Gene

KWMTBOMO15657  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000828

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_DNA_replication_licensing_factor_Mcm6-like_[Bombyx_mori]

Location

Bomo_Chr26(-):5352385-5362096      View in EpiBrowser

Full name

DNA helicase       + More
DNA replication licensing factor Mcm6      

Location in the cell

Cytoplasmic   Reliability : 2.562

CDS

ATGGATGTAGCTGACACATATGCCACACAGAGTCAAGTAAAAGATGAAGTGGGAATTCGATGCCAAAAGCTTTTTCAAGACTTCTTAGAAGAATTTAAGGAAGATAACGAAATCAAATATGAGAAACATGCTAAGGAACTATTGAAACCAGAGCTCAGTACCCTTGAAGTTAGTTTTGATGATGTTGAAAAGTACAACCAGAATCTTGCTACCACAATAATTGAAGAGTATTATAGGATATATCCATTTCTAAACAGAGCCATTTTGAATTACATACTCAGTCTTGCGGAAACTGGAATGAAAAAAGATCTACAAGATAAAGAATGCTATGTTTCATTTGTTGATGTACCAACAAGACACAAAGTAAGGGAGTTAACCACAGCAAAGATTGGTACTCTCATAAGGATCTCTGGGCAGATTGTAAGGACACATCCAGTTCACCCTGAATTAGTTCAGGGCACATTTGTGTGCTTAGATTGTCAAACAGTTATTAAAAATGTAGAGCAACAGTTTAAGTACACAATTCCAACAATCTGCCGTAATCCTGTATGTGCTAATAGAAGGCGTTTTATGCTGGACGCAGACAAGAGCGTTTTTGTTGACTTCCAAAAGATACGAATCCAGGAAACCCAAGCTGAATTGCCCCGTGGTTGCATACCCAGATCTCTTGAAGTGATATTGAGGGCTGAAGCTGTTGAATCTGTGCAGGCTGGTGACCGTTATGATTTTACAGGAACACTGATTGTAGTGCCTGATGTGGGAGCCTTGTCAATGCCAGGCTCCAGGGCTGAGATTACAACCAGGACTAAATTAGCAAATGAAGGTCAAATGGAAGGCATAAAGGGACTCAAGGCTCTTGGAGTGCGAGAACTGCATTATAAAACAGCATTTTTAGCATGCAGTGTACAAGCTGTTTCTAGAAGGTTTGGTACTGCAGAGTTGCCTACACATGACCTAACAACTGAAGACATGAGGAAACAAATGACTGACAAAGAATGGGACAAGGTTTATGAAATGTCTCGAGATCGCAATTTATATAATAATTTAATCACGAGCTTGTTTCCAAGCATTCATGGAAATAATGAGGTGAAGCGAGGCGTCCTATTGATGTTGTTTGGAGGGGTCGCCAAAACTACTATTGAAGGAACAACACTTCGAGGCGACATAAACGTGTGCATCGTAGGAGACCCGAGTACAGCCAAGTCCCAGTTACTGAAGCAAGTCAGTGAGATCACACCCCGAGCCGTGTACACTAGCGGAAAGGCTTCCTCTGCTGCTGGTCTCACTGCAGCTGTTGTTAGGGACGAAGAATCCTTCGATTTCGTGATCGAAGCAGGCGCTTTAATGTTAGCTGACAACGGTGTGTGCTGTATTGACGAGTTCGACAAGATGGATCCTGGTGATCAAGTTGCAATACACGAGGCCATGGAACAACAAACAATTTCCTTGGCTAAGGCCGGAGTGAGGGCTACCCTAAATGCACGTACGTCGATACTTGCTGCCGCAAATCCTATTGGCGGACGATACGATCGAGCTAAATCCTTACAACAAAACGTCGCACTGAGCCCCCCCATTATGTCACGTTTCGATTTGTTCTTCATATTGATAGACGAGAGCAGTGAAATGGTTGATTACGCAATAGCAAGGAAAATTGTCGATCTGCACTGCAATAAAGAGGAGAGCTATGATTGTGTTTACTCAAGGGACGACCTGCTCAGGTACATTGCGTTCGCGAGGTCATTCAAGCCCGTCATTACCGAGGAGGCAGGCAAGTTACTGGTGGAGTACTACGCGTTGCTGCGGGGCCGTGAGGGGGGCGCGGGGGGCGGCGCGTGGCGCATCACGGTGCGCCAGCTCGAGTCCATGGTGCGGCTCGCCGAGGGCGTCGCCAAGATGCACTGCAGCGGACACGTCACGCCCGCGCACGTGCACGAGGCCTACCGATTACTAAATAAATCCATTATTCGCGTGGAGCAGCCCGATATACATTTGGACGAGGATGAACCTCAATGCGAGCCGAGCATGGATGTGGATCAAGACGAACCTAATGGCACTGCAGAAACTCCCAGCAATGGTGATTCGGCGCCTAAAAAGAAACTGGCGCTTTCATTCGAAGAATACAAAAGCCTCAGTAATATGCTGGTCGTGTACATGAGGAAGGAAGAGGCTGAAGCGGAGACGAGAGACGAGGAGAGCTCCGGTATGCACAAGTCTGCCGTAGTGAGCTGGTACCTAGAACAGCTGGTGGCACAAGGACAAATCGAAAGCGAAGACGAGTTACTTGAACGAAAGACACTAGTTGAGAAAGTCATTGATAGACTTATGTACCATGTCATAAATTCTGTCACATGTTTAATGTAA

Protein

MDVADTYATQSQVKDEVGIRCQKLFQDFLEEFKEDNEIKYEKHAKELLKPELSTLEVSFDDVEKYNQNLATTIIEEYYRIYPFLNRAILNYILSLAETGMKKDLQDKECYVSFVDVPTRHKVRELTTAKIGTLIRISGQIVRTHPVHPELVQGTFVCLDCQTVIKNVEQQFKYTIPTICRNPVCANRRRFMLDADKSVFVDFQKIRIQETQAELPRGCIPRSLEVILRAEAVESVQAGDRYDFTGTLIVVPDVGALSMPGSRAEITTRTKLANEGQMEGIKGLKALGVRELHYKTAFLACSVQAVSRRFGTAELPTHDLTTEDMRKQMTDKEWDKVYEMSRDRNLYNNLITSLFPSIHGNNEVKRGVLLMLFGGVAKTTIEGTTLRGDINVCIVGDPSTAKSQLLKQVSEITPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGVCCIDEFDKMDPGDQVAIHEAMEQQTISLAKAGVRATLNARTSILAAANPIGGRYDRAKSLQQNVALSPPIMSRFDLFFILIDESSEMVDYAIARKIVDLHCNKEESYDCVYSRDDLLRYIAFARSFKPVITEEAGKLLVEYYALLRGREGGAGGGAWRITVRQLESMVRLAEGVAKMHCSGHVTPAHVHEAYRLLNKSIIRVEQPDIHLDEDEPQCEPSMDVDQDEPNGTAETPSNGDSAPKKKLALSFEEYKSLSNMLVVYMRKEEAEAETRDEESSGMHKSAVVSWYLEQLVAQGQIESEDELLERKTLVEKVIDRLMYHVINSVTCLM

Description

Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity).
Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity Required for DNA replication and cell proliferation. Required for mitotic cycles, endocycles, and the special S phase associated with the amplification of chorion genes; has a role in origin unwinding or fork elongation at chorion loci (By similarity).
Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity Required for DNA replication and cell proliferation. Required for mitotic cycles, endocycles, and the special S phase associated with the amplification of chorion genes; has a role in origin unwinding or fork elongation at chorion loci.

Catalytic Activity

ATP + H2O = ADP + H(+) + phosphate

Subunit

Component of the Mcm2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order Mcm2-Mcm6-Mcm4-Mcm7-Mcm3-Mcm5 (By simililarity). The heterodimers of Mcm4/Mcm6 and Mcm3/Mcm5 interact with Mcm2 and Mcm7 (By similarity).
Component of the Mcm2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order Mcm2-Mcm6-Mcm4-Mcm7-Mcm3-Mcm5. The heterodimers of mcm4/mcm6 and mcm3/mcm5 interact with mcm2 and mcm7 (By similarity).
Component of the Mcm2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order Mcm2-Mcm6-Mcm4-Mcm7-Mcm3-Mcm5 (Probable). The heterodimers of Mcm4/Mcm6 and Mcm3/Mcm5 interact with Mcm2 and Mcm7.

Similarity

Belongs to the MCM family.

Keywords

ATP-binding   Cell cycle   Cell division   Complete proteome   DNA replication   DNA-binding   Helicase   Hydrolase   Metal-binding   Mitosis   Nucleotide-binding   Nucleus   Reference proteome   Zinc   Zinc-finger  

Feature

chain  DNA replication licensing factor Mcm6

Uniprot

H9IU98   A0A2H1VSP1   A0A2W1BKG5   A0A3S2TK09   A0A212FA39   A0A194QCB2   + More
A0A2A4J5H3   B0WPF1   A0A1Q3EVC8   A0A182FMV2   A0A2J7RDP5   A0A182HC06   A0A084WD26   W5JLP0   A0A182J130   A0A067RF20   A0A182N8Q8   A0A182QHU7   A0A336LRZ0   A0A182R6W1   A0A182MQ41   A0A182PV53   A0A182VSY2   Q16LS4   A0A2P8XKU6   A0A182XB67   A0A182KJS4   A0A1I8NVM4   A0A182I0R1   A0A182URP9   Q7Q0Q1   A0A0A1WQ29   A0A182JPH2   A0A034VW54   A0A1W4XIQ3   W8B565   T1P8H7   A0A1A9WKB8   A0A089HMH5   A0A0K8V2U0   A0A182YHC6   A0A1B0CE05   A0A0L0CNC4   B3MS81   A0A1A9ZNZ9   B4L5X6   A0A1A9VQ30   A0A1A9Y544   B4JMY9   A0A0M4FAP2   Q29JI9   D0QWF4   A0A0C9PH07   B4NPC9   A0A3B0JF20   B4PYU3   N6T4M5   A0A1W4VEJ0   B3NXU3   B4M7G8   B4R5N4   C6SUY3   Q9V461   D6X3S8   A0A1B6J7E9   B4I083   K7IXP3   U4UD49   A0A182TR97   A0A1B6ECS9   A0A1J1I3Q6   A0A087ZNB8   A0A154PRR2   A0A0J7L6G6   A0A146M089   A0A0A9X784   A0A2A3E600   A0A026WMD9   A0A023F4Y8   A0A151X131   V4BFH9   A0A2R7WPJ4   A0A1B0BXW1   A0A151I153   T1I9N9   A0A158NMR3   F4WN06   E2BEY5   A0A151IBU6   A0A151JVN1   A0A1Y1M0A5   E2ALN2   E9J2F5   A0A1B0D5I2   A0A1S3K5V8   A0A1S3I664   A0A310SE60   A0A0B7B3B6   A0A0L7R4F7   A0A0B7AZT6  

EC Number

3.6.4.12

Pubmed

19121390    28756777    22118469    26354079    26483478    24438588    + More
20920257    23761445    24845553    17510324    29403074    20966253    12364791    25830018    25348373    24495485    25315136    25244985    26108605    17994087    15632085    19859648    17550304    23537049    9795205    10023044    11854416    10731132    12537572    12537569    16798881    20122406    18362917    19820115    20075255    26823975    25401762    24508170    30249741    25474469    23254933    21347285    21719571    20798317    28004739    21282665   

EMBL

BABH01041643    BABH01041644    BABH01041645    BABH01041646    ODYU01004216    SOQ43855.1    + More
KZ150086    PZC73767.1    RSAL01000087    RVE48249.1    AGBW02009523    OWR50601.1    KQ459193    KPJ03183.1    NWSH01002958    PCG67221.1    DS232023    EDS32330.1    GFDL01015785    JAV19260.1    NEVH01005287    PNF38953.1    JXUM01032592    KQ560961    KXJ80194.1    ATLV01022923    KE525338    KFB48120.1    ADMH02001180    ETN63820.1    KK852676    KDR18687.1    AXCN02001859    UFQT01000086    SSX19493.1    AXCM01000229    CH477894    EAT35274.1    PYGN01001830    PSN32621.1    APCN01005234    AAAB01008980    GBXI01013769    JAD00523.1    GAKP01011381    GAKP01011380    JAC47571.1    GAMC01014317    JAB92238.1    KA644959    AFP59588.1    KM036514    AIP98401.1    GDHF01019409    JAI32905.1    AJWK01008460    JRES01000147    KNC33820.1    CH902622    EDV34636.1    CH933811    EDW06585.1    CH916371    EDV92082.1    CP012528    ALC49507.1    CH379063    EAL32312.1    FJ821027    ACN94664.1    GBYB01000143    JAG69910.1    CH964291    EDW86369.1    OUUW01000003    SPP78802.1    CM000162    EDX01029.1    APGK01044211    KB741021    ENN75064.1    CH954180    EDV47394.1    CH940653    EDW62735.1    CM000366    EDX17271.1    BT088975    ACT82957.1    AB010108    AF124744    AE014298    AY052102    AAD32858.1    AAF46184.1    AAK93526.1    BAA34732.1    KQ971326    EEZ97375.1    GECU01012609    JAS95097.1    CH480819    EDW52914.1    KB632003    ERL87840.1    GEDC01016650    GEDC01001601    JAS20648.1    JAS35697.1    CVRI01000038    CRK94228.1    KQ435031    KZC14034.1    LBMM01000485    KMQ98246.1    GDHC01005371    JAQ13258.1    GBHO01028961    JAG14643.1    KZ288357    PBC27135.1    KK107152    QOIP01000007    EZA57232.1    RLU20550.1    GBBI01002609    JAC16103.1    KQ982588    KYQ54107.1    KB202849    ESO87684.1    KK855225    PTY21523.1    JXJN01022373    JXJN01022374    KQ976593    KYM79671.1    ACPB03017705    ADTU01020709    GL888225    EGI64419.1    GL447885    EFN85750.1    KQ978078    KYM97194.1    KQ981689    KYN37892.1    GEZM01045606    JAV77725.1    GL440609    EFN65641.1    GL767845    EFZ12998.1    AJVK01025284    KQ760761    OAD59139.1    HACG01039745    CEK86610.1    KQ414657    KOC65762.1    HACG01039743    HACG01039744    CEK86608.1    CEK86609.1   

Proteomes

UP000005204    UP000283053    UP000007151    UP000053268    UP000218220    UP000002320    + More
UP000069272    UP000235965    UP000069940    UP000249989    UP000030765    UP000000673    UP000075880    UP000027135    UP000075884    UP000075886    UP000075900    UP000075883    UP000075885    UP000075920    UP000008820    UP000245037    UP000076407    UP000075882    UP000095300    UP000075840    UP000075903    UP000007062    UP000075881    UP000192223    UP000095301    UP000091820    UP000076408    UP000092461    UP000037069    UP000007801    UP000092445    UP000009192    UP000078200    UP000092443    UP000001070    UP000092553    UP000001819    UP000007798    UP000268350    UP000002282    UP000019118    UP000192221    UP000008711    UP000008792    UP000000304    UP000000803    UP000007266    UP000001292    UP000002358    UP000030742    UP000075902    UP000183832    UP000005203    UP000076502    UP000036403    UP000242457    UP000053097    UP000279307    UP000075809    UP000030746    UP000092460    UP000078540    UP000015103    UP000005205    UP000007755    UP000008237    UP000078542    UP000078541    UP000000311    UP000092462    UP000085678    UP000053825   

PRIDE

H9IU98    Q7Q0Q1    Q29JI9    C6SUY3    Q9V461   

Pfam

PF18263   MCM6_C        + More
PF14551   MCM_N
PF00493   MCM
PF17207   MCM_OB
PF17855   MCM_lid
PF03253   UT

Interpro

IPR008049   MCM6        + More
IPR012340   NA-bd_OB-fold       
IPR031327   MCM       
IPR001208   MCM_dom       
IPR041562   MCM_lid       
IPR027417   P-loop_NTPase       
IPR033762   MCM_OB       
IPR041024   Mcm6_C       
IPR018525   MCM_CS       
IPR027925   MCM_N       
IPR029020   Ammonium/urea_transptr       
IPR004937   Urea_transporter       

SUPFAM

SSF50249   SSF50249        + More
SSF52540   SSF52540       

Gene 3D

1.10.3430.10    

ProteinModelPortal

H9IU98   A0A2H1VSP1   A0A2W1BKG5   A0A3S2TK09   A0A212FA39   A0A194QCB2   + More
A0A2A4J5H3   B0WPF1   A0A1Q3EVC8   A0A182FMV2   A0A2J7RDP5   A0A182HC06   A0A084WD26   W5JLP0   A0A182J130   A0A067RF20   A0A182N8Q8   A0A182QHU7   A0A336LRZ0   A0A182R6W1   A0A182MQ41   A0A182PV53   A0A182VSY2   Q16LS4   A0A2P8XKU6   A0A182XB67   A0A182KJS4   A0A1I8NVM4   A0A182I0R1   A0A182URP9   Q7Q0Q1   A0A0A1WQ29   A0A182JPH2   A0A034VW54   A0A1W4XIQ3   W8B565   T1P8H7   A0A1A9WKB8   A0A089HMH5   A0A0K8V2U0   A0A182YHC6   A0A1B0CE05   A0A0L0CNC4   B3MS81   A0A1A9ZNZ9   B4L5X6   A0A1A9VQ30   A0A1A9Y544   B4JMY9   A0A0M4FAP2   Q29JI9   D0QWF4   A0A0C9PH07   B4NPC9   A0A3B0JF20   B4PYU3   N6T4M5   A0A1W4VEJ0   B3NXU3   B4M7G8   B4R5N4   C6SUY3   Q9V461   D6X3S8   A0A1B6J7E9   B4I083   K7IXP3   U4UD49   A0A182TR97   A0A1B6ECS9   A0A1J1I3Q6   A0A087ZNB8   A0A154PRR2   A0A0J7L6G6   A0A146M089   A0A0A9X784   A0A2A3E600   A0A026WMD9   A0A023F4Y8   A0A151X131   V4BFH9   A0A2R7WPJ4   A0A1B0BXW1   A0A151I153   T1I9N9   A0A158NMR3   F4WN06   E2BEY5   A0A151IBU6   A0A151JVN1   A0A1Y1M0A5   E2ALN2   E9J2F5   A0A1B0D5I2   A0A1S3K5V8   A0A1S3I664   A0A310SE60   A0A0B7B3B6   A0A0L7R4F7   A0A0B7AZT6  

PDB

6HV9     E-value=1.0644e-172,     Score=1560

KEGG

101741108    K02542 DNA replication licensing factor MCM6 [EC:3.6.4.12] | (RefSeq) DNA replication licensing fact

PATHWAY

03030    DNA replication - Bombyx mori (domestic silkworm)

GO

GO:0005634   GO:0006270   GO:0003678   GO:0003677   GO:0005524   GO:0042555   GO:0004386   GO:0006260   GO:0006267   GO:0006268   GO:0003697   GO:0046872   GO:1902969   GO:0003688   GO:0000727   GO:0051301   GO:0043138   GO:0007307   GO:0007049   GO:0016021   GO:0015204   GO:0003707   GO:0006281   GO:0006259  

PANTHER

PTHR11630  

Subcellular location

Nucleus  

Length:

786

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0702199999999997

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00386

outside

1  -  786

 

 

Pi

198.19032

Theta

171.073044

Tajima's D

0.751162

CLR

0.038683

CSRT

0.587520623968802

Interpretation

Uncertain