Gene

KWMTBOMO15653

Pre Gene Modal

BGIBMGA010701

Annotation

PREDICTED:_sideroflexin-1_isoform_X1_[Papilio_polytes]

Location

Bomo_Chr26(+):5299247-5316063      View in EpiBrowser

Full name

Sidoreflexin       + More
Sideroflexin-1      

Location in the cell

PlasmaMembrane   Reliability : 3.731

CDS

ATGGGCAGCCCACAAATAGATCTGGACAAACCTCGATACGATCAGAGCACGTATTCGGGTAGAGCCAAGCACTTCCTGCAACTGACCAACCCTCTCAACGTGTTGGCTTCGGATGCGGAACTCGACGAGGCACAGAGGATCGTTGCTGAATTCAGAAAAACACGTCGTATGCCGCCCGGATACGATGAAGAGAAGTTATGGAGTACTAAATATTTGTACGACAGCGCCTTCCATCCAGACACGGGAGAGAAAATGTTCGTGCTCGGACGCATGGCGGCACAGGCTCCCATGAACACTATCATTACGGGATGTATGATAACGTTCTACAAGACAACGCCGGCCACGGTTTTCTGGCAATGGGTGAATCAGACCTTCAACGCTGTCGTGAACTACACGAATCGATCAGGAGATGCACCTATAAGTACATCACGTCTATTGGCTTCATATTGCGCTGCCTGCGGAGGCGCTCTCGGTACAGCTTTGTATCTTAATAGCAAAGTTAAGAACATGAAACCGATCTACGCCCGTTTGGTTCCATTCGCGGCCGTCTGCGGAGCTAATTTCATCAATATTCCCATGATGAGGAGCAATGAGATAGCGAACGGCACGCCGGTGTTCACGGCGGACGGCGAACGCGTCGGCGAGTCTAAGACCGCCGCGCGGAGCGGCATCGCTTTAGTCTGCATCTCTAGGGTACTCATGGCCGTACCGGGAATGACCTTGACGCCAATGATCACGAACTACGCCACACGTCGCGGCATGTTCTGCCGCTGGCCCCTGCTGGTGGTGCCGTTCCAGCTGTCGCTGGTGGGGCTGTGCGTCACGTTCGCGACGCCGCTCTGCTGCGCCCTCTTCAGTCAGACCGCCGCCATAGCTGTCGACAGTCTCGAAGCCGATCTGAAGGAAATCGTAAAGAAGAAACACCCTCAAGTCAAGGAGTTGTATTACAATAAGGGACTCTAA

Protein

MGSPQIDLDKPRYDQSTYSGRAKHFLQLTNPLNVLASDAELDEAQRIVAEFRKTRRMPPGYDEEKLWSTKYLYDSAFHPDTGEKMFVLGRMAAQAPMNTIITGCMITFYKTTPATVFWQWVNQTFNAVVNYTNRSGDAPISTSRLLASYCAACGGALGTALYLNSKVKNMKPIYARLVPFAAVCGANFINIPMMRSNEIANGTPVFTADGERVGESKTAARSGIALVCISRVLMAVPGMTLTPMITNYATRRGMFCRWPLLVVPFQLSLVGLCVTFATPLCCALFSQTAAIAVDSLEADLKEIVKKKHPQVKELYYNKGL

Description

Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). Transports both D-serine and L-serine (PubMed:30442778). Also able to transport other amino-acids, such as alanine (PubMed:30442778). May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity).

Biophysicochemical Properties

170 uM for serine
371 uM for alanine

Similarity

Belongs to the sideroflexin family.

Keywords

Acetylation   Amino-acid transport   Complete proteome   Direct protein sequencing   Membrane   Mitochondrion   Mitochondrion inner membrane   One-carbon metabolism   Polymorphism   Reference proteome   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Sideroflexin-1
sequence variant  In dbSNP:rs17065105.

Uniprot

H9JME8   A0A3S2PDI1   A0A0N1IPZ1   A0A212EJ51   A0A194QCA7   A0A2A4K3B4   + More
A0A2A4K2V4   A0A2W1B6P9   A0A2A4J6S1   A0A2H1V5K9   A0A182GG74   A0A0P6IVD0   A0A1Y1LNJ0   U5EL09   A0A182JLB7   A0A182VG34   A0A182TLT9   A0A182XIG6   A0A182KZH3   Q7Q9Z0   A0A182HYR3   A0A182T0A1   A0A182RE21   A0A182W3I2   A0A182PHW0   A0A084VB87   H2YDI0   H2YDI2   A0A182QYW9   A0A182Y8Q6   A0A2M3ZHA3   A0A182K0F1   A0A2M4BU77   B4MC25   W5JN68   A0A2M4ADS5   W4YHV2   A0A182N9X7   J3JTL1   B4JGF6   F5HLH3   A0A2I0LSS0   A0A182MFN6   A0A093SYH0   A0A1Q3FHI0   K1QCT0   H2YDI1   W8B7F2   W8BC15   A0A1Q3FHE8   A0A131XB11   L7M8W5   A0A023FLE6   A0A023GIB6   A0A1W4YU70   A0A131YUC5   A0A224YEV1   G3MRB9   A0A1E1XUA1   B0WL46   A0A091EG03   A0A0Q3M3T5   A0A183SXP6   R7UYD5   N6UT56   A0A093PQD8   A0A3L8SJU0   A0A091UJQ9   A0A1E1X8A2   A0A1S3SWJ5   B3P1Z7   A0A067QW89   A0A1S3SWJ6   A0A1D2N844   F6TZ34   T1PGS5   A0A1W2WEK8   U3K2C9   A0A0L0CH45   H2LSY6   A0A3P9HL21   A0A3P9K4S6   A0A131XYQ3   B7QKD8   A0A1V4KIQ5   A0A0M4ELG3   H0ZIF7   H3CTC7   A0A1I8PA22   G3SQ35   A0A2K6NV79   B4PTR5   A0A1L8EDI9   H2QS19   A0A2D0SFP8   G3QYR9   G1QIB8   H2PHF3   Q9H9B4   A0A1L8EDJ9  

Pubmed

19121390    26354079    22118469    28756777    26483478    26999592    + More
28004739    20966253    12364791    14747013    17210077    24438588    25244985    17994087    18057021    20920257    23761445    22516182    23371554    22992520    24495485    28049606    25576852    26830274    28797301    22216098    29209593    23254933    23537049    30282656    28503490    24845553    27289101    12481130    15114417    25315136    26108605    17554307    20360741    15496914    25362486    17550304    16136131    22398555    14702039    17974005    15372022    15489334    19413330    21269460    22814378    24275569    25944712    30442778   

EMBL

BABH01040065    RSAL01000087    RVE48252.1    KQ459941    KPJ19166.1    AGBW02014523    + More
OWR41514.1    KQ459193    KPJ03178.1    NWSH01000220    PCG78263.1    PCG78258.1    KZ150431    PZC70901.1    NWSH01002958    PCG67224.1    ODYU01000804    SOQ36135.1    JXUM01011367    JXUM01011368    KQ560329    KXJ83010.1    GDUN01000183    JAN95736.1    GEZM01055091    GEZM01055090    JAV73156.1    GANO01001627    JAB58244.1    AAAB01008898    EAA09209.4    APCN01005402    ATLV01006068    KE524335    KFB35231.1    AXCN02001605    GGFM01007163    MBW27914.1    GGFJ01007411    MBW56552.1    CH940656    EDW58646.1    KRF78379.1    ADMH02001067    ETN64219.1    GGFK01005608    MBW38929.1    AAGJ04051570    BT126568    AEE61532.1    CH916369    EDV92625.1    EGK97192.1    AKCR02000109    PKK20479.1    AXCM01000353    KL672980    KFW87569.1    GFDL01008063    JAV26982.1    JH816162    EKC28929.1    GAMC01012038    JAB94517.1    GAMC01012037    JAB94518.1    GFDL01008059    JAV26986.1    GEFH01004482    JAP64099.1    GACK01005461    JAA59573.1    GBBK01002999    JAC21483.1    GBBM01001772    JAC33646.1    GEDV01005724    JAP82833.1    GFPF01005091    MAA16237.1    JO844420    AEO36037.1    GFAA01000560    JAU02875.1    DS231979    EDS30209.1    KK718294    KFO55562.1    LMAW01002767    KQK77333.1    UYSU01034973    VDL95379.1    AMQN01006769    KB299094    ELU08441.1    APGK01017167    KB739998    ENN81932.1    KL669486    KFW76460.1    QUSF01000017    RLW02838.1    KL409688    KFQ91169.1    GFAC01003693    JAT95495.1    CH954181    EDV47770.1    KK853179    KDR10209.1    LJIJ01000169    ODN01146.1    EAAA01002581    KA647083    AFP61712.1    AGTO01010811    JRES01000409    KNC31522.1    GEFM01003989    JAP71807.1    ABJB010983713    DS959025    EEC19310.1    LSYS01003057    OPJ84285.1    CP012526    ALC46127.1    ABQF01027057    CM000160    EDW95648.1    GFDG01002085    JAV16714.1    AACZ04058941    GABF01009313    GABD01000788    JAA12832.1    JAA32312.1    CABD030042473    ADFV01075924    ADFV01075925    ADFV01075926    ABGA01228364    ABGA01228365    ABGA01306084    ABGA01306085    ABGA01306086    ABGA01306087    ABGA01306088    NDHI03003371    PNJ78030.1    AF327346    AK022287    AK022938    AK056915    BX648188    AC091393    CH471062    BC020517    BC063241    GFDG01002084    JAV16715.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000007151    UP000053268    UP000218220    + More
UP000069940    UP000249989    UP000075880    UP000075903    UP000075902    UP000076407    UP000075882    UP000007062    UP000075840    UP000075901    UP000075900    UP000075920    UP000075885    UP000030765    UP000007875    UP000075886    UP000076408    UP000075881    UP000008792    UP000000673    UP000007110    UP000075884    UP000001070    UP000053872    UP000075883    UP000053258    UP000005408    UP000192224    UP000002320    UP000052976    UP000051836    UP000050788    UP000275846    UP000014760    UP000019118    UP000276834    UP000053283    UP000087266    UP000008711    UP000027135    UP000094527    UP000008144    UP000095301    UP000016665    UP000037069    UP000001038    UP000265200    UP000265180    UP000001555    UP000190648    UP000092553    UP000007754    UP000007303    UP000095300    UP000007646    UP000233200    UP000002282    UP000002277    UP000221080    UP000001519    UP000001073    UP000001595    UP000005640   

PRIDE

H9JME8    Q9H9B4   

Pfam

PF03820   Mtc        + More
PF00096   zf-C2H2

Interpro

IPR004686   Mtc        + More
IPR036236   Znf_C2H2_sf       
IPR013087   Znf_C2H2_type       

SUPFAM

SSF57667   SSF57667       

ProteinModelPortal

H9JME8   A0A3S2PDI1   A0A0N1IPZ1   A0A212EJ51   A0A194QCA7   A0A2A4K3B4   + More
A0A2A4K2V4   A0A2W1B6P9   A0A2A4J6S1   A0A2H1V5K9   A0A182GG74   A0A0P6IVD0   A0A1Y1LNJ0   U5EL09   A0A182JLB7   A0A182VG34   A0A182TLT9   A0A182XIG6   A0A182KZH3   Q7Q9Z0   A0A182HYR3   A0A182T0A1   A0A182RE21   A0A182W3I2   A0A182PHW0   A0A084VB87   H2YDI0   H2YDI2   A0A182QYW9   A0A182Y8Q6   A0A2M3ZHA3   A0A182K0F1   A0A2M4BU77   B4MC25   W5JN68   A0A2M4ADS5   W4YHV2   A0A182N9X7   J3JTL1   B4JGF6   F5HLH3   A0A2I0LSS0   A0A182MFN6   A0A093SYH0   A0A1Q3FHI0   K1QCT0   H2YDI1   W8B7F2   W8BC15   A0A1Q3FHE8   A0A131XB11   L7M8W5   A0A023FLE6   A0A023GIB6   A0A1W4YU70   A0A131YUC5   A0A224YEV1   G3MRB9   A0A1E1XUA1   B0WL46   A0A091EG03   A0A0Q3M3T5   A0A183SXP6   R7UYD5   N6UT56   A0A093PQD8   A0A3L8SJU0   A0A091UJQ9   A0A1E1X8A2   A0A1S3SWJ5   B3P1Z7   A0A067QW89   A0A1S3SWJ6   A0A1D2N844   F6TZ34   T1PGS5   A0A1W2WEK8   U3K2C9   A0A0L0CH45   H2LSY6   A0A3P9HL21   A0A3P9K4S6   A0A131XYQ3   B7QKD8   A0A1V4KIQ5   A0A0M4ELG3   H0ZIF7   H3CTC7   A0A1I8PA22   G3SQ35   A0A2K6NV79   B4PTR5   A0A1L8EDI9   H2QS19   A0A2D0SFP8   G3QYR9   G1QIB8   H2PHF3   Q9H9B4   A0A1L8EDJ9  

PDB

5DRN     E-value=0.0800963,     Score=83

KEGG

101736404    K23500 sideroflexin-1/3 | (RefSeq) sideroflexin-1

GO

GO:0015075   GO:0031966   GO:0016021   GO:0003676   GO:0016020   GO:0015194   GO:0030218   GO:0006826   GO:0006730   GO:0031305   GO:0140300   GO:0042945   GO:0022889   GO:0042942   GO:0005739   GO:0015825   GO:0006811   GO:0000287   GO:0051287   GO:0030117   GO:0006418   GO:0003707   GO:0006281   GO:0006259   GO:0055085  

PANTHER

PTHR11153  

Subcellular location

Mitochondrion membrane  
Mitochondrion inner membrane  

Length:

320

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

98.31988

Exp number, first 60 AAs:

0.00033

Total prob of N-in:

0.66732

inside

1  -  98

TMhelix

99  -  121

outside

122  -  142

TMhelix

143  -  165

inside

166  -  171

TMhelix

172  -  194

outside

195  -  222

TMhelix

223  -  245

inside

246  -  257

TMhelix

258  -  280

outside

281  -  320

 

 

Pi

29.351984

Theta

166.40572

Tajima's D

1.653619

CLR

0.400997

CSRT

0.818659067046648

Interpretation

Uncertain