Gene

KWMTBOMO15409

Annotation

PREDICTED:_probable_cleavage_and_polyadenylation_specificity_factor_subunit_2?_partial_[Bombyx_mori]

Location

Bomo_Chr25(-):11870497-11884267      View in EpiBrowser

Full name

Cleavage and polyadenylation specificity factor subunit 2       + More
Probable cleavage and polyadenylation specificity factor subunit 2      

Alternative Name

Cleavage and polyadenylation specificity factor 100 kDa subunit

Location in the cell

Cytoplasmic   Reliability : 3.038

CDS

ATGACTTCAATAATTAAATTACATTGCTTATCTGGTGCTGGTGAGGAAACTCCTCCGTGCTATGTGCTCCAAATAGATGAATTCAAATTCCTCCTGGATTGCGGATGGGACGAGAAATTCGATATGGTTTTCATTAAAGAACTTAAAAGACATGTAAATTCAATAGATGCTGTACTAATATCACACTCGGATCCTCTACATTTAGGAGCTCTTCCATATGCAGTTGGAAAACTCGGTCTTAGCTGTCCAATATATGCAACTCTACCGGTATACAAAATGGGGCAGATGTTCATGTACGATTTATACCAAGCCCATAAGAATGTGTCCGAGTTCGATTTGTTCACACTGGATGATGTTGATATGGCTTTTGACAGAATCGTACAGTTGAAATACAATCAGAGCATTGAAATGAAAGGAAAAGGTCTAGGTCTCCGCATTACACCACTCCCAGCTGGCCATTCCCTTGGTGGAACAATATGGCGCATATCCGCCCCCGGCGAGGAAGATATTGTTTACGCGCCTGACTTCAACCACAAGAAAGAGAGACATCTGAATGGATGTGACATCGAAAGACTGATGAGACCCTCTCTGATGCTGTTGGGAGCTATGAATGCTGATTACGTGCAACAGAGGAGAAGACTGAGAGATGAAAAATTGATGACAACAATTCTTACAACGCTGCGAGGAGGCGGTTGCGTTTTGGTATGCACAGACACAGCCGGTCGAGTCCTAGAATTGGCCCACATGCTGGACCAACTGTGGAGGAACAAGGATTCCGGGCTCGTGGCCTATTCGTTACTTCTCCTGTCCAACGTCAGTTACAATGTCGTAGAGTTCGCTAAATCTCAGATAGAGTGGATGAGCGACAAACTGACGAGGGCGTTTGAAGGGGCTCGCAGTAATCCCTTTGCTTTGAGACACGTGCAGCTGTGTCACTCGGCCGGTGACGTCACTAGGACCCCGGGACCGAAGGTCGTCCTGGCCTCGTTCCCGGACCTGGAGGCGGGCTTCGCCAGAGACCTGTTCCTCCAGTGGGCCCCACACTCCCACAACTCGATCGTGCTGACGGCCAGAACATCCCCCGGCACACTGGCAAGAGATCTGATAGACAACGGGGGGGACCGCGTCATCGAGCTGGTGGTTCGACGGAGGGTGAAGCTGGAGGGCGCCGAGCTCGAGGAGTTCCTGCAGCAGCAGAGAATGAACGTCACCAATACCGTGAGGGAGGAGGTGGCCGGCATCTCGTCGGACTCTGACTCCGAAGACGAGCTGGAGATGTGCGTGGTGACCGGGAGACACGACATCCCCGTGCGCCTGGAGACCAGGCTGGGCGGCTGCTTCAAGTCCAACAAGCGGCACCACGCCATCTACCCCTTCCACGAGGAGCGGACCAGGGCTGATGACTACGGAGAGATCATTAAGCCAGAAGATTACAGACTTGCCGAGATAGTGGACGCCGAAGGGGAGATCCGGGACGTGCCCCCCACTGCCCCCATCAAACAGGAACAAGATGAGGAAATGTCGGAGGTCCCGAGCAAGTGCGTGTCCTCGGTGCGGCAGGTACACGTCAAGGCGCACGTCGAGTACATCGAGCTGGAAGGGCGCTGCGATGGGGAGTCCCTGCTCAGGGTCGTGTCGCAGACCAAGCCCTGGGCAGTGGTGGGGCTCCGGGCCAGCGAGGCGGCGCTGCACACCCTCAAAAAACATTGTGAGTCTGAAGGAATCGAAAAGGTGTTCTTACCGTCCGTTGGGGAAACCGTCGACGCCACGACAGAGTCACACATCTATCAGGTGAAACTGACGGACGGGCTGATGCGGGGCCTGGTGTGGCGGCAGGCCGGGGACGCCGAGCTGGCCTGGCTGTCCGCCGTCGTGGCGCCGCGCACGCACGCCCGGGAGAGCGACGCCGCCCCCGAGGAGGGCGGCGGTGCGGTGTCGCTGGAGGCGGGTGCGGGGCGGCCGCGCGCGGCTGCGTTCGTGAACACGGTGCGGCTGCACGAGCTGCGCGCCGCCCTCGCCCGCGCCGGCCTGCAGCCCGACCTCGGCGCCGGCACGCTCACCTGCTGCTCCGGGACGCTCGCCGTGCGCAGGATGGAAAACGGCCAAGTTTCTTTAGAAGGAGTCCTGTCTGAAGAGTATTACAAAGTGCGAGAACTCTTGTACGAACAATTCGCGATAGTCTGA

Protein

MTSIIKLHCLSGAGEETPPCYVLQIDEFKFLLDCGWDEKFDMVFIKELKRHVNSIDAVLISHSDPLHLGALPYAVGKLGLSCPIYATLPVYKMGQMFMYDLYQAHKNVSEFDLFTLDDVDMAFDRIVQLKYNQSIEMKGKGLGLRITPLPAGHSLGGTIWRISAPGEEDIVYAPDFNHKKERHLNGCDIERLMRPSLMLLGAMNADYVQQRRRLRDEKLMTTILTTLRGGGCVLVCTDTAGRVLELAHMLDQLWRNKDSGLVAYSLLLLSNVSYNVVEFAKSQIEWMSDKLTRAFEGARSNPFALRHVQLCHSAGDVTRTPGPKVVLASFPDLEAGFARDLFLQWAPHSHNSIVLTARTSPGTLARDLIDNGGDRVIELVVRRRVKLEGAELEEFLQQQRMNVTNTVREEVAGISSDSDSEDELEMCVVTGRHDIPVRLETRLGGCFKSNKRHHAIYPFHEERTRADDYGEIIKPEDYRLAEIVDAEGEIRDVPPTAPIKQEQDEEMSEVPSKCVSSVRQVHVKAHVEYIELEGRCDGESLLRVVSQTKPWAVVGLRASEAALHTLKKHCESEGIEKVFLPSVGETVDATTESHIYQVKLTDGLMRGLVWRQAGDAELAWLSAVVAPRTHARESDAAPEEGGGAVSLEAGAGRPRAAAFVNTVRLHELRAALARAGLQPDLGAGTLTCCSGTLAVRRMENGQVSLEGVLSEEYYKVRELLYEQFAIV

Description

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA.

Subunit

Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of at least Clp, Cpsf73, Cpsf100 and Cpsf160. Interacts with Sym and Cpsf73 forming a core cleavage factor required for both polyadenylated and histone mRNA processing. Interacts with Slbp and Lsm11.

Similarity

Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.

Keywords

Complete proteome   mRNA processing   Nucleus   Phosphoprotein   Reference proteome   RNA-binding  

Feature

chain  Probable cleavage and polyadenylation specificity factor subunit 2

Uniprot

A0A2A4JZW4   S4P5K0   A0A194Q7M5   A0A212FPY6   D6WP71   A0A1W4WPS5   + More
A0A067RD17   A0A1I8NZS9   A0A1B6EDG6   E9J8R8   F4WAT5   A0A151IHA7   A0A151IV75   A0A0K8UAC7   A0A158P3K2   K7J1K2   A0A195F093   A0A3L8DH36   A0A151XDK9   A0A232EY66   E1ZX64   A0A154PH25   A0A026WYH7   A0A0A1X2P0   A0A2A3EIW9   A0A1Y1M0V5   A0A087ZQ62   Q17Q35   A0A310SIA7   W8BAF9   A0A0L7R440   A0A2J7QXR1   A0A1I8M3S6   A0A3B0KHW8   A0A182H7P4   A0A1S4EUZ6   A0A034WQU1   A0A182FT51   W5JIQ1   A0A0P6IU15   A0A1B0CL15   A0A195BYZ2   A0A1A9X1U9   A0A1B0GEA0   A0A1A9US68   B4PQ87   B3P5M6   A0A0C9QTZ5   Q9V3D6   N6T7L6   A0A336LAG3   B4JTB6   A0A1W4VVQ4   E0VYY6   B3LXN9   A0A182Q328   A0A182JRJ0   A0A2M4BEN8   A0A182R368   B4KDT1   A0A182VXE7   Q7QC68   B4HZ45   B0WQG5   A0A084WRC4   A0A182M9G5   B4NF98   A0A182XWV9   A0A182T530   A0A182PAF6   A0A182XI04   A0A182LF29   A0A182HSY5   A0A182IJ44   A0A182VCI4   A0A182TFD9   A0A1A9YBU3   A0A0M4F298   A0A1B0BXC6   A0A182NLA6   T1J0U4   A0A1J1I7W1   B5DYG6   A0A0A9YR18   A0A0K8SNA9   A0A2R7WYN0   A0A1Q3F2G1   A0A1S3HFG1   A0A0V0G937   A0A023F389   R7V1Z3   A0A131YJH7   A0A0M9A4Q2   A0A1A9Z6W8   A0A0P4VNT6   A0A1E1XLS1   E9H4K8   A0A087SZA3   A0A3Q3B974  

Pubmed

23622113    26354079    22118469    18362917    19820115    24845553    + More
21282665    21719571    21347285    20075255    30249741    28648823    20798317    24508170    25830018    28004739    17510324    24495485    25315136    26483478    25348373    20920257    23761445    26999592    17994087    17550304    10731132    12537572    10731138    18327897    19450530    23537049    20566863    12364791    24438588    25244985    20966253    15632085    25401762    25474469    23254933    26830274    27129103    29209593    21292972   

EMBL

NWSH01000346    PCG77218.1    GAIX01005494    JAA87066.1    KQ459324    KPJ01523.1    + More
AGBW02000323    OWR55794.1    KQ971352    EFA07272.1    KK852540    KDR21766.1    GEDC01001336    JAS35962.1    GL769036    EFZ10838.1    GL888053    EGI68691.1    KQ977636    KYN01143.1    KQ980924    KYN11412.1    GDHF01028682    JAI23632.1    ADTU01008167    KQ981880    KYN33898.1    QOIP01000008    RLU19492.1    KQ982268    KYQ58464.1    NNAY01001671    OXU23263.1    GL435030    EFN74154.1    KQ434904    KZC11186.1    KK107064    EZA60898.1    GBXI01009364    JAD04928.1    KZ288229    PBC31715.1    GEZM01044356    JAV78280.1    CH477187    EAT48881.1    KQ767768    OAD53310.1    GAMC01012537    JAB94018.1    KQ414658    KOC65642.1    NEVH01009372    PNF33368.1    OUUW01000013    SPP88060.1    JXUM01116783    KQ566020    KXJ70452.1    GAKP01002834    JAC56118.1    ADMH02001133    ETN63991.1    GDUN01000593    JAN95326.1    AJWK01016831    KQ976394    KYM93138.1    CCAG010012178    CM000160    EDW98356.2    CH954182    EDV53276.1    GBYB01007214    GBYB01012073    GBYB01012076    GBYB01012077    JAG76981.1    JAG81840.1    JAG81843.1    JAG81844.1    AE014297    AF160933    APGK01049397    KB741150    KB632095    ENN73673.1    ERL88780.1    UFQS01001426    UFQT01001426    SSX10828.1    SSX30508.1    CH916373    EDV95006.1    DS235848    EEB18592.1    CH902617    EDV43933.1    AXCN02000116    GGFJ01002374    MBW51515.1    CH933806    EDW14928.1    AAAB01008859    EAA08192.4    CH480819    EDW53302.1    DS232039    EDS32836.1    ATLV01026020    KE525405    KFB52768.1    AXCM01000492    CH964251    EDW82965.1    APCN01000376    CP012526    ALC45525.1    JXJN01022185    AFFK01020674    CVRI01000043    CRK96399.1    CM000070    EDY67988.3    GBHO01009538    JAG34066.1    GBRD01011091    JAG54733.1    KK856018    PTY24658.1    GFDL01013302    JAV21743.1    GECL01001727    JAP04397.1    GBBI01002994    JAC15718.1    AMQN01000769    KB295623    ELU12868.1    GEDV01009440    JAP79117.1    KQ435756    KOX75893.1    GDKW01000222    JAI56373.1    GFAA01003493    JAT99941.1    GL732592    EFX73157.1    KK112648    KFM58192.1   

Proteomes

UP000218220    UP000053268    UP000007151    UP000007266    UP000192223    UP000027135    + More
UP000095300    UP000007755    UP000078542    UP000078492    UP000005205    UP000002358    UP000078541    UP000279307    UP000075809    UP000215335    UP000000311    UP000076502    UP000053097    UP000242457    UP000005203    UP000008820    UP000053825    UP000235965    UP000095301    UP000268350    UP000069940    UP000249989    UP000069272    UP000000673    UP000092461    UP000078540    UP000091820    UP000092444    UP000078200    UP000002282    UP000008711    UP000000803    UP000019118    UP000030742    UP000001070    UP000192221    UP000009046    UP000007801    UP000075886    UP000075881    UP000075900    UP000009192    UP000075920    UP000007062    UP000001292    UP000002320    UP000030765    UP000075883    UP000007798    UP000076408    UP000075901    UP000075885    UP000076407    UP000075882    UP000075840    UP000075880    UP000075903    UP000075902    UP000092443    UP000092553    UP000092460    UP000075884    UP000183832    UP000001819    UP000085678    UP000014760    UP000053105    UP000092445    UP000000305    UP000054359    UP000264800   

PRIDE

Q9V3D6   

Pfam

PF16661   Lactamase_B_6        + More
PF07521   RMMBL
PF10996   Beta-Casp
PF13299   CPSF100_C

Interpro

IPR025069   Cpsf2_C        + More
IPR035639   CPSF2_MBL       
IPR027075   CPSF2       
IPR001279   Metallo-B-lactamas       
IPR011108   RMMBL       
IPR036866   RibonucZ/Hydroxyglut_hydro       
IPR022712   Beta_Casp       

SUPFAM

SSF56281   SSF56281       

Gene 3D

3.60.15.10    

CDD

cd16293  CPSF2-like_MBL-fold

ProteinModelPortal

A0A2A4JZW4   S4P5K0   A0A194Q7M5   A0A212FPY6   D6WP71   A0A1W4WPS5   + More
A0A067RD17   A0A1I8NZS9   A0A1B6EDG6   E9J8R8   F4WAT5   A0A151IHA7   A0A151IV75   A0A0K8UAC7   A0A158P3K2   K7J1K2   A0A195F093   A0A3L8DH36   A0A151XDK9   A0A232EY66   E1ZX64   A0A154PH25   A0A026WYH7   A0A0A1X2P0   A0A2A3EIW9   A0A1Y1M0V5   A0A087ZQ62   Q17Q35   A0A310SIA7   W8BAF9   A0A0L7R440   A0A2J7QXR1   A0A1I8M3S6   A0A3B0KHW8   A0A182H7P4   A0A1S4EUZ6   A0A034WQU1   A0A182FT51   W5JIQ1   A0A0P6IU15   A0A1B0CL15   A0A195BYZ2   A0A1A9X1U9   A0A1B0GEA0   A0A1A9US68   B4PQ87   B3P5M6   A0A0C9QTZ5   Q9V3D6   N6T7L6   A0A336LAG3   B4JTB6   A0A1W4VVQ4   E0VYY6   B3LXN9   A0A182Q328   A0A182JRJ0   A0A2M4BEN8   A0A182R368   B4KDT1   A0A182VXE7   Q7QC68   B4HZ45   B0WQG5   A0A084WRC4   A0A182M9G5   B4NF98   A0A182XWV9   A0A182T530   A0A182PAF6   A0A182XI04   A0A182LF29   A0A182HSY5   A0A182IJ44   A0A182VCI4   A0A182TFD9   A0A1A9YBU3   A0A0M4F298   A0A1B0BXC6   A0A182NLA6   T1J0U4   A0A1J1I7W1   B5DYG6   A0A0A9YR18   A0A0K8SNA9   A0A2R7WYN0   A0A1Q3F2G1   A0A1S3HFG1   A0A0V0G937   A0A023F389   R7V1Z3   A0A131YJH7   A0A0M9A4Q2   A0A1A9Z6W8   A0A0P4VNT6   A0A1E1XLS1   E9H4K8   A0A087SZA3   A0A3Q3B974  

PDB

6I1D     E-value=1.48599e-27,     Score=308

KEGG

101741574    K14402 cleavage and polyadenylation specificity factor subunit 2 | (RefSeq) probable cleavage and po

PATHWAY

03015    mRNA surveillance pathway - Bombyx mori (domestic silkworm)

GO

GO:0003723   GO:0006378   GO:0005847   GO:0006379   GO:0005634   GO:0006397   GO:0016021   GO:0006398   GO:0004527  

PANTHER

PTHR45922  

Subcellular location

Nucleus  

Length:

727

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.603359999999999

Exp number, first 60 AAs:

0.00066

Total prob of N-in:

0.02211

outside

1  -  727

 

 

Pi

265.834437

Theta

167.892463

Tajima's D

1.923741

CLR

0.361363

CSRT

0.872056397180141

Interpretation

Uncertain