Gene

KWMTBOMO15571

Pre Gene Modal

BGIBMGA010730

Annotation

PREDICTED:_facilitated_trehalose_transporter_Tret1-like_[Bombyx_mori]

Location

Bomo_Chr26(-):2964835-2969114      View in EpiBrowser

Full name

Facilitated trehalose transporter Tret1-2 homolog       + More
Facilitated trehalose transporter Tret1      

Location in the cell

PlasmaMembrane   Reliability : 4.973

CDS

ATGTCGGAGAGATTACGTTGTTTGATCGGCTTCTGTTTGGGTCCGTACCTCTCCTACCTCCAGTTTGGATTCGTGCCTATAATTTTAATAATAATATTCATTGCGCTCAGCTTCTTCTTGAACGAATCTCCAGTGTATTTTGTTATTAAGGGCGACGAAGAATCAGCCAAAAAGGCTCTAAATTACTTTGGTCGCAGCAAAGATGTAAATTACGAACTGAAAATTATGCTTCAAAATGCAAAAGAGAACGCACAAGGAAAAAGGAAATGGCTTGAACTGTTTCAGAGGAGTAACAGAAGAGCACTCCTGATTATTATTCCATTATATATAATCGAACAAGCAAGCGGTGTTATAGCTGTTATATTAAATGCAACAGCAATTTTCAAATTAGCCGGCTCATCAGTTGAACCGGCAGTTGCGACCATGATAGTTGGCGTTACTAATCTGACGGGAAGCTTAATCTCGCCATTTGTCGTGGATAGGTATGGAAGGAAGGTGCTTTTGTTGTTTTCAGCAGGAGGGTGCTGTCTGGCAATGACTGCTTTAGGAACTTATTTTTATTTTCGACAAATGTTTCCGGAGTCTGTTGGATCCCTGGGCTGGTTACCGCTTACTGCTTTAGTTGCAGCTCTGTTTACGTACAGCGTTGGTCTGACAATAATACCACACGCTCTAGCAGGGGAAATGTTTAGTCCGAAAATGCGTGGGCTAGGCACCTCTCTAGGTTTGACAGTCGCCAATGGCTCCGGTCTGATAACCACCAGCATTTATTCTTACCTAGCAGTAAACGTCGGCATCCATTACGCTTTCTGGATGTTCGCTGTCTTTGACTTGGTTGGCGTCATCTTCACCATCTATGTCGTGCCGGAGACCAAAGGAAAAAGCTTATCTGACATTAACGCTATGCTAGCAAAATAA

Protein

MSERLRCLIGFCLGPYLSYLQFGFVPIILIIIFIALSFFLNESPVYFVIKGDEESAKKALNYFGRSKDVNYELKIMLQNAKENAQGKRKWLELFQRSNRRALLIIIPLYIIEQASGVIAVILNATAIFKLAGSSVEPAVATMIVGVTNLTGSLISPFVVDRYGRKVLLLFSAGGCCLAMTALGTYFYFRQMFPESVGSLGWLPLTALVAALFTYSVGLTIIPHALAGEMFSPKMRGLGTSLGLTVANGSGLITTSIYSYLAVNVGIHYAFWMFAVFDLVGVIFTIYVVPETKGKSLSDINAMLAK

Description

Fails to transport trehalose.
High-capacity facilitative transporter for trehalose, required to induce anhydrobiosis. Anhydrobiotic larvae can survive almost complete dehydration. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph.
High-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph.
High-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph (By similarity).
Low-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph (By similarity).

Biophysicochemical Properties

114.5 mM for trehalose
45.74 mM for trehalose

Similarity

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.

Keywords

Cell membrane   Complete proteome   Glycoprotein   Membrane   Reference proteome   Transmembrane   Transmembrane helix   Stress response   Sugar transport   Transport   Alternative splicing   Phosphoprotein  

Feature

chain  Facilitated trehalose transporter Tret1-2 homolog
splice variant  In isoform B.

Uniprot

A0A0N0PFE7   A0A212FHD3   A0A0N0PFE6   A0A0N1PEX2   A0A212ELA9   A0A0L7LF84   + More
A0A2H1VYV7   A0A2W1BNG5   A0A2P8YD54   A0A0N0PFQ6   A0A1L8DFA9   A0A0J9RBH4   B4QBN3   A0A1L8DF29   A0A067RCA0   A0A182T6H7   A0A2H1V3K1   Q16SU5   A0A1L8DFC4   A0A2M4A4V5   A0A194R1W3   A0A2A4JZZ4   A0A194PW18   A0A2P8XWS8   A0A2H1WAI1   A0A1I8MXU6   A0A182NLP8   A0A2A4J788   A0A0P9BY82   W5JNP3   B4HNS1   A0A182GL69   A0A182GVZ1   A0A0R1DWD3   A0A182K5N6   A5LGM7   A0A084VDW1   A0A2M3YZE1   A0A2M4A3H1   A0A182T9M2   A0A182MM04   A0A2M4A537   T1DE67   T1DKQ7   A0A182KX77   A0NBZ0   A0A1Y9J057   A0A182FCI5   A0A182TSI6   A0A2M4BMJ9   Q8MKK4   A0A2M4A4U2   A0A1B0C869   D4AHX3   A0A182VIR9   A0A182J8U1   A0A194PK39   A0A2C9GQB0   A0A2M4BKT8   A0A1L8DF37   A0A1L8DF53   A0A182Y131   Q7PIR5-2   A0A182HLX0   A0A182TY80   A0A182X524   A0A182S579   S4P7H5   T1DG93   A0A1W4VCC4   A0A2M3ZF95   A0A336M0J9   A0A182RMH4   E0W471   A0A182MWR6   K7IP31   A0A182WKF0   A0A182GLX7   A0A182YLM9   A0A2M3ZFG5   A0A0R3NRR1   A0A2M4CVC5   W5J543   A0A1B0C868   U5EQL0   B0WC46   B3NSE1   A0A182QT48   A0A0Q9WFV5   A0A182VS58   B3MG58   A0A182HJZ0   A0A0K8W3N6   A0A182Q863   B4P624   A0A1Y9H2R2   W8B3Q4   A0A1L8DIL5   A0A2H1WAF6  

Pubmed

26354079    22118469    26227816    28756777    29403074    22936249    + More
17994087    24845553    17510324    25315136    20920257    23761445    26483478    17550304    17606922    20035867    24438588    24330624    20966253    12364791    14747013    17210077    10731132    12537572    12537569    20705135    25244985    23622113    20566863    20075255    15632085    24495485   

EMBL

LADJ01026996    KPJ21154.1    AGBW02008505    OWR53139.1    KPJ21151.1    KQ459078    + More
KPJ03807.1    AGBW02014089    OWR42276.1    JTDY01001327    KOB74188.1    ODYU01005306    SOQ46029.1    KZ150025    PZC74817.1    PYGN01000690    PSN42188.1    KPJ21152.1    GFDF01009044    JAV05040.1    CM002911    KMY93024.1    CM000362    EDX06650.1    GFDF01009043    JAV05041.1    KK852731    KDR17493.1    ODYU01000519    SOQ35423.1    CH477665    EAT37543.1    GFDF01009007    JAV05077.1    GGFK01002478    MBW35799.1    KQ460870    KPJ11682.1    NWSH01000363    PCG76972.1    KQ459589    KPI97522.1    PYGN01001230    PSN36458.1    ODYU01007368    SOQ50068.1    NWSH01002911    PCG67310.1    CH902619    KPU76395.1    ADMH02000542    ETN65997.1    CH480816    EDW47436.1    JXUM01071368    JXUM01071369    KQ562660    KXJ75378.1    JXUM01091981    JXUM01091982    KQ563956    KXJ73021.1    CM000158    KRJ99505.1    AB272983    BAF63703.1    ATLV01011809    KE524723    KFB36155.1    GGFM01000865    MBW21616.1    GGFK01002032    MBW35353.1    AXCM01000233    GGFK01002603    MBW35924.1    GALA01001167    JAA93685.1    GAMD01000836    JAB00755.1    AAAB01008820    EAA45316.3    EAA45318.1    EAA45319.1    EGK96331.1    GGFJ01004857    MBW53998.1    AB369551    AE013599    AY122079    AAM52591.1    AAM68715.1    BAF96745.1    GGFK01002450    MBW35771.1    AJWK01000224    AJWK01000225    AB550001    BAI83422.1    KQ459601    KPI93687.1    APCN01004269    GGFJ01004545    MBW53686.1    GFDF01009012    JAV05072.1    GFDF01009013    JAV05071.1    AAAB01008960    AB369548    BAF96742.1    EAA44045.3    GAIX01004609    JAA87951.1    GAMD01002846    JAA98744.1    GGFM01006410    MBW27161.1    UFQT01000389    SSX23856.1    DS235886    EEB20427.1    AXCM01005103    JXUM01001466    KQ560121    KXJ84364.1    GGFM01006409    MBW27160.1    CM000071    KRT01871.1    GGFL01004973    MBW69151.1    ADMH02002130    ETN58528.1    GANO01004191    JAB55680.1    DS231885    EDS43198.1    CH954179    EDV56443.1    AXCN02000090    CH940648    KRF79918.1    EDV36753.1    APCN01002224    GDHF01014137    GDHF01006620    JAI38177.1    JAI45694.1    AXCN02000985    EDW90899.1    GAMC01018654    JAB87901.1    GFDF01007792    JAV06292.1    SOQ50069.1   

Proteomes

UP000053240    UP000007151    UP000053268    UP000037510    UP000245037    UP000000304    + More
UP000027135    UP000075901    UP000008820    UP000218220    UP000095301    UP000075884    UP000007801    UP000000673    UP000001292    UP000069940    UP000249989    UP000002282    UP000075881    UP000030765    UP000075883    UP000075882    UP000007062    UP000076407    UP000069272    UP000075902    UP000000803    UP000092461    UP000075903    UP000075880    UP000075840    UP000076408    UP000075900    UP000192221    UP000009046    UP000002358    UP000075920    UP000001819    UP000002320    UP000008711    UP000075886    UP000008792   

PRIDE

Q8MKK4    Q7PIR5    B3NSE1    B3MG58    B4P624   

Pfam

PF00083   Sugar_tr

Interpro

IPR036259   MFS_trans_sf        + More
IPR005829   Sugar_transporter_CS       
IPR020846   MFS_dom       
IPR003663   Sugar/inositol_transpt       
IPR005828   MFS_sugar_transport-like       

SUPFAM

SSF103473   SSF103473       

CDD

cd06174  MFS

ProteinModelPortal

A0A0N0PFE7   A0A212FHD3   A0A0N0PFE6   A0A0N1PEX2   A0A212ELA9   A0A0L7LF84   + More
A0A2H1VYV7   A0A2W1BNG5   A0A2P8YD54   A0A0N0PFQ6   A0A1L8DFA9   A0A0J9RBH4   B4QBN3   A0A1L8DF29   A0A067RCA0   A0A182T6H7   A0A2H1V3K1   Q16SU5   A0A1L8DFC4   A0A2M4A4V5   A0A194R1W3   A0A2A4JZZ4   A0A194PW18   A0A2P8XWS8   A0A2H1WAI1   A0A1I8MXU6   A0A182NLP8   A0A2A4J788   A0A0P9BY82   W5JNP3   B4HNS1   A0A182GL69   A0A182GVZ1   A0A0R1DWD3   A0A182K5N6   A5LGM7   A0A084VDW1   A0A2M3YZE1   A0A2M4A3H1   A0A182T9M2   A0A182MM04   A0A2M4A537   T1DE67   T1DKQ7   A0A182KX77   A0NBZ0   A0A1Y9J057   A0A182FCI5   A0A182TSI6   A0A2M4BMJ9   Q8MKK4   A0A2M4A4U2   A0A1B0C869   D4AHX3   A0A182VIR9   A0A182J8U1   A0A194PK39   A0A2C9GQB0   A0A2M4BKT8   A0A1L8DF37   A0A1L8DF53   A0A182Y131   Q7PIR5-2   A0A182HLX0   A0A182TY80   A0A182X524   A0A182S579   S4P7H5   T1DG93   A0A1W4VCC4   A0A2M3ZF95   A0A336M0J9   A0A182RMH4   E0W471   A0A182MWR6   K7IP31   A0A182WKF0   A0A182GLX7   A0A182YLM9   A0A2M3ZFG5   A0A0R3NRR1   A0A2M4CVC5   W5J543   A0A1B0C868   U5EQL0   B0WC46   B3NSE1   A0A182QT48   A0A0Q9WFV5   A0A182VS58   B3MG58   A0A182HJZ0   A0A0K8W3N6   A0A182Q863   B4P624   A0A1Y9H2R2   W8B3Q4   A0A1L8DIL5   A0A2H1WAF6  

PDB

4YBQ     E-value=1.56893e-19,     Score=235

KEGG

101737464    no KO assigned | (RefSeq) facilitated trehalose transporter Tret1-like

GO

GO:0016021   GO:0022857   GO:0008643   GO:0005886   GO:0015771   GO:0015574   GO:0005887   GO:0005351   GO:0016020   GO:0032440   GO:0043565   GO:0032549   GO:0007165   GO:0006418   GO:0003707   GO:0006281   GO:0006259   GO:0055085  

Subcellular location

Cell membrane  

Length:

305

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

158.05241

Exp number, first 60 AAs:

23.52985

Total prob of N-in:

0.08685

POSSIBLE N-term signal

sequence

outside

1  -  17

TMhelix

18  -  40

inside

41  -  104

TMhelix

105  -  127

outside

128  -  136

TMhelix

137  -  159

inside

160  -  165

TMhelix

166  -  188

outside

189  -  202

TMhelix

203  -  225

inside

226  -  236

TMhelix

237  -  259

outside

260  -  268

TMhelix

269  -  288

inside

289  -  305

 

 

Pi

196.740787

Theta

167.292623

Tajima's D

0.598323

CLR

0.140831

CSRT

0.541772911354432

Interpretation

Uncertain