Gene

KWMTBOMO15385  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005091

Annotation

PREDICTED:_neuroendocrine_convertase_2_[Bombyx_mori]

Location

Bomo_Chr25(+):10940146-10982060      View in EpiBrowser

Location in the cell

Extracellular   Reliability : 2.279

CDS

ATGCTTTTCGTGTGTTCAGTAAACGCCCCGAGGGTACTAGGTTCTGAGACGGAATGGCATTTCGCGCATCGCGGCTTGCCACACGCTCGTCCAAGGCGTTCGATCGCGCACACAAGGATCCTGAAACAGCATCCATTGGTACACACTGCAGTCCAGCAGACTGGTTTCAAACGCGTCAAAAGAGGATATCGTCCTCTGCGCCTGCCGGAGACAGTACCGGCCTCTGAGCCCCGTGATCCCTACTTTCCGCTGCAGTGGTACCTGAAGAACACGGGACAAAACGGCGGGAAACCCAAGCTTGATCTGAACGTGGAAGCAGCTTGGGCTCAAGGGTACACTGGCGTCAACGTAACCACAGCTATCATGGATGATGGTGTCGATTACATGCATCCCGACTTAAAATATAATTACAATGCGGAGGCTTCGTACGACTTCAGCAGCAACGATCCGTTTCCTTATCCACGCTACACGGATGACTGGTTTAACAGTCACGGAACGAGGTGCGCTGGTGAAGTGGCCGCAGCTCGCGACAACGGCGTCTGTGGTGTCGGCGTCGCTTATCACTCCAAAGTTGCCGGTATAAGAATGTTAGACCAGCCGTACATGACAGATCTCATCGAAGCCAATTCTATGGGTCATGAGCCCCACAAGATTCACATATACAGTGCCTCGTGGGGTCCTACAGACGACGGTCGTACTGTAGATGGACCAAGAAACGCGACTATGAGAGCTATTGTGAGAGGAGTTAATGAGGGTCGTAATGGCCTCGGTAATATCTACGTATGGGCGAGTGGTGATGGGGGCGAGGACGACGATTGCAATTGTGATGGCTACGCTGCGTCTATGTGGACTATTTCAATTAATAGTGCAATAAATGACGGTCAAAACGCGCATTACGACGAATCATGTTCGTCTACGCTCGCGAGCACATTCAGCAATGGTGCTCGCGATCCTAGTACTGGAGTGGCGACCACTGATTTGTACGGAAAATGTACTGCGACCCACTCGGGGACATCAGCTGCGGCGCCAGAAGCTGCTGGGGTATTCGCTCTGGCTTTACATGCCAATCCGAATCTGACGTGGCGCGACATCCAGCATCTAACAGTATTGACTTCGAAAAGAAATTCGCTGTACGATGCAAAGGGACGTTTTCACTGGACTATGAATGGAGTGGGCTTAGAATTCAATCACTTGTTCGGTTTTGGGGTACTGGACGCCGGTGCGATGACCGCTCTGGCTGCTAATTGGCGCTCCGTGCCTCCGAGATATCATTGTGAAGCAGGATCTGTTAATACTCACACCGAGATCCCGACCGATGGCAGCGTGACCTTGAAGATCGACACCACAGCATGCGCGGGCTCCCCCAGCGAGGTGCGCTACCTGGAACACGTGCAGGCCGTTGTCAGCGCCAACGGCACGCGACGCGGCGACCTGGAGTTCTTCCTCACCAGTCCAATGGGAACCAGATCCATGATTTTAAGCAGACGGGCCAACGATGGCGACTCCCGGGACGGCTTCACAAAGTGGCCCTTCATGACCACACATACATGGGGAGAATATCCACAGGGCACATGGATCCTAGAGGCTCGGTACAACGGTGGGGGCTCGTCGGGGGGAGAGTGGTCCGGCTGGGTGCGCGGCTGGTCGCTAGTGCTGCACGGCACGCGCGCGCCGCCCTACGCCCAACTCCAGCCTCAGGACCCGCACTCCAAGCTCGCCGTCGTCAAGAAAGCACACGAGGACGCGCTCGCCAAGTAA

Protein

MLFVCSVNAPRVLGSETEWHFAHRGLPHARPRRSIAHTRILKQHPLVHTAVQQTGFKRVKRGYRPLRLPETVPASEPRDPYFPLQWYLKNTGQNGGKPKLDLNVEAAWAQGYTGVNVTTAIMDDGVDYMHPDLKYNYNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGVCGVGVAYHSKVAGIRMLDQPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGRTVDGPRNATMRAIVRGVNEGRNGLGNIYVWASGDGGEDDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGARDPSTGVATTDLYGKCTATHSGTSAAAPEAAGVFALALHANPNLTWRDIQHLTVLTSKRNSLYDAKGRFHWTMNGVGLEFNHLFGFGVLDAGAMTALAANWRSVPPRYHCEAGSVNTHTEIPTDGSVTLKIDTTACAGSPSEVRYLEHVQAVVSANGTRRGDLEFFLTSPMGTRSMILSRRANDGDSRDGFTKWPFMTTHTWGEYPQGTWILEARYNGGGSSGGEWSGWVRGWSLVLHGTRAPPYAQLQPQDPHSKLAVVKKAHEDALAK

Similarity

Belongs to the peptidase S8 family.

Uniprot

A0A194Q7T7   A0A194RKU8   A0A3S2PC85   A0A0C9R9H3   U5EZ39   A0A336MD00   + More
D6WTB9   A0A182RFU5   A0A182QA44   A0A088AB96   A0A182PEB4   A0A182UN58   A0A067R765   A0A182VYE1   A0A1B6EK08   A0A182LYW3   A0A2A3ES43   Q7QK68   A0A182NMW0   A0A034W2T3   A0A0K8WI44   A0A1W7R7Z7   A0A1S3D4G7   W8AXD2   Q16G47   A0A182J4E5   A0A1S4G2J0   W5J6P0   A0A1Q3G599   A0A182FQN8   E2BET8   A0A1B6D466   A0A1J1J4S6   A0A0A1XDK9   F4WPU9   A0A195FEG1   T1P7X4   Q299W8   B4JGF8   A0A026WW40   A0A1W4VMD6   A0A195AWU5   B3M3D0   A0A158NHZ8   B4G387   A0A1Y1KJ75   A0A3B0K643   E2AZX1   K7J1H6   B4PSD8   A0A0M3QXM5   Q9VBC7   A0A195CKQ8   B4QWQ8   Q9UAE7   B4ICP4   B4NKN6   B3P649   Q94977   B4MC27   T1HZ79   A0A3L8D8Z0   E9IBK9   B4K6X0   A0A1B6MPI1   A0A1A9VQP5   A0A1B0A453   E0VP88   A0A146M7H5   A0A1A9YF58   A0A0K8SQZ7   A0A195EFZ9   A0A1A9WSU7   A0A182XWI2   A0A226EUM0   A0A0N8EPI7   A0A162P5G0   T1L3Y3   A0A1Y1KIN1   I6M2I5   A0A151WRB3   E9G2S6   T1JNR2   A0A182ULK9   A0A154P2P7   A0A0P6CVK6   B2ZRZ7   A0A1I8PWV3   A0A2P2IA82   B0WZQ8   N6TFV4   Q9BKJ6   A0A1D1WA97   A0A2J7QU79   A0A0K2T4N2   A0A1B0GLF5   A0A0M3I2U5   F1KXW7   A0A1B0AWM7   A0A158P9A4  

Pubmed

26354079    18362917    19820115    24845553    12364791    14747013    + More
17210077    25348373    24495485    17510324    20920257    23761445    20798317    25830018    21719571    25315136    15632085    17994087    24508170    21347285    28004739    20075255    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    10436051    10469247    26108605    30249741    21282665    20566863    26823975    25244985    22634957    21292972    23537049    11955623    27649274    21685128   

EMBL

KQ459324    KPJ01454.1    KQ460045    KPJ18049.1    RSAL01000107    RVE47270.1    + More
GBYB01004770    JAG74537.1    GANO01001484    JAB58387.1    UFQS01000731    UFQT01000731    SSX06430.1    SSX26779.1    KQ971352    EFA06312.2    AXCN02001551    KK852656    KDR19261.1    GECZ01031538    JAS38231.1    AXCM01004865    KZ288194    PBC33861.1    AAAB01008799    EAA03763.5    GAKP01009943    JAC49009.1    GDHF01020505    GDHF01001496    JAI31809.1    JAI50818.1    GEHC01000386    JAV47259.1    GAMC01012946    GAMC01012945    JAB93610.1    CH478333    EAT33216.1    ADMH02002134    ETN58434.1    GFDL01000071    JAV34974.1    GL447857    EFN85804.1    GEDC01016799    JAS20499.1    CVRI01000070    CRL07391.1    GBXI01005252    JAD09040.1    GL888255    EGI63778.1    KQ981636    KYN38766.1    KA644652    AFP59281.1    CM000070    EAL27583.2    CH916369    EDV92627.1    KK107078    EZA60237.1    KQ976725    KYM76527.1    CH902617    EDV43591.1    ADTU01016117    CH479179    EDW24959.1    GEZM01085033    JAV60300.1    OUUW01000005    SPP81086.1    GL444280    EFN61020.1    CM000160    EDW98600.1    CP012526    ALC46129.1    AE014297    AY119509    AAF56615.1    AAM50163.1    KQ977622    KYN01306.1    CM000364    EDX14575.1    AF033117    AAD49105.1    CH480828    EDW45140.1    CH964272    EDW84097.1    CH954182    EDV53519.1    Y08898    Y08899    JRES01000032    CAA70106.1    KNC34786.1    CH940656    EDW58648.1    ACPB03016132    QOIP01000011    RLU16776.1    GL762111    EFZ22208.1    CH933806    EDW15257.2    GEBQ01018559    GEBQ01006911    GEBQ01003446    GEBQ01002109    GEBQ01000521    JAT21418.1    JAT33066.1    JAT36531.1    JAT37868.1    JAT39456.1    DS235357    EEB15194.1    GDHC01003902    JAQ14727.1    GBRD01010178    JAG55646.1    KQ978957    KYN27190.1    LNIX01000002    OXA60857.1    GDIQ01006572    JAN88165.1    LRGB01000512    KZS18539.1    CAEY01001062    GEZM01085032    JAV60301.1    JF906729    AEI52301.1    KQ982813    KYQ50341.1    GL732530    EFX86097.1    JH432008    KQ434809    KZC06196.1    GDIQ01087886    JAN06851.1    EU683032    ACD63025.1    IACF01005337    LAB70923.1    DS232214    EDS37733.1    APGK01029410    APGK01029411    APGK01029412    APGK01029413    APGK01029414    APGK01029415    KB740734    ENN79264.1    AF241263    AAK28328.1    BDGG01000016    GAV08149.1    NEVH01011187    PNF32142.1    HACA01003632    CDW20993.1    AJWK01034904    AJWK01034905    AJWK01034906    AJWK01034907    JI167737    ADY42721.1    JXJN01004828    JXJN01004829    JXJN01004830    JXJN01004831   

Proteomes

UP000053268    UP000053240    UP000283053    UP000007266    UP000075900    UP000075886    + More
UP000005203    UP000075885    UP000075903    UP000027135    UP000075920    UP000075883    UP000242457    UP000007062    UP000075884    UP000079169    UP000008820    UP000075880    UP000000673    UP000069272    UP000008237    UP000183832    UP000007755    UP000078541    UP000095301    UP000001819    UP000001070    UP000053097    UP000192221    UP000078540    UP000007801    UP000005205    UP000008744    UP000268350    UP000000311    UP000002358    UP000002282    UP000092553    UP000000803    UP000078542    UP000000304    UP000001292    UP000007798    UP000008711    UP000037069    UP000008792    UP000015103    UP000279307    UP000009192    UP000078200    UP000092445    UP000009046    UP000092443    UP000078492    UP000091820    UP000076408    UP000198287    UP000076858    UP000015104    UP000075809    UP000000305    UP000075902    UP000076502    UP000095300    UP000002320    UP000019118    UP000186922    UP000235965    UP000092461    UP000036681    UP000092460    UP000035642   

PRIDE

Q9VBC7    Q9UAE7   

Pfam

PF01483   P_proprotein        + More
PF00082   Peptidase_S8
PF16470   S8_pro-domain
PF03878   YIF1
PF01431   Peptidase_M13
PF05649   Peptidase_M13_N

Interpro

IPR038466   S8_pro-domain_sf        + More
IPR015500   Peptidase_S8_subtilisin-rel       
IPR000209   Peptidase_S8/S53_dom       
IPR022398   Peptidase_S8_His-AS       
IPR008979   Galactose-bd-like_sf       
IPR036852   Peptidase_S8/S53_dom_sf       
IPR032815   S8_pro-domain       
IPR034182   Kexin/furin       
IPR023828   Peptidase_S8_Ser-AS       
IPR023827   Peptidase_S8_Asp-AS       
IPR002884   P_dom       
IPR005578   Yif1_fam       
IPR021109   Peptidase_aspartic_dom_sf       
IPR000718   Peptidase_M13       
IPR018497   Peptidase_M13_C       
IPR008753   Peptidase_M13_N       
IPR024079   MetalloPept_cat_dom_sf       
IPR042089   Peptidase_M13_dom_2       

SUPFAM

SSF52743   SSF52743        + More
SSF49785   SSF49785       
SSF50630   SSF50630       

Gene 3D

2.60.120.260     3.30.70.850     3.40.50.200     2.40.70.10     1.10.1380.10     3.40.390.10    

CDD

cd04059  Peptidases_S8_Protein_converta
cd08662  M13

ProteinModelPortal

A0A194Q7T7   A0A194RKU8   A0A3S2PC85   A0A0C9R9H3   U5EZ39   A0A336MD00   + More
D6WTB9   A0A182RFU5   A0A182QA44   A0A088AB96   A0A182PEB4   A0A182UN58   A0A067R765   A0A182VYE1   A0A1B6EK08   A0A182LYW3   A0A2A3ES43   Q7QK68   A0A182NMW0   A0A034W2T3   A0A0K8WI44   A0A1W7R7Z7   A0A1S3D4G7   W8AXD2   Q16G47   A0A182J4E5   A0A1S4G2J0   W5J6P0   A0A1Q3G599   A0A182FQN8   E2BET8   A0A1B6D466   A0A1J1J4S6   A0A0A1XDK9   F4WPU9   A0A195FEG1   T1P7X4   Q299W8   B4JGF8   A0A026WW40   A0A1W4VMD6   A0A195AWU5   B3M3D0   A0A158NHZ8   B4G387   A0A1Y1KJ75   A0A3B0K643   E2AZX1   K7J1H6   B4PSD8   A0A0M3QXM5   Q9VBC7   A0A195CKQ8   B4QWQ8   Q9UAE7   B4ICP4   B4NKN6   B3P649   Q94977   B4MC27   T1HZ79   A0A3L8D8Z0   E9IBK9   B4K6X0   A0A1B6MPI1   A0A1A9VQP5   A0A1B0A453   E0VP88   A0A146M7H5   A0A1A9YF58   A0A0K8SQZ7   A0A195EFZ9   A0A1A9WSU7   A0A182XWI2   A0A226EUM0   A0A0N8EPI7   A0A162P5G0   T1L3Y3   A0A1Y1KIN1   I6M2I5   A0A151WRB3   E9G2S6   T1JNR2   A0A182ULK9   A0A154P2P7   A0A0P6CVK6   B2ZRZ7   A0A1I8PWV3   A0A2P2IA82   B0WZQ8   N6TFV4   Q9BKJ6   A0A1D1WA97   A0A2J7QU79   A0A0K2T4N2   A0A1B0GLF5   A0A0M3I2U5   F1KXW7   A0A1B0AWM7   A0A158P9A4  

PDB

6HZD     E-value=2.04676e-119,     Score=1100

KEGG

101740216    K01360 proprotein convertase subtilisin/kexin type 2 [EC:3.4.21.94] | (RefSeq) neuroendocrine conver

GO

GO:0004252   GO:0008236   GO:0005615   GO:0016020   GO:0016486   GO:0043005   GO:0016485   GO:0016021   GO:0005576   GO:0035180   GO:0035187   GO:0002165   GO:0033500   GO:0008233   GO:0006508   GO:0007218   GO:0004222   GO:0008237   GO:0000150   GO:0000724   GO:0003690   GO:0003697   GO:0008094   GO:0005524   GO:0006281   GO:0006259  

Length:

585

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.1017

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00049

outside

1  -  585

 

 

Pi

247.860238

Theta

177.311447

Tajima's D

1.322898

CLR

0.379175

CSRT

0.745012749362532

Interpretation

Uncertain