Gene

KWMTBOMO15500  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010790

Annotation

succinate_dehydrogenase_[Danaus_plexippus]

Location

Bomo_Chr26(+):857796-859164      View in EpiBrowser

Full name

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial      

Alternative Name

Iron-sulfur subunit of complex II

Location in the cell

Extracellular   Reliability : 1.611 Mitochondrial   Reliability : 2.13

CDS

ATGCCTTTGCTTAGGCTGACGACTGGTACCTTCGGGCAGCTGCGTACGTTTGCTACGTCAGCATCCCTCGCAAAACGTGTTAAGACCTTCGCAGTCTATCGATGGAACCCCGATGAGCCCGACAAGAAACCTTATACGCAAAATTTCGAAGTGGATTTGGACGACTGCGCACCTATGGTATTGGACGCTTTGCTGAAGATTAAGAACGAAGTAGACCCAACCCTGACCTTCAGACGTTCGTGCCGAGAGGGCGTTTGTGGTTCTTGTGCGATGAATATCGACGGCGTCAACACTCTGGCCTGCATCAGCCATATCGATCAAAACATTTCCAAGCCGACGAAGATTTATCCTCTACCTCACATGTACGTCGTCAAAGACTTGGTCCCCGATCTGACCAACTTTTACCGGCAGTACCAGTCTATCGAGCCGTGGCTGCAGCGTGAAAATGAAGCTGTTAAAGGTAAGGAGACTCAATTGCTCCAGGACGTAGAGGACCGCGTCAAGTTGGATGGTCTCTATGAATGTGTGCTATGTGCTTGCTGTTCGACGAGTTGCCCGTCCTACTGGTGGAATGGAGATAAGTACCTAGGCCCTGCTGTCCTCATGCAGGCCTACAGGTGGATCATTGACTCCCGAGATGAAGCCACTGAGAAACGTTTATCAAAACTCAAGGACACATACTCGGTATACCGTTGCCATACAATCATGAACTGCACTCGCACATGCCCTAAAGGTCTGAACCCAGGCCGGGCCATTGCCCAGATCAAAACCTTACTCTCGGGTATAGTTAAGAAGCAGCCACCTATAATGGACCCTGCTGGCTTGCAGAAGCAGACAGCGAGCAATTAA

Protein

MPLLRLTTGTFGQLRTFATSASLAKRVKTFAVYRWNPDEPDKKPYTQNFEVDLDDCAPMVLDALLKIKNEVDPTLTFRRSCREGVCGSCAMNIDGVNTLACISHIDQNISKPTKIYPLPHMYVVKDLVPDLTNFYRQYQSIEPWLQRENEAVKGKETQLLQDVEDRVKLDGLYECVLCACCSTSCPSYWWNGDKYLGPAVLMQAYRWIIDSRDEATEKRLSKLKDTYSVYRCHTIMNCTRTCPKGLNPGRAIAQIKTLLSGIVKKQPPIMDPAGLQKQTASN

Description

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

Catalytic Activity

a quinone + succinate = a quinol + fumarate

Cofactor

[2Fe-2S] cluster
[3Fe-4S] cluster
[4Fe-4S] cluster

Subunit

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.

Similarity

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Keywords

2Fe-2S   3Fe-4S   4Fe-4S   Complete proteome   Electron transport   Iron   Iron-sulfur   Membrane   Metal-binding   Mitochondrion   Mitochondrion inner membrane   Oxidoreductase   Reference proteome   Transit peptide   Transport   Tricarboxylic acid cycle  

Feature

chain  Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Uniprot

H9JMN7   A0A0N1I5J0   A0A194PK15   A0A2W1BX81   A0A2A4JSJ5   A0A2H1VIJ5   + More
S4PC61   A0A212EV40   A0A0L7LNH6   D6X2Q0   U5EQE4   T1RTD7   A0A1L8E0S5   A0A1L8E0V1   A0A0K8TTF2   A0A067RP06   A0A336MIX3   A0A0K8UXQ3   A0A034VQX5   A0A336KDL9   A0A182I2Y3   A0A0A1WNK2   A0A182Q5D3   A0A1A9WEH1   W8BSL4   A0A1A9YKJ6   A0A182WJJ9   A0A182WZ23   Q7PF83   A0A1A9V700   A0A1A9Z829   D3TR09   A0A1B0BYT9   A0A182NKL7   A0A1B0FII9   T1DQM8   A0A182XYJ6   A0A182RU08   A0A154PCT3   A0A2M3Z5S0   A0A182MRP5   A0A182IZL3   A0A2M3Z5P3   A0A2M4CTU9   A0A182GN48   A0A2M4AB25   A0A182KQX0   T1PF50   A0A182P1Z7   W5JEB2   A0A2M3Z625   A0A1I8M520   A0A1Q3G4Y2   A0A182JXE6   Q16TA7   A0A1L8EH78   N6TW07   A0A0L0CDM2   A0A1B6C235   A0A1J1J215   A0A0M8ZPV7   A0A336M8I4   A0A0M5IZT2   A0A182UGJ5   B3MIM9   T1GM75   B4J6T2   B4LK89   A0A0N7ZRN7   V5SKI1   A0A0P5K0W9   A0A2J7Q9L0   A0A162QUE8   A0A1W4VE97   A0A0P6FY31   A0A310SPL2   A0A0P5HKN3   B4P190   A0A0P5J103   B3NB16   A0A2A3EJQ4   A0A0P5G4Q0   B4KNG7   B4QDQ8   P21914   A0A0N8BEC9   B4HQC4   A0A0N8DAQ9   A0A0P4WIX1   Q292X9   B4GC97   C1C2I4   A0A0P6IDW0   A0A3B0J261   Q4PP85   A0A2R7VS39   C1BV23   A0A0P4XQR5   B4MY40   A0A1D2N897  

EC Number

1.3.5.1

Pubmed

19121390    26354079    28756777    23622113    22118469    26227816    + More
18362917    19820115    26369729    24845553    25348373    25830018    24495485    12364791    14747013    17210077    20353571    25244985    26483478    20966253    20920257    23761445    25315136    17510324    23537049    26108605    17994087    17550304    22936249    7958999    10731132    12537572    12537569    2494655    15632085    27289101   

EMBL

BABH01016560    KQ461003    KPJ10014.1    KQ459601    KPI93662.1    KZ149908    + More
PZC78234.1    NWSH01000657    PCG74981.1    ODYU01002556    SOQ40222.1    GAIX01005617    JAA86943.1    AGBW02012241    OWR45368.1    JTDY01000481    KOB76985.1    KQ971372    EFA10709.2    GANO01003305    JAB56566.1    KC569746    AGO46415.1    GFDF01001741    JAV12343.1    GFDF01001753    JAV12331.1    GDAI01000165    JAI17438.1    KK852510    KDR22350.1    UFQT01001398    SSX30374.1    GDHF01025242    GDHF01020870    JAI27072.1    JAI31444.1    GAKP01014974    JAC43978.1    UFQS01000246    UFQT01000246    SSX01972.1    SSX22349.1    APCN01000188    GBXI01013663    JAD00629.1    AXCN02000551    GAMC01004428    JAC02128.1    AAAB01008807    EAA45422.4    EZ423861    ADD20137.1    JXJN01022823    CCAG010023101    GAMD01001070    JAB00521.1    KQ434874    KZC09633.1    GGFM01003112    MBW23863.1    AXCM01001272    GGFM01003074    MBW23825.1    GGFL01004423    MBW68601.1    JXUM01075681    JXUM01075682    JXUM01075683    JXUM01075684    JXUM01075685    JXUM01075686    KQ562900    KXJ74873.1    GGFK01004591    MBW37912.1    KA647422    AFP62051.1    ADMH02001632    ETN61683.1    GGFM01003209    MBW23960.1    GFDL01000219    JAV34826.1    CH477656    EAT37706.1    GFDG01000794    JAV18005.1    APGK01059303    KB741292    KB632203    ENN70482.1    ERL90079.1    JRES01000655    KNC29574.1    GEDC01029715    JAS07583.1    CVRI01000067    CRL06431.1    KQ435922    KOX68680.1    SSX01971.1    SSX22348.1    CP012524    ALC42186.1    CH902619    EDV38105.1    CAQQ02176024    CH916367    EDW02013.1    CH940648    EDW61680.1    GDIP01219241    GDIP01077813    GDIQ01037538    JAJ04161.1    JAN57199.1    KF647636    AHB50498.1    GDIQ01196321    JAK55404.1    NEVH01016348    PNF25275.1    LRGB01000261    KZS19960.1    GDIQ01187483    GDIQ01043936    JAN50801.1    KQ761346    OAD57844.1    GDIQ01249013    JAK02712.1    CM000157    EDW89092.1    GDIQ01231166    JAK20559.1    CH954177    EDV59781.1    KZ288232    PBC31492.1    GDIQ01247313    JAK04412.1    CH933808    EDW08926.1    CM000362    CM002911    EDX05920.1    KMY91816.1    L27705    AE013599    AY118923    GDIQ01186027    JAK65698.1    CH480816    EDW46663.1    GDIP01052175    JAM51540.1    GDIP01254694    JAI68707.1    CM000071    EAL24732.1    CH479181    EDW31415.1    BT081063    ACO15487.1    GDIQ01006747    JAN87990.1    OUUW01000001    SPP73043.1    DQ062228    AAY63983.1    KK854044    PTY10169.1    BT078452    BT120985    ACO12876.1    ADD37915.1    GDIP01242061    JAI81340.1    CH963894    EDW77029.1    LJIJ01000150    ODN01472.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000007151    UP000037510    + More
UP000007266    UP000027135    UP000075840    UP000075886    UP000091820    UP000092443    UP000075920    UP000076407    UP000007062    UP000078200    UP000092445    UP000092460    UP000075884    UP000092444    UP000076408    UP000075900    UP000076502    UP000075883    UP000075880    UP000069940    UP000249989    UP000075882    UP000075885    UP000000673    UP000095301    UP000075881    UP000008820    UP000019118    UP000030742    UP000037069    UP000183832    UP000053105    UP000092553    UP000075902    UP000007801    UP000015102    UP000001070    UP000008792    UP000235965    UP000076858    UP000192221    UP000002282    UP000008711    UP000242457    UP000009192    UP000000304    UP000000803    UP000001292    UP000001819    UP000008744    UP000268350    UP000007798    UP000094527   

PRIDE

H9JMN7    P21914   

Pfam

PF13085   Fer2_3

Interpro

IPR009051   Helical_ferredxn        + More
IPR025192   Succ_DH/fum_Rdtase_N       
IPR006058   2Fe2S_fd_BS       
IPR012675   Beta-grasp_dom_sf       
IPR017896   4Fe4S_Fe-S-bd       
IPR017900   4Fe4S_Fe_S_CS       
IPR004489   Succ_DH/fum_Rdtase_Fe-S       
IPR001041   2Fe-2S_ferredoxin-type       
IPR036010   2Fe-2S_ferredoxin-like_sf       

SUPFAM

SSF46548   SSF46548        + More
SSF54292   SSF54292       

Gene 3D

1.10.1060.10     3.10.20.30    

CDD

cd00207  fer2

ProteinModelPortal

H9JMN7   A0A0N1I5J0   A0A194PK15   A0A2W1BX81   A0A2A4JSJ5   A0A2H1VIJ5   + More
S4PC61   A0A212EV40   A0A0L7LNH6   D6X2Q0   U5EQE4   T1RTD7   A0A1L8E0S5   A0A1L8E0V1   A0A0K8TTF2   A0A067RP06   A0A336MIX3   A0A0K8UXQ3   A0A034VQX5   A0A336KDL9   A0A182I2Y3   A0A0A1WNK2   A0A182Q5D3   A0A1A9WEH1   W8BSL4   A0A1A9YKJ6   A0A182WJJ9   A0A182WZ23   Q7PF83   A0A1A9V700   A0A1A9Z829   D3TR09   A0A1B0BYT9   A0A182NKL7   A0A1B0FII9   T1DQM8   A0A182XYJ6   A0A182RU08   A0A154PCT3   A0A2M3Z5S0   A0A182MRP5   A0A182IZL3   A0A2M3Z5P3   A0A2M4CTU9   A0A182GN48   A0A2M4AB25   A0A182KQX0   T1PF50   A0A182P1Z7   W5JEB2   A0A2M3Z625   A0A1I8M520   A0A1Q3G4Y2   A0A182JXE6   Q16TA7   A0A1L8EH78   N6TW07   A0A0L0CDM2   A0A1B6C235   A0A1J1J215   A0A0M8ZPV7   A0A336M8I4   A0A0M5IZT2   A0A182UGJ5   B3MIM9   T1GM75   B4J6T2   B4LK89   A0A0N7ZRN7   V5SKI1   A0A0P5K0W9   A0A2J7Q9L0   A0A162QUE8   A0A1W4VE97   A0A0P6FY31   A0A310SPL2   A0A0P5HKN3   B4P190   A0A0P5J103   B3NB16   A0A2A3EJQ4   A0A0P5G4Q0   B4KNG7   B4QDQ8   P21914   A0A0N8BEC9   B4HQC4   A0A0N8DAQ9   A0A0P4WIX1   Q292X9   B4GC97   C1C2I4   A0A0P6IDW0   A0A3B0J261   Q4PP85   A0A2R7VS39   C1BV23   A0A0P4XQR5   B4MY40   A0A1D2N897  

PDB

4YXD     E-value=8.57422e-108,     Score=996

KEGG

101746165    K00235 succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1] | (RefSeq) succinate de

PATHWAY

00020    Citrate cycle (TCA cycle) - Bombyx mori (domestic silkworm)
00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0051539   GO:0006099   GO:0009055   GO:0051538   GO:0051537   GO:0008177   GO:0005743   GO:0046872   GO:0022904   GO:0009060   GO:0031966   GO:0006121   GO:0048039   GO:0005749   GO:0016491   GO:0051536   GO:0043565   GO:0003677   GO:0003707   GO:0006281   GO:0006259   GO:0055114  

Subcellular location

Mitochondrion inner membrane  

Length:

282

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00512

Exp number, first 60 AAs:

0.00202

Total prob of N-in:

0.01306

outside

1  -  282

 

 

Pi

138.495359

Theta

143.997367

Tajima's D

0.035853

CLR

1.612618

CSRT

0.372031398430078

Interpretation

Uncertain