Gene

KWMTBOMO15481

Pre Gene Modal

BGIBMGA010769

Annotation

PREDICTED:_trichohyalin_[Bombyx_mori]

Location

Bomo_Chr26(-):450442-451800      View in EpiBrowser

Full name

Dynein assembly factor 1, axonemal homolog       + More
Dynein assembly factor 1, axonemal      

Alternative Name

Leucine-rich repeat-containing protein 50

Location in the cell

Cytoplasmic   Reliability : 2.773

CDS

ATGATCAGTGAAAACATTCCTAAAAATTTCCAGGGTTTTTCGAAGATTGAAAATTTGGAAGAGTACACGGGTTTGAAGTGTATATTTCTCGAAAACAATGGGATCGAGAGGATTGAAGGATTAGATACGTTATCTGAATTGAAATGTCTATATCTACATTACAACGTCGTGAGGAAAATTGAGAATCTCACTGGATGCCCTAAGCTGGACACTCTGAACTTGGATCATAATTTTATACGGACGATTGAGAATTTGGATGCAGTGCCTGATCTTCATACGCTTAGCATTGCACACAATATGCTGACAACAGTTGATGACCTAGAACACTTAAAATTATGCAAGAACCTGTCAGTCCTAGATTTGTCTTACAATCGTCTCGAAGATCCCTTAATTGTGGATGTGCTATCTGATATGATTTTGCTAAAAGTTTTGGTTTTGACTGGAAATCCGGTTGTGAAGAATATACCAGCTTACAGGAAAACCTTGACGCTTCGTTTGAAGGAATTATTAAACTTGGACAATAGGCCGGTGTTCCCCAGAGACAGAGCGTGTGCTGAAGCCTGGCAGCGTGGAGGAGTGCAGGAGGAGATTGCAGAGAGGAAACGGTATGTTCATTGCATGTCGTAG

Protein

MISENIPKNFQGFSKIENLEEYTGLKCIFLENNGIERIEGLDTLSELKCLYLHYNVVRKIENLTGCPKLDTLNLDHNFIRTIENLDAVPDLHTLSIAHNMLTTVDDLEHLKLCKNLSVLDLSYNRLEDPLIVDVLSDMILLKVLVLTGNPVVKNIPAYRKTLTLRLKELLNLDNRPVFPRDRACAEAWQRGGVQEEIAERKRYVHCMS

Description

Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli.
Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms (By similarity). Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (By similarity).

Similarity

Belongs to the DNAAF1 family.

Keywords

Alternative splicing   Cell projection   Ciliopathy   Cilium   Complete proteome   Cytoplasm   Cytoskeleton   Disease mutation   Kartagener syndrome   Leucine-rich repeat   Phosphoprotein   Polymorphism   Primary ciliary dyskinesia   Reference proteome   Repeat  

Feature

chain  Dynein assembly factor 1, axonemal
splice variant  In isoform 2.
sequence variant  In CILD13.

Uniprot

H9JML6   A0A3S2L564   A0A2H1WJL9   A0A212FCI0   A0A194PKX5   A0A0N1IC99   + More
A0A2A4J8G6   A0A2W1BT27   C3ZDF8   N6TTW6   U4UPM5   D2A475   C3ZYS5   A0A1W4XU83   H0X0C2   A0A091LX76   Q8NEP3-3   A0A3Q0DYU8   M3WFB2   A0A2Y9NXK3   A0A0D9S1F3   H0Z8L1   A0A337SP11   G1NZ79   A0A2Y9P0E9   A0A2Y9NXJ7   A0A341AL88   A0A2I3NDL0   A0A093FWA2   A0A091HXR4   A0A091WJ84   A0A2Y9NUT1   A0A2Y9P5Y0   A0A091WJM2   A0A2Y9P8W2   A0A091KWU5   S7PCC7   A0A091QRK8   W5PKX4   A0A096MNR8   A0A2B4RID6   A0A2Y9DNA3   A0A2K6CGX1   A0A2K5WX51   A0A099YZ20   A0A2J8T9T2   Q9D2H9   A0A2K5WX45   A0A2J8LEN7   A0A2K6AL67   A0A2K6CGS4   R0L9J7   A0A091U9J1   A0A2K6AL76   A0A093H992   A0A384A5W4   A0A1D5Q469   A0A2K6CGU5   A0A140VJN4   Q8NEP3   A0A093R1K4   A0A340WUF7   A0A093HVM3   A0A2K5WX34   A0A2K5H7I3   A0A0G2K5B1   Q6AYH9   F6UPU7   A0A091JGB6   E9IQ28   A0A091FP99   A0A093IUN8   A0A2A3EE27   Q4R6N1   A0A093QXM1   G3RM43   A0A099ZX83   A0A087VI56   A0A2K6L7R2   H2NRM4   A0A093IGX5   A0A2U4BUN5   L5JQR7   A0A094L3H7   A0A094L9H9   U3ICA8   F1S5U4   A0A384C0P8   H2R3D3   A0A091UF83   A0A087QX84   A0A3Q7TH76   A0A091FWD2   A0A2Y9SPY6   A7STQ2   A0A2J8LEP0   A0A2U3Y825   G1KN78   L8I4G5   A0A091R3R3  

Pubmed

19121390    22118469    26354079    28756777    18563158    23537049    + More
18362917    19820115    14702039    15616553    15489334    17974005    18385425    19944400    19944405    25186273    17975172    20360741    21993624    20809919    16141072    21183079    17431167    15057822    22673903    21282665    15944441    22398555    23258410    23749191    30723633    16136131    17615350    22751099   

EMBL

BABH01016523    BABH01016524    RSAL01000143    RVE46000.1    ODYU01009043    SOQ53166.1    + More
AGBW02009182    OWR51455.1    KQ459601    KPI93648.1    KQ461003    KPJ10027.1    NWSH01002624    PCG67824.1    KZ149908    PZC78218.1    GG666612    EEN48764.1    APGK01019170    KB740092    ENN81483.1    KB632310    ERL92106.1    KQ971348    EFA05627.1    GG666735    EEN42310.1    AAQR03081076    AAQR03081077    AAQR03081078    AAQR03081079    KK510645    KFP62967.1    AK057238    AK058059    AK295990    AC009123    AC040169    BC024009    AL137334    AL833328    AL833336    AANG04002512    AQIB01129881    AQIB01129882    ABQF01035920    AAPE02014407    AAPE02014408    AHZZ02019150    AHZZ02019151    KK398530    KFV58631.1    KL528476    KFO91998.1    KL410965    KFR01636.1    KK735695    KFR15330.1    KK545372    KFP32184.1    KE161800    EPQ05447.1    KK666870    KFQ12034.1    AMGL01027238    AMGL01027239    AMGL01027240    LSMT01000478    PFX17361.1    AQIA01043820    AQIA01043821    KL887256    KGL74717.1    NDHI03003514    PNJ29763.1    AK006656    AK019633    BC050751    NBAG03000295    PNI45732.1    KB743829    EOA96917.1    KK420973    KFQ86535.1    KK620907    KFV51233.1    JSUE03026762    HM005423    AEE61021.1    KL224844    KFW64899.1    KL206526    KFV83047.1    AABR07044002    BC079038    KK502030    KFP19622.1    GL764659    EFZ17377.1    KK719362    KFO63110.1    KK599711    KFW05378.1    KZ288289    PBC29261.1    AB169151    BAE01244.1    KL420935    KFW88657.1    CABD030102459    CABD030102460    CABD030102461    CABD030102462    CABD030102463    KL870139    KGL86879.1    KL494346    KFO12298.1    ABGA01313380    ABGA01313381    ABGA01313382    ABGA01313383    ABGA01313384    KK557158    KFV98861.1    KB031158    ELK00453.1    KL361800    KFZ65943.1    KL282999    KFZ67998.1    ADON01112715    AEMK02000039    DQIR01029302    DQIR01113122    HCZ84777.1    AACZ04051371    KK449656    KFQ72775.1    KL225962    KFM05838.1    KL447421    KFO73389.1    DS469800    EDO32918.1    PNI45733.1    JH882006    ELR51400.1    KK689967    KFQ16169.1   

Proteomes

UP000005204    UP000283053    UP000007151    UP000053268    UP000053240    UP000218220    + More
UP000001554    UP000019118    UP000030742    UP000007266    UP000192223    UP000005225    UP000005640    UP000189704    UP000011712    UP000248483    UP000029965    UP000007754    UP000001074    UP000252040    UP000028761    UP000053283    UP000053605    UP000002356    UP000225706    UP000248480    UP000233120    UP000233100    UP000053641    UP000000589    UP000233140    UP000261681    UP000006718    UP000054081    UP000265300    UP000053584    UP000233080    UP000002494    UP000053119    UP000052976    UP000242457    UP000001519    UP000053858    UP000233180    UP000001595    UP000245320    UP000010552    UP000016666    UP000008227    UP000261680    UP000002277    UP000053286    UP000286640    UP000053760    UP000001593    UP000245341    UP000001646   

PRIDE

H9JML6    Q8NEP3    Q9D2H9    A0A140VJN4    Q6AYH9    F1S5U4    + More

Pfam

PF01094   ANF_receptor

Interpro

IPR001611   Leu-rich_rpt        + More
IPR027734   DNAAF1       
IPR032675   LRR_dom_sf       
IPR001828   ANF_lig-bd_rcpt       
IPR028082   Peripla_BP_I       

SUPFAM

SSF53822   SSF53822       

Gene 3D

3.80.10.10    

ProteinModelPortal

H9JML6   A0A3S2L564   A0A2H1WJL9   A0A212FCI0   A0A194PKX5   A0A0N1IC99   + More
A0A2A4J8G6   A0A2W1BT27   C3ZDF8   N6TTW6   U4UPM5   D2A475   C3ZYS5   A0A1W4XU83   H0X0C2   A0A091LX76   Q8NEP3-3   A0A3Q0DYU8   M3WFB2   A0A2Y9NXK3   A0A0D9S1F3   H0Z8L1   A0A337SP11   G1NZ79   A0A2Y9P0E9   A0A2Y9NXJ7   A0A341AL88   A0A2I3NDL0   A0A093FWA2   A0A091HXR4   A0A091WJ84   A0A2Y9NUT1   A0A2Y9P5Y0   A0A091WJM2   A0A2Y9P8W2   A0A091KWU5   S7PCC7   A0A091QRK8   W5PKX4   A0A096MNR8   A0A2B4RID6   A0A2Y9DNA3   A0A2K6CGX1   A0A2K5WX51   A0A099YZ20   A0A2J8T9T2   Q9D2H9   A0A2K5WX45   A0A2J8LEN7   A0A2K6AL67   A0A2K6CGS4   R0L9J7   A0A091U9J1   A0A2K6AL76   A0A093H992   A0A384A5W4   A0A1D5Q469   A0A2K6CGU5   A0A140VJN4   Q8NEP3   A0A093R1K4   A0A340WUF7   A0A093HVM3   A0A2K5WX34   A0A2K5H7I3   A0A0G2K5B1   Q6AYH9   F6UPU7   A0A091JGB6   E9IQ28   A0A091FP99   A0A093IUN8   A0A2A3EE27   Q4R6N1   A0A093QXM1   G3RM43   A0A099ZX83   A0A087VI56   A0A2K6L7R2   H2NRM4   A0A093IGX5   A0A2U4BUN5   L5JQR7   A0A094L3H7   A0A094L9H9   U3ICA8   F1S5U4   A0A384C0P8   H2R3D3   A0A091UF83   A0A087QX84   A0A3Q7TH76   A0A091FWD2   A0A2Y9SPY6   A7STQ2   A0A2J8LEP0   A0A2U3Y825   G1KN78   L8I4G5   A0A091R3R3  

PDB

6HKW     E-value=2.63001e-14,     Score=188

KEGG

101744819    K19750 dynein assembly factor 1, axonemal | (RefSeq) trichohyalin

GO

GO:0044458   GO:0005929   GO:0016607   GO:0035469   GO:0005886   GO:0030324   GO:0005930   GO:0003356   GO:0070840   GO:0003341   GO:0071910   GO:0005829   GO:0001947   GO:0060972   GO:0071907   GO:0036158   GO:0036159   GO:0070286   GO:0005737   GO:0000922   GO:0060271   GO:0060287   GO:0016021   GO:0005515   GO:0008270   GO:0043401   GO:0003700   GO:0005634   GO:0043565   GO:0003677   GO:0003707   GO:0006281   GO:0006259  

PANTHER

PTHR45973:SF9  

Subcellular location

  
Cell projection  
Cilium  
Cytoplasm  
Cytoskeleton  
Spindle pole  

Length:

208

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.26973

Exp number, first 60 AAs:

0

Total prob of N-in:

0.08224

outside

1  -  208

 

 

Pi

204.454397

Theta

178.083595

Tajima's D

0.319556

CLR

0.983974

CSRT

0.461126943652817

Interpretation

Uncertain