Gene

KWMTBOMO15629  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010847

Annotation

N-phosphoacetylglucosamine_mutase_[Cnaphalocrocis_medinalis]

Location

Bomo_Chr26(+):4697083-4711225      View in EpiBrowser

Full name

Phosphoacetylglucosamine mutase      

Alternative Name

Acetylglucosamine phosphomutase
N-acetylglucosamine-phosphate mutase

Location in the cell

Cytoplasmic   Reliability : 2.927

CDS

ATGCCGCCGAGTAGCTTACGAGTCGTGTACGCGTTCGCCAGAGAAATGCATCCGAAGACAACTGACATTTTTATTGAATACGGCACTGCCGGATTTCGTACAAAGGCCAATTTATTGGAGCATGTCGTGTATCGTATGGGTCTCTTGGCTGTCATTCGTTCCAGAGTTAAAAATGGACGCACCATCGGCATCATGATAACAGCATCGCACAATCTCGAGCCCGACAACGGTGTGAAGCTCATCGATCCAGATGGCGAGATGCTTGAGCAGAGCTGGGAGGCGATAGCCACTAAACTAGCTAATGTCAGTGACAATGACTTGGAAGCGACAACTGCTGAGATTATAAAAGAAGTGAATGCTAATATGACACTCAAAACGAGTATATTCATTGGAATGGACACAAGATACACAAGTCCCCGTCTAGCACAGGCGGCTGCTAATGGAGTCATGGCGCTGAAGGGAACGCCCAAGGAGTTCGGAATTGTTACCACTCCAATGCTGCATTTCTTCGTAAAATGTCGTAACGATAATACATATGGAACTCCAACCGAGGAAGGATATTATGAGAAAATCGTTGGTGCTTTCAAGAATATACGTCAAAAACTACCCGTTTACGGTAATTATAGTACAACGTTGTACGTAGACGGCGCTAACGGCGTCGGTGGAAAGAAACTTAATATCATCAAGAAGACCCTCGATGGTGAATTGGATCTGAAGCTGTTCAATTTAGGCGGGAACGGAGGAAAGTTGAATTTGAATTGCGGTGCTGATTTCGTGAAAGTATCACAGAAGCCGCCCGTCGGCGTAGAGCACGTGCCGATGCAGCGAGTGGCCTCACTGGACGGGGACTCCGATCGCATCGTCTATTACTACGTCGACGATAAAGATAAAATGCACTTGTTGGACGGCGATCGTATAGCCACATTACTGGCCAGCTACATCACCGAATTGCTGACGGCCAGCGAAGCGAAACATTTGAAACTAGGCCTCGTGCAAACGGCCTACGCTAACGGTGCATCCACTGCTTATATAACGCAGAAGCTGAAAGTCCCGGTGAGCTGCGTGAAGACAGGAGTGAAGCATCTCCATCACGCAGCGCTTTCGTATGACATCGGCGTCTACTTTGAAGCGAACGGGCACGGCACAGTCATATACAGTCACGACGCTAAGAAGACGATCAGCAAAATTGCCGAAGAGGGGGAGTCGGAACAAAGGAAGGCGGCGCAGTTGCTTCTGGACTTCATCGACATGACCAACGAGACGGTCGGAGACGCCATATCGGACCTGTTCCTCGTCGAGACGGTGCTCTGCGCTCGAGGACTGGACGCCGAGCAGTGGCTCTCCACGTACGACGACCTGCCCTGCAGACAAGTAAAAGTAACAGTACAGGATCGTAACGTGATATCTACGGCGGACGCGGAGCGCGTGTGCACGTCGCCCGAGGGACTGCAGACGCGTATCGACGAGCTCGTCGCTGCGTACGCGGACGGACGCGCCTTCGTGCGTCCCTCCGGCACCGAGGACGTGGTGCGAGTGTACGCGGAAGCGGATACGCAGCAGTCAGCAGATAAACTCGCCGCAGAAGTATCACAGGCCGTTTACGATTTGGCCGGCGGCGTTGGAAATCGGCCAGAGTTGCCAGCTTAA

Protein

MPPSSLRVVYAFAREMHPKTTDIFIEYGTAGFRTKANLLEHVVYRMGLLAVIRSRVKNGRTIGIMITASHNLEPDNGVKLIDPDGEMLEQSWEAIATKLANVSDNDLEATTAEIIKEVNANMTLKTSIFIGMDTRYTSPRLAQAAANGVMALKGTPKEFGIVTTPMLHFFVKCRNDNTYGTPTEEGYYEKIVGAFKNIRQKLPVYGNYSTTLYVDGANGVGGKKLNIIKKTLDGELDLKLFNLGGNGGKLNLNCGADFVKVSQKPPVGVEHVPMQRVASLDGDSDRIVYYYVDDKDKMHLLDGDRIATLLASYITELLTASEAKHLKLGLVQTAYANGASTAYITQKLKVPVSCVKTGVKHLHHAALSYDIGVYFEANGHGTVIYSHDAKKTISKIAEEGESEQRKAAQLLLDFIDMTNETVGDAISDLFLVETVLCARGLDAEQWLSTYDDLPCRQVKVTVQDRNVISTADAERVCTSPEGLQTRIDELVAAYADGRAFVRPSGTEDVVRVYAEADTQQSADKLAAEVSQAVYDLAGGVGNRPELPA

Description

Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.

Catalytic Activity

N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate

Cofactor

Mg(2+)

Similarity

Belongs to the phosphohexose mutase family.

Uniprot

A0A1C9CW41   A0A3S2M0H4   A0A0G2RLT8   A0A194QC94   A0A2A4JC27   A0A212EW76   + More
A0A0N0PE63   A0A2H1VM40   B4PGS6   V5GWV2   B3NHC2   A0A1Y1M850   Q9VTZ4   A0A1W4UGY7   D6X3A7   B4QRP0   A0A1B0CKT3   A0A0T6B8G5   A0A1L8E2L9   A0A336LSL1   Q2M0L7   A0A336LW80   B3MB25   A0A3B0KMN4   A0A1W4WEH6   A0A1W4W2M4   A0A336M7Q0   B4L0Q6   B4N332   B4LGP2   Q16PT5   A0A182GUX6   B4IX69   A0A3B0JSG8   B4NMG7   Q58I85   A0A1I8NN57   A0A0K8VIJ8   B0WVX0   W8BLH0   A0A1Q3F954   A0A1Q3F971   A0A0M5J3X5   B0X482   A0A034VJK5   A0A1J1IP77   A0A0A1XQ05   A0A0L0CL80   A0A182R3J0   A0A182JC50   A0A182PP35   A0A182WJR6   A0A182MN30   A0A084WES1   A0A182YML6   A0A182KQN4   A0A2C9GRT4   A0A182TJB0   Q7QJ25   A0A182VJ82   T1PG23   A0A1I8NAA5   A0A182N917   A0A2Z4BZJ4   D3TNI4   A0A1A9UTQ9   A0A182QQ20   A0A1B0GA53   A0A182FGD0   W5J6K1   A0A182XLJ6   K7J1K6   A0A1B6FN26   B4GRG5   E9GZ07   A0A067RFT3   A0A0P5VCP7   A0A0P6AG10   A0A0P5SY06   A0A0P5WWJ7   A0A0P5TZI9   A0A1B0AR70   A0A0P6IC12   A0A0P5VVA3   A0A0P5UWV5   A0A0P5UWP2   A0A0P4ZCJ5   A0A1B6KB84   A0A0P4YNT6   A0A0P5NPK9   A0A3R7PN50   R7UDD6   A0A0N7ZZG9   A0A1S3IPZ1   A0A3G2KJL5   A0A3P8WV03   G3WU51   K1QVE8   A0A2J7QDT1   A0A3B4ZQD2  

EC Number

5.4.2.3

Pubmed

26354079    22118469    17994087    17550304    28004739    10731132    + More
12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    18362917    19820115    22936249    15632085    17510324    26483478    24495485    25348373    25830018    26108605    24438588    25244985    20966253    12364791    14747013    17210077    25315136    20353571    20920257    23761445    20075255    21292972    24845553    23254933    26383154    30326269    24487278    21709235    22992520   

EMBL

KX130001    AON76440.1    RSAL01000087    RVE48266.1    KP000845    AJG44540.1    + More
KQ459193    KPJ03163.1    NWSH01002183    PCG68953.1    AGBW02012063    OWR45745.1    KQ459941    KPJ19152.1    ODYU01003314    SOQ41905.1    CM000159    EDW94315.1    GALX01003713    JAB64753.1    CH954178    EDV51579.1    GEZM01037864    JAV81873.1    AE014296    AY069309    AAF49901.1    AAL39454.1    KQ971372    EFA09778.2    CM000363    CM002912    EDX10254.1    KMY99259.1    AJWK01016608    LJIG01009161    KRT83634.1    GFDF01001339    JAV12745.1    UFQS01000155    UFQT01000155    SSX00594.1    SSX20974.1    CH379069    EAL30913.1    UFQT01000150    SSX20913.1    CH902618    EDV40291.1    OUUW01000009    SPP85068.1    UFQT01000659    SSX26235.1    CH933809    EDW18133.1    CH964062    EDW78771.1    CH940647    EDW70507.1    CH477773    EAT36375.1    JXUM01018692    JXUM01018693    KQ560519    KXJ82014.1    CH916366    EDV97401.1    SPP85067.1    CH964282    EDW85556.1    AY944754    AAX47077.1    GDHF01019812    GDHF01013949    JAI32502.1    JAI38365.1    DS232134    EDS35802.1    GAMC01006898    JAB99657.1    GFDL01010940    JAV24105.1    GFDL01010914    JAV24131.1    CP012525    ALC44344.1    DS232331    EDS40159.1    GAKP01017259    GAKP01017258    JAC41693.1    CVRI01000054    CRL00297.1    GBXI01001347    GBXI01001164    JAD12945.1    JAD13128.1    JRES01000240    KNC33055.1    AXCM01002191    ATLV01023246    KE525341    KFB48715.1    APCN01000178    AAAB01008807    EAA04228.3    KA647767    AFP62396.1    MH119583    AWU68201.1    EZ422986    ADD19262.1    AXCN02000540    CCAG010015850    ADMH02002070    ETN59626.1    GECZ01018208    JAS51561.1    CH479188    EDW40350.1    GL732576    EFX75314.1    KK852714    KDR17892.1    GDIP01102141    JAM01574.1    GDIP01043245    LRGB01000687    JAM60470.1    KZS16738.1    GDIP01138493    JAL65221.1    GDIP01080792    JAM22923.1    GDIP01137188    JAL66526.1    JXJN01002268    GDIQ01023112    JAN71625.1    GDIP01095800    JAM07915.1    GDIP01107588    JAL96126.1    GDIP01107589    JAL96125.1    GDIP01217477    GDIP01215078    JAJ08324.1    GEBQ01031264    JAT08713.1    GDIP01224575    JAI98826.1    GDIQ01139576    JAL12150.1    QCYY01002239    ROT71834.1    AMQN01008178    KB302363    ELU04395.1    GDIP01197385    JAJ26017.1    MH320769    AYN59160.1    AEFK01168771    JH818113    EKC40852.1    NEVH01015814    PNF26738.1   

Proteomes

UP000283053    UP000053268    UP000218220    UP000007151    UP000053240    UP000002282    + More
UP000008711    UP000000803    UP000192221    UP000007266    UP000000304    UP000092461    UP000001819    UP000007801    UP000268350    UP000192223    UP000009192    UP000007798    UP000008792    UP000008820    UP000069940    UP000249989    UP000001070    UP000095300    UP000002320    UP000092553    UP000183832    UP000037069    UP000075900    UP000075880    UP000075885    UP000075920    UP000075883    UP000030765    UP000076408    UP000075882    UP000075840    UP000075902    UP000007062    UP000075903    UP000095301    UP000075884    UP000078200    UP000075886    UP000092444    UP000069272    UP000000673    UP000076407    UP000002358    UP000008744    UP000000305    UP000027135    UP000076858    UP000092460    UP000283509    UP000014760    UP000085678    UP000265120    UP000007648    UP000005408    UP000235965    UP000261400   

PRIDE

Q9VTZ4   

Pfam

PF00408   PGM_PMM_IV        + More
PF02878   PGM_PMM_I
PF02880   PGM_PMM_III
PF14740   DUF4471
PF14737   DUF4470
PF00405   Transferrin

Interpro

IPR005843   A-D-PHexomutase_C        + More
IPR016055   A-D-PHexomutase_a/b/a-I/II/III       
IPR036900   A-D-PHexomutase_C_sf       
IPR005844   A-D-PHexomutase_a/b/a-I       
IPR016657   PAGM       
IPR016066   A-D-PHexomutase_CS       
IPR005846   A-D-PHexomutase_a/b/a-III       
IPR027974   DUF4470       
IPR028235   DNAAF3_C       
IPR015915   Kelch-typ_b-propeller       
IPR018195   Transferrin_Fe_BS       
IPR001156   Transferrin-like_dom       

SUPFAM

SSF53738   SSF53738        + More
SSF55957   SSF55957       
SSF117281   SSF117281       

Gene 3D

2.120.10.80    

CDD

cd03086  PGM3

ProteinModelPortal

A0A1C9CW41   A0A3S2M0H4   A0A0G2RLT8   A0A194QC94   A0A2A4JC27   A0A212EW76   + More
A0A0N0PE63   A0A2H1VM40   B4PGS6   V5GWV2   B3NHC2   A0A1Y1M850   Q9VTZ4   A0A1W4UGY7   D6X3A7   B4QRP0   A0A1B0CKT3   A0A0T6B8G5   A0A1L8E2L9   A0A336LSL1   Q2M0L7   A0A336LW80   B3MB25   A0A3B0KMN4   A0A1W4WEH6   A0A1W4W2M4   A0A336M7Q0   B4L0Q6   B4N332   B4LGP2   Q16PT5   A0A182GUX6   B4IX69   A0A3B0JSG8   B4NMG7   Q58I85   A0A1I8NN57   A0A0K8VIJ8   B0WVX0   W8BLH0   A0A1Q3F954   A0A1Q3F971   A0A0M5J3X5   B0X482   A0A034VJK5   A0A1J1IP77   A0A0A1XQ05   A0A0L0CL80   A0A182R3J0   A0A182JC50   A0A182PP35   A0A182WJR6   A0A182MN30   A0A084WES1   A0A182YML6   A0A182KQN4   A0A2C9GRT4   A0A182TJB0   Q7QJ25   A0A182VJ82   T1PG23   A0A1I8NAA5   A0A182N917   A0A2Z4BZJ4   D3TNI4   A0A1A9UTQ9   A0A182QQ20   A0A1B0GA53   A0A182FGD0   W5J6K1   A0A182XLJ6   K7J1K6   A0A1B6FN26   B4GRG5   E9GZ07   A0A067RFT3   A0A0P5VCP7   A0A0P6AG10   A0A0P5SY06   A0A0P5WWJ7   A0A0P5TZI9   A0A1B0AR70   A0A0P6IC12   A0A0P5VVA3   A0A0P5UWV5   A0A0P5UWP2   A0A0P4ZCJ5   A0A1B6KB84   A0A0P4YNT6   A0A0P5NPK9   A0A3R7PN50   R7UDD6   A0A0N7ZZG9   A0A1S3IPZ1   A0A3G2KJL5   A0A3P8WV03   G3WU51   K1QVE8   A0A2J7QDT1   A0A3B4ZQD2  

PDB

5OAW     E-value=6.21032e-128,     Score=1173

KEGG

101743243    K01836 phosphoacetylglucosamine mutase [EC:5.4.2.3] | (RefSeq) phosphoacetylglucosamine mutase

PATHWAY

00520    Amino sugar and nucleotide sugar metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006048   GO:0004610   GO:0046872   GO:0005975   GO:0060438   GO:0045743   GO:0001710   GO:0000287   GO:0005576   GO:0016868   GO:0016020   GO:0020037   GO:0030117   GO:0006418   GO:0003707   GO:0006281   GO:0006259   GO:0071704  

Length:

548

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00523999999999998

Exp number, first 60 AAs:

0.00283

Total prob of N-in:

0.00064

outside

1  -  548

 

 

Pi

179.617485

Theta

154.803411

Tajima's D

0.88129

CLR

1.93603

CSRT

0.623868806559672

Interpretation

Uncertain