Pre Gene Modal
BGIBMGA010745
Annotation
U3_small_nucleolar_ribonucleoprotein_component_[Operophtera_brumata]
Full name
NADPH-dependent diflavin oxidoreductase 1
Alternative Name
NADPH-dependent FMN and FAD-containing oxidoreductase
Location in the cell
Mitochondrial Reliability : 1.283 Nuclear Reliability : 1.934
Sequence
CDS
ATGTGTCAAATAGGCAGACTGACGGTGCTGTACGGTAGTCAAACATTCACGGCTCAAGAAATAGCCGAAAGAATATGGCGTACGACAAAAGCTTTGGGTTTTCGCGGGCCCGTTCAAGCGATGAACGAGTATCCCATTTCTATGCTGATTCATGAAGAATTTGCGATATTTGTGTGCGCTACGACGGGTCAAGGCGATGAACCGGATAATATGAAGAAATTCTGGAAGTTTCTGTTGAGGAAAAATCTACCGGCGAATTCGTTAATTAAATTGAAATTTGGAGTGTTGGGCTTAGGAGATTCTTCATATTCAGAGTTCAATTTTGTCGCTAAGAAGCTTCACAAGCGCCTCATTCAATTAGGAGCCAGACCATTAATAGATGTTGGTTTATGTGACTACCAACATGACCTGGGCCACGATGGTGTAGTTTCCCCATGGATCAAAGAATACTTTGTACGACTCAAAGAATATTTTCCGAGTATACAGACAGATGTAAAATCAGAATTCATTCCTCGTTGGAAGGTCTCTATGTTGAAGGACAAAGCTGATGTTAAAAGTGGATTTTGTGAAGATATATATTTTGGTCACGAAAACAGCAATAACCAAGAAGCTTTGTTGTTGGAGGTGGATAGTAATGTTAGAACTACGGATGAATCTCATTTTCAGGATGTAAGACTAATATCATTCAAATCTGTTAGTAAATGCTTAACCTACAAACCTGGTGATGTTTTCAATATAAGACCTCGGAACTCAAAGGAGGACATTGATGACCTATTTAACATACTTGAAAGTAACAATATTGATATTAAGCCCCATTATAGATTACTAGTTGAAGAATATCATGATGTTATCGAATTCAACTATAGTAACGACAAACCAAAAATGCTGCGACGACAGGCGCGATTACGCCGCGAGTATTTATACCGGAAATCGGCTGAAGAAAAACAAAAAAGTATACAAGCTAAAAAAGATCAGATCAAACGTAGTCTTGAAGAGAATATACCTATACATGGTGATTTACGGAAGGATGCCATCGCCTTACAGAAGAGAATTGAATATGAAGATAAAGGACCGGAAAGAGTGGCGGTAATCGGAGGATTCAGTGGTGGGGCAAACACACTCAATTCACAGGATGATGAATACAGATATGCAGGTGTCGAGGATCCGAAGATCATGATTACCACATCAAGAGAGCCTAGTGCTAGGCTCAAGATGTTTGTAAAAGAACTGAGGTTAATATTTCCGAACAGTCAGCGTATGAACAGAGGTGGTTATGAGATGTCACAATTGATTCATGCCTGTCGAGCCAATGATGTAACAGATTTCATAGTTGTACACGAGCATCGAGGAGTTCCAGACAGTTTGGTAATATGCCACCTCCCATATGGTCCAACAGCATCCTTCACATTATCGGGTGTTGTGATGAGACATGATATACCTGATATAGGACCAATGAGTGAACAGTATCCACATCTCATATTCCATAACTTTAAGAGTAATCTTGGTTTACGTACAATGAGTATATTAAAGTACCTGTTTCCTGTACCAAAACCCGATTCAAAGAGAGTTATATCATTTGCGAACCATGATGATTACATATGCTTCAGGCAACATACATATAAAAAGGCAGGCAAGGATATTGAATTAACAGAAGTGGGTCCACGTTTCCAAATGAGGTTATATGAGATCAAGCTCGGCACCCTGGAATCCCTGACGGCCGCCGACACCGAGTGGGCGCTCCGCCCCTACATGAATACGGCTGCCAAGAGACGCTTCCTCAATATGCCTGTGCCTGAGTTCCTATGTCACCCCTTGACTTTATACGAAGTGGCCGAACAGTATTGGGACCTGCGATGCTACGCCACTCAGTATGTTTTCTCCATTCTGGCACTTGTGTCCCAGGACAAGTTAGAGAGGGACAAATGTATAGAGCTCAGTTCCCCAGAGGGTCAGGAGGACTGGCTGAATTATTGTAGGAGAACGAAGAGAACCGTTATAGAAGTGCTGCAGGACTTCCACCGCTCGGCCGCGCGGCTCACCATACAGACGCTGTTCGAGTTGTTCTCGATTATAAAGCCGCGCTCGTTCTCGATAGCGAGCGCGTGCGGCGCGGCGGCGGCGGGGCGCGGCCTGCAGCTGCTGGTGGCGGCGGTCCGGTACCGCACGGCGCTGCGCCGCCCGCGCCTCGGCCTCGCCTCCAACTGGCTCGCGGCGCTGCCCCCCGGTCACAAGGTCTACGGGTGGATCAAAAAGGGGACCTTTGTTTTTCCTGATGATGCGAGCGTGCCTCACATAATGGTGGGGCCAGGCACGGGGCTCGCTCCCTTCAGGAGTTTGCTCCAAGAAAGGGTTCACTACGGCACAGCGTCCAAGGACATCATGCATCTGTTCTTCGGGTGTCGGTACAAAGAGAAGGACTACCACTGCAGGGAAGAGTTGGAGGGGATGGTGGGAGATGGGAACTTGAGTTTGTACTGCGCTTTTTCTAGAGACCAGGAAGATAAGATCTACGTCCAGCACAAGATATTCGAGAACCGCGAGACGATCTGGCGACTGCTGAACAACAACGCCCACGTGTTCATATCCGGCAACGCCAAGAGCATGCCGGACAACGTGCGGGAGGCGCTCGCTGACGTCATCCGGGTGTGCTCCGGGACCAGCGCGGCCGCCAGCAGCGACGCCGTGCGCAGCCTGCAGGAGCAAGGTCGACTCCAGGTCGAGACCTGGTGA
Protein
MCQIGRLTVLYGSQTFTAQEIAERIWRTTKALGFRGPVQAMNEYPISMLIHEEFAIFVCATTGQGDEPDNMKKFWKFLLRKNLPANSLIKLKFGVLGLGDSSYSEFNFVAKKLHKRLIQLGARPLIDVGLCDYQHDLGHDGVVSPWIKEYFVRLKEYFPSIQTDVKSEFIPRWKVSMLKDKADVKSGFCEDIYFGHENSNNQEALLLEVDSNVRTTDESHFQDVRLISFKSVSKCLTYKPGDVFNIRPRNSKEDIDDLFNILESNNIDIKPHYRLLVEEYHDVIEFNYSNDKPKMLRRQARLRREYLYRKSAEEKQKSIQAKKDQIKRSLEENIPIHGDLRKDAIALQKRIEYEDKGPERVAVIGGFSGGANTLNSQDDEYRYAGVEDPKIMITTSREPSARLKMFVKELRLIFPNSQRMNRGGYEMSQLIHACRANDVTDFIVVHEHRGVPDSLVICHLPYGPTASFTLSGVVMRHDIPDIGPMSEQYPHLIFHNFKSNLGLRTMSILKYLFPVPKPDSKRVISFANHDDYICFRQHTYKKAGKDIELTEVGPRFQMRLYEIKLGTLESLTAADTEWALRPYMNTAAKRRFLNMPVPEFLCHPLTLYEVAEQYWDLRCYATQYVFSILALVSQDKLERDKCIELSSPEGQEDWLNYCRRTKRTVIEVLQDFHRSAARLTIQTLFELFSIIKPRSFSIASACGAAAAGRGLQLLVAAVRYRTALRRPRLGLASNWLAALPPGHKVYGWIKKGTFVFPDDASVPHIMVGPGTGLAPFRSLLQERVHYGTASKDIMHLFFGCRYKEKDYHCREELEGMVGDGNLSLYCAFSRDQEDKIYVQHKIFENRETIWRLLNNNAHVFISGNAKSMPDNVREALADVIRVCSGTSAAASSDAVRSLQEQGRLQVETW
Summary
Description
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog.
Cofactor
FAD
FMN
FMN
Similarity
Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
In the N-terminal section; belongs to the flavodoxin family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
In the N-terminal section; belongs to the flavodoxin family.
Uniprot
EC Number
1.18.1.-
Pubmed
Proteomes
Interpro
IPR008254
Flavodoxin/NO_synth
+ More
IPR023173 NADPH_Cyt_P450_Rdtase_alpha
IPR017927 FAD-bd_FR_type
IPR017938 Riboflavin_synthase-like_b-brl
IPR039261 FNR_nucleotide-bd
IPR003097 CysJ-like_FAD-binding
IPR029039 Flavoprotein-like_sf
IPR007109 Brix
IPR001094 Flavdoxin-like
IPR028879 NDOR1
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR001433 OxRdtase_FAD/NAD-bd
IPR023173 NADPH_Cyt_P450_Rdtase_alpha
IPR017927 FAD-bd_FR_type
IPR017938 Riboflavin_synthase-like_b-brl
IPR039261 FNR_nucleotide-bd
IPR003097 CysJ-like_FAD-binding
IPR029039 Flavoprotein-like_sf
IPR007109 Brix
IPR001094 Flavdoxin-like
IPR028879 NDOR1
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR001433 OxRdtase_FAD/NAD-bd
Gene 3D
ProteinModelPortal
PDB
5WYK
E-value=5.52719e-78,
Score=744
Ontologies
GO
Topology
Subcellular location
Cytoplasm
Length:
909
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.819319999999999
Exp number, first 60 AAs:
0.00610000000000001
Total prob of N-in:
0.00064
outside
1 - 909
Population Genetic Test Statistics
Pi
255.241953
Theta
210.10731
Tajima's D
1.740986
CLR
0.061269
CSRT
0.83670816459177
Interpretation
Uncertain
