SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO15648
Pre Gene Modal
BGIBMGA010689
Annotation
PREDICTED:_E3_ubiquitin-protein_ligase_MARCH5_[Papilio_machaon]
Full name
E3 ubiquitin-protein ligase MARCH5      
Alternative Name
Membrane-associated RING finger protein 5
Membrane-associated RING-CH protein V
RING-type E3 ubiquitin transferase MARCH5
Mitochondrial ubiquitin ligase
RING finger protein 153
Location in the cell
PlasmaMembrane   Reliability : 4.654
 

Sequence

CDS
ATGTCGGGTGAATCTAATGAGTGTCATGGAACCAGCGTTAGTAGTTCACAAGCTTTGCAGCCAGCTGAAGATGAAAATGCCAAGTCTTGTTGGGTCTGCTTCGCTACAGAGGCAGACGATAAACTCGCGGCGTGGGTACAACCGTGTAAATGTATCGGAACAACAAAATGGGTTCATCAGTCATGTCTCCAAAGATGGGTCGATGAGAAGCAGCGGGGCAACATCACACGCAAGGTTCTCTGCCCTCAGTGTAAAGCGGAATACATTGTCGTGTTTCCGTCCATGGGTGCCTTCGTAGCCATGCTCGATGCTATGGAAGAGATCACCCACAAGATATGTCCATTTATTGCTGGTGGAGTGCTACTTGGCTCCATATATTGGATTGCCATTACATACGGAGCGGTCACTGTCATGCAGGTAGTAGGCCATCGCGAAGGTCTCGAGATGATGGAGTCGGCGGACCCCTTGGTTTTACTCGTGCTACTGCCCACGATCCCAGTGACCCTCATCAGTGCGAAGATGTATAACTGGGAGGATTCCGTTCTCCTGTTCCTCAGGAAGTACTGCGCTAAGATACCTGTCTTGGCTTATATTCTGCCTTTCGGAAACGTAGACAATGATCGCGCTATAGTGGCCGGTCAGACGACGCCACAGAACCCAAACGCGAGCCATCTATCCCCGACAAGGATATTCTGTTCGGCTCTGTTGCTACCAACGATATCGACGATCATAGGAAAGATATTCTTCCGTTCGATACAGAATAACCTCCACAGAACAATGCTCGGAGGCCTGACTTATATCACGTTGAAAGGGGCCTTGAAAATATATCACAAACAAATGCTGTACGTGAGGCATTCCAGTAGAAAGATATTGGATTACACGGAATCTAATTTGAAATTATACAGGAATTCGACAACCCTAGCGACCGATGCCGTTTCCAGTAGGGACGACAGCGAACAAGTCGTTTGA
Protein
MSGESNECHGTSVSSSQALQPAEDENAKSCWVCFATEADDKLAAWVQPCKCIGTTKWVHQSCLQRWVDEKQRGNITRKVLCPQCKAEYIVVFPSMGAFVAMLDAMEEITHKICPFIAGGVLLGSIYWIAITYGAVTVMQVVGHREGLEMMESADPLVLLVLLPTIPVTLISAKMYNWEDSVLLFLRKYCAKIPVLAYILPFGNVDNDRAIVAGQTTPQNPNASHLSPTRIFCSALLLPTISTIIGKIFFRSIQNNLHRTMLGGLTYITLKGALKIYHKQMLYVRHSSRKILDYTESNLKLYRNSTTLATDAVSSRDDSEQVV

Summary

Description
Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.
Catalytic Activity
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
Subunit
Monomer and homodimer. Interacts with MFN1, MFN2, DNM1L and FIS1.
Miscellaneous
By binding to and ubiquitinating two ALS1 variants of SOD1 (mSOD1 variants Arg-86 and Ala-94) it attenuates their cytotoxicity.
Keywords
Complete proteome   Endoplasmic reticulum   Membrane   Metal-binding   Mitochondrion   Mitochondrion outer membrane   Reference proteome   Transferase   Transmembrane   Transmembrane helix   Ubl conjugation   Ubl conjugation pathway   Zinc   Zinc-finger  
Feature
chain  E3 ubiquitin-protein ligase MARCH5
EC Number
2.3.2.27
EMBL
KQ459941    KPJ19163.1    KQ459193    KPJ03174.1    NWSH01000220    PCG78270.1    + More
GAIX01004771    JAA87789.1    JTDY01001030    KOB75083.1    ODYU01004268    SOQ43958.1    AGBW02009060    OWR51769.1    PYGN01000512    PSN45061.1    GL438494    EFN68890.1    KQ977329    KYN03527.1    KQ979701    KYN19513.1    KQ981477    KYN41443.1    KQ983028    KYQ48155.1    NEVH01004410    PNF39614.1    GL888578    EGI59365.1    KK107364    EZA51925.1    LJIG01022500    KRT80242.1    GL452318    EFN77572.1    LBMM01010715    KMQ87300.1    GFDF01004710    JAV09374.1    GBYB01015156    JAG84923.1    KK853305    KDR08720.1    APGK01052696    KB741213    KB631874    ENN72671.1    ERL86868.1    KQ976606    KYM79326.1    KQ414731    KOC62428.1    GEZM01102898    JAV51741.1    KQ435750    KOX76292.1    KZ288293    PBC28992.1    CCAG010007645    KQ435130    KZC14858.1    DS234996    EEB10132.1    JXJN01030051    KQ971372    EFA10490.1    AJFE02089241    AJFE02089242    AJFE02089243    AJFE02089244    AJFE02089245    AJFE02089246    AJFE02089247    AJFE02089248    AJFE02089249    AJFE02089250    KB201362    ESO96851.1    GEBF01001227    JAO02406.1    AGTP01072989    GFFW01002814    JAV41974.1    AAKN02053761    AAKN02053762    AC103056    BC158801    CH473953    AAI58802.1    EDM13194.1    BC132455    BC132457    CH466534    AAI32456.1    EDL41781.1    AAGW02036317    AAGW02036318    AAGW02036319    GABZ01007359    JAA46166.1    CABD030075335    CABD030075336    CABD030075337    CABD030075338    CABD030075339    CABD030075340    ADFV01114829    ADFV01114830    ADFV01114831    ADFV01114832    ADFV01114833    ADFV01114834    ADFV01114835    ADFV01114836    AEMK02000096    AQIB01042863    AQIB01042864    AQIB01042865    HAAF01001798    CCP73624.1    AHZZ02035779    AHZZ02035780    AANG04000273    ABGA01344827    ABGA01344828    ABGA01344829    ABGA01344830    ABGA01344831    ABGA01344832    ABGA01344833    ABGA01344834    ABGA01344835    ABGA01344836    NDHI03003280    PNJ89437.1    AQIA01071989    AQIA01071990    AQIA01071991    AQIA01071992    CM001284    EHH64882.1    AACZ04051057    GABC01009800    GABC01009799    GABF01001453    GABD01007721    GABE01001630    NBAG03000216    JAA01538.1    JAA20692.1    JAA25379.1    JAA43109.1    PNI82326.1    JSUE03043984    JSUE03043985    JSUE03043986    JU320794    JU471454    JU471455    JV047445    CM001261    AFE64550.1    AFH28258.1    AFI37516.1    EHH19228.1    GAMT01000136    GAMS01007764    GAMR01007664    GAMQ01003536    GAMP01006224    JAB11725.1    JAB15372.1    JAB26268.1    JAB38315.1    JAB46531.1    AK003478    AK009232    BC064752    BC107215    AB191202    AK000452    AL158040    AL161652    BC015480    AB212856    BC102966    HACG01018421    CEK65286.1    CM004478    OCT71622.1    AEYP01026409    AEYP01026410    AEYP01026411    AEYP01026412    AEYP01026413    AEYP01026414    AEYP01026415    AEYP01026416    AEYP01026417    AEYP01026418    AKHW03001467    KYO42294.1   
Proteomes
UP000053240    UP000053268    UP000218220    UP000037510    UP000007151    UP000245037    + More
UP000000311    UP000078542    UP000078492    UP000078541    UP000075809    UP000235965    UP000007755    UP000053097    UP000008237    UP000192223    UP000036403    UP000027135    UP000019118    UP000030742    UP000095301    UP000078540    UP000053825    UP000005203    UP000095300    UP000053105    UP000091820    UP000242457    UP000092445    UP000092444    UP000078200    UP000076502    UP000009046    UP000001645    UP000002279    UP000092460    UP000007266    UP000286641    UP000240080    UP000030746    UP000081671    UP000005215    UP000189706    UP000005447    UP000002494    UP000233120    UP000261680    UP000291021    UP000001811    UP000001519    UP000001073    UP000252040    UP000008227    UP000233140    UP000029965    UP000002281    UP000248480    UP000245320    UP000028761    UP000233020    UP000248484    UP000002280    UP000233200    UP000248481    UP000245341    UP000011712    UP000233060    UP000286640    UP000079721    UP000248483    UP000245340    UP000233080    UP000233040    UP000233220    UP000233160    UP000286642    UP000001595    UP000009130    UP000233100    UP000002277    UP000006718    UP000008225    UP000000589    UP000005640    UP000009136    UP000186698    UP000000715    UP000050525   
Pfam
PF12906   RINGv        + More
PF03345   DDOST_48kD
Interpro
IPR013083   Znf_RING/FYVE/PHD        + More
IPR011016   Znf_RING-CH       
IPR005013   DDOST_48_kDa_subunit       
Gene 3D
PDB
2D8S     E-value=0.000666952,     Score=101

Ontologies

Topology

Subcellular location
Mitochondrion outer membrane  
Endoplasmic reticulum membrane  
Length:
322
Number of predicted TMHs:
4
Exp number of AAs in TMHs:
80.4385599999999
Exp number, first 60 AAs:
0.0007
Total prob of N-in:
0.85223
inside
1  -  87
TMhelix
88  -  105
outside
106  -  119
TMhelix
120  -  142
inside
143  -  154
TMhelix
155  -  177
outside
178  -  226
TMhelix
227  -  249
inside
250  -  322
 
 

Population Genetic Test Statistics

Pi
224.367619
Theta
159.934281
Tajima's D
1.217099
CLR
0.447024
CSRT
0.71596420178991
Interpretation
Uncertain
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