Gene

KWMTBOMO15492  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010763

Annotation

aminopeptidase_N_precursor_[Bombyx_mori]

Location

Bomo_Chr26(-):638938-662235      View in EpiBrowser

Full name

Aminopeptidase      

Location in the cell

PlasmaMembrane   Reliability : 1.328

CDS

ATGGCGTGCTTGCATTTTATTTTATTGTTGTCCTGTGCGCTGCTGTCCACGGGCGAATACCTGCTGCCCGGCGATGTGGTGCCGACATTCTACGACGTGCTCCTCATTTACGACGTGGATCCGGCGACGAACTTCAGCTACTTCGGCCGTGTCGACATTAAATTAAACATCCTCAAACCGACCTCAAAGATCGTGCTCCACGCGCAAGGCTTCAGCATACCGGAAGAGGAAGTGACCCTGACAGGGCCCAAGGAGGTGGCAGTTGACAATGTCAAACTGAACGACACGTTCAATTTATTGACACTGTCGCTGAGTCAGCAGTTGGATGAAGGCGACAACTACGTGCTGCGAATACCTTTCTACGGCAATCTGCAGCAAGATCTGGATGGGACCTACATCAGTAAATACGTCGATAAGAAAACAAAGAAAAATGAATATTTGGTGACGACGCAATTCGAGGCGATATCAGCTAGAAAAGGTTTCCCGTGCTTTGACGAACCGATGTACAAGGCGCCCTTCAAGATATCCATCGGCCATCACATCAATTATGTTGCCGTTTCCAACATGCCTCTAGTGTCGACGGATAATTATAATGTCCTGGAGGAAACATGGCCTTGGAAAACTATCGGACAAAAGTTCAATAAAGCCGTTTACGATTTCGTCTGGGACCACTTCGACGTGTCCCTGTCAATGTCAACGTATCTCGTCGCTTACGTCATTTCGAAGTTCACATACGAGGAGAGCCCGCCCGAGCTGTCCGACACTAAGTTCAGGATCTGGGCTAACAAGGACACTATTGACCAGGCCGCCTACGCTAAGTCGATAGCGCCAAAAGTGCTGACACACTTCGAGAAGTGGTTCGACGTGAAATACCCGCTGCCTAAACAGGACATGATCGCCATTCCGGACTTCGCGGCCGGCGCCATGGAGAACTGGGGCCTCATAACCTACAGGGAGACCACCTTGCTCTACGATAAGAAGCACTCCTCGTTCTTGAACAAGGAAAGAGTAGCAGAGGTGATAGCGCACGAGCTGGCCCACCAGTGGTTCGGGAACCTGGTCACGATGAAGTGGTGGTCCGACCTGTGGCTGAACGAGGGGTTCGCGACGTACGCGGCGTCCGTGGGCGTGGCGGCCGTGGAGCCCACGTGGCGCGCGGACAACAACTACGCCGTCGACAACATGCTGGCCGTGCTCAACCTCGACGCCTTGGAGTCTTCGCACCCTGTGTCGGTCACAATAGACGACCCGAAGCGCATCTTCGAGATATTCGATGAGATCTCGTACAAGAAGGGCTCCACACTCATCAGGATGATGGTCATGTTCCTCGGAGAAGACGTCTTCAGGAAAGCCATTAAAAATTACCTCGTGAAGTACACGTTGAAGAACGCCGAACAAGATGACCTGTGGCACGAGCTCACTGAAGAGAGTAAGAGGCAGGGAGGGATCGCGAACAACGTGACCATCAAGGAGATAATGGACACGTGGACCACGCAAACCGGATACCCGATCCTGACCGTCACCAGGGATTATATAGACAAGTCTGTCAGCGTCACTCAGCGGCGGTACTTGTCGCTGGGGGCGCGCGCGGCGTCGCACCGCTCGTGGTGGGTGCCACTGCGCGTGGCGGCCGCGGGCGAGCAGCCCGAGCCCTCGCTGCACTGGCTCGCGACGCACCAGGGCCTGGACGAGCCCTACCGCTTCCCGCACGACGCAGAGCCCACCGACTGGATGCTCTTCAATCCCGATATGATCGCACCTTATCGCGTCAATTATGATGCTCGTAACTGGGAACTTCTTTCGGAGACACTGCTCAGCGACAAGTACGATGAGATCCCAGTACTGGGCAGAGTGCAACTGATATCGGACGCCTTCGCTCTGGCGGCCACCAACAGACTCAACTATTCCACTACACTGATTCTTGCAAGCTACCTCCAGAGAGAGAGGGAGTACCTGCCTCTGTCGACAGCGCTGAGAGGGTTGGCCAAGATTGAGAACCTCTTGAAGCGCAGCGGAGACTACAGCGCCTTCCAGAGCTACATCAGGCATCTGGTGCAGAACTCGTATCGAAGGGCTGGAGGCCTCTCCGTCAAGCGTATCGTTAATGGCGACGATCTGAACAGCGTAAAACTGCAGGTGTTGACCAGCGGCTGGGCCTGTCGCGCGCTGATACCGGGCTGCGAGGAAAACGCCATGGAGCTGTTCCAAATGTGGATGAACACTTCCAATCCGGATGAAAATAATCCGCAAGTTTTCTTTATTTTTTCATCTAAGGACACGATCGATGGGGATCACAAGTCGATGTCTCAATTTAAAACGACCCGCGCGGGGATGAAGATCCCGCTGGACCTGCGGCGCACGGTGTGGTGCGCGGGCGCGGCGCGCGGCGGCGAGCGCGAGTGGCGCTTCCTCACGCTGCGGCTGCAGGCCGCGCGCGTTGCCGCCGCCCGCGACGCCATGCTCGCCGCCATGGCCTGCACCAGGCAGGTCTGGCTGCTCAACCAGTTCCTCGAATGGGCGGTGTCGGAGAACTCCCCGGTGCGCAAGCAGGACGCGGCCGCCGTGGTCGGTAACGTGGCCCGCACGCCGGTCGGCTACTACGTCGCGCGGGAGTTCTTCTACAACCGAATCGACGATCTGTTTAAGACTTTCAACGGTCAGAGCCGCCGTTTCGGCTATATCATCAAGACTCTGCTGGACCAGTTCACGACTCAGAGAGAATTGGACGAGTTTCTCATTTTCCACGACAAGAACCCTAAATATTTCGAGGAGACGAAGCTGGCCGTCGTTCAGGCGATTGAGAAAGCCAAAGTGAACATCGACTGGGTCGACCAAAACAAAGATTTAGTTATGAGTGAATAA

Protein

MACLHFILLLSCALLSTGEYLLPGDVVPTFYDVLLIYDVDPATNFSYFGRVDIKLNILKPTSKIVLHAQGFSIPEEEVTLTGPKEVAVDNVKLNDTFNLLTLSLSQQLDEGDNYVLRIPFYGNLQQDLDGTYISKYVDKKTKKNEYLVTTQFEAISARKGFPCFDEPMYKAPFKISIGHHINYVAVSNMPLVSTDNYNVLEETWPWKTIGQKFNKAVYDFVWDHFDVSLSMSTYLVAYVISKFTYEESPPELSDTKFRIWANKDTIDQAAYAKSIAPKVLTHFEKWFDVKYPLPKQDMIAIPDFAAGAMENWGLITYRETTLLYDKKHSSFLNKERVAEVIAHELAHQWFGNLVTMKWWSDLWLNEGFATYAASVGVAAVEPTWRADNNYAVDNMLAVLNLDALESSHPVSVTIDDPKRIFEIFDEISYKKGSTLIRMMVMFLGEDVFRKAIKNYLVKYTLKNAEQDDLWHELTEESKRQGGIANNVTIKEIMDTWTTQTGYPILTVTRDYIDKSVSVTQRRYLSLGARAASHRSWWVPLRVAAAGEQPEPSLHWLATHQGLDEPYRFPHDAEPTDWMLFNPDMIAPYRVNYDARNWELLSETLLSDKYDEIPVLGRVQLISDAFALAATNRLNYSTTLILASYLQREREYLPLSTALRGLAKIENLLKRSGDYSAFQSYIRHLVQNSYRRAGGLSVKRIVNGDDLNSVKLQVLTSGWACRALIPGCEENAMELFQMWMNTSNPDENNPQVFFIFSSKDTIDGDHKSMSQFKTTRAGMKIPLDLRRTVWCAGAARGGEREWRFLTLRLQAARVAAARDAMLAAMACTRQVWLLNQFLEWAVSENSPVRKQDAAAVVGNVARTPVGYYVAREFFYNRIDDLFKTFNGQSRRFGYIIKTLLDQFTTQRELDEFLIFHDKNPKYFEETKLAVVQAIEKAKVNIDWVDQNKDLVMSE

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M1 family.

Feature

chain  Aminopeptidase

Uniprot

I3VR83   A0A220K8P2   A0A2W1BT37   A0A212EYJ4   A0A0N1IFL5   A0A194PRA0   + More
A0A2A4JS21   A0A2H1VHB7   D6WB37   A0A1I9WL50   A0A2L1IQ82   A0A1B6D6B8   A0A1B6HB93   A0A1Y1LUJ7   A0A2H8TQM9   E0VS66   N6TGU3   X1X0P5   A0A0K8V993   A0A0A1X3N6   A0A034VBT7   A0A0K8U897   A0A1J1IVX7   A0A1J1IZ42   W8BKE0   U5EU86   A0A1B6LLZ7   A0A182QC88   Q16MQ9   A0A224XI48   A0A1W4XNR6   A0A182GQP1   A0A182Y4U1   B3MTC9   A0A182FM81   A0A182RM22   B4JYJ5   B4K5Y1   A0A084W9N5   A0A182V1G0   A0A0Q9XBS5   A0A182SPU1   J9KGQ7   A0A182WY28   A0A2K8JME3   Q7Q4T0   A0A1W4U620   A0A336M458   A0A3B0JKK2   W5JLT5   J9JLW8   A0A0Q9WV74   B4NFN7   A0A182VV47   B4QZJ5   Q29BX5   A0A1Q3FSF6   Q9NH67   A0A023F109   B4HZ87   Q0KI00   B4MBV1   B4GPI5   A0A182K329   B3P5I4   A0A0M4F678   B4PQ42   A0A336KKE2   Q6IDH1   B3MTC8   A0A0N7Z8X1   A0A182PL06   A0A069DXR4   A0A0R1E4S0   A0A182N0H6   A0A1W4UH69   A0A224X6V4   A0A1B6GC72   A0A1W4UH28   B4PQ46   B3P5I7   A0A0V0G587   B3P5I5   A0A182TL54   A0A0T6AUS1   A0A0L0BPV0   B4QZJ4   A0A1I8N5N4   A0A0R1E4R4   B4PQ45   A0A0R1E9Q7   B4PQ43   B4QZJ3   A0A1I8PCE0   E2BB79   A0A182HMT5   B0X825   K7INE5  

EC Number

3.4.11.-

Pubmed

28630352    28756777    22118469    26354079    18362917    19820115    + More
27538518    29415259    28004739    20566863    23537049    25830018    25348373    24495485    17510324    26483478    25244985    17994087    24438588    12364791    14747013    17210077    20920257    23761445    15632085    25474469    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    27129103    26334808    26108605    25315136    20798317    20075255   

EMBL

JQ061154    AFK85028.1    MF319742    ASJ26456.1    KZ149908    PZC78228.1    + More
AGBW02011488    OWR46566.1    KQ461003    KPJ10021.1    KQ459601    KPI93655.1    NWSH01000721    PCG74619.1    ODYU01002553    SOQ40207.1    KQ971311    EEZ99336.1    KU932234    APA33870.1    MF741655    AVD96938.1    GEDC01016064    JAS21234.1    GECU01035837    JAS71869.1    GEZM01046358    GEZM01046357    JAV77303.1    GFXV01004127    MBW15932.1    DS235745    EEB16222.1    APGK01027780    APGK01027781    APGK01027782    APGK01027783    APGK01027784    APGK01027785    KB740671    ENN79629.1    ABLF02020109    GDHF01016887    JAI35427.1    GBXI01008343    JAD05949.1    GAKP01019737    JAC39215.1    GDHF01029538    JAI22776.1    CVRI01000060    CRL03858.1    CRL03857.1    GAMC01009092    JAB97463.1    GANO01002430    JAB57441.1    GEBQ01015299    JAT24678.1    AXCN02001411    CH477852    EAT35628.1    GFTR01008306    JAW08120.1    JXUM01080917    KQ563216    KXJ74267.1    CH902623    EDV30519.1    CH916377    EDV90757.1    CH933806    EDW16218.2    ATLV01021848    KE525324    KFB46929.1    KRG01998.1    ABLF02013994    KY031093    ATU82844.1    AAAB01008963    EAA12046.5    UFQS01000417    UFQT01000417    SSX03766.1    SSX24131.1    OUUW01000005    SPP81333.1    ADMH02001160    ETN63860.1    CH964251    KRF99732.1    EDW83104.2    CM000364    EDX14833.1    CM000070    EAL26872.1    GFDL01004639    JAV30406.1    AF231040    AAF34809.1    GBBI01003749    JAC14963.1    CH480819    EDW53344.1    AE014297    BT133378    AAF56884.1    AFH36363.1    CH940656    EDW58572.1    CH479186    EDW39068.1    CH954182    EDV53234.1    CP012526    ALC47157.1    CM000160    EDW98311.1    SSX03765.1    SSX24130.1    BT014634    AAT27258.1    EDV30518.1    GDKW01002163    JAI54432.1    GBGD01000392    JAC88497.1    KRK04205.1    GFTR01008270    JAW08156.1    GECZ01009731    JAS60038.1    EDW98315.1    EDV53237.1    GECL01003570    JAP02554.1    EDV53235.1    LJIG01022766    KRT78825.1    JRES01001565    KNC22036.1    EDX14832.1    KRK04208.1    EDW98314.1    KRK04210.1    EDW98312.1    EDX14831.1    GL446946    EFN87052.1    APCN01004903    DS232472    EDS42294.1   

Proteomes

UP000007151    UP000053240    UP000053268    UP000218220    UP000007266    UP000009046    + More
UP000019118    UP000007819    UP000183832    UP000075886    UP000008820    UP000192223    UP000069940    UP000249989    UP000076408    UP000007801    UP000069272    UP000075900    UP000001070    UP000009192    UP000030765    UP000075903    UP000075901    UP000076407    UP000007062    UP000192221    UP000268350    UP000000673    UP000007798    UP000075920    UP000000304    UP000001819    UP000001292    UP000000803    UP000008792    UP000008744    UP000075881    UP000008711    UP000092553    UP000002282    UP000075885    UP000075884    UP000075902    UP000037069    UP000095301    UP000095300    UP000008237    UP000075840    UP000002320    UP000002358   

PRIDE

I3VR83    Q9NH67    Q0KI00    Q6IDH1   

Pfam

PF11838   ERAP1_C        + More
PF01433   Peptidase_M1

Interpro

IPR042097   Aminopeptidase_N-like_N        + More
IPR024571   ERAP1-like_C_dom       
IPR014782   Peptidase_M1_dom       
IPR034016   M1_APN-typ       
IPR001930   Peptidase_M1       
IPR033581   APN2       

Gene 3D

2.60.40.1730    

CDD

cd09601  M1_APN_2

ProteinModelPortal

I3VR83   A0A220K8P2   A0A2W1BT37   A0A212EYJ4   A0A0N1IFL5   A0A194PRA0   + More
A0A2A4JS21   A0A2H1VHB7   D6WB37   A0A1I9WL50   A0A2L1IQ82   A0A1B6D6B8   A0A1B6HB93   A0A1Y1LUJ7   A0A2H8TQM9   E0VS66   N6TGU3   X1X0P5   A0A0K8V993   A0A0A1X3N6   A0A034VBT7   A0A0K8U897   A0A1J1IVX7   A0A1J1IZ42   W8BKE0   U5EU86   A0A1B6LLZ7   A0A182QC88   Q16MQ9   A0A224XI48   A0A1W4XNR6   A0A182GQP1   A0A182Y4U1   B3MTC9   A0A182FM81   A0A182RM22   B4JYJ5   B4K5Y1   A0A084W9N5   A0A182V1G0   A0A0Q9XBS5   A0A182SPU1   J9KGQ7   A0A182WY28   A0A2K8JME3   Q7Q4T0   A0A1W4U620   A0A336M458   A0A3B0JKK2   W5JLT5   J9JLW8   A0A0Q9WV74   B4NFN7   A0A182VV47   B4QZJ5   Q29BX5   A0A1Q3FSF6   Q9NH67   A0A023F109   B4HZ87   Q0KI00   B4MBV1   B4GPI5   A0A182K329   B3P5I4   A0A0M4F678   B4PQ42   A0A336KKE2   Q6IDH1   B3MTC8   A0A0N7Z8X1   A0A182PL06   A0A069DXR4   A0A0R1E4S0   A0A182N0H6   A0A1W4UH69   A0A224X6V4   A0A1B6GC72   A0A1W4UH28   B4PQ46   B3P5I7   A0A0V0G587   B3P5I5   A0A182TL54   A0A0T6AUS1   A0A0L0BPV0   B4QZJ4   A0A1I8N5N4   A0A0R1E4R4   B4PQ45   A0A0R1E9Q7   B4PQ43   B4QZJ3   A0A1I8PCE0   E2BB79   A0A182HMT5   B0X825   K7INE5  

PDB

6BV4     E-value=4.81329e-136,     Score=1245

KEGG

101745887    K11140 aminopeptidase N [EC:3.4.11.2] | (RefSeq) aminopeptidase N

PATHWAY

00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0008237   GO:0004177   GO:0008270   GO:0016021   GO:0043171   GO:0042277   GO:0005737   GO:0070006   GO:0006508   GO:0043401   GO:0003700   GO:0005634   GO:0043565   GO:0003677   GO:0003707   GO:0006281   GO:0006259  

PANTHER

PTHR11533:SF246  

SignalP

Position:   1 - 18,         Likelihood:  0.977212

 

 

Length:

953

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.961269999999999

Exp number, first 60 AAs:

0.95679

Total prob of N-in:

0.04433

outside

1  -  953

 

 

Pi

220.398907

Theta

160.095999

Tajima's D

-0.844946

CLR

0.26506

CSRT

0.165741712914354

Interpretation

Uncertain