SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO15604
Pre Gene Modal
BGIBMGA010836
Annotation
PREDICTED:_phosphatidylinositide_phosphatase_SAC2_isoform_X2_[Bombyx_mori]
Full name
Phosphatidylinositide phosphatase SAC2      
Alternative Name
Inositol polyphosphate 5-phosphatase F
Sac domain-containing inositol phosphatase 2
Sac domain-containing phosphoinositide 4-phosphatase 2
Location in the cell
Nuclear   Reliability : 3.457
 

Sequence

CDS
ATGGAATTATTTCGTTCGGAACTCTATTACATTTTCGTCAGAAATGAGTCAAGTTTGTGGTGGAACAGATTATCGGGGGCTTTTTCTGTGCGATCAGCCTGGGACATGTCTGACATAGAAGATATAGAATGCCTCGGTATAACTGAAGGTATTATTGGAAAGGTCGAGCATTCCAATATATTCGAACCCCGCTTAATGATAATCAAAGAAAGTGCTCCCGTCGGCAACATATACTTTCATCACACCATTCATAAAGTAAAATCAATATGTTTTTTAAACATGGGCATAGCAAACCAAGAACTTGAACTGTGTCCTTGCACTAAACATGGCTCTTCCACATCTGTGCTGAGTTCTAATAAAAAAATAGGCAGTCGTCTGTTTGAAAATTCAGCATTTTTGAATAAAACTGTTGGAGCTGTAAAGAATGTAAGCAACACTATTAAAACAACTACACAGCAAGCAGCTACACAGGTGAAACAAACAGTAAAAAAGCAAAGAGATCCTAAAGTGGCAGAACGTTTTGAGAAGCGGCTCACGGATGAATTGCATAAAATCTTCGATGATTCACACAACTTTTATTATTCGAGAACATTGGACTTGACAAACAGCCTCCAAAGACAATATGAGATAGAAAAGATGTTGGAAACTGAAGAAGGTACCGGACGACCGGTCACAGACATAACGAGATGGTGGAAACATGTTGATGATAGATTCTTCTGGAATAAACATATGTTGAAAGATATTATTGCACTTGGGAGTCCAGATTGTGATCAGTGGATATTGCCAATAATTCAAGGATTCGTACATCTGTCTCAAATAGCCGTGGATCCAGCTGATTCTAACCCATTGAACACGGAATCTCTCACAAACACGAGCACATGTGATGAAACATTTACTCTCGGTTTAATATCCAGACGGTCAAGATATCAAGCTGGGACTCGTTACAATCGACGCGGTATCGAACAAAGCGGAAAAGTGGCTAATTATGTTGAAACCGAGCAAATTGTGTCGATAATTTGTTCGGATAGCATCCACAGGGCTTCATTTGTACAGGTACGAGGTTCGGTTCCAATCTTCTGGAGCCAGCCTGAATACAAGTTTCGTCCGCCACCACGACTTGATAAAACCGAAGAGGAGTCCCATGCCGCCTTCAAGAAGCATTTCGAAGAACAACTGAACACTTACAAGCAAGTGTGCATAGTGAACTTAGTCGAGCAGCAGGGCAGAGAACGCGTGATATGGGAGGCGTACGGCAACCACGTCCTCAAATACGACAACCCTAATCTCATATATGCGACCTTTGACTTCCACGAGTACTGCCGCGGTATGCACTACGAAAACGTGAGCATCCTCATCAACGCAATAGCGGACATAATAACCGACATGCGTTTCTGTTGGCGTGACGACCGCGGCGTTATATGCACGCAGAACGGCGTCTTCAGAGTCAACTGCATCGATTGTCTGGATAGAACGAACGTCGTACAAACTGCTATCGCTAAATACGTGTTGGAGTTGCAACTGTGCCGGCTGGGGTTGGGCACGCCTGGCTGTGGTCTGCCGCCGCCGCTTCAGAGGGCGTTCCTCACCATGTGGGCGGACAACGGCGATGTCGTGTCGAGGCAATACGCCGGAACGAAGGCCCTCAAGGGGGACTACACACGTACAGGCGAACGAAAGATCACGGGAATGATGAAGGACGGCGTTGCATCAGCAAATCGATATTATTTGTCAACTTTCAAGGATGCGCTGCGTCAAGTGGCCATAGACGTAATGACGGGCGAATCGAAAACGATACCGGAACAACTGATCGTGCCGGACTGCAGCCGATGCACTTCCGTTAAGGATCAAGCTGCCCCGGACACCGCTGCGATGGCGCAACACGTCAAGTCCCTAATCGACGACTGCAAGAAAATGTTGGTCGATACAGAACCGATACTTGGATCGTGGGGTCTGATCGACGCGGATCCACACACGGGCGATCCCCACGAAACGGAAATGGATAGCGTATTAGTTCTGACTAGTGAAGCCTACTACGTGGCGGACTACGACGAGACGTCGGACAGGCTGCTGTCCGTGCAGAGGGTGCCGCTGCGTGACGTCATCTCCATAGAGCTGGGAACGTTCGACGCAAGTTCCACTATTTTCGGCGTCGGTCGCAAGTCAAATTCGGAGACGGTATACTGCATGCGCATCAATTACAGTTACAACGGCGATAGTGGATACTTCCACATGTTCAGGTCGACCTCGCTTCGGTTCTTCAACAACATGGCGGTCGCAATCAACACCAGAGACGAGATGATAGAATCGCTGCACTCCATATGCGAATCCATGGTGGTGGCCCGTGAGGTCGCCAAGCTGCCGCCGATACCCTTCCACGATGGCATCAAATTGGAAAAGAGGAAATCGAAGGTACATCCGAATCACACTCAAGCCGGGGGAGCCCGTGCGTCTCCTTACCTGGACCTCTCTCGTCTGCCGACCCTCACCAGGAACGTCAGCGAGACGCAACTGGTGGCCGACATTCGGAGCGTCGGATCGAAGGCGTTCAACAACATGACGGAACAGTTCAGCAAACTAAACAAACTCAGTCACTCTCTGAACGCCAGAGCTAGACCGAGCCTCCAGCTAAAGTTCGACCAGAACACGACGAAAACGAAAAAATTATTCACGTTAGGTCAAAACAAAAGCGACAACAAGAAGAAGGGCAGCCTATCGGACGGCATGAGCTCCGATTACTCGTCGGACGATGAAAACCGGACCAACATATTCGAGCCGACCCTGGACAACTTCGAGAACACGCAGCACTACATCGGGAAACCGAACAGTTCGGGAAACGAAAACGACTGCGAACTTATCGAGAATCCACTGTATTCATCGAAAATCGAACCAAACGACAACCAAGAAGTCTTCATCGCGAATGAAACACCGCCCGCCGTCAACTTGCCGAAAACGCCGACTAATATCGGCAAAGTAAACCCGTTCAATTCGGAGAGGGCGCCCGAAATACAAATCGAGACGGAAGGTTCCGGAAAACCGGCACCACCGAACTCTCTGATGCTCTCGCAGAAGCTGTCCCACAGCTCGAACGATGTCAATTATGGGGAGAGCGATGGGGTCAATTACCACGTGAGGTCGAACTCCCAGCACGAGATCGTGCTGAATATCGCATCGTCCCACAGCGAGTCCGCTTTGAGGCACCTCAACTATATCTCCAGTCCAGTTTCCAGCACCAGCACGACCAAAGACCTGGTGCTTTCGCCCTTAACGAAGCTGGCTAAAGGAGTACAAAATCTTGGTGCTAATTTAGATCCGAGGAAGATAAAGGGTTCAGCGGCAGTTAAGCATGTAACGGAACAACAGTATGTCGAACATAGGAAGTTGCAGGAGAAATGGCGCGACTGTAACACCAGACTCGTTGCGTTGTAA
Protein
MELFRSELYYIFVRNESSLWWNRLSGAFSVRSAWDMSDIEDIECLGITEGIIGKVEHSNIFEPRLMIIKESAPVGNIYFHHTIHKVKSICFLNMGIANQELELCPCTKHGSSTSVLSSNKKIGSRLFENSAFLNKTVGAVKNVSNTIKTTTQQAATQVKQTVKKQRDPKVAERFEKRLTDELHKIFDDSHNFYYSRTLDLTNSLQRQYEIEKMLETEEGTGRPVTDITRWWKHVDDRFFWNKHMLKDIIALGSPDCDQWILPIIQGFVHLSQIAVDPADSNPLNTESLTNTSTCDETFTLGLISRRSRYQAGTRYNRRGIEQSGKVANYVETEQIVSIICSDSIHRASFVQVRGSVPIFWSQPEYKFRPPPRLDKTEEESHAAFKKHFEEQLNTYKQVCIVNLVEQQGRERVIWEAYGNHVLKYDNPNLIYATFDFHEYCRGMHYENVSILINAIADIITDMRFCWRDDRGVICTQNGVFRVNCIDCLDRTNVVQTAIAKYVLELQLCRLGLGTPGCGLPPPLQRAFLTMWADNGDVVSRQYAGTKALKGDYTRTGERKITGMMKDGVASANRYYLSTFKDALRQVAIDVMTGESKTIPEQLIVPDCSRCTSVKDQAAPDTAAMAQHVKSLIDDCKKMLVDTEPILGSWGLIDADPHTGDPHETEMDSVLVLTSEAYYVADYDETSDRLLSVQRVPLRDVISIELGTFDASSTIFGVGRKSNSETVYCMRINYSYNGDSGYFHMFRSTSLRFFNNMAVAINTRDEMIESLHSICESMVVAREVAKLPPIPFHDGIKLEKRKSKVHPNHTQAGGARASPYLDLSRLPTLTRNVSETQLVADIRSVGSKAFNNMTEQFSKLNKLSHSLNARARPSLQLKFDQNTTKTKKLFTLGQNKSDNKKKGSLSDGMSSDYSSDDENRTNIFEPTLDNFENTQHYIGKPNSSGNENDCELIENPLYSSKIEPNDNQEVFIANETPPAVNLPKTPTNIGKVNPFNSERAPEIQIETEGSGKPAPPNSLMLSQKLSHSSNDVNYGESDGVNYHVRSNSQHEIVLNIASSHSESALRHLNYISSPVSSTSTTKDLVLSPLTKLAKGVQNLGANLDPRKIKGSAAVKHVTEQQYVEHRKLQEKWRDCNTRLVAL

Summary

Description
Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling.
Catalytic Activity
a myo-inositol phosphate + H2O = myo-inositol + phosphate
Keywords
Coated pit   Complete proteome   Endosome   Hydrolase   Membrane   Reference proteome  
Feature
chain  Phosphatidylinositide phosphatase SAC2
EC Number
3.1.3.25
EMBL
NWSH01001646    PCG70578.1    AGBW02011486    OWR46571.1    KQ459875    KPJ19614.1    + More
GEZM01030106    JAV85803.1    KQ760549    OAD59920.1    GBYB01014482    JAG84249.1    KK852660    KDR19126.1    DS235231    EEB13673.1    GAMC01009808    JAB96747.1    UFQT01000610    SSX25709.1    CH478175    EAT33690.1    GAKP01013663    JAC45289.1    GEDC01028429    JAS08869.1    CH940650    KRF83573.1    GEFM01000359    JAP75437.1    GDHC01010499    JAQ08130.1    GANP01002767    JAB81701.1    CH933806    KRG01537.1    GDHF01031455    JAI20859.1    ATLV01015187    KE525003    KFB40168.1    GFDL01010309    JAV24736.1    DS232072    EDS33914.1    AE014297    ACZ94971.1    GAMC01009807    JAB96748.1    AAAB01008846    EAA06429.4    GBBI01004450    JAC14262.1    GBXI01008418    JAD05874.1    GBXI01001030    JAD13262.1    CH964251    KRF99757.1    ADMH02000018    ETN68075.1    CM000160    KRK03049.1    GFTR01008399    JAW08027.1    AAX52970.3    OUUW01000005    SPP80679.1    BT044234    AAF55899.2    ACH92299.1    AY119613    AAM50267.1    GBXI01006772    JAD07520.1    GANP01002766    JAB81702.1    GBXI01002218    JAD12074.1    CM000364    EDX12073.1    CM000070    EIM52510.1    GFPF01012163    MAA23309.1    GAKP01013664    JAC45288.1    GDHF01024766    JAI27548.1    GEDV01006785    JAP81772.1    CH902617    EDV43664.2    GGFK01004096    MBW37417.1    GDRN01063020    JAI65019.1    LJIG01009806    KRT82343.1    GL732660    EFX68224.1    GDIP01051236    LRGB01002190    JAM52479.1    KZS08589.1    GDIQ01214331    JAK37394.1    CAEY01002009    GDIQ01039794    JAN54943.1    GDIQ01171447    JAK80278.1    GDIQ01101082    JAL50644.1    GDIQ01226982    JAK24743.1    GDIQ01183292    JAK68433.1    GDIQ01005319    JAN89418.1    MUZQ01000180    OWK55979.1    RJVU01026577    ROL49564.1    AADN05000306    ABQF01046771    BX005252    BX530079    GFFV01000584    JAV39361.1   
Pfam
PF02383   Syja_N        + More
PF12456   hSac2
Interpro
IPR034753   hSac2        + More
IPR022158   Inositol_phosphatase       
IPR002013   SAC_dom       
PDB
4TU3     E-value=3.41362e-64,     Score=626

Ontologies

Topology

Subcellular location
Membrane   Also found on macropinosomes.   With evidence from 1 publications.
Clathrin-coated pit   Also found on macropinosomes.   With evidence from 1 publications.
Early endosome   Also found on macropinosomes.   With evidence from 1 publications.
Recycling endosome   Also found on macropinosomes.   With evidence from 1 publications.
Length:
1141
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.000460000000000001
Exp number, first 60 AAs:
0.00016
Total prob of N-in:
0.00002
outside
1  -  1141
 
 

Population Genetic Test Statistics

Pi
28.720354
Theta
27.35354
Tajima's D
-1.874485
CLR
1.596886
CSRT
0.0223988800559972
Interpretation
Possibly Positive selection
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