Gene

KWMTBOMO15618

Pre Gene Modal

BGIBMGA010715

Annotation

PREDICTED:_dynein_light_chain_roadblock-type_2_[Amyelois_transitella]

Location

Bomo_Chr26(-):4301832-4302758      View in EpiBrowser

Full name

Dynein light chain roadblock      

Location in the cell

Cytoplasmic   Reliability : 1.695

CDS

ATGGCCAATGAAGCTGAGGACACAATTCGAAAACTGTCGACGTACAAAGGCGTGGTTGGCGTCGTCGTTGTAAACGGAGAAGGAATACCGATAAAAACCACTTTAGATAATCACATTTCCGTACAATACGCGGGCCTATTGACCGCGTTGGTGGACAAAGCGAAAACTGTCGTGCGAGACCTGGATCCGTCTAATGACTTGACATTTTTGAGGATAAGAAGCAAAAAAAGCGAAGTAATGGTGGCGCCCGATAAAGAATTTATATTAATAGTAGTTCAAAATCCTGTTGAGTAA

Protein

MANEAEDTIRKLSTYKGVVGVVVVNGEGIPIKTTLDNHISVQYAGLLTALVDKAKTVVRDLDPSNDLTFLRIRSKKSEVMVAPDKEFILIVVQNPVE

Description

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

Subunit

Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.

Similarity

Belongs to the GAMAD family.

Uniprot

H9JMG2   A0A194QDX9   A0A0N1IC30   A0A2A4IYT4   A0A212F2U0   A0A2H1W2P3   + More
A0A0L7LRZ1   J3JTY4   A0A1W4X676   D6WQQ5   K7JA95   A0A0J7KY16   A0A026WJ25   A0A2A3EMM9   A0A088ADJ6   A0A067RH23   A0A1B6KJ82   A0A158NYD5   A0A1B6F9X3   A0A195AYE1   A0A2S2PVG4   A0A151WJ12   A0A151JRJ4   E2BRK4   A0A151IN50   A0A154PC50   A0A2S2PD67   A0A2H8TPR3   C4WVV2   E0W0E9   A0A1L8DX00   A0A1W4VCE7   B4LPW2   B4KQZ2   A0A3B0J522   Q291G9   B4GAR3   B4P7Z5   A0A0M5IXC9   B3MG72   B4NNF3   B4J925   B3NNR1   B4QAU0   B4HMM0   Q7KMS3   A0A0K8TPR0   A0A1B0GJT0   A0A1I8PM73   A0A1L8EGK4   A0A1I8MN78   T1D5K7   A0A1Q3FIA4   B0W4E5   Q17AA0   A0A023ECK0   U5EKI8   A0A1Y2HZV2   A0A3B0JPV3   T1DQJ3   A0A2M3ZIQ8   A0A2M4AQW6   A0A182MI57   A0A182PCW5   A0A182V2N0   W5JFP9   A0A182K785   A0A182VYA3   A0A182XKC0   Q5TSL8   A0A182HJM2   D3TRW5   A0A182QHH1   A0A1Y2ECB2   A0A224Y1Q6   A0A0V0G8H2   A0A069DNV8   I3MWU1   A0A2K6KE40   A0A2K6PVH6   A0A1Y2ATV3   A0A3P9AMS4   A0A0L0RWQ7   A0A023FAQ0   A0A182XWL5   A0A182RFX8   M3W1J3   A0A139AX07   A0A0P4VTR1   R4FMK9   F7B1T3   W5LEA2   A0A0L7RGT0   F4WSY8   A0A195F756   E2AZ45   A0A1S3KPY1   C1BGV4   D4A0A0   E2RQD9  

Pubmed

19121390    26354079    22118469    26227816    22516182    23537049    + More
18362917    19820115    20075255    24508170    30249741    24845553    21347285    20798317    20566863    17994087    15632085    17550304    22936249    10402468    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    26369729    25315136    24330624    17510324    24945155    20920257    23761445    12364791    14747013    17210077    20353571    26334808    25362486    25069045    25474469    25244985    17975172    25977457    27129103    19892987    25329095    21719571    15057822    15632090    16341006   

EMBL

BABH01016863    KQ459193    KPJ03155.1    KQ459941    KPJ19144.1    NWSH01004564    + More
PCG64921.1    AGBW02010685    OWR48046.1    ODYU01005946    SOQ47365.1    JTDY01000233    KOB78144.1    APGK01054226    BT126694    KB741248    KB632305    AEE61656.1    ENN71942.1    ERL91859.1    KQ971354    EFA07590.1    AAZX01013217    AAZX01014215    LBMM01001988    KMQ95442.1    KK107178    QOIP01000006    EZA56047.1    RLU21236.1    KZ288206    PBC33063.1    KK852686    KDR18463.1    GEBQ01028481    JAT11496.1    ADTU01003759    GECZ01022743    JAS47026.1    KQ976701    KYM77216.1    GGMS01000325    MBY69528.1    KQ983055    KYQ47814.1    KQ978607    KYN29914.1    GL449965    EFN81696.1    KQ976963    KYN06777.1    KQ434864    KZC09004.1    GGMR01014784    MBY27403.1    GFXV01000619    GFXV01003827    MBW12424.1    MBW15632.1    ABLF02022556    AK341692    BAH72022.1    DS235858    EEB19105.1    GFDF01003101    JAV10983.1    CH940648    EDW61302.1    CH933808    EDW10348.2    OUUW01000001    SPP74682.1    CM000071    EAL25143.1    CH479181    EDW32015.1    CM000158    EDW92150.1    CP012524    ALC41081.1    CH902619    EDV36767.1    CH964282    EDW85892.1    CH916367    EDW01374.1    CH954179    EDV55618.2    CM000362    CM002911    EDX07491.1    KMY94544.1    CH480816    CH481394    EDW48288.1    EDW54727.1    AF141920    AF141921    AE013599    AY071587    KX532053    AAD45987.1    AAF57861.1    AAL49209.1    ANY27863.1    GDAI01001485    JAI16118.1    AJWK01022211    GFDG01000949    JAV17850.1    GALA01000463    JAA94389.1    GFDL01007812    JAV27233.1    DS231836    EDS33230.1    CH477337    EAT43191.1    GAPW01006516    GAPW01006515    GEHC01000027    JAC07082.1    JAV47618.1    GANO01001797    JAB58074.1    MCFL01000003    ORZ40135.1    SPP74681.1    GAMD01002449    JAA99141.1    GGFM01007638    MBW28389.1    GGFK01009842    MBW43163.1    AXCM01006045    ADMH02001529    GGFL01004252    ETN62168.1    MBW68430.1    AAAB01008904    EAA09669.4    APCN01002188    EZ424167    ADD20443.1    AXCN02000300    MCOG01000045    ORY69208.1    GFTR01001474    JAW14952.1    GECL01001689    JAP04435.1    GBGD01003612    JAC85277.1    AGTP01010344    MCOG01000206    ORY26003.1    GG745328    GG745330    KNE54539.1    KNE56187.1    GBBI01000729    GEMB01001187    JAC17983.1    JAS01961.1    AANG04002512    KQ965733    KXS21239.1    GDKW01000570    JAI56025.1    ACPB03005914    GAHY01000948    JAA76562.1    KQ414596    KOC70038.1    GL888331    EGI62692.1    KQ981768    KYN36017.1    GL444080    EFN61303.1    BT073833    BT074039    BT074166    ACO08257.1    AABR07043941    AABR07043942    CH473972    EDL92633.1    AAEX03004043   

Proteomes

UP000005204    UP000053268    UP000053240    UP000218220    UP000007151    UP000037510    + More
UP000019118    UP000030742    UP000192223    UP000007266    UP000002358    UP000036403    UP000053097    UP000279307    UP000242457    UP000005203    UP000027135    UP000005205    UP000078540    UP000075809    UP000078492    UP000008237    UP000078542    UP000076502    UP000007819    UP000009046    UP000192221    UP000008792    UP000009192    UP000268350    UP000001819    UP000008744    UP000002282    UP000092553    UP000007801    UP000007798    UP000001070    UP000008711    UP000000304    UP000001292    UP000000803    UP000092461    UP000095300    UP000095301    UP000002320    UP000008820    UP000193411    UP000075883    UP000075885    UP000075903    UP000000673    UP000075881    UP000075920    UP000076407    UP000007062    UP000075840    UP000075886    UP000193920    UP000005215    UP000233180    UP000233200    UP000265140    UP000054350    UP000076408    UP000075900    UP000011712    UP000070544    UP000015103    UP000002281    UP000018467    UP000053825    UP000007755    UP000078541    UP000000311    UP000087266    UP000002494    UP000002254   

PRIDE

H9JMG2    Q7KMS3   

Pfam

PF03259   Robl_LC7        + More
PF00096   zf-C2H2

Interpro

IPR004942   Roadblock/LAMTOR2_dom        + More
IPR016561   DYNLRB1/2       
IPR013087   Znf_C2H2_type       
IPR036236   Znf_C2H2_sf       

SUPFAM

SSF57667   SSF57667       

ProteinModelPortal

H9JMG2   A0A194QDX9   A0A0N1IC30   A0A2A4IYT4   A0A212F2U0   A0A2H1W2P3   + More
A0A0L7LRZ1   J3JTY4   A0A1W4X676   D6WQQ5   K7JA95   A0A0J7KY16   A0A026WJ25   A0A2A3EMM9   A0A088ADJ6   A0A067RH23   A0A1B6KJ82   A0A158NYD5   A0A1B6F9X3   A0A195AYE1   A0A2S2PVG4   A0A151WJ12   A0A151JRJ4   E2BRK4   A0A151IN50   A0A154PC50   A0A2S2PD67   A0A2H8TPR3   C4WVV2   E0W0E9   A0A1L8DX00   A0A1W4VCE7   B4LPW2   B4KQZ2   A0A3B0J522   Q291G9   B4GAR3   B4P7Z5   A0A0M5IXC9   B3MG72   B4NNF3   B4J925   B3NNR1   B4QAU0   B4HMM0   Q7KMS3   A0A0K8TPR0   A0A1B0GJT0   A0A1I8PM73   A0A1L8EGK4   A0A1I8MN78   T1D5K7   A0A1Q3FIA4   B0W4E5   Q17AA0   A0A023ECK0   U5EKI8   A0A1Y2HZV2   A0A3B0JPV3   T1DQJ3   A0A2M3ZIQ8   A0A2M4AQW6   A0A182MI57   A0A182PCW5   A0A182V2N0   W5JFP9   A0A182K785   A0A182VYA3   A0A182XKC0   Q5TSL8   A0A182HJM2   D3TRW5   A0A182QHH1   A0A1Y2ECB2   A0A224Y1Q6   A0A0V0G8H2   A0A069DNV8   I3MWU1   A0A2K6KE40   A0A2K6PVH6   A0A1Y2ATV3   A0A3P9AMS4   A0A0L0RWQ7   A0A023FAQ0   A0A182XWL5   A0A182RFX8   M3W1J3   A0A139AX07   A0A0P4VTR1   R4FMK9   F7B1T3   W5LEA2   A0A0L7RGT0   F4WSY8   A0A195F756   E2AZ45   A0A1S3KPY1   C1BGV4   D4A0A0   E2RQD9  

PDB

3L9K     E-value=1.76042e-24,     Score=272

KEGG

101742280    K10419 dynein light chain roadblock-type | (RefSeq) dynein light chain roadblock-type 2-like

GO

GO:0005737   GO:0007018   GO:0005868   GO:0003774   GO:0005874   GO:0045505   GO:0003676   GO:0005813   GO:0005858   GO:0016319   GO:0048813   GO:0030286   GO:0042623   GO:0005875   GO:0005524   GO:0008026   GO:0030126   GO:0030117   GO:0006418   GO:0003707   GO:0006281   GO:0006259  

Subcellular location

  

Length:

97

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.48911

Exp number, first 60 AAs:

0.48874

Total prob of N-in:

0.48330

outside

1  -  97

 

 

Pi

217.086736

Theta

188.284286

Tajima's D

0.48139

CLR

6.914161

CSRT

0.503424828758562

Interpretation

Uncertain