Gene

KWMTBOMO15617  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010840

Annotation

MLE_protein_[Bombyx_mori]

Location

Bomo_Chr26(+):4276899-4301766      View in EpiBrowser

Full name

Dosage compensation regulator      

Alternative Name

ATP-dependent RNA helicase mle
Protein male-less
Protein maleless
Protein no action potential

Location in the cell

Nuclear   Reliability : 2.257

CDS

ATGGATATTAAATCATTTTTATATACTTGGTGTGCTAAGAAAGGCTTAACTCCGCTTTTCGATATCCGGGCCACAGGTCCTAAACACCGCCAACGCTTTCTGTGCGAAGTCCGCGTCGAAGGATTTTCATATTTAGGAGCTGGAAACTCTACTACCAAAAAAGATGCACAGATGAACGCCGCTAAGGACTTTGTTAGTTATCTAGTTAGAGCGGGGCAAATCCCACAGGCTGATGTTCCTGAAGATGTGAAGGCAAAGGCAATTGAGGAATCTACTAATGAAGAATCTGTCGAGAATAATGGTGGTCAACAACCTAAGCAAGTCTTTCAGGATGGAATGGGTCCAGAAGTTATAGGACCAGCGTACCAAGCTTATGGAGGTGAAAATGACAAGAAATTTTCATACATAGATCGCATGCAACAACAGAAAAATGTTGAAGAAGCTGAAGATCTGGACATAAACTCCAGTCTCCATGGCAACTGGACAATGGAGAATGCTAAGTCAAAACTTCATCAGTTTTTACAGATGAATAAAATAAATGCAGACTATGTTTACAAAGCAGTTGGACCTGATCATACACGGAGTTTCGCTTGTGAGCTAACAATATATGTGAGTCAATTGGGACGCAATGTCACCGGTCGGGAGACCGCCTCAAACAAGCAAACCGCCAGCAAGTCATGTGCACTGTCGATCGTGAGACAGCTATACCATCTTGGAGTCATTGAGGCATACAGCGGTACGCTAAAAAGGGACAGATCCTCAGAGGGTATTATGAAACCATATCCAGTTGCTATATGCCCGGAACTTGAACAACAATTAGAAGATACCTTACAAGAATTAGAAATCGAGCCAGTTAATGTCGACGCACCAAGCCAAGATAACCAAGAGGGGAGTGCTGTGACTCTGTTGCAAAAAGATCGCGCGAAGGCTATGAGAGAAGCGAAGCCTATGCCGGCTGGTGTTGTGACGTGGTCTCCTCCGCAGCCGAATTGGAACGCTTGGACAGGGTGTAACATCGACGAGGGCGCTTTAGCAACTGCCTCCATGGACGAGATTAGCGCTGACCTGGAGAAATGTCACAGGAATATTTGTCAGAATAGCAAATTGTACCAGGAAAGCCTCAATGAAAGAGAACATTTGCCGGTGTTCTCCATGAAATCACAGATAATGGAAGCGATCAACGAGAACCCTGTGATCATCATCCGTGGTAATACTGGCTGCGGTAAAACTACACAGGTGTGCCAGTTCATCCTCGACGACTACATAGCGAGCGGTCAGGGCGCGTGGGCCAACGTGTGCGTGACGCAACCGCGCCGAATCTCCGCCGTCAGTGTCGCCGAGCGCGTCGCGGCTGAGAGGTGCGAAGAGCTCGGGAACACCGTCGGGTATTCAGTGCGTTTCGAGTCAGTGCTACCGCGGCCTTATGGGTCAATCATGTTCTGTACCGTCGGGGTGCTGCTGAGGAAACTGGAAGGCGGTCTGAGGGGTGTCAGCCACGTTTTAGTCGACGAGGTACACGAACGCGATGCCGATACGGACTTTGCTCTGATCCTGCTGCGAGACATGGCCCACACCTACCCCGACCTGCGCATCATTCTGATGTCGGCCACGGTCGACACCACGCTATTCGTAAAGTACTTCGGAGGCTGTCCAGTCATTGAGGTGCCAGGTCGAACGTATCCAGTGACGCAGTACTTCTTGGAAGACTCGATAGAGCTGACCAAGTTCATGCCCCCGCCGATCACTAGGAAACGGAAATCTACAGGAAAACGAGCGAATAAAGACGACGAAGATGACGACGACGAGGATGATTTGGATGAGCCTTACGAAGATTTGAACAAGCAATGCAGCTTGGGAGACGGATACTCTCAAGCCACAGTGGACGCTTTACAACAGTTGTCCGAGAGAGATTTCAGCTTCGAGTTGGTCCAAGCGATCCTCATGTACATCGATGGACTGGGAGGCGACGGCGCTGTCCTCGTGTTCCTCCCCGGGTGGAACCTCATCTTCGCGCTGATGAAGCACCTGTTGCAGCACAGACTCTTTGGAGATCCATCAAAATACGTTATACTGCCTCTGCACAGTCAAATACCGAGGGAGGATCAAAAGAAAGTGTTCATTACCCCACCGGAAGGGATCACTAAAGTGATCCTGTCAACCAACATAGCGGAGACTTCGATAACCATCAACGACGTGGTATACGTCATCGACTCGTGCAAGGCGAAAATGAAGCTGTTCACGTCCCACAACAACATGACGTCATACGCCACCGTATGGGCGAGTAAGACCAACCTCGAACAGCGCAAGGGGCGTGCGGGGCGCGTGCGGCCCGGCGTGTGCTTCACGCTGTGCACGTACGCGCGCTACGAGAAACTTGAGGAACATTTGGCCGCCGAAATGTTTAGGACTCCGCTACACGAGCTTGCTTTGAGCATAAAGCTCCTCCGCCTGGGTGCGATCGGTCACTTCCTGTCGAAGGCCCCGGAGCCCCCGCCGCTGGACGCTGTCATCGAGGCGGAGGCTCTGCTCCGCGAGCTGGGCTGTCTGGACGCCGAGGACGCGCTCACGCCACTCGGGACCATCCTCGCCAAGCTGCCGATAGAACCTCGCCTCGGCAAAATGATGGTGTTAGGCTTTGTGCTTGGCGTTGGAGACGCCCTGACCACGATGGCGGCTAATTCTACAACGTTCCCGGAAATATTCGTGCTCGAAGGCCGGAGGAGACTGTCGATGCACCAGAGAGCCCTGGGCGGAGACCGGGCCTCCGACCACGTGGCCATGTTGAATGCATTCCAGATGTGGGAGAGAGAACACAACAAAGGCGAAGAGGCAGAGCTACGGTGGTGCGAATGGAAGGGCGTACAGCAGACCACGCTGCGTGTTACTTACGAGGCTAAACATCAATTGATAAATATCCTCACGACCGCAATAGGCTTCAACGAAGAATGCTGTGTTCCACAACGTTGGATGCCGAACGGACCGGACCCAACTTTGGACTTGGTCATAGCCCTCATGTGCATGGGCCTGTACCCTAACGTTTGTCTACACCAAGGGAAGAGGAAGGTATTAACGACGGAAGGGAAACCGGCATTGATACACAAGACCTCAGTGAACTGCAGCAACATGGAGCAGAAGTTCCCCTCGCCTCTGTTCGTTTTCGGCGAGAAGGTGCGCACCCGGGCCATCAGCTGCAAGCAGACCACCATGGTCGCTCCCATACATCTGCTGCTCTTCGGCTGTAACAAAGTGGAATGGGTGGACAACGTGGTGCGGCTGGACAACTGGCTGAACTTCCAGATGTCGCCGCGATCGGCCGCCCTCATCATAGCGCTGCGGCCCGCCATCGAGAGGATCGTGGAGCGCGCGGCGGCCCAACCCGACGCGGCGCTGCAGTTCTCGCCGGCAGAGCGAAAGGTGGTAGAATGTCTGCGGGAGCTTTGTGTGACGGACGCCGGTGACTACAACATAAAACGAGACGTCAACATGCCATCGTTCCGATCCGAAGGTCCAAAACGATCCATGAGAGGATGGGGAACTAACGGACCTCGAAGTGGTTTTGGTGGTGGAGGGACCACAGGCAGAGGCTTTACCCAAGGATTAGGAAACCAAGGTGCTTTCGGGACGCGCTTCGGAAATGGTGGTATCAGCACTCAAAGCAGTCAAGGCGGTTTTTGGAATCAAGGTGGCAACTTTGGCGGAAGAGGCGATTTTAATAGCGGCCGTGGAAGTTTTGGTAACCAAGGAAGCTATGGTAACCAAGGAAGCTATGGTAACCAAGGAAGCTATGGTAACCAAGGAAGCTTCGGTAACCAAGGTAGCTTTGGTAACCAAGGAAGCTTGGGTAACCATGGAAGCTTTGGTAGTTCTAGGGGATCCGGGTTCGGTAACAGAAATCAGGGAAACTCTAGTTGGACACAACGTTATTAA

Protein

MDIKSFLYTWCAKKGLTPLFDIRATGPKHRQRFLCEVRVEGFSYLGAGNSTTKKDAQMNAAKDFVSYLVRAGQIPQADVPEDVKAKAIEESTNEESVENNGGQQPKQVFQDGMGPEVIGPAYQAYGGENDKKFSYIDRMQQQKNVEEAEDLDINSSLHGNWTMENAKSKLHQFLQMNKINADYVYKAVGPDHTRSFACELTIYVSQLGRNVTGRETASNKQTASKSCALSIVRQLYHLGVIEAYSGTLKRDRSSEGIMKPYPVAICPELEQQLEDTLQELEIEPVNVDAPSQDNQEGSAVTLLQKDRAKAMREAKPMPAGVVTWSPPQPNWNAWTGCNIDEGALATASMDEISADLEKCHRNICQNSKLYQESLNEREHLPVFSMKSQIMEAINENPVIIIRGNTGCGKTTQVCQFILDDYIASGQGAWANVCVTQPRRISAVSVAERVAAERCEELGNTVGYSVRFESVLPRPYGSIMFCTVGVLLRKLEGGLRGVSHVLVDEVHERDADTDFALILLRDMAHTYPDLRIILMSATVDTTLFVKYFGGCPVIEVPGRTYPVTQYFLEDSIELTKFMPPPITRKRKSTGKRANKDDEDDDDEDDLDEPYEDLNKQCSLGDGYSQATVDALQQLSERDFSFELVQAILMYIDGLGGDGAVLVFLPGWNLIFALMKHLLQHRLFGDPSKYVILPLHSQIPREDQKKVFITPPEGITKVILSTNIAETSITINDVVYVIDSCKAKMKLFTSHNNMTSYATVWASKTNLEQRKGRAGRVRPGVCFTLCTYARYEKLEEHLAAEMFRTPLHELALSIKLLRLGAIGHFLSKAPEPPPLDAVIEAEALLRELGCLDAEDALTPLGTILAKLPIEPRLGKMMVLGFVLGVGDALTTMAANSTTFPEIFVLEGRRRLSMHQRALGGDRASDHVAMLNAFQMWEREHNKGEEAELRWCEWKGVQQTTLRVTYEAKHQLINILTTAIGFNEECCVPQRWMPNGPDPTLDLVIALMCMGLYPNVCLHQGKRKVLTTEGKPALIHKTSVNCSNMEQKFPSPLFVFGEKVRTRAISCKQTTMVAPIHLLLFGCNKVEWVDNVVRLDNWLNFQMSPRSAALIIALRPAIERIVERAAAQPDAALQFSPAERKVVECLRELCVTDAGDYNIKRDVNMPSFRSEGPKRSMRGWGTNGPRSGFGGGGTTGRGFTQGLGNQGAFGTRFGNGGISTQSSQGGFWNQGGNFGGRGDFNSGRGSFGNQGSYGNQGSYGNQGSYGNQGSFGNQGSFGNQGSLGNHGSFGSSRGSGFGNRNQGNSSWTQRY

Description

Required in males for dosage compensation of X chromosome linked genes. Mle, msl-1 and msl-3 are colocalized on X chromosome. Each of the msl proteins requires all the other msls for wild-type X-chromosome binding. Probably unwinds double-stranded DNA and RNA in a 3' to 5' direction.

Catalytic Activity

ATP + H2O = ADP + H(+) + phosphate

Subunit

Interacts with Top2.

Similarity

Belongs to the DEAD box helicase family. DEAH subfamily.

Keywords

3D-structure   Alternative splicing   ATP-binding   Chromosome   Complete proteome   Helicase   Hydrolase   Nucleotide-binding   Nucleus   Reference proteome   Repeat  

Feature

chain  Dosage compensation regulator
splice variant  In isoform B.

Uniprot

A5JPM0   H9JMT7   A0A194PL29   A0A0E3T0T7   A0A1W4XQL2   A0A2P8Y1S8   + More
A0A0N0U6F1   E2AJX4   A0A1Y1MYC3   A0A154PBM7   D6WEI4   A0A195FJ67   A0A195E515   A0A067REK5   A0A026WEH8   A0A195BT45   A0A158P2N2   A0A0L7R9U8   A0A310SAZ9   A0A0C9RMC0   A0A195D312   A0A151X2S4   E2C021   A0A2J7R184   A0A087ZRK5   A0A232F4E4   K7J0N6   A0A224X5G5   A0A023F369   A0A069DY95   F4W6K4   A0A2A3ENZ3   A0A1B6BXD9   A0A146LDN6   U5EXL1   A0A0L0CKH7   T1PI79   O77403   A0A336M9P6   A0A1I8MSX9   A0A1I8P1P2   A0A0K8V382   U4UXZ4   E0W3Q0   W8BUA8   A0A1J1ILZ8   A0A0A1X440   N6UDI4   A0A1A9ZS37   A0A1B0FDM8   A0A1A9WLJ1   A0A1A9V464   A0A182GDT3   A0A3R5WVZ0   B3N3H1   B3STH3   B3STH0   B3STG2   B3STG6   P24785   B3STG3   B3STH6   B3STI2   B3STG7   B4QCQ3   B3STI1   B3STG9   B3STH2   B3STG5   A0A182WBR6   B3STH7   B3STH8   B3STH9   A0A182VNR7   A0A182M585   B4II22   B3STG4   A0A182UEC7   B3STI0   B3STI3   Q7Q577   A0A182X4I0   B4NYW3   A0A3B0J7F0   A0A182I4H7   A0A182R947   A0A182QSZ8   A0A182Y2K8   A0A182NIA7   Q28YQ6   A0A182JYZ5   A8ILB3   B4GJ01   B3MJ84   A0A087TNK7   B4MDY4   A0A1W4V2D0   A8IL99   A0A1A9YEF3   A0A182JE01  

EC Number

3.6.4.13

Pubmed

19121390    26354079    29403074    20798317    28004739    18362917    + More
19820115    24845553    24508170    21347285    28648823    20075255    25474469    26334808    21719571    26823975    26108605    11102379    25315136    23537049    20566863    24495485    25830018    26483478    17994087    1653648    10731132    12537572    23989663    22936249    12364791    17550304    25244985    15632085    18039888   

EMBL

EF554693    ABQ51917.1    BABH01016861    BABH01016862    BABH01016863    KQ459601    + More
KPI93703.1    KP236739    AKB96195.1    PYGN01001041    PSN38206.1    KQ435742    KOX76701.1    GL440100    EFN66290.1    GEZM01017457    JAV90663.1    KQ434869    KZC09251.1    KQ971318    EFA00345.2    KQ981523    KYN40307.1    KQ979657    KYN19949.1    KK852517    KDR22182.1    KK107250    EZA54348.1    KQ976408    KYM91133.1    ADTU01007051    KQ414625    KOC67531.1    KQ762031    OAD56377.1    GBYB01009460    JAG79227.1    KQ976885    KYN07300.1    KQ982580    KYQ54504.1    GL451712    EFN78717.1    NEVH01008213    PNF34584.1    NNAY01001035    OXU25399.1    GFTR01008689    JAW07737.1    GBBI01003111    JAC15601.1    GBGD01000152    JAC88737.1    GL887707    EGI70339.1    KZ288202    PBC33485.1    GEDC01031628    JAS05670.1    GDHC01012880    JAQ05749.1    GANO01002490    JAB57381.1    JRES01000534    JRES01000356    KNC30377.1    KNC31969.1    KA647845    AFP62474.1    Y18119    CAA77038.1    UFQT01000602    SSX25629.1    GDHF01019259    JAI33055.1    KB632411    ERL95241.1    DS235882    EEB20256.1    GAMC01003773    JAC02783.1    CVRI01000054    CRL00094.1    GBXI01008859    JAD05433.1    APGK01032721    APGK01032722    KB740848    ENN78686.1    CCAG010004130    JXUM01016703    MG708324    QAB02864.1    CH954177    EDV59853.1    EF682050    ABV48872.1    EF682047    EF682048    EF682051    ABV48869.1    ABV48870.1    ABV48873.1    EF682039    ABV48861.1    EF682043    EF682045    EF682052    JQ663522    ABV48865.1    ABV48867.1    ABV48874.1    AFI26242.1    M74121    AE013599    BT003785    BT010267    EF682040    ABV48862.1    EF682053    ABV48875.1    EF682059    ABV48881.1    EF682044    ABV48866.1    CM000362    CM002911    EDX05842.1    KMY91671.1    EF682058    ABV48880.1    EF682046    ABV48868.1    EF682049    ABV48871.1    EF682042    ABV48864.1    EF682054    ABV48876.1    EF682055    ABV48877.1    EF682056    ABV48878.1    AXCM01000119    CH480841    EDW49548.1    EF682041    ABV48863.1    EF682057    ABV48879.1    EF682060    ABV48882.1    AAAB01008960    EAA11305.4    CM000157    EDW89814.1    OUUW01000001    SPP75832.1    APCN01002313    AXCN02000879    CM000071    EAL25909.2    EU167133    ABV82525.1    CH479183    EDW36419.1    CH902619    EDV38178.1    KK116061    KFM66696.1    CH940662    EDW58749.2    EU167129    ABV82521.1   

Proteomes

UP000005204    UP000053268    UP000192223    UP000245037    UP000053105    UP000000311    + More
UP000076502    UP000007266    UP000078541    UP000078492    UP000027135    UP000053097    UP000078540    UP000005205    UP000053825    UP000078542    UP000075809    UP000008237    UP000235965    UP000005203    UP000215335    UP000002358    UP000007755    UP000242457    UP000037069    UP000095301    UP000095300    UP000030742    UP000009046    UP000183832    UP000019118    UP000092445    UP000092444    UP000091820    UP000078200    UP000069940    UP000008711    UP000000803    UP000000304    UP000075920    UP000075903    UP000075883    UP000001292    UP000075902    UP000007062    UP000076407    UP000002282    UP000268350    UP000075840    UP000075900    UP000075886    UP000076408    UP000075884    UP000001819    UP000075881    UP000008744    UP000007801    UP000054359    UP000008792    UP000192221    UP000092443    UP000075880   

PRIDE

A5JPM0    H9JMT7    B3STG2    P24785    B3STH2   

Pfam

PF07717   OB_NTP_bind        + More
PF04408   HA2
PF00271   Helicase_C
PF00035   dsrm
PF00270   DEAD
PF13967   RSN1_TM
PF02714   RSN1_7TM
PF14703   PHM7_cyt

Interpro

IPR027417   P-loop_NTPase        + More
IPR002464   DNA/RNA_helicase_DEAH_CS       
IPR007502   Helicase-assoc_dom       
IPR014001   Helicase_ATP-bd       
IPR001650   Helicase_C       
IPR014720   dsRBD_dom       
IPR011709   DUF1605       
IPR011545   DEAD/DEAH_box_helicase_dom       
IPR003864   RSN1_7TM       
IPR032880   Csc1_N       
IPR027815   PHM7_cyt       

SUPFAM

SSF52540   SSF52540       

CDD

cd00048  DSRM
cd00079  HELICc

ProteinModelPortal

A5JPM0   H9JMT7   A0A194PL29   A0A0E3T0T7   A0A1W4XQL2   A0A2P8Y1S8   + More
A0A0N0U6F1   E2AJX4   A0A1Y1MYC3   A0A154PBM7   D6WEI4   A0A195FJ67   A0A195E515   A0A067REK5   A0A026WEH8   A0A195BT45   A0A158P2N2   A0A0L7R9U8   A0A310SAZ9   A0A0C9RMC0   A0A195D312   A0A151X2S4   E2C021   A0A2J7R184   A0A087ZRK5   A0A232F4E4   K7J0N6   A0A224X5G5   A0A023F369   A0A069DY95   F4W6K4   A0A2A3ENZ3   A0A1B6BXD9   A0A146LDN6   U5EXL1   A0A0L0CKH7   T1PI79   O77403   A0A336M9P6   A0A1I8MSX9   A0A1I8P1P2   A0A0K8V382   U4UXZ4   E0W3Q0   W8BUA8   A0A1J1ILZ8   A0A0A1X440   N6UDI4   A0A1A9ZS37   A0A1B0FDM8   A0A1A9WLJ1   A0A1A9V464   A0A182GDT3   A0A3R5WVZ0   B3N3H1   B3STH3   B3STH0   B3STG2   B3STG6   P24785   B3STG3   B3STH6   B3STI2   B3STG7   B4QCQ3   B3STI1   B3STG9   B3STH2   B3STG5   A0A182WBR6   B3STH7   B3STH8   B3STH9   A0A182VNR7   A0A182M585   B4II22   B3STG4   A0A182UEC7   B3STI0   B3STI3   Q7Q577   A0A182X4I0   B4NYW3   A0A3B0J7F0   A0A182I4H7   A0A182R947   A0A182QSZ8   A0A182Y2K8   A0A182NIA7   Q28YQ6   A0A182JYZ5   A8ILB3   B4GJ01   B3MJ84   A0A087TNK7   B4MDY4   A0A1W4V2D0   A8IL99   A0A1A9YEF3   A0A182JE01  

PDB

5AOR     E-value=0,     Score=3437

KEGG

100101216    K13184 ATP-dependent RNA helicase A [EC:3.6.4.13] | (RefSeq) MLE; MLE protein

GO

GO:0005524   GO:0004386   GO:0003723   GO:0050684   GO:1990904   GO:0045944   GO:0043140   GO:0005634   GO:0005730   GO:0004003   GO:0034459   GO:0016021   GO:0016787   GO:0007549   GO:0072487   GO:0048675   GO:0000785   GO:0016887   GO:0031453   GO:0005829   GO:0008340   GO:0001069   GO:0003682   GO:0005700   GO:0000228   GO:0000805   GO:0045433   GO:0003690   GO:0032508   GO:2000765   GO:0005694   GO:0009047   GO:0016456   GO:0016457   GO:2000373   GO:0003724   GO:0008026   GO:0003725   GO:0003676   GO:0030126   GO:0030117   GO:0006418   GO:0003707   GO:0006281   GO:0006259  

Subcellular location

Nucleus  
Chromosome  

Length:

1308

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.19370000000001

Exp number, first 60 AAs:

0.00192

Total prob of N-in:

0.00040

outside

1  -  1308

 

 

Pi

232.504595

Theta

196.718611

Tajima's D

0.963932

CLR

0.08586

CSRT

0.653917304134793

Interpretation

Uncertain