Gene

KWMTBOMO15569

Pre Gene Modal

BGIBMGA010732

Annotation

PREDICTED:_uncharacterized_protein_LOC106116160_[Papilio_xuthus]

Location

Bomo_Chr26(-):2940836-2949804      View in EpiBrowser

Full name

Spermatogenesis-defective protein 39 homolog      

Alternative Name

VPS33B-interacting protein in apical-basolateral polarity regulator
VPS33B-interacting protein in polarity and apical restriction

Location in the cell

Extracellular   Reliability : 1.645

CDS

ATGGATGATGACGATTATTGGAATACGAGTGACACTAAAGCGAAAGCATTCAGCTTTGACGATGATGTGTTATCTCCGCAAGAGATCTTGGCTATTGGGCAGAAAACATATCCCGGACAGAAGGAAGAGAGCATTTTCAGTTCGAGCAGTATTAGTACGGTGAAGGTTGCTCAGATTCCATTAATGAGTTTAGTTACACCCAAAGTTTTAGATTTGATTCTTTTAGCACAATCAGGGAAAGATCCAGCCCAAGAACAGAGTCAAGAATCTCCAGAGACCGTGGCAGTTACATTGAAAAGGCTGGTCCTCGGTAGGCGATGTGCTCTCCATGTACACCGCACAATGAAGAGCAAGACTGAACTGTTAGACGGAGCTGTGGCAATAGGAGATGGGAATGCTATACTAACGGTGGTGCTCTTTTTAATTGCAACATTGAACAAGAAATTAGTATATGAATTATTATCTTCGAGGCTCATAGCACTAAACCATTACATAAGCTTTCTACAAAATGAAGGAAAAATCACTGAACTAACTGATTTACTTACCATGCTTGGAAGGAGTCCTGATGCGGCAATGGCGCACTTCCAGCACGCCGTTAAGACGCAGGGCAACAACGTGGACGGCTTGCTGCGGAAGGTGACCAATATCCTGGCGAACCACTTCAACCAGCCCGGCGTGGACGCGCACCAAACCAAAATGGTTGATGCTTACGTTAAGTTACTCGAATGGCAGAAACTGGCGAACCTGCCGGAGTTGAGCAACAGGTCGGCGTTACAGTGTCTGGCGTACACGTGCTCGCGACACTGGACCGAAGGTGCCGGCGCCGCCATGTCCCCGCTGACCTTGGGCCAGCGTCAGCAGATAAGTCCGTTGCAGTTCGACTGGGTCGTTTTGAACGTTCATGCTAAATCCGGAAAGTGGGACATCCTCGAATCGCTGTTCACGAAAAAGGACTGGCTGGGGCGGAGCACGGTGTCGTCGCACGTGCCGGCGCAGTGCCTGCTGAGGCGGCTCAGCGAGCTGGGGGCCAGCTCCCGGCTCATGGCCGCCTGCCTCGCCAAGCTGCCGAGCGCCGACGAACGACTCGCTCTGGCGCTCAATTACAAAGTCCACTGCGTGGTGATACAGACTTACGCGAAACAAAAGGACCGACTGGCCCTAACCAACTACAAGATGACGCTGAACCCTCAGAGCGAGGAGTACATACTCGCCGAGAACACGCTGAGGGATCCTTCAATCAAATGGAAAAATTAG

Protein

MDDDDYWNTSDTKAKAFSFDDDVLSPQEILAIGQKTYPGQKEESIFSSSSISTVKVAQIPLMSLVTPKVLDLILLAQSGKDPAQEQSQESPETVAVTLKRLVLGRRCALHVHRTMKSKTELLDGAVAIGDGNAILTVVLFLIATLNKKLVYELLSSRLIALNHYISFLQNEGKITELTDLLTMLGRSPDAAMAHFQHAVKTQGNNVDGLLRKVTNILANHFNQPGVDAHQTKMVDAYVKLLEWQKLANLPELSNRSALQCLAYTCSRHWTEGAGAAMSPLTLGQRQQISPLQFDWVVLNVHAKSGKWDILESLFTKKDWLGRSTVSSHVPAQCLLRRLSELGASSRLMAACLAKLPSADERLALALNYKVHCVVIQTYAKQKDRLALTNYKMTLNPQSEEYILAENTLRDPSIKWKN

Description

Proposed to be involved in endosomal maturation implicating in part vps33b. In epithelial cells, the vps33b:vipas39 complex may play a role in the apical rab11a-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of vps33b. May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin.

Subunit

Interacts with vps33b.

Similarity

Belongs to the SPE39 family.

Keywords

Complete proteome   Cytoplasm   Cytoplasmic vesicle   Differentiation   Endosome   Protein transport   Reference proteome   Spermatogenesis   Transcription   Transcription regulation   Transport  

Feature

chain  Spermatogenesis-defective protein 39 homolog

Uniprot

A0A2H1WAK0   A0A2A4J5Z9   A0A2H1V573   A0A2W1BSW1   A0A1E1WER2   A0A194R8G6   + More
A0A194QI74   A0A212F370   A0A2J7RNM1   A0A2J7RNM0   A0A154PPR3   A0A067RAP6   A0A1B6DLI8   A0A1B6E093   A0A2A3E9R5   A0A087ZVA5   T1HJD8   A0A0N0BED5   A0A0P4VNV5   A0A1B6EET8   A0A2R7X1B3   A0A0L7RG98   A0A069DYZ6   A0A023EYW4   A0A0V0G9F8   A0A182VJM9   B0WK87   A0A182X9E3   A0A182HKC9   A0A182TLR3   A0A182PRU1   E0VPD5   Q7PUB5   A0A182QZJ9   A0A182VVZ4   A0A1B0CDX5   A0A182RSC0   A0A2M4AUD5   A0A1Q3F3J0   A0A2M4AUD2   A0A182YHY3   A0A182JUR9   A0A2P8XWV1   A0A026X0S9   A0A1L8DBH9   A0A2M4BMT3   A0A2M4BMT1   A0A182FS16   W5J583   A0A084W042   A0A232FFB1   A0A0A9ZDE8   A0A1L8DBE5   A0A182M8G5   A0A336MZU5   A0A158NQB9   A0A151WGD9   A0A2M4CP05   A0A151I555   A0A1Q3F2Z5   A0A1J1IPW7   U5ER82   A0A0P6ISS7   A0A182GUV6   E2C575   A0A151JP82   A0A1W4WKJ1   A0A1B6GG77   A0A195FU43   A0A1B6J664   A0A1B6LGY4   A0A210Q4K2   A0A1S3I7S9   A0A151IJ32   V5H0S2   V3ZPZ8   A0A1D2MKP0   A0A131YBE3   A0A226EP84   A0A2B4RSG1   A0A087T5B4   A0A224ZBW7   A0A1E1XC99   T1FPT6   A0A1E1XJ57   L7MIL6   A0A2C9L1S8   Q5TYV4   A0A0R4IF88   A0A1I8Q4E4   A0A3P8XNT9   R7VJZ9   W5U801  

Pubmed

28756777    26354079    22118469    24845553    27129103    26334808    + More
25474469    20566863    12364791    14747013    17210077    25244985    29403074    24508170    30249741    20920257    23761445    24438588    28648823    25401762    26823975    21347285    26999592    26483478    20798317    28812685    25765539    23254933    27289101    28797301    28503490    29209593    25576852    15562597    15520368    23594743    20190753    25069045    23127152   

EMBL

ODYU01007368    SOQ50067.1    NWSH01002911    PCG67309.1    ODYU01000519    SOQ35424.1    + More
KZ150025    PZC74813.1    GDQN01008477    GDQN01005608    JAT82577.1    JAT85446.1    KQ460615    KPJ13794.1    KQ458761    KPJ05217.1    AGBW02010610    OWR48180.1    NEVH01002154    PNF42418.1    PNF42419.1    KQ435007    KZC13424.1    KK852777    KDR16749.1    GEDC01010818    JAS26480.1    GEDC01005950    JAS31348.1    KZ288331    PBC27916.1    ACPB03005729    KQ435830    KOX71731.1    GDKW01000176    JAI56419.1    GEDC01000863    JAS36435.1    KK856192    PTY25180.1    KQ414598    KOC69844.1    GBGD01001525    JAC87364.1    GBBI01004319    JAC14393.1    GECL01001462    JAP04662.1    DS231968    EDS29661.1    APCN01000826    DS235363    EEB15241.1    AAAB01008987    EAA01789.6    AXCN02001502    AJWK01008351    GGFK01011063    MBW44384.1    GFDL01012920    JAV22125.1    GGFK01011062    MBW44383.1    PYGN01001224    PSN36491.1    KK107039    QOIP01000006    EZA61897.1    RLU21746.1    GFDF01010302    JAV03782.1    GGFJ01005224    MBW54365.1    GGFJ01005246    MBW54387.1    ADMH02002101    ETN59141.1    ATLV01019085    KE525262    KFB43586.1    NNAY01000334    OXU29138.1    GBHO01027966    GBHO01015345    GBHO01000322    GBHO01000314    GBRD01004208    GBRD01004207    GDHC01019016    GDHC01002597    JAG15638.1    JAG28259.1    JAG43282.1    JAG43290.1    JAG61613.1    JAP99612.1    JAQ16032.1    GFDF01010303    JAV03781.1    AXCM01002705    UFQS01001247    UFQS01001461    UFQT01001247    UFQT01001461    UFQT01005042    SSX09909.1    SSX11096.1    SSX35872.1    ADTU01023079    KQ983176    KYQ46906.1    GGFL01002876    MBW67054.1    KQ976457    KYM84834.1    GFDL01013146    JAV21899.1    CVRI01000057    CRL02263.1    GANO01003876    JAB55995.1    GDUN01001115    JAN94804.1    JXUM01089766    KQ563796    KXJ73290.1    GL452767    EFN76896.1    KQ978756    KYN28593.1    GECZ01008321    JAS61448.1    KQ981272    KYN43812.1    GECU01013039    JAS94667.1    GEBQ01017011    JAT22966.1    NEDP02005034    OWF43657.1    KQ977412    KYN02868.1    GANP01013994    JAB70474.1    KB203083    ESO86407.1    LJIJ01000963    ODM93523.1    GEFM01000525    JAP75271.1    LNIX01000002    OXA59443.1    LSMT01000346    PFX19733.1    KK113487    KFM60303.1    GFPF01013326    MAA24472.1    GFAC01002359    JAT96829.1    AMQM01000554    KB096324    ESO06112.1    GFAA01004156    JAT99278.1    GACK01001199    JAA63835.1    AY394945    BX679672    BX510992    BC097010    AAH97010.1    AAQ94572.1    CAH68911.1    FQ377663    AMQN01004321    KB293181    ELU16345.1    JT407232    AHH37915.1   

Proteomes

UP000218220    UP000053240    UP000053268    UP000007151    UP000235965    UP000076502    + More
UP000027135    UP000242457    UP000005203    UP000015103    UP000053105    UP000053825    UP000075903    UP000002320    UP000076407    UP000075840    UP000075902    UP000075885    UP000009046    UP000007062    UP000075886    UP000075920    UP000092461    UP000075900    UP000076408    UP000075881    UP000245037    UP000053097    UP000279307    UP000069272    UP000000673    UP000030765    UP000215335    UP000075883    UP000005205    UP000075809    UP000078540    UP000183832    UP000069940    UP000249989    UP000008237    UP000078492    UP000192223    UP000078541    UP000242188    UP000085678    UP000078542    UP000030746    UP000094527    UP000198287    UP000225706    UP000054359    UP000015101    UP000076420    UP000000437    UP000095300    UP000265140    UP000014760    UP000221080   

Pfam

PF04840   Vps16_C        + More
PF00096   zf-C2H2
PF17906   HTH_48
PF00241   Cofilin_ADF

Interpro

IPR006925   Vps16_C        + More
IPR040057   Spe-39       
IPR038132   Vps16_C_sf       
IPR013087   Znf_C2H2_type       
IPR036236   Znf_C2H2_sf       
IPR041426   Mos1_HTH       
IPR017904   ADF/Cofilin       
IPR002108   ADF-H       
IPR029006   ADF-H/Gelsolin-like_dom_sf       

SUPFAM

SSF57667   SSF57667       

Gene 3D

1.10.150.780     3.40.20.10    

CDD

cd11286  ADF_cofilin_like

ProteinModelPortal

A0A2H1WAK0   A0A2A4J5Z9   A0A2H1V573   A0A2W1BSW1   A0A1E1WER2   A0A194R8G6   + More
A0A194QI74   A0A212F370   A0A2J7RNM1   A0A2J7RNM0   A0A154PPR3   A0A067RAP6   A0A1B6DLI8   A0A1B6E093   A0A2A3E9R5   A0A087ZVA5   T1HJD8   A0A0N0BED5   A0A0P4VNV5   A0A1B6EET8   A0A2R7X1B3   A0A0L7RG98   A0A069DYZ6   A0A023EYW4   A0A0V0G9F8   A0A182VJM9   B0WK87   A0A182X9E3   A0A182HKC9   A0A182TLR3   A0A182PRU1   E0VPD5   Q7PUB5   A0A182QZJ9   A0A182VVZ4   A0A1B0CDX5   A0A182RSC0   A0A2M4AUD5   A0A1Q3F3J0   A0A2M4AUD2   A0A182YHY3   A0A182JUR9   A0A2P8XWV1   A0A026X0S9   A0A1L8DBH9   A0A2M4BMT3   A0A2M4BMT1   A0A182FS16   W5J583   A0A084W042   A0A232FFB1   A0A0A9ZDE8   A0A1L8DBE5   A0A182M8G5   A0A336MZU5   A0A158NQB9   A0A151WGD9   A0A2M4CP05   A0A151I555   A0A1Q3F2Z5   A0A1J1IPW7   U5ER82   A0A0P6ISS7   A0A182GUV6   E2C575   A0A151JP82   A0A1W4WKJ1   A0A1B6GG77   A0A195FU43   A0A1B6J664   A0A1B6LGY4   A0A210Q4K2   A0A1S3I7S9   A0A151IJ32   V5H0S2   V3ZPZ8   A0A1D2MKP0   A0A131YBE3   A0A226EP84   A0A2B4RSG1   A0A087T5B4   A0A224ZBW7   A0A1E1XC99   T1FPT6   A0A1E1XJ57   L7MIL6   A0A2C9L1S8   Q5TYV4   A0A0R4IF88   A0A1I8Q4E4   A0A3P8XNT9   R7VJZ9   W5U801  

KEGG

101739000    K23287 VPS33B-interacting protein in polarity and apical restriction | (RefSeq) spermatogenesis-defe

GO

GO:0005737   GO:0006886   GO:0003676   GO:0005769   GO:0007283   GO:0055037   GO:0061008   GO:0030154   GO:0005770   GO:0003779   GO:0015629   GO:0030042   GO:0043565   GO:0032549   GO:0022857   GO:0007165   GO:0006418   GO:0003707   GO:0006281   GO:0006259  

PANTHER

PTHR13364  

Subcellular location

Cytoplasm  
Cytoplasmic vesicle  
Early endosome  
Recycling endosome  
Late endosome  

Length:

417

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

17.10642

Exp number, first 60 AAs:

0.06868

Total prob of N-in:

0.69910

outside

1  -  417

 

 

Pi

204.891948

Theta

179.362293

Tajima's D

0.339366

CLR

0.424169

CSRT

0.462576871156442

Interpretation

Uncertain