304    UP000268350    UP000092553    UP000001070    UP000008744    UP000001819    UP000000803    UP000001292    UP000007798    UP000008711    UP000007801    UP000008792    UP000015103    UP000009192    UP000002282    UP000095300    UP000095301    UP000037069    UP000027135    UP000245037    UP000198287    UP000078200    UP000092444    UP000092443    UP000092460    UP000092445    UP000094527    UP000002358    UP000215335    UP000000311    UP000008237    UP000007755    UP000005205    UP000053825    UP000075809    UP000053097    UP000076502    UP000242457    UP000279307   

PRIDE

H9IYE4    A9ZLX6    P41596   

Pfam

PF00001   7tm_1

Interpro

IPR000276   GPCR_Rhodpsn        + More
IPR017452   GPCR_Rhodpsn_7TM       
IPR000929   Dopamine_rcpt       

ProteinModelPortal

H9IYE4   A9ZLX6   A0A0K0QVU3   A0A0N1PHN8   A0A194QI65   A0A2W1BCZ2   + More
A0A212EWQ1   U4TY40   N6UC11   N1NTX2   D6X2C4   A9NJ55   A0A1W4URH6   B4R0G6   A0A3B0KNB2   A0A0M4F308   A0A1Z2RSH3   B4K025   B4G4U7   I5ANU3   P41596-3   B4HF43   B4N9I8   B3P0M9   P41596-2   A0A0B4K6H0   P41596   B3LYB5   B4M048   T1ICS3   B4KDV5   A0A0B4KHI2   B4PTB2   A0A126GUU2   A0A1I8PSI5   A0A1I8MJ91   A0A0L0BR86   A0A067RC96   A0A2P8YCS4   A0A226DLA0   A0A1A9VG05   A0A1B0FEI1   A0A1A9YST9   A0A1B0B2Q4   A0A1A9ZYZ2   A0A1D2NMV5   A0A2S2N7W3   K7INX8   A0A232FJJ9   A0A2R7W0S5   A0A0C9S1R7   E2A2Z0   E2BH27   A0A0B5H6U8   F4X4A8   A0A158NXC2   A0A0L7QKS6   A0A151WQW0   A0A026WC04   A0A154PGY0   O44198   E9ICA7   A0A2A3ECL1   A0A3L8DZP5  

PDB

6CM4     E-value=1.67031e-08,     Score=134

KEGG

100141434    K04144 dopamine receptor D1 | (RefSeq) Dopr1; dopamine receptor-1

GO

GO:0004930   GO:0016021   GO:0005886   GO:0035240   GO:0007191   GO:0001588   GO:0001965   GO:0007212   GO:0042594   GO:1990834   GO:0007612   GO:0043052   GO:0007613   GO:0009744   GO:0040040   GO:0099509   GO:0008542   GO:0008306   GO:0008355   GO:0071329   GO:0004952   GO:0005887   GO:0090328   GO:0098793   GO:0007186   GO:0004983   GO:0005634   GO:0006270   GO:0042555   GO:0003707   GO:0006281   GO:0006259  

Subcellular location

Cell membrane  

Length:

108

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

6.39125

Exp number, first 60 AAs:

6.3911

Total prob of N-in:

0.05611

outside

1  -  108

 

 

Pi

130.826685

Theta

187.63539

Tajima's D

-0.94734

CLR

7.767483

CSRT

0.149892505374731

Interpretation

Uncertain