Gene

KWMTBOMO15484

Pre Gene Modal

BGIBMGA010784

Annotation

PREDICTED:_TBC1_domain_family_member_7-like_[Papilio_machaon]

Location

Bomo_Chr26(+):462631-466075      View in EpiBrowser

Full name

TBC1 domain family member 7      

Alternative Name

Cell migration-inducing protein 23

Location in the cell

Cytoplasmic   Reliability : 3.343

CDS

ATGACGGACGAACGTAACTTCCGTTCGTCCTACTACGAGAAAGTCGGTTGCCGCGGAGTAGAAGAGAAGAAAACATTGGAAATTCTCATGAAAGAAAAACCTTGGGATCGAGTTAAATTGAAGCAATTTTGTCTAAGATTTACAGTTTTCGCTGATTACAGGAATTTAGTCTGGAAAGTACTACTAGACATCCTGCCTGTTTACCCAGATTCGTATGAATACGTGATGAAACAGCGGACAGAGCAATATCAGGATCTCCTATATGCGGTTGAGAAGTTACAATTGATTGAACCATCAGAAATATATGACGGTTCAGGTACCCCTCAGAGCAAAGTATTCCTGGAGATGTGGGTTTTAGAAAATGAAGAATGGAAACCACCTATATTCCCAGAGACAAACTTTAATTCTGCAGATACATTTCTCCCAATTGCTAAGACACTCAGGGAACTTTATGATGATCCAGTGGATGTGTATTGGTTCAGTAAGAGATTTACAGAGGTTGTGAAGAACATGCAGAAAGATCTCAACAAATTGAAGGAAGCATTCTATAATATGTTGGACAAACAAGATGGAGAATTGTATATTTACTTGCAAGATATAAATGCATTGGAAGTAATACCATTGGTGAACTGGTTTAACTGCTGCTTTGCTGGAATATTGGATGATACATCTTTACCGAAAATATGGGACAAAGTGTGCAGCGGAGCACCTAAAATTTTAGCATATGCTGCTGTGATGCTTGTCATTACTTTACGCCGCAATATTCTAAAAGCTAAAAATGCTGATGAAGTTGTAAAATGTGTAACAGAGATTCCAAAGCAATGTGAGGAGGTAGTGGCCAACAAAGCGATTGACTTGTGGCAATATTACGGAGCCCAACCGCAAAGCGACCAACTGGCGAAGAAATGA

Protein

MTDERNFRSSYYEKVGCRGVEEKKTLEILMKEKPWDRVKLKQFCLRFTVFADYRNLVWKVLLDILPVYPDSYEYVMKQRTEQYQDLLYAVEKLQLIEPSEIYDGSGTPQSKVFLEMWVLENEEWKPPIFPETNFNSADTFLPIAKTLRELYDDPVDVYWFSKRFTEVVKNMQKDLNKLKEAFYNMLDKQDGELYIYLQDINALEVIPLVNWFNCCFAGILDDTSLPKIWDKVCSGAPKILAYAAVMLVITLRRNILKAKNADEVVKCVTEIPKQCEEVVANKAIDLWQYYGAQPQSDQLAKK

Description

Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.

Subunit

Component of the TSC-TBC complex (also named Rhebulator complex), composed of the TSC1-TSC2 heterodimer and TBC1D7. Interacts with TSC1 (via C-terminal half of the coiled-coil domain).

Similarity

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

Keywords

Alternative splicing   Complete proteome   Cytoplasmic vesicle   GTPase activation   Reference proteome   3D-structure   Polymorphism  

Feature

chain  TBC1 domain family member 7
splice variant  In isoform 2.
sequence variant  In dbSNP:rs543580.

Uniprot

H9JMN1   A0A2W1BT38   A0A2A4J8V2   A0A2H1WJB3   A0A1E1WQM1   A0A0N0PBG0   + More
S4NXH8   A0A212FCI9   A0A194PLN9   A0A0L7LCJ7   A0A2P8YJ97   A0A2J7PT35   A0A067QXG3   D6X1P7   E0VFS3   A0A336N1M4   A0A2A3EEU0   N6TM20   J3JV08   A0A232FAS6   K7IXX5   A0A1B6C0Y6   E2AMK7   A0A026W5N2   E9GLF0   U5EYJ8   U4UIC9   A0A1B6K8B6   E2BJX5   A0A182M7E1   A0A1B0GMI1   A0A1Y1KZY2   A0A0T6BG58   A0A1W4XDZ7   A0A1Q3F2R1   A0A154P214   A0A2M4AS64   A0A182HT82   A0A0L7QQT5   A0A0P5K270   A0A182YKI3   A0A1C7CZV8   Q7QC09   A0A182JX80   A0A182J6Y1   A0A182V7N6   A0A182UC53   A0A182SXF7   A0A182PA60   A0A182VX56   W5JL26   A0A0P5NLA5   A0A182XI95   A0A0P4XJM8   A0A1B0CL08   A0A158NU81   F4WR61   A0A182QD42   A0A084W1N9   A0A151WET4   A0A182NA85   T1E8R3   A0A1S3HUP4   A0A1S3HDP5   E9J2N0   A0A2K5ITY5   A0A2K5XB13   A0A096NL01   A0A2K5KTA2   A0A2K6QVL7   A0A2K6L3Y2   A0A151J377   A0A0D9R5A0   A0A182GCP5   A0A1S3WWM7   V4BZW1   A0A151IQF2   B0WS62   A0A2I2YE76   Q9D0K0   G1QJ66   A0A2R9CS18   A0A2I3T1E4   A0A2J8WN18   A0A024QZX0   Q9P0N9   G1T2E1   A0A2K6BL71   G7MQR4   G7P4F8   A0A1A8PLC4   A0A1A8QBX7   A0A195BAR2   A0A3Q0CJ09   A0A195FJL9   H9FVD2   A0A1A8KBR6   A0A1A8BI44   A0A1A8VIU1   D4AAY4  

Pubmed

19121390    28756777    26354079    23622113    22118469    26227816    + More
29403074    24845553    18362917    19820115    20566863    23537049    22516182    28648823    20075255    20798317    24508170    30249741    21292972    28004739    25244985    20966253    12364791    14747013    17210077    20920257    23761445    21347285    21719571    24438588    21282665    25362486    26483478    23254933    22398555    16141072    15489334    21183079    22795129    22722832    16136131    11181995    19077034    14702039    11042152    14574404    17658474    23687350    24515783    21993624    22002653    25319552    15057822   

EMBL

BABH01016525    KZ149908    PZC78219.1    NWSH01002624    PCG67823.1    ODYU01009043    + More
SOQ53165.1    GDQN01001837    JAT89217.1    KQ461003    KPJ10026.1    GAIX01014195    JAA78365.1    AGBW02009182    OWR51454.1    KQ459601    KPI93649.1    JTDY01001702    KOB73120.1    PYGN01000555    PSN44323.1    NEVH01021921    PNF19492.1    KK853244    KDR09437.1    KQ971371    EFA10139.1    DS235124    EEB12229.1    UFQS01000739    UFQT01000739    UFQT01004060    SSX06490.1    SSX35469.1    KZ288271    PBC29792.1    APGK01058789    KB741292    ENN70300.1    BT127073    AEE62035.1    NNAY01000552    OXU27722.1    GEDC01030388    JAS06910.1    GL440824    EFN65327.1    KK107390    QOIP01000007    EZA51380.1    RLU20185.1    GL732551    EFX79502.1    GANO01001959    JAB57912.1    KB632334    ERL92772.1    GECU01000035    JAT07672.1    GL448708    EFN83984.1    AXCM01000651    AJVK01024552    GEZM01074853    JAV64457.1    LJIG01000658    KRT86282.1    GFDL01013228    JAV21817.1    KQ434803    KZC05975.1    GGFK01010325    MBW43646.1    APCN01000421    KQ414785    KOC60993.1    GDIQ01216409    JAK35316.1    AAAB01008859    EAA08097.4    ADMH02001252    ETN63459.1    GDIQ01162786    JAK88939.1    GDIP01242060    LRGB01000626    JAI81341.1    KZS17580.1    AJWK01016825    ADTU01026286    GL888284    EGI63288.1    AXCN02000218    ATLV01019399    KE525269    KFB44133.1    KQ983238    KYQ46360.1    GAMD01002543    JAA99047.1    GL767899    EFZ12926.1    AHZZ02024147    KQ980298    KYN16837.1    AQIB01159363    JXUM01054531    KQ561824    KXJ77422.1    KB201751    ESO94704.1    KQ976780    KYN08381.1    DS232065    EDS33685.1    CABD030043362    CABD030043363    CABD030043364    AK011356    AK156543    CH466546    BC125307    BC125309    BC145156    BC145157    ADFV01015625    ADFV01015626    AJFE02080831    AJFE02080832    AACZ04065916    GABC01008906    GABF01007189    GABD01001234    GABD01001233    GABE01005653    NBAG03000244    JAA02432.1    JAA14956.1    JAA31866.1    JAA39086.1    PNI62803.1    PNI62807.1    PNI62814.1    ABGA01346201    ABGA01346202    ABGA01346203    ABGA01346204    ABGA01346205    ABGA01346206    NDHI03003384    PNJ71168.1    PNJ71170.1    PNJ71171.1    CH471087    EAW55326.1    AB449888    AY826820    AK057228    AF151073    AY542308    AK223445    AL008729    AL589984    BC050465    BC007054    AAGW02052177    CM001256    EHH17960.1    AQIA01052735    AQIA01052736    CM001279    EHH52721.1    HAEI01002872    HAEH01012699    SBR82210.1    HAEF01008235    HAEG01012039    SBR91310.1    KQ976532    KYM81636.1    KQ981512    KYN40855.1    JU334838    JU475865    JV047269    AFE78591.1    AFH32669.1    AFI37340.1    HAED01022354    HAEE01009815    SBR29865.1    HADZ01003346    HAEA01014195    SBP67287.1    HADY01013685    HAEJ01019020    SBS59477.1    AABR07027309   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000053268    UP000037510    + More
UP000245037    UP000235965    UP000027135    UP000007266    UP000009046    UP000242457    UP000019118    UP000215335    UP000002358    UP000000311    UP000053097    UP000279307    UP000000305    UP000030742    UP000008237    UP000075883    UP000092462    UP000192223    UP000076502    UP000075840    UP000053825    UP000076408    UP000075882    UP000007062    UP000075881    UP000075880    UP000075903    UP000075902    UP000075901    UP000075885    UP000075920    UP000000673    UP000076407    UP000076858    UP000092461    UP000005205    UP000007755    UP000075886    UP000030765    UP000075809    UP000075884    UP000085678    UP000233080    UP000233140    UP000028761    UP000233060    UP000233200    UP000233180    UP000078492    UP000029965    UP000069940    UP000249989    UP000079721    UP000030746    UP000078542    UP000002320    UP000001519    UP000000589    UP000001073    UP000240080    UP000002277    UP000001595    UP000005640    UP000001811    UP000233120    UP000009130    UP000233100    UP000078540    UP000189706    UP000078541    UP000002494   

PRIDE

H9JMN1    Q9D0K0    A0A024QZX0    Q9P0N9    D4AAY4   

Pfam

PF00566   RabGAP-TBC        + More
PF00083   Sugar_tr

Interpro

IPR035969   Rab-GTPase_TBC_sf        + More
IPR039842   TBC1D7       
IPR000195   Rab-GTPase-TBC_dom       
IPR005829   Sugar_transporter_CS       
IPR005828   MFS_sugar_transport-like       
IPR020846   MFS_dom       
IPR036259   MFS_trans_sf       
IPR003663   Sugar/inositol_transpt       

SUPFAM

SSF47923   SSF47923        + More
SSF103473   SSF103473       

CDD

cd06174  MFS

ProteinModelPortal

H9JMN1   A0A2W1BT38   A0A2A4J8V2   A0A2H1WJB3   A0A1E1WQM1   A0A0N0PBG0   + More
S4NXH8   A0A212FCI9   A0A194PLN9   A0A0L7LCJ7   A0A2P8YJ97   A0A2J7PT35   A0A067QXG3   D6X1P7   E0VFS3   A0A336N1M4   A0A2A3EEU0   N6TM20   J3JV08   A0A232FAS6   K7IXX5   A0A1B6C0Y6   E2AMK7   A0A026W5N2   E9GLF0   U5EYJ8   U4UIC9   A0A1B6K8B6   E2BJX5   A0A182M7E1   A0A1B0GMI1   A0A1Y1KZY2   A0A0T6BG58   A0A1W4XDZ7   A0A1Q3F2R1   A0A154P214   A0A2M4AS64   A0A182HT82   A0A0L7QQT5   A0A0P5K270   A0A182YKI3   A0A1C7CZV8   Q7QC09   A0A182JX80   A0A182J6Y1   A0A182V7N6   A0A182UC53   A0A182SXF7   A0A182PA60   A0A182VX56   W5JL26   A0A0P5NLA5   A0A182XI95   A0A0P4XJM8   A0A1B0CL08   A0A158NU81   F4WR61   A0A182QD42   A0A084W1N9   A0A151WET4   A0A182NA85   T1E8R3   A0A1S3HUP4   A0A1S3HDP5   E9J2N0   A0A2K5ITY5   A0A2K5XB13   A0A096NL01   A0A2K5KTA2   A0A2K6QVL7   A0A2K6L3Y2   A0A151J377   A0A0D9R5A0   A0A182GCP5   A0A1S3WWM7   V4BZW1   A0A151IQF2   B0WS62   A0A2I2YE76   Q9D0K0   G1QJ66   A0A2R9CS18   A0A2I3T1E4   A0A2J8WN18   A0A024QZX0   Q9P0N9   G1T2E1   A0A2K6BL71   G7MQR4   G7P4F8   A0A1A8PLC4   A0A1A8QBX7   A0A195BAR2   A0A3Q0CJ09   A0A195FJL9   H9FVD2   A0A1A8KBR6   A0A1A8BI44   A0A1A8VIU1   D4AAY4  

PDB

3QWL     E-value=2.60808e-55,     Score=544

KEGG

101745446    K20396 TBC1 domain family member 7 | (RefSeq) TBC1 domain family member 7

PATHWAY

04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0090630   GO:0032007   GO:0005096   GO:0017137   GO:0016021   GO:0022857   GO:0070848   GO:0031398   GO:1902018   GO:0036064   GO:0031410   GO:0043547   GO:0005829  

PANTHER

PTHR13530  

Subcellular location

Cytoplasmic vesicle   Localizes in the cytoplasmic vesicles of the endomembrane in association with TSC1-TSC2 complex.   With evidence from 1 publications.

Length:

302

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.27673

Exp number, first 60 AAs:

0.01213

Total prob of N-in:

0.10468

outside

1  -  302

 

 

Pi

225.660562

Theta

134.39946

Tajima's D

2.462869

CLR

0.312178

CSRT

0.939753012349383

Interpretation

Uncertain