Pre Gene Modal
BGIBMGA010804
Annotation
PREDICTED:_DNA-directed_RNA_polymerase_I_subunit_RPA2_isoform_X2_[Amyelois_transitella]
Full name
DNA-directed RNA polymerase subunit beta
+ More
DNA-directed RNA polymerase I subunit RPA2
DNA-directed RNA polymerase I subunit RPA2
Alternative Name
RPA135
Location in the cell
Cytoplasmic Reliability : 1.125 Mitochondrial Reliability : 1.438
Sequence
CDS
ATGGAGGACGCCATGATCCTGAACAAGGCGTCGTACGAGCGCGGGCTGGCGGCCGGCTTCGTGTACAAGTCGGAGTTCGTGGAGCTCGGCCACCCCGCCTCGCACTTCGGGCGCGAGGGGGGCCGCGCCGACCCCCCCGGGCCCCTGGACGCGGACGGGCTGCCCGCCCCCGGGGCCCGCCTGCTGCCCGACGACCCCTTCTACAGTTATTACGACGGTGAGAAAAACAAGTACGTGGTGGGGCGCTACCACGGGAAAGAGGAGGTGATCGTGGACAGCGTCCGGCTGTGCGGGGACTTCAGCGCCAAGCCGCTGGCCAAGGCCTGCATCACGCTCAGGATACAGCGCAACCCAACGGTGGGCGACAAGTTCGCGTCGCGCGCCGGCCAGAAGGGCATCTGCTCGCAGAAGTGGCCGGCCGAGGACCTGCCCTTCACGGAGTCGGGGCTGGTCCCGGACATACTGTTCAACCCGCACGGCTTCCCCAGCCGGATGACCATCGCCATGATGATCGAGTGCATGGCAGGCAAGGCGGCCAGCCTGCACGGACACGTGCACGACGCGACTCCCTTCCGCTTCAACGAGAAGGACACCGCCATCGACTACTTCGGGCGGCTGTTGGAAGCCGGCGGCTACAACTACTACGGCACCGAGCGCATGTACAGCGGCGTGGACGGCCGCGAGATGACCGCGGACATCTTCTTCGGCGTCATACACTACCAGCGACTCCGGCACATGGTCTCCGACAAGTGGCAGGTCCGCACCACCGGGCCCGTGGACGCGCTGACCCGGCAGCCGGTGAAGGGGCGGCGGCGCGGGGGCGGCGTGCGGCTGGGGGAGATGGAGCGGGACGCGCTGGTGTCGCACGGCGCCGCCTTCCTGCTGCAGGACCGCCTGCTGCGCTGCTCCGACGAGACAGAGATGGCGGTGTGCACGTCGTGCGGCAGCGTGGCGGGCGCGCGGGGGGGCGGCGCGTGCGCGTGCGGGGGGCGGGCGGGCGCGGTGCGGGCGCCGCACGTCTACAAGCTGTTCGCGACGCAACTCGCGGCGTTGCACGTCAACTGCAGCCTCAAGTGCGTCGACAAAACTATACAACAATAA
Protein
MEDAMILNKASYERGLAAGFVYKSEFVELGHPASHFGREGGRADPPGPLDADGLPAPGARLLPDDPFYSYYDGEKNKYVVGRYHGKEEVIVDSVRLCGDFSAKPLAKACITLRIQRNPTVGDKFASRAGQKGICSQKWPAEDLPFTESGLVPDILFNPHGFPSRMTIAMMIECMAGKAASLHGHVHDATPFRFNEKDTAIDYFGRLLEAGGYNYYGTERMYSGVDGREMTADIFFGVIHYQRLRHMVSDKWQVRTTGPVDALTRQPVKGRRRGGGVRLGEMERDALVSHGAAFLLQDRLLRCSDETEMAVCTSCGSVAGARGGGACACGGRAGAVRAPHVYKLFATQLAALHVNCSLKCVDKTIQQ
Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
Catalytic Activity
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
Subunit
Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
Similarity
Belongs to the RNA polymerase beta chain family.
Keywords
Complete proteome
DNA-directed RNA polymerase
Metal-binding
Nucleotidyltransferase
Nucleus
Reference proteome
Transcription
Transferase
Zinc
Zinc-finger
Feature
chain DNA-directed RNA polymerase I subunit RPA2
Uniprot
A0A2H1VPA4
A0A2W1BZB1
S4PXS6
A0A194PJT3
A0A3S2NX40
A0A212FAC3
+ More
A0A0N1ICC8 A0A0C9PV84 A0A310SMN7 E2B687 A0A1B6CSM5 K7IWJ3 A0A154NVW8 A0A232EXH0 A0A2J7Q9C1 T1PJG3 A0A088A2A1 A0A1B0DPH4 A0A2A3EBT9 A0A1B6CFG7 D6WVZ3 A0A1B6M535 A0A1B6K312 A0A1B6G6E8 A0A2J7Q9B5 A0A0K8UKU8 U4U813 A0A1Y1KKJ0 A0A0A1XSL8 A0A1B0C7K9 A0A0L0CDA1 A0A026WUS5 W8B904 A0A2P8XIL6 A0A1I8M669 A0A224XGY9 A0A1I8QCQ3 A0A0V0G7L3 A0A1L8DGP8 A0A1A9WUR2 A0A023F422 A0A224XFY6 E9IAZ0 B4KFJ3 E2AY84 B4JDN9 A0A2S2QW78 Q29N37 B4N0U3 A0A151JXF7 B4G8A6 A0A151HZI2 A0A151IL56 A0A0M4E8V9 A0A1A9V0X0 A0A0K8SBD6 A0A1A9ZQR0 B4LTK7 A0A1A9YSF8 A0A3B0K840 A0A151XDM1 A0A1B0FD37 A0A158P3I7 A0A2H8TU91 A0A151J8Q7 J9K6G2 A0A182GJ47 J9E9J9 A0A1B0CWN7 B3N7P8 B4P2D8 B4ICW4 B4Q634 P20028 B3MUI2 A0A0P4VRX0 A0A1J1HL88 A0A1W4V455 A0A084VPA9 A0A0A9VR72 A0A146LJQ4 E0V8Y6 B0W5T2 A0A1Q3EXN9 A0A2M4AHX0 A0A2M4AIY3 A0A2M4CVF7 A0A2M4CU57 A0A182F4E3 A0A182Q1G0 A0A0P5LR78 A0A182NE81 A0A182Y5R7 A0A182P955 A0A182JYE9 A0A067QQ90
A0A0N1ICC8 A0A0C9PV84 A0A310SMN7 E2B687 A0A1B6CSM5 K7IWJ3 A0A154NVW8 A0A232EXH0 A0A2J7Q9C1 T1PJG3 A0A088A2A1 A0A1B0DPH4 A0A2A3EBT9 A0A1B6CFG7 D6WVZ3 A0A1B6M535 A0A1B6K312 A0A1B6G6E8 A0A2J7Q9B5 A0A0K8UKU8 U4U813 A0A1Y1KKJ0 A0A0A1XSL8 A0A1B0C7K9 A0A0L0CDA1 A0A026WUS5 W8B904 A0A2P8XIL6 A0A1I8M669 A0A224XGY9 A0A1I8QCQ3 A0A0V0G7L3 A0A1L8DGP8 A0A1A9WUR2 A0A023F422 A0A224XFY6 E9IAZ0 B4KFJ3 E2AY84 B4JDN9 A0A2S2QW78 Q29N37 B4N0U3 A0A151JXF7 B4G8A6 A0A151HZI2 A0A151IL56 A0A0M4E8V9 A0A1A9V0X0 A0A0K8SBD6 A0A1A9ZQR0 B4LTK7 A0A1A9YSF8 A0A3B0K840 A0A151XDM1 A0A1B0FD37 A0A158P3I7 A0A2H8TU91 A0A151J8Q7 J9K6G2 A0A182GJ47 J9E9J9 A0A1B0CWN7 B3N7P8 B4P2D8 B4ICW4 B4Q634 P20028 B3MUI2 A0A0P4VRX0 A0A1J1HL88 A0A1W4V455 A0A084VPA9 A0A0A9VR72 A0A146LJQ4 E0V8Y6 B0W5T2 A0A1Q3EXN9 A0A2M4AHX0 A0A2M4AIY3 A0A2M4CVF7 A0A2M4CU57 A0A182F4E3 A0A182Q1G0 A0A0P5LR78 A0A182NE81 A0A182Y5R7 A0A182P955 A0A182JYE9 A0A067QQ90
EC Number
2.7.7.6
Pubmed
28756777
23622113
26354079
22118469
20798317
20075255
+ More
28648823 18362917 19820115 23537049 28004739 25830018 26108605 24508170 30249741 24495485 29403074 25315136 25474469 21282665 17994087 15632085 21347285 26483478 17510324 17550304 22936249 2482932 10731132 12537572 12537569 25858587 27129103 24438588 25401762 26823975 20566863 25244985 24845553
28648823 18362917 19820115 23537049 28004739 25830018 26108605 24508170 30249741 24495485 29403074 25315136 25474469 21282665 17994087 15632085 21347285 26483478 17510324 17550304 22936249 2482932 10731132 12537572 12537569 25858587 27129103 24438588 25401762 26823975 20566863 25244985 24845553
EMBL
ODYU01003647
SOQ42660.1
KZ149936
PZC77143.1
GAIX01004523
JAA88037.1
+ More
KQ459601 KPI93691.1 RSAL01000118 RVE46764.1 AGBW02009499 OWR50682.1 KQ459910 KPJ19329.1 GBYB01005307 GBYB01005308 GBYB01005309 JAG75074.1 JAG75075.1 JAG75076.1 KQ761976 OAD56425.1 GL445930 EFN88780.1 GEDC01021045 JAS16253.1 KQ434769 KZC03787.1 NNAY01001730 OXU23104.1 NEVH01016943 PNF25172.1 KA648834 AFP63463.1 AJVK01018282 KZ288311 PBC28511.1 GEDC01025130 JAS12168.1 KQ971359 EFA08638.2 GEBQ01008946 JAT31031.1 GECU01001857 JAT05850.1 GECZ01011759 JAS58010.1 PNF25173.1 GDHF01025007 JAI27307.1 KB632064 ERL88468.1 GEZM01085172 GEZM01085171 GEZM01085170 JAV60155.1 GBXI01000276 JAD14016.1 JXJN01028952 JRES01000561 KNC30197.1 KK107088 QOIP01000008 EZA59800.1 RLU19525.1 GAMC01011438 JAB95117.1 PYGN01002005 PSN31851.1 GFTR01008584 JAW07842.1 GECL01002690 JAP03434.1 GFDF01008570 JAV05514.1 GBBI01002988 JAC15724.1 GFTR01008924 JAW07502.1 GL762091 EFZ22265.1 CH933807 EDW13108.2 GL443762 EFN61619.1 CH916368 EDW03409.1 GGMS01012803 MBY82006.1 CH379060 EAL33506.2 CH963920 EDW77706.1 KQ981604 KYN39719.1 CH479180 EDW28586.1 KQ976710 KYM77038.1 KQ977133 KYN05487.1 CP012523 ALC38514.1 GBRD01015347 JAG50479.1 CH940649 EDW64980.2 OUUW01000004 SPP79698.1 KQ982268 KYQ58474.1 CCAG010003896 ADTU01008085 ADTU01008086 ADTU01008087 ADTU01008088 GFXV01006019 MBW17824.1 KQ979488 KYN21228.1 ABLF02026514 JXUM01067297 KQ562443 KXJ75905.1 CH477305 EJY57536.1 AJWK01032718 AJWK01032719 CH954177 EDV57224.1 CM000157 EDW87134.1 CH480829 EDW45390.1 CM000361 CM002910 EDX03218.1 KMY87306.1 X17298 AE014134 AY075569 CH902624 EDV33511.1 GDKW01000777 JAI55818.1 CVRI01000010 CRK88797.1 ATLV01014994 KE524999 KFB39803.1 GBHO01044682 JAF98921.1 GDHC01011513 JAQ07116.1 DS234986 EEB09842.1 DS231844 EDS35735.1 GFDL01014970 JAV20075.1 GGFK01007065 MBW40386.1 GGFK01007247 MBW40568.1 GGFL01004640 MBW68818.1 GGFL01004641 MBW68819.1 AXCN02000868 GDIQ01166404 JAK85321.1 KK853598 KDR06420.1
KQ459601 KPI93691.1 RSAL01000118 RVE46764.1 AGBW02009499 OWR50682.1 KQ459910 KPJ19329.1 GBYB01005307 GBYB01005308 GBYB01005309 JAG75074.1 JAG75075.1 JAG75076.1 KQ761976 OAD56425.1 GL445930 EFN88780.1 GEDC01021045 JAS16253.1 KQ434769 KZC03787.1 NNAY01001730 OXU23104.1 NEVH01016943 PNF25172.1 KA648834 AFP63463.1 AJVK01018282 KZ288311 PBC28511.1 GEDC01025130 JAS12168.1 KQ971359 EFA08638.2 GEBQ01008946 JAT31031.1 GECU01001857 JAT05850.1 GECZ01011759 JAS58010.1 PNF25173.1 GDHF01025007 JAI27307.1 KB632064 ERL88468.1 GEZM01085172 GEZM01085171 GEZM01085170 JAV60155.1 GBXI01000276 JAD14016.1 JXJN01028952 JRES01000561 KNC30197.1 KK107088 QOIP01000008 EZA59800.1 RLU19525.1 GAMC01011438 JAB95117.1 PYGN01002005 PSN31851.1 GFTR01008584 JAW07842.1 GECL01002690 JAP03434.1 GFDF01008570 JAV05514.1 GBBI01002988 JAC15724.1 GFTR01008924 JAW07502.1 GL762091 EFZ22265.1 CH933807 EDW13108.2 GL443762 EFN61619.1 CH916368 EDW03409.1 GGMS01012803 MBY82006.1 CH379060 EAL33506.2 CH963920 EDW77706.1 KQ981604 KYN39719.1 CH479180 EDW28586.1 KQ976710 KYM77038.1 KQ977133 KYN05487.1 CP012523 ALC38514.1 GBRD01015347 JAG50479.1 CH940649 EDW64980.2 OUUW01000004 SPP79698.1 KQ982268 KYQ58474.1 CCAG010003896 ADTU01008085 ADTU01008086 ADTU01008087 ADTU01008088 GFXV01006019 MBW17824.1 KQ979488 KYN21228.1 ABLF02026514 JXUM01067297 KQ562443 KXJ75905.1 CH477305 EJY57536.1 AJWK01032718 AJWK01032719 CH954177 EDV57224.1 CM000157 EDW87134.1 CH480829 EDW45390.1 CM000361 CM002910 EDX03218.1 KMY87306.1 X17298 AE014134 AY075569 CH902624 EDV33511.1 GDKW01000777 JAI55818.1 CVRI01000010 CRK88797.1 ATLV01014994 KE524999 KFB39803.1 GBHO01044682 JAF98921.1 GDHC01011513 JAQ07116.1 DS234986 EEB09842.1 DS231844 EDS35735.1 GFDL01014970 JAV20075.1 GGFK01007065 MBW40386.1 GGFK01007247 MBW40568.1 GGFL01004640 MBW68818.1 GGFL01004641 MBW68819.1 AXCN02000868 GDIQ01166404 JAK85321.1 KK853598 KDR06420.1
Proteomes
UP000053268
UP000283053
UP000007151
UP000053240
UP000008237
UP000002358
+ More
UP000076502 UP000215335 UP000235965 UP000005203 UP000092462 UP000242457 UP000007266 UP000030742 UP000092460 UP000037069 UP000053097 UP000279307 UP000245037 UP000095301 UP000095300 UP000091820 UP000009192 UP000000311 UP000001070 UP000001819 UP000007798 UP000078541 UP000008744 UP000078540 UP000078542 UP000092553 UP000078200 UP000092445 UP000008792 UP000092443 UP000268350 UP000075809 UP000092444 UP000005205 UP000078492 UP000007819 UP000069940 UP000249989 UP000008820 UP000092461 UP000008711 UP000002282 UP000001292 UP000000304 UP000000803 UP000007801 UP000183832 UP000192221 UP000030765 UP000009046 UP000002320 UP000069272 UP000075886 UP000075884 UP000076408 UP000075885 UP000075881 UP000027135
UP000076502 UP000215335 UP000235965 UP000005203 UP000092462 UP000242457 UP000007266 UP000030742 UP000092460 UP000037069 UP000053097 UP000279307 UP000245037 UP000095301 UP000095300 UP000091820 UP000009192 UP000000311 UP000001070 UP000001819 UP000007798 UP000078541 UP000008744 UP000078540 UP000078542 UP000092553 UP000078200 UP000092445 UP000008792 UP000092443 UP000268350 UP000075809 UP000092444 UP000005205 UP000078492 UP000007819 UP000069940 UP000249989 UP000008820 UP000092461 UP000008711 UP000002282 UP000001292 UP000000304 UP000000803 UP000007801 UP000183832 UP000192221 UP000030765 UP000009046 UP000002320 UP000069272 UP000075886 UP000075884 UP000076408 UP000075885 UP000075881 UP000027135
PRIDE
Pfam
Interpro
IPR007120
DNA-dir_RNAP_su2_dom
+ More
IPR007121 RNA_pol_bsu_CS
IPR015712 DNA-dir_RNA_pol_su2
IPR037033 DNA-dir_RNAP_su2_hyb_sf
IPR014724 RNA_pol_RPB2_OB-fold
IPR007641 RNA_pol_Rpb2_7
IPR007645 RNA_pol_Rpb2_3
IPR009674 Rpa2_dom_4
IPR007644 RNA_pol_bsu_protrusion
IPR037034 RNA_pol_Rpb2_2_sf
IPR007642 RNA_pol_Rpb2_2
IPR007121 RNA_pol_bsu_CS
IPR015712 DNA-dir_RNA_pol_su2
IPR037033 DNA-dir_RNAP_su2_hyb_sf
IPR014724 RNA_pol_RPB2_OB-fold
IPR007641 RNA_pol_Rpb2_7
IPR007645 RNA_pol_Rpb2_3
IPR009674 Rpa2_dom_4
IPR007644 RNA_pol_bsu_protrusion
IPR037034 RNA_pol_Rpb2_2_sf
IPR007642 RNA_pol_Rpb2_2
Gene 3D
ProteinModelPortal
A0A2H1VPA4
A0A2W1BZB1
S4PXS6
A0A194PJT3
A0A3S2NX40
A0A212FAC3
+ More
A0A0N1ICC8 A0A0C9PV84 A0A310SMN7 E2B687 A0A1B6CSM5 K7IWJ3 A0A154NVW8 A0A232EXH0 A0A2J7Q9C1 T1PJG3 A0A088A2A1 A0A1B0DPH4 A0A2A3EBT9 A0A1B6CFG7 D6WVZ3 A0A1B6M535 A0A1B6K312 A0A1B6G6E8 A0A2J7Q9B5 A0A0K8UKU8 U4U813 A0A1Y1KKJ0 A0A0A1XSL8 A0A1B0C7K9 A0A0L0CDA1 A0A026WUS5 W8B904 A0A2P8XIL6 A0A1I8M669 A0A224XGY9 A0A1I8QCQ3 A0A0V0G7L3 A0A1L8DGP8 A0A1A9WUR2 A0A023F422 A0A224XFY6 E9IAZ0 B4KFJ3 E2AY84 B4JDN9 A0A2S2QW78 Q29N37 B4N0U3 A0A151JXF7 B4G8A6 A0A151HZI2 A0A151IL56 A0A0M4E8V9 A0A1A9V0X0 A0A0K8SBD6 A0A1A9ZQR0 B4LTK7 A0A1A9YSF8 A0A3B0K840 A0A151XDM1 A0A1B0FD37 A0A158P3I7 A0A2H8TU91 A0A151J8Q7 J9K6G2 A0A182GJ47 J9E9J9 A0A1B0CWN7 B3N7P8 B4P2D8 B4ICW4 B4Q634 P20028 B3MUI2 A0A0P4VRX0 A0A1J1HL88 A0A1W4V455 A0A084VPA9 A0A0A9VR72 A0A146LJQ4 E0V8Y6 B0W5T2 A0A1Q3EXN9 A0A2M4AHX0 A0A2M4AIY3 A0A2M4CVF7 A0A2M4CU57 A0A182F4E3 A0A182Q1G0 A0A0P5LR78 A0A182NE81 A0A182Y5R7 A0A182P955 A0A182JYE9 A0A067QQ90
A0A0N1ICC8 A0A0C9PV84 A0A310SMN7 E2B687 A0A1B6CSM5 K7IWJ3 A0A154NVW8 A0A232EXH0 A0A2J7Q9C1 T1PJG3 A0A088A2A1 A0A1B0DPH4 A0A2A3EBT9 A0A1B6CFG7 D6WVZ3 A0A1B6M535 A0A1B6K312 A0A1B6G6E8 A0A2J7Q9B5 A0A0K8UKU8 U4U813 A0A1Y1KKJ0 A0A0A1XSL8 A0A1B0C7K9 A0A0L0CDA1 A0A026WUS5 W8B904 A0A2P8XIL6 A0A1I8M669 A0A224XGY9 A0A1I8QCQ3 A0A0V0G7L3 A0A1L8DGP8 A0A1A9WUR2 A0A023F422 A0A224XFY6 E9IAZ0 B4KFJ3 E2AY84 B4JDN9 A0A2S2QW78 Q29N37 B4N0U3 A0A151JXF7 B4G8A6 A0A151HZI2 A0A151IL56 A0A0M4E8V9 A0A1A9V0X0 A0A0K8SBD6 A0A1A9ZQR0 B4LTK7 A0A1A9YSF8 A0A3B0K840 A0A151XDM1 A0A1B0FD37 A0A158P3I7 A0A2H8TU91 A0A151J8Q7 J9K6G2 A0A182GJ47 J9E9J9 A0A1B0CWN7 B3N7P8 B4P2D8 B4ICW4 B4Q634 P20028 B3MUI2 A0A0P4VRX0 A0A1J1HL88 A0A1W4V455 A0A084VPA9 A0A0A9VR72 A0A146LJQ4 E0V8Y6 B0W5T2 A0A1Q3EXN9 A0A2M4AHX0 A0A2M4AIY3 A0A2M4CVF7 A0A2M4CU57 A0A182F4E3 A0A182Q1G0 A0A0P5LR78 A0A182NE81 A0A182Y5R7 A0A182P955 A0A182JYE9 A0A067QQ90
PDB
6HLS
E-value=3.22761e-84,
Score=794
Ontologies
GO
PANTHER
Topology
Subcellular location
Length:
366
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.01093
Exp number, first 60 AAs:
0.00041
Total prob of N-in:
0.01660
outside
1 - 366
Population Genetic Test Statistics
Pi
333.461526
Theta
186.782812
Tajima's D
2.216559
CLR
0.3831
CSRT
0.912754362281886
Interpretation
Uncertain
