Silkworm Genome Informatics Database

Gene

KWMTBOMO15526

Pre Gene Modal

BGIBMGA010747

Annotation

PREDICTED:_G_protein-coupled_receptor_kinase_2_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr26(-):1846858-1854015 View in EpiBrowser

Full name

G protein-coupled receptor kinase + More
G protein-coupled receptor kinase 2

Location in the cell

Cytoplasmic Reliability : 1.728 Mitochondrial Reliability : 1.791

CDS

ATGTACTTCCACCGGTACCTCCAGTGGAAGTGGCTGGAGGCTCAGCCGGTCACGCAGAACACCTTCAGGATGTACCGAGTCCTCGGGAAGGGCGGCTTCGGCGAGGTTTGCGCTTGTCAGGTTCGGGCGACCGGCAAAATGTACGCTTGTAAGAAATTAGAAAAGAAAAGGATCAAGAAGCGCAAAGGTGAAGCGATGGTGCTGATCGAGAAGCAGATCCTGCAGAGGATCAATTCTCGCTTCGTCGTCAACTTGGCCTACGCGTACGAAACGAAAGACGCACTGTGTCTAGTCCTCACTATCATGAACGGTGGCGATCTAAAGTTTCACATTTACAACATGTGCGGCGCGGAGACGGGCCTGGGACTGGAGCGCGCGAGGTTCTACGCGGCGCAGGTGGCGTGTGGCCTCGAGCATCTACACAAGATGGGCATAGTTTACAGAGACTGCAAGCCGGAGAATATATTATTGGACGACGCGGGTCACGTGCGCATCTCTGACCTCGGGCTGGCGGTGGACGTGCCGGAGGGGGGCTCTGTGCGGGGGAGGGTGGGGACCGTCGGGTACATGGCGCCCGAAGTGATCGACAACGAGCGGTACACGTTCAGTCCGGACTGGTTCTCGTTCGGTTGCCTGGTGTATGAGATGATCGAGGGTAGAGCGCCGTTTCGGGCCAGAAAAGAAAAGGTCAAAAGGGAAGATGTCGACAGGAGGGTAAAGCACGAGCCGGAGAAGTACTCGAGCAAGTTCAGCGAGTGCAGCCGCGCGCTGTGCTCGTCGCTGCTGAGCAAGGCGGCGGGCGCGCGGCTGGGCTGCGGCGCGGGGCGGCGGGGGGCGGCGCTCGTCAAGGCGCACCGGTTCTTCGCGCACCTCAACTGGGCGCGCCTCGAGGCCGGCATGGTGCCTGCGCCCTTCGTGCCAGACCCGCACGCCGTCTACGCCAAGGACGTCCTCGACATCGAGCAGTTCAGCACCGTGAAGGGCGTCAACCTGGACGCGGCCGACGACACGTTCTACGGCAAGTTCAACACGGGCAGCGTGTCCATACCCTGGCAGGCCGAGATGATCGAGACCGGCTGCTTCAAGGAGCTAAACGTTTTCGCGTCGACGGAGGAGGGTCGGGAGGCTCCGACGGTGGATCTGCAGCTGGTGCCTTCCACCGCCGCCGCCGAGGAAGAGAAGGGATGCTTCGTTTTCGCAAGACGAGTATTGTGTCCTCAAAAGAAAGTCCCGGCGCGCCTCCGTCCCGTGTCGGTCCCGGAGCACCTCCTGCCGCCGCCCGCTGCCTCTAGCTGA

Protein

MYFHRYLQWKWLEAQPVTQNTFRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMVLIEKQILQRINSRFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMCGAETGLGLERARFYAAQVACGLEHLHKMGIVYRDCKPENILLDDAGHVRISDLGLAVDVPEGGSVRGRVGTVGYMAPEVIDNERYTFSPDWFSFGCLVYEMIEGRAPFRARKEKVKREDVDRRVKHEPEKYSSKFSECSRALCSSLLSKAAGARLGCGAGRRGAALVKAHRFFAHLNWARLEAGMVPAPFVPDPHAVYAKDVLDIEQFSTVKGVNLDAADDTFYGKFNTGSVSIPWQAEMIETGCFKELNVFASTEEGREAPTVDLQLVPSTAAAEEEKGCFVFARRVLCPQKKVPARLRPVSVPEHLLPPPAASS

Description

Specifically phosphorylates the activated forms of G protein-coupled receptors (By similarity). Required during oogenesis and embryogenesis; component of a signaling pathway that functions during egg chamber maturation.

Catalytic Activity

[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)

Similarity

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

Keywords

ATP-binding Complete proteome Developmental protein Differentiation Kinase Membrane Nucleotide-binding Oogenesis Phosphoprotein Reference proteome Repeat Transferase

Feature

chain G protein-coupled receptor kinase 2

Uniprot

H9JMJ4 A0A2H1V954 A0A3S2P6R4 A0A194PL03 A0A2A4JQW5 A0A1Y1L675 + More
A0A1W4XLR8 A0A1W4XWR6 A0A0T6AZ63 A0A1B6GR23 D6X0V3 B4GYT9 B4NG39 A0A1W4U6Z6 Q29BB5 A0A0B4KI69 A0A2J7PI58 B3P540 P32866 B4QSM6 B4I027 B3M096 A0A3B0JFG3 B4PNE0 A0A1L8DKG0 W8BDD7 A0A1L8DKF8 A0A1L8DKC4 A0A0K8VXQ6 A0A0A1WZ01 A0A0K8V160 A0A034VE27 A0A067QPB3 A0A069DZB0 A0A084W393 A0A2C9GSP1 A0A023F5Q5 B4K8A6 A0A0L0CU95 A0A1B6DBE1 A0A182M4W0 A0A1I8NVT6 A0A1B6C906 A0A1B0GFP4 A0A182N5M7 A0A1A9V7M1 A0A1Q3FU19 A0A1Q3FU25 A0A2J7PI36 A0A2C9H6H0 B4JRX4 A0A1B0AA08 A0A2C9H8E6 A0A182QN22 A0A2C9H5S4 A0A1S4GK59 A0A182II07 T1PKV8 A0A2C9GWR0 A0A0M4EWE2 A0A1I8N714 A0A2J7PI59 B4LWZ6 A0A0A9ZGM9 A0A2M4CTV0 A0A2M4AIB5 A0A2M3ZHW7 A0A2C9GGV1 W5JH35 A0A1B6D437 A0A088ADE1 A0A182L7I9 A0A3F2YWJ4 A0A0C9RAD6 K7IM99 A0A154NXH7 A0A2H8TNZ6 E2BNK4 Q7PQK8 A0A3L8DKI1 E0VBQ6 E2AIQ4 A0A0J7L259 A0A232F0X5 A0A0P4WEW5 A0A182U7J7 A0A0P6G8F0 A0A195D498 A0A195FY24 A0A151IZ93 F4WLF2 A0A158NVI8 A0A151WMM5 N6SYS6 A0A195BPH6 A0A0P5F6K4 A0A2H4WAM2 T1L358 A0A0P4WJQ8 J9JZV8

EC Number

2.7.11.-
2.7.11.16

Pubmed

19121390 26354079 28004739 18362917 19820115 17994087 + More
15632085 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 9217001 12537569 1662381 18327897 17550304 24495485 25830018 25348373 24845553 26334808 24438588 25474469 18057021 26108605 12364791 25315136 25401762 26823975 20920257 23761445 20966253 20075255 20798317 30249741 20566863 28648823 21719571 21347285 23537049 29182505

EMBL

BABH01016669 BABH01016670 BABH01016671 ODYU01001064 SOQ36784.1 RSAL01000010 + More
RVE53755.1 KQ459601 KPI93678.1 NWSH01000745 PCG74445.1 GEZM01063224 JAV69183.1 LJIG01022456 KRT80495.1 GECZ01004910 JAS64859.1 KQ971372 EFA09544.1 CH479198 EDW27957.1 CH964251 EDW83256.1 CM000070 EAL27083.2 AE014297 AGB96522.1 NEVH01025129 PNF16013.1 CH954182 EDV52954.1 AF004674 BT031258 AY051949 M80494 CM000364 EDX15123.1 CH480819 EDW53634.1 CH902617 EDV42053.1 OUUW01000005 SPP81134.1 CM000160 EDW99222.1 GFDF01007136 JAV06948.1 GAMC01015389 JAB91166.1 GFDF01007183 JAV06901.1 GFDF01007182 JAV06902.1 GDHF01008675 JAI43639.1 GBXI01010215 JAD04077.1 GDHF01019665 JAI32649.1 GAKP01018912 JAC40040.1 KK853096 KDR11459.1 GBGD01000955 JAC87934.1 ATLV01019862 ATLV01019863 ATLV01019864 ATLV01019865 ATLV01019866 ATLV01019867 KE525281 KFB44687.1 GBBI01002210 JAC16502.1 CH933806 EDW16488.1 KRG02164.1 JRES01000007 KNC34929.1 GEDC01014348 JAS22950.1 AXCM01001728 GEDC01027553 JAS09745.1 CCAG010018480 GFDL01003946 JAV31099.1 GFDL01003945 JAV31100.1 PNF16010.1 CH916373 EDV94514.1 AXCN02001159 AXCN02001160 AAAB01008880 APCN01002580 KA648588 AFP63217.1 CP012526 ALC47842.1 PNF16011.1 CH940650 EDW67743.1 KRF83435.1 GBHO01000886 GBHO01000883 GDHC01010192 GDHC01008117 JAG42718.1 JAG42721.1 JAQ08437.1 JAQ10512.1 GGFL01004596 MBW68774.1 GGFK01007205 MBW40526.1 GGFM01007361 MBW28112.1 ADMH02001206 ETN63677.1 GEDC01016868 JAS20430.1 GBYB01010035 GBYB01010037 JAG79802.1 JAG79804.1 KQ434766 KZC03738.1 GFXV01003836 MBW15641.1 GL449414 EFN82783.1 EAA08674.6 QOIP01000007 RLU20409.1 AAZO01000777 DS235035 EEB10812.1 GL439853 EFN66691.1 LBMM01001120 KMQ96887.1 NNAY01001325 OXU24355.1 GDRN01037376 JAI67299.1 GDIP01170326 GDIQ01048273 LRGB01001361 JAJ53076.1 JAN46464.1 KZS12418.1 KQ976870 KYN07713.1 KQ981169 KYN45336.1 KQ980725 KYN14029.1 GL888207 EGI65115.1 ADTU01027210 KQ982944 KYQ49051.1 APGK01059049 KB741292 ENN70383.1 KQ976433 KYM87357.1 GDIQ01264975 JAJ86749.1 MG020528 AUC64084.1 CAEY01001012 GDRN01037377 JAI67298.1 ABLF02032300

Proteomes

UP000005204 UP000283053 UP000053268 UP000218220 UP000192223 UP000007266 + More
UP000008744 UP000007798 UP000192221 UP000001819 UP000000803 UP000235965 UP000008711 UP000000304 UP000001292 UP000007801 UP000268350 UP000002282 UP000027135 UP000030765 UP000075880 UP000009192 UP000037069 UP000075883 UP000095300 UP000092444 UP000075884 UP000078200 UP000075920 UP000001070 UP000092445 UP000076407 UP000075886 UP000075903 UP000075840 UP000075900 UP000092553 UP000095301 UP000008792 UP000069272 UP000000673 UP000005203 UP000075882 UP000075885 UP000002358 UP000076502 UP000008237 UP000007062 UP000279307 UP000009046 UP000000311 UP000036403 UP000215335 UP000075902 UP000076858 UP000078542 UP000078541 UP000078492 UP000007755 UP000005205 UP000075809 UP000019118 UP000078540 UP000015104 UP000007819

PRIDE

H9JMJ4 P32866

Pfam

PF00615   RGS        + More
PF00069   Pkinase
PF18701   DUF5641
PF00665   rve
PF17921   Integrase_H2C2
PF03388   Lectin_leg-like

Interpro

IPR011009   Kinase-like_dom_sf        + More
IPR016137   RGS
IPR017441   Protein_kinase_ATP_BS
IPR000239   GPCR_kinase
IPR000719   Prot_kinase_dom
IPR000961   AGC-kinase_C
IPR036305   RGS_sf
IPR012337   RNaseH-like_sf
IPR001584   Integrase_cat-core
IPR041588   Integrase_H2C2
IPR036397   RNaseH_sf
IPR040676   DUF5641
IPR035664   VIP36_lectin
IPR013320   ConA-like_dom_sf
IPR005052   Lectin_leg
IPR007096   RNA-dir_Rpol_phage_catalytic
IPR008271   Ser/Thr_kinase_AS

SUPFAM

SSF56112   SSF56112        + More
SSF48097   SSF48097
SSF53098   SSF53098
SSF49899   SSF49899

Gene 3D

3.30.420.10

CDD

cd06901 lectin_VIP36_VIPL

ProteinModelPortal

H9JMJ4 A0A2H1V954 A0A3S2P6R4 A0A194PL03 A0A2A4JQW5 A0A1Y1L675 + More
A0A1W4XLR8 A0A1W4XWR6 A0A0T6AZ63 A0A1B6GR23 D6X0V3 B4GYT9 B4NG39 A0A1W4U6Z6 Q29BB5 A0A0B4KI69 A0A2J7PI58 B3P540 P32866 B4QSM6 B4I027 B3M096 A0A3B0JFG3 B4PNE0 A0A1L8DKG0 W8BDD7 A0A1L8DKF8 A0A1L8DKC4 A0A0K8VXQ6 A0A0A1WZ01 A0A0K8V160 A0A034VE27 A0A067QPB3 A0A069DZB0 A0A084W393 A0A2C9GSP1 A0A023F5Q5 B4K8A6 A0A0L0CU95 A0A1B6DBE1 A0A182M4W0 A0A1I8NVT6 A0A1B6C906 A0A1B0GFP4 A0A182N5M7 A0A1A9V7M1 A0A1Q3FU19 A0A1Q3FU25 A0A2J7PI36 A0A2C9H6H0 B4JRX4 A0A1B0AA08 A0A2C9H8E6 A0A182QN22 A0A2C9H5S4 A0A1S4GK59 A0A182II07 T1PKV8 A0A2C9GWR0 A0A0M4EWE2 A0A1I8N714 A0A2J7PI59 B4LWZ6 A0A0A9ZGM9 A0A2M4CTV0 A0A2M4AIB5 A0A2M3ZHW7 A0A2C9GGV1 W5JH35 A0A1B6D437 A0A088ADE1 A0A182L7I9 A0A3F2YWJ4 A0A0C9RAD6 K7IM99 A0A154NXH7 A0A2H8TNZ6 E2BNK4 Q7PQK8 A0A3L8DKI1 E0VBQ6 E2AIQ4 A0A0J7L259 A0A232F0X5 A0A0P4WEW5 A0A182U7J7 A0A0P6G8F0 A0A195D498 A0A195FY24 A0A151IZ93 F4WLF2 A0A158NVI8 A0A151WMM5 N6SYS6 A0A195BPH6 A0A0P5F6K4 A0A2H4WAM2 T1L358 A0A0P4WJQ8 J9JZV8

KEGG

101747093 K08291 G protein-coupled receptor kinase [EC:2.7.11.16] | (RefSeq) G protein-coupled receptor kinase

PATHWAY

04144 Endocytosis - Bombyx mori (domestic silkworm)
04341 Hedgehog signaling pathway - fly - Bombyx mori (domestic silkworm)

GO

GO:0005524 GO:0007165 GO:0004703 GO:0045879 GO:0048601 GO:0045880 GO:0070273 GO:0009898 GO:0005737 GO:0048260 GO:0007476 GO:0045752 GO:0006963 GO:0003384 GO:0043950 GO:0050830 GO:0005886 GO:0004674 GO:0006468 GO:0016021 GO:0019079 GO:0003968 GO:0004672 GO:0006418 GO:0003707 GO:0006281 GO:0006259

Subcellular location

Membrane

Length:

431

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.43426

Exp number, first 60 AAs:

0.0113

Total prob of N-in:

0.03015

outside

1 - 431

Pi

157.740161

Theta

152.485825

Tajima's D

0.415214

CLR

0.261503

CSRT

0.48347582620869

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics