Gene

KWMTBOMO15395

Annotation

PREDICTED:_hypoxia-inducible_factor_1-alpha-like_[Bombyx_mori]

Location

Bomo_Chr25(-):11412023-11420941      View in EpiBrowser

Full name

Protein similar      

Transcription factor

bHLH

Location in the cell

Nuclear   Reliability : 2.264

CDS

ATGTCCGCTTACAAGAACAATGAGAAACGCAAGGAGAAGTCGCGTGTCGCGGCCCGGTGCCGTCGCACCAAAGAGATGCAGATCTTTTCGGAGCTCACGGCGGCCCTGCCTGCAAAAAAGGAGGAAGTTGAGCAACTCGACAAAGCGTCCGTCATGCGTCTGGCTATATCGTACCTTCGCGTACGTGATGTAGTCTCGATGCTTCCAGATGTCAACTCGGATCAATCCAAGATGCAGAATCCCGAAGGCTTCGAAGAGTTAGCTTCAGAGCTGTCATACATGAGGGCTTTGGATGGCTTCGTTCTGGTGCTCTCTCAACAAGGAGACATCGTCTACTGTAGTGACAATATAGCCGAACATCTTGGAGTTTCGCAGACGAAGATGATCTCGCTGTACTAA

Protein

MSAYKNNEKRKEKSRVAARCRRTKEMQIFSELTAALPAKKEEVEQLDKASVMRLAISYLRVRDVVSMLPDVNSDQSKMQNPEGFEELASELSYMRALDGFVLVLSQQGDIVYCSDNIAEHLGVSQTKMISLY

Description

Functions as a transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters.

Subunit

Efficient DNA binding requires dimerization with another bHLH protein. Interacts with Vhl.

Similarity

Belongs to the tetraspanin (TM4SF) family.

Keywords

Activator   Coiled coil   Complete proteome   Cytoplasm   DNA-binding   Nucleus   Reference proteome   Repeat   Transcription   Transcription regulation  

Feature

chain  Protein similar

Uniprot

I4DRJ3   A0A2A4JPD3   A0A2W1BY39   A0A2A4JQ85   A0A140CTX5   A0A194Q7C3   + More
A0A3S2NGW4   A0A194RKJ2   A0A212EZ70   D6WMG7   A0A346QUN2   A0A1Y1LZ17   A0A1Y1LUG8   A0A182JM31   B0W9S7   Q16E64   Q17MC1   A0A1S4EXS9   A0A2P8YCX4   A0A1Q3FJP6   A0A1Q3FJB4   A0A182PR07   A0A182G9V7   A0A1Q3FL92   A0A1B0CAF2   A0A182HTZ9   A0A084W762   A0A1W4VUG7   A0A0K8U5K2   A0A154P5J5   Q8MQV4   B7Z0S3   A0A0L7R7C1   A0A182XHE7   A0A182VP20   A0A182LG42   R9QCX3   Q7PRA0   A0A182JXV3   F4WPX1   B3P7Y5   A0A0J7KS15   Q5U0W0   A0A182QSP3   A0A1L8DGH2   A0A2M4APB6   A0A2M4AP99   A0A0A1XHC8   A0A1L8DGP2   A0A2M4AP63   A0A1W4VGE5   A0A1L8DGH6   A0A1L8DGR9   A0A0K8UI14   Q24167   A0A195AWW6   A0A1W4VTP6   A0A0C9RQD5   B9ER22   B4PLS5   A0A3L8D7M0   B7QI82   A0A026WIE6   W8AKS8   A0A0B4LIX2   D7R4L2   A0A2J7PP09   A0A1B6D4M5   A0A182FL36   A0A310SG20   A0A151WR93   A0A034VAI8   A0A1B6C398   A0A1B6MKJ9   A0A158NHX9   A0A195CKS2   A0A1B6M2U3   A0A131XHJ6   A0A195FEY9   Q5I8Q9   A0A182RND7   A0A2A3E4J2   A0A195EG49   A0A182MJS4   A0A088A014   E0W068   B4R1I3   B4HZL9   V5G121   A0A2R4PB61   A0A3B0JFQ1   W5J2R8   A0A0R3NJU3   A0A182TJF9   B4M6J0   B4JES7   V5HIH3   A0A131Y389   A0A182VYM2  

Pubmed

22651552    28756777    26354079    22118469    18362917    19820115    + More
28004739    17510324    29403074    26483478    24438588    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    20966253    12364791    21719571    17994087    25830018    8682312    9731218    11006129    12215541    17550304    30249741    24508170    24495485    25348373    21347285    28049606    16311910    20566863    29630918    20920257    23761445    15632085    23185243    25765539   

EMBL

AK405145    BAM20533.1    NWSH01000838    PCG73925.1    KZ149949    PZC76683.1    + More
PCG73926.1    KU552106    AMH87782.1    KQ459324    KPJ01442.1    RSAL01000107    RVE47261.1    KQ460045    KPJ18057.1    AGBW02011351    OWR46795.1    KQ971343    EFA04586.2    MG011449    AXS00615.1    GEZM01046369    JAV77285.1    GEZM01046370    JAV77284.1    DS231865    EDS40396.1    CH479045    EAT32521.1    CH477207    EAT47828.1    PYGN01000696    PSN42112.1    GFDL01007301    JAV27744.1    GFDL01007335    JAV27710.1    JXUM01049761    JXUM01049762    KQ561619    KXJ77990.1    GFDL01006740    JAV28305.1    AJWK01003743    AJWK01003744    AJWK01003745    AJWK01003746    ATLV01021144    ATLV01021145    ATLV01021146    ATLV01021147    ATLV01021148    ATLV01021149    ATLV01021150    KE525314    KFB46056.1    GDHF01030498    JAI21816.1    KQ434809    KZC06400.1    AY122269    AAM52781.1    AE014297    ACL83585.1    KQ414643    KOC66656.1    JN228344    AFL70631.1    AAAB01008859    EAA07597.6    GL888255    EGI63800.1    CH954182    EDV53112.1    LBMM01003871    KMQ93034.1    BT016132    AAV37017.1    AXCN02000341    GFDF01008526    JAV05558.1    GGFK01009315    MBW42636.1    GGFK01009266    MBW42587.1    GBXI01005514    GBXI01003935    JAD08778.1    JAD10357.1    GFDF01008527    JAV05557.1    GGFK01009255    MBW42576.1    GFDF01008525    JAV05559.1    GFDF01008524    JAV05560.1    GDHF01026111    JAI26203.1    U43090    KQ976725    KYM76547.1    GBYB01009416    JAG79183.1    BT058097    ACM89953.1    CM000160    EDW99062.1    QOIP01000012    RLU16093.1    ABJB010008711    ABJB010089786    ABJB010570512    ABJB010651084    DS944282    EEC18554.1    KK107185    EZA55822.1    GAMC01021252    JAB85303.1    AHN57598.1    HM032914    ADH01740.1    NEVH01023281    PNF18058.1    GEDC01023846    GEDC01016705    JAS13452.1    JAS20593.1    KQ764717    OAD54410.1    KQ982813    KYQ50321.1    GAKP01019418    JAC39534.1    GEDC01029444    JAS07854.1    GEBQ01003554    JAT36423.1    ADTU01016101    ADTU01016102    KQ977622    KYN01325.1    GEBQ01009708    JAT30269.1    GEFH01002916    JAP65665.1    KQ981636    KYN38787.1    AY845427    AAW31092.1    KZ288379    PBC26608.1    KQ978957    KYN27213.1    AXCM01007259    DS235857    EEB19024.1    CM000364    EDX14971.1    CH480819    EDW53476.1    GALX01004756    JAB63710.1    MG552486    AVX48316.1    OUUW01000005    SPP80955.1    ADMH02002130    ETN58582.1    CM000070    KRS99540.1    KRS99541.1    CH940652    EDW59266.2    CH916369    EDV93208.1    GANP01001023    JAB83445.1    GEFM01002966    JAP72830.1   

Proteomes

UP000218220    UP000053268    UP000283053    UP000053240    UP000007151    UP000007266    + More
UP000075880    UP000002320    UP000008820    UP000245037    UP000075885    UP000069940    UP000249989    UP000092461    UP000030765    UP000192221    UP000076502    UP000000803    UP000053825    UP000076407    UP000075903    UP000075882    UP000007062    UP000075881    UP000007755    UP000008711    UP000036403    UP000075886    UP000078540    UP000002282    UP000279307    UP000001555    UP000053097    UP000235965    UP000069272    UP000075809    UP000005205    UP000078542    UP000078541    UP000075900    UP000242457    UP000078492    UP000075883    UP000005203    UP000009046    UP000000304    UP000001292    UP000268350    UP000000673    UP000001819    UP000075902    UP000008792    UP000001070    UP000075920   

PRIDE

Q8MQV4    Q5U0W0    Q24167   

Pfam

PF00989   PAS        + More
PF08447   PAS_3
PF08778   HIF-1a_CTAD
PF13426   PAS_9
PF00010   HLH
PF17906   HTH_48
PF00335   Tetraspanin
PF11413   HIF-1

Interpro

IPR011598   bHLH_dom        + More
IPR000014   PAS       
IPR001067   Nuc_translocat       
IPR036638   HLH_DNA-bd_sf       
IPR013767   PAS_fold       
IPR035965   PAS-like_dom_sf       
IPR013655   PAS_fold_3       
IPR001610   PAC       
IPR014887   HIF-1_TAD_C       
IPR041426   Mos1_HTH       
IPR008952   Tetraspanin_EC2_sf       
IPR018499   Tetraspanin/Peripherin       
IPR021537   HIF_alpha_subunit       

SUPFAM

SSF47459   SSF47459        + More
SSF55785   SSF55785       
SSF48652   SSF48652       

Gene 3D

4.10.280.10     1.10.1450.10    

CDD

cd00083  HLH
cd00130  PAS

ProteinModelPortal

I4DRJ3   A0A2A4JPD3   A0A2W1BY39   A0A2A4JQ85   A0A140CTX5   A0A194Q7C3   + More
A0A3S2NGW4   A0A194RKJ2   A0A212EZ70   D6WMG7   A0A346QUN2   A0A1Y1LZ17   A0A1Y1LUG8   A0A182JM31   B0W9S7   Q16E64   Q17MC1   A0A1S4EXS9   A0A2P8YCX4   A0A1Q3FJP6   A0A1Q3FJB4   A0A182PR07   A0A182G9V7   A0A1Q3FL92   A0A1B0CAF2   A0A182HTZ9   A0A084W762   A0A1W4VUG7   A0A0K8U5K2   A0A154P5J5   Q8MQV4   B7Z0S3   A0A0L7R7C1   A0A182XHE7   A0A182VP20   A0A182LG42   R9QCX3   Q7PRA0   A0A182JXV3   F4WPX1   B3P7Y5   A0A0J7KS15   Q5U0W0   A0A182QSP3   A0A1L8DGH2   A0A2M4APB6   A0A2M4AP99   A0A0A1XHC8   A0A1L8DGP2   A0A2M4AP63   A0A1W4VGE5   A0A1L8DGH6   A0A1L8DGR9   A0A0K8UI14   Q24167   A0A195AWW6   A0A1W4VTP6   A0A0C9RQD5   B9ER22   B4PLS5   A0A3L8D7M0   B7QI82   A0A026WIE6   W8AKS8   A0A0B4LIX2   D7R4L2   A0A2J7PP09   A0A1B6D4M5   A0A182FL36   A0A310SG20   A0A151WR93   A0A034VAI8   A0A1B6C398   A0A1B6MKJ9   A0A158NHX9   A0A195CKS2   A0A1B6M2U3   A0A131XHJ6   A0A195FEY9   Q5I8Q9   A0A182RND7   A0A2A3E4J2   A0A195EG49   A0A182MJS4   A0A088A014   E0W068   B4R1I3   B4HZL9   V5G121   A0A2R4PB61   A0A3B0JFQ1   W5J2R8   A0A0R3NJU3   A0A182TJF9   B4M6J0   B4JES7   V5HIH3   A0A131Y389   A0A182VYM2  

PDB

4ZPR     E-value=1.07529e-22,     Score=257

KEGG

101739525    K08268 hypoxia-inducible factor 1 alpha | (RefSeq) hypoxia-inducible factor 1-alpha-like

PATHWAY

04137    Mitophagy - animal - Bombyx mori (domestic silkworm)
04140    Autophagy - animal - Bombyx mori (domestic silkworm)

GO

GO:0046983   GO:0005634   GO:0005737   GO:0003700   GO:0005667   GO:0003677   GO:0006355   GO:0000981   GO:0006357   GO:0045944   GO:0060438   GO:0071456   GO:0010508   GO:0030308   GO:0008286   GO:0048477   GO:0090575   GO:0005829   GO:0032869   GO:0030334   GO:0045088   GO:0001228   GO:0003989   GO:0016021   GO:0043565   GO:0008134   GO:0019904   GO:0003697   GO:0008094   GO:0005524   GO:0006281   GO:0006259  

Subcellular location

Nucleus  
Cytoplasm  

Length:

132

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00263

Exp number, first 60 AAs:

0.00012

Total prob of N-in:

0.70563

inside

1  -  132

 

 

Pi

149.980829

Theta

157.892059

Tajima's D

-0.508915

CLR

11.802575

CSRT

0.23938803059847

Interpretation

Uncertain