Gene

KWMTBOMO15525  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010797

Annotation

PREDICTED:_methionine--tRNA_ligase?_mitochondrial_[Papilio_xuthus]

Location

Bomo_Chr26(+):1825356-1836590      View in EpiBrowser

Full name

Methionine--tRNA ligase, mitochondrial      

Alternative Name

Mitochondrial methionyl-tRNA synthetase

Location in the cell

Mitochondrial   Reliability : 2.538

CDS

ATGCGGTTGACTTTGCGCTTACTATCCTCGGCGATCGCAAAAAGACCATTCTATGTCACGACTCCGATATTTTACGTTAACGCTCCACCACACATCGGTCACTTGTACTCAGCAGTAGTAGCAGATGCCATACAGAGGTTTGAAAAGCTCATCAGTCCTGACTGTAATGTCATATTCAGTACGGGTACAGACGAACACGGTACAAAGATCCAGCAAGCAGCATTAAAAGCTAACCTCTCCTTACCGCACTACTGTGACACCGTGAGCAATGAGTACAGGCAATTATTCAAGGATTTTGATGTCGAATACACGGATTTTATACGTACAACTGAGGAAAGACATACTAAAGCAGTTACACATTTCTGGAACGAGCTGCTCAAAAATGATTACATTTACAAAGCAAAATATTCAGGATGGTACAGCGTTAACGATGAGGCTTTTGTACCCGAGACACACATTAAAGAAGAGATCAGAGACGGTGAGAAGATAAAAGTGGCAACGGACTCGGGGCATCCCGTCGAGTGGACTGAAGAGTCCAACTATATGTTCAGGATGAGCGCCTTCAGAACTCACCTTCAGGAGTGGCTCAGGACTGATGGTGTTGTGACACCGGCCAAATACCAAAAGCAGCTTCTGGACATGCTGAGAAACGACACTTATTTCCCGGACATATCCGTCAGCAGACCTTCGTCCAGAGTGCACTGGGCCATTAGGGTCCCGAACGATGAGGAGCAAAGCATATACGTGTGGCTGGACGCTCTGATCAACTATCTGACCGTGATCGGCTACCCTGACGACGACGCGATGAAGCTCCGCGGCCGACCCTGGCCGGCCGACGTCCACGTCATCGGGAAGGACATCCTCAAGTTCCACGGGCTGTACTGGCCCGCGTTCCTGATGGCGGCGCGCCGGCCCCCGCCGCGGCGGCTGCTGTGCCACGCGCACTGGACCGTGGACGGCAGCAAGATGTCAAAGTCGCGCCGCAACGCCGTGCCCCCCCGCCGCGTGCCCGCGCCCCCCGCCGCGCTGCGCTACCTGCTGCTGCGGGGGAGCACCCTGCCGCACGACGCCAACTACAGCGAGACGAAGCTGATCAACATCGCGAACTCCGAGCTGGCGGACACGCTCGGCAACCTCGCCTCGCGCTGCTGCGGCGCCGCGCTCAACCCGCGACAAGAGTTCCCCGCGCTGCGCCGCCCGCACCCCCGCGCGCGCCCGCTGCGACACGCGCTCGACCGCCTGCCCGACGCATGCTACGAACACTACTCGAACTATGAGTTCTACAAGGTGGCAGATGCGGTGATGCACTGCCTCCACCAAGCGAACCTGTTCTTCGAGACTGAGAGGCCCTGGGAGTTGAAGAACAAGGCCGAGTGTCAGTCGGAGCTGGACGCGGTGCTGCACATCACGATGGAGACGCTGCGGCTGTGCGGCATCGTGCTGCAGCCGCTGGTGCCGGGGCTGGCGGGGCGGCTGCTGGACCGGCTGGCGGTGGCCGAGCGGGGCTGGCGGGACCTGCGCCCCTCGTGGCAAGCCGCCGACGCCATACACGAGACCAGACGCATCCAGGGCGGGAAGTTCGTACTGTTTCCCAGGATTAGTAAAGACAAGGACAATTTGCACAAGAAGCAGGCGAGTGCGTGA

Protein

MRLTLRLLSSAIAKRPFYVTTPIFYVNAPPHIGHLYSAVVADAIQRFEKLISPDCNVIFSTGTDEHGTKIQQAALKANLSLPHYCDTVSNEYRQLFKDFDVEYTDFIRTTEERHTKAVTHFWNELLKNDYIYKAKYSGWYSVNDEAFVPETHIKEEIRDGEKIKVATDSGHPVEWTEESNYMFRMSAFRTHLQEWLRTDGVVTPAKYQKQLLDMLRNDTYFPDISVSRPSSRVHWAIRVPNDEEQSIYVWLDALINYLTVIGYPDDDAMKLRGRPWPADVHVIGKDILKFHGLYWPAFLMAARRPPPRRLLCHAHWTVDGSKMSKSRRNAVPPRRVPAPPAALRYLLLRGSTLPHDANYSETKLINIANSELADTLGNLASRCCGAALNPRQEFPALRRPHPRARPLRHALDRLPDACYEHYSNYEFYKVADAVMHCLHQANLFFETERPWELKNKAECQSELDAVLHITMETLRLCGIVLQPLVPGLAGRLLDRLAVAERGWRDLRPSWQAADAIHETRRIQGGKFVLFPRISKDKDNLHKKQASA

Catalytic Activity

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)

Similarity

Belongs to the class-I aminoacyl-tRNA synthetase family.

Keywords

Aminoacyl-tRNA synthetase   ATP-binding   Complete proteome   Ligase   Mitochondrion   Nucleotide-binding   Protein biosynthesis   Reference proteome   Transit peptide  

Feature

chain  Methionine--tRNA ligase, mitochondrial

Uniprot

H9JMP4   A0A2A4JQY3   A0A3S2TSB0   A0A2W1BHX4   A0A194PK29   A0A212FL50   + More
A0A1Y1L3G8   A0A139WCD0   A0A1B0D4P1   A0A034WBY6   A0A1B0CGA3   A0A1B6KB66   A0A336KJ67   A0A0K8UA58   A0A0A1XJZ0   A0A336N013   A0A0K8UWH9   A0A2P8YCR6   A0A1B6G566   W8BAT5   B3LYB0   A0A2J7PUV2   B0W122   B4N9J4   B4M054   T1PJE8   A0A182IYZ3   B4KDU9   A0A1W4UT34   A0A1I8NIF3   Q17E70   A0A1S4F637   A0A1B6E4L4   A0A084W1N0   A0A3B0K459   B4K031   A0A182VFK9   A0A1I8NMG0   Q298Y4   B3P0N7   Q7QC00   A0A182TKX8   A0A182HT90   B4G4V4   A0A182G136   A0A182LFB4   A0A182F8C2   A0A2R7W1L7   A0A0M4EM70   Q9VFL5   B4R0F8   B4PTA2   A0A182XIA3   B4HF35   A0A182KBE6   A0A2M4AKY2   A0A1B0B2R2   A0A067R322   A0A182PA52   A0A2M4AL39   A0A1A9YST8   A0A182Y774   A0A2M4BIY4   A0A2M4BJ11   T1HLP4   A0A1B0FEF5   A0A182RYF6   A0A2M4BJ36   A0A2M4BJA8   A0A1A9ZYZ1   A0A182NA77   W5JRB3   A0A2J7PUU2   A0A2M3ZIF8   A0A2M3Z9E8   A0A0A9XWG0   A0A146KN59   A0A023F1R9   A0A182W2W2   A0A1A9VG17   A0A131YKU6   A0A224YTD7   L7MFY6   A0A182QE22   A0A1A9W7E1   V5HHF2   A0A224XI02   A0A131Y315   B7QJS1   A0A2S2NK23   A0A131XD33   A0A0C9PHT7   A0A2H8U011   A0A0C9QB31   A0A1D2N0K8   A0A1J1J2J2   F4X4A7   A0A158NWS5   A0A195E3T4  

EC Number

6.1.1.10

Pubmed

19121390    28756777    26354079    22118469    28004739    18362917    + More
19820115    25348373    25830018    29403074    24495485    17994087    25315136    17510324    24438588    15632085    12364791    14747013    17210077    26483478    20966253    10731132    12537572    12537569    22448145    17550304    24845553    25244985    20920257    23761445    25401762    26823975    25474469    26830274    28797301    25576852    25765539    28049606    27289101    21719571    21347285   

EMBL

BABH01016667    BABH01016668    BABH01016669    NWSH01000745    PCG74447.1    RSAL01000010    + More
RVE53756.1    KZ150188    PZC72436.1    KQ459601    KPI93677.1    AGBW02007856    OWR54473.1    GEZM01067904    JAV67331.1    KQ971371    KYB25592.1    AJVK01011552    GAKP01007120    JAC51832.1    AJWK01010900    GEBQ01031297    JAT08680.1    UFQS01000505    UFQT01000505    SSX04487.1    SSX24851.1    GDHF01028762    JAI23552.1    GBXI01002598    JAD11694.1    UFQT01003780    SSX35275.1    GDHF01021373    JAI30941.1    PYGN01000699    PSN42055.1    GECZ01012202    JAS57567.1    GAMC01012407    JAB94148.1    CH902617    EDV44014.2    NEVH01021192    PNF20112.1    DS231819    EDS42839.1    CH964232    EDW81670.1    CH940650    EDW68304.1    KA648038    AFP62667.1    CH933806    EDW14946.1    CH477285    EAT44749.1    GEDC01004426    JAS32872.1    ATLV01019399    KE525269    KFB44124.1    OUUW01000013    SPP88073.1    CH916384    EDV91633.1    CM000070    EAL27820.2    CH954181    EDV48863.1    AAAB01008859    EAA07531.4    APCN01000423    CH479179    EDW24620.1    JXUM01135890    KQ568348    KXJ69033.1    KK854226    PTY13328.1    CP012526    ALC45538.1    AE014297    AY069128    CM000364    EDX12973.1    CM000160    EDW97601.1    CH480815    EDW42209.1    GGFK01008122    MBW41443.1    JXJN01007687    KK852731    KDR17489.1    GGFK01008121    MBW41442.1    GGFJ01003851    MBW52992.1    GGFJ01003853    MBW52994.1    ACPB03014349    CCAG010001987    GGFJ01003852    MBW52993.1    GGFJ01003922    MBW53063.1    ADMH02000650    ETN65445.1    PNF20115.1    GGFM01007479    MBW28230.1    GGFM01004307    MBW25058.1    GBHO01018487    JAG25117.1    GDHC01021110    JAP97518.1    GBBI01003297    JAC15415.1    GEDV01008634    JAP79923.1    GFPF01009700    MAA20846.1    GACK01002124    JAA62910.1    AXCN02000218    GANP01009791    JAB74677.1    GFTR01006988    JAW09438.1    GEFM01003380    JAP72416.1    ABJB011061153    DS953774    EEC19093.1    GGMR01004914    MBY17533.1    GEFH01004581    JAP64000.1    GBYB01000438    GBYB01000440    JAG70205.1    JAG70207.1    GFXV01007287    MBW19092.1    GBYB01000439    JAG70206.1    LJIJ01000319    ODM98823.1    CVRI01000066    CRL06004.1    GL888633    EGI58703.1    ADTU01000451    KQ979685    KYN19808.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000007151    UP000007266    + More
UP000092462    UP000092461    UP000245037    UP000007801    UP000235965    UP000002320    UP000007798    UP000008792    UP000075880    UP000009192    UP000192221    UP000095301    UP000008820    UP000030765    UP000268350    UP000001070    UP000075903    UP000095300    UP000001819    UP000008711    UP000007062    UP000075902    UP000075840    UP000008744    UP000069940    UP000249989    UP000075882    UP000069272    UP000092553    UP000000803    UP000000304    UP000002282    UP000076407    UP000001292    UP000075881    UP000092460    UP000027135    UP000075885    UP000092443    UP000076408    UP000015103    UP000092444    UP000075900    UP000092445    UP000075884    UP000000673    UP000075920    UP000078200    UP000075886    UP000091820    UP000001555    UP000094527    UP000183832    UP000007755    UP000005205    UP000078492   

PRIDE

H9JMP4    Q9VFL5   

Pfam

PF09334   tRNA-synt_1g        + More
PF08264   Anticodon_1

Interpro

IPR009080   tRNAsynth_Ia_anticodon-bd        + More
IPR015413   Methionyl/Leucyl_tRNA_Synth       
IPR033911   MetRS_core       
IPR014729   Rossmann-like_a/b/a_fold       
IPR014758   Met-tRNA_synth       
IPR013155   M/V/L/I-tRNA-synth_anticd-bd       
IPR041872   Anticodon_Met       
IPR011990   TPR-like_helical_dom_sf       
IPR003107   HAT       

SUPFAM

SSF47323   SSF47323        + More
SSF48452   SSF48452       

Gene 3D

3.40.50.620     1.25.40.10    

CDD

cd00814  MetRS_core
cd07957  Anticodon_Ia_Met

ProteinModelPortal

H9JMP4   A0A2A4JQY3   A0A3S2TSB0   A0A2W1BHX4   A0A194PK29   A0A212FL50   + More
A0A1Y1L3G8   A0A139WCD0   A0A1B0D4P1   A0A034WBY6   A0A1B0CGA3   A0A1B6KB66   A0A336KJ67   A0A0K8UA58   A0A0A1XJZ0   A0A336N013   A0A0K8UWH9   A0A2P8YCR6   A0A1B6G566   W8BAT5   B3LYB0   A0A2J7PUV2   B0W122   B4N9J4   B4M054   T1PJE8   A0A182IYZ3   B4KDU9   A0A1W4UT34   A0A1I8NIF3   Q17E70   A0A1S4F637   A0A1B6E4L4   A0A084W1N0   A0A3B0K459   B4K031   A0A182VFK9   A0A1I8NMG0   Q298Y4   B3P0N7   Q7QC00   A0A182TKX8   A0A182HT90   B4G4V4   A0A182G136   A0A182LFB4   A0A182F8C2   A0A2R7W1L7   A0A0M4EM70   Q9VFL5   B4R0F8   B4PTA2   A0A182XIA3   B4HF35   A0A182KBE6   A0A2M4AKY2   A0A1B0B2R2   A0A067R322   A0A182PA52   A0A2M4AL39   A0A1A9YST8   A0A182Y774   A0A2M4BIY4   A0A2M4BJ11   T1HLP4   A0A1B0FEF5   A0A182RYF6   A0A2M4BJ36   A0A2M4BJA8   A0A1A9ZYZ1   A0A182NA77   W5JRB3   A0A2J7PUU2   A0A2M3ZIF8   A0A2M3Z9E8   A0A0A9XWG0   A0A146KN59   A0A023F1R9   A0A182W2W2   A0A1A9VG17   A0A131YKU6   A0A224YTD7   L7MFY6   A0A182QE22   A0A1A9W7E1   V5HHF2   A0A224XI02   A0A131Y315   B7QJS1   A0A2S2NK23   A0A131XD33   A0A0C9PHT7   A0A2H8U011   A0A0C9QB31   A0A1D2N0K8   A0A1J1J2J2   F4X4A7   A0A158NWS5   A0A195E3T4  

PDB

3KFL     E-value=5.77824e-81,     Score=768

KEGG

101735767    K01874 methionyl-tRNA synthetase [EC:6.1.1.10] | (RefSeq) methionine--tRNA ligase, mitochondrial

PATHWAY

00450    Selenocompound metabolism - Bombyx mori (domestic silkworm)
00970    Aminoacyl-tRNA biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004825   GO:0006431   GO:0005524   GO:0004812   GO:0006412   GO:0005739   GO:0005759   GO:0006396   GO:0000166   GO:0005737   GO:0006418   GO:0003707   GO:0006281   GO:0006259  

Subcellular location

Mitochondrion matrix  

Length:

547

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.21561

Exp number, first 60 AAs:

0.19618

Total prob of N-in:

0.00999

outside

1  -  547

 

 

Pi

200.079886

Theta

151.495363

Tajima's D

1.879864

CLR

0.169591

CSRT

0.864756762161892

Interpretation

Uncertain