Gene

KWMTBOMO15375  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005086

Annotation

NAD-dependent_deacetylase_sirtuin_2_homolog_[Bombyx_mori]

Location

Bomo_Chr25(+):10800196-10805478      View in EpiBrowser

Full name

NAD-dependent protein deacetylase      

Location in the cell

Cytoplasmic   Reliability : 3.128

CDS

ATGTCGGCAAATTCGCCTCCCGGAAAAAGTGGCGGTCACGAAACCGTGGATGAGTCACCGCAGAATGTCCCGCCAACAACTTCGATGGAAAGCCTCAGAAATATGTTTCGCGATCTCGACGTGGATGACGTTCGAATGTACTTGGCCTTAAAACTCGGACTCTTCAGCCCTCAGGATCTTGAACCGGCAGAACCACCAGAAAAAGTTTTGGATGAGGTCAGCCTTGATGGTATTGTCAGGTGGATCAAGAGCGATAGGTGCAAGAAGATCATAACACTTTCAGGAGCTGGTATTTCTACCTCTGCTGGAATTCCAGACTTCCGTAGTCCCGAAACAGGATTATATCATAACTTACAGAAGTACGAACTACCTCAACCACAGGCGATATTCGAAATAAATTTCTTCAGGCAAAATCCCAAACCTTTCTTCACATTAGCAAAGGAATTATTTCCAGGAAGCTTTAAGCCTACAATTTCACATTATTTCATAAGACTTCTACATGAGAAAGGGCTCTTATTACGTCATTATACACAAAACATTGACACATTAGAGCGAGGAGCCGGCATTCCCGAAGAAAAATTAGTCGAAGCACACGGAACGTTCTACACATCACATTGTCTGGATTGCCGCAAGGAATACCCACTGGAGTTTGTCAAAGAAAGGATATTTGCTGACCAGATCCCAATCTGCACTGAATGCCCTGGTGTTGTGAAGCCTGACATTGTGTTCTTCGGTGAGAGTCTGCCCGAGAGGTTCCAGATGTGTCTAGAGGAGGACTTCAAGCAATGTGACATGCTCATTATTATGGGATCTTCACTTGAAGTGCAACCATTTGCATCACTTATAGATATGGTCCCAGATTCGTGTCCTCGACTTCTGATAAACCGTGAGAAGGCCGGCGTGAGACCACCTATATTGAGAATAAGAGGATTAATGTGTGGAGGTTTACAGTTAGACGAAGGTTCCTATAGAGATGTGGCGAGGCTAGGAGATTGTGATGAAGGCTGCCAGGACTTGGCAGACAGACTGGGATGGGGGGATGAACTTCGAGCATTAGTAGCCCGTGAACATGAACGCTTGGACCAAGAACTATTGACTGCGTCTCCCCATGCCCCGGTACTGATACCTTCAGAAGCAAACGCGGGACCCAGTGCCTCGGAATGA

Protein

MSANSPPGKSGGHETVDESPQNVPPTTSMESLRNMFRDLDVDDVRMYLALKLGLFSPQDLEPAEPPEKVLDEVSLDGIVRWIKSDRCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFTLAKELFPGSFKPTISHYFIRLLHEKGLLLRHYTQNIDTLERGAGIPEEKLVEAHGTFYTSHCLDCRKEYPLEFVKERIFADQIPICTECPGVVKPDIVFFGESLPERFQMCLEEDFKQCDMLIIMGSSLEVQPFASLIDMVPDSCPRLLINREKAGVRPPILRIRGLMCGGLQLDEGSYRDVARLGDCDEGCQDLADRLGWGDELRALVAREHERLDQELLTASPHAPVLIPSEANAGPSASE

Description

NAD-dependent protein deacetylase.

Catalytic Activity

H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide

Cofactor

Zn(2+)

Similarity

Belongs to the sirtuin family. Class I subfamily.

Uniprot

Q5R1T8   H9J6E4   A0A2H1VNG0   A0A2W1BNR5   A0A2A4JYW2   A0A1X9ZE53   + More
A0A212EZA7   A0A194Q7G2   S4PWH6   A0A194RKT9   A0A067QQH3   A0A347ZJG5   A0A1B6JNI0   A0A1B6IKC6   A0A2J7PDE6   N6TN36   D6WU58   J3JZ84   A0A1B6F187   A0A1Y1KNG4   T1IPY0   A0A0T6B625   A0A1B6EET5   A0A1W4WW89   A0A2J7PDE8   A0A195BH35   K7IUV9   E0VSM4   A0A026W657   C3Z3T3   A0A3L8D6E3   A0A2A3ECV9   A0A195F1S0   A0A151WHD4   V9IJE9   A0A385NHD3   A0A151JSD0   A0A336MJZ4   A0A336MSQ3   A0A0K8TSI2   A0A182J105   A0A1J1J3J6   A0A195BYW4   A0A3R7M8U0   E2BWB7   A0A1W2W011   Q1RL34   A0A023ESR7   V4B5Z2   A0A2J7PDG4   A0A0M9A6I4   H2ZEV4   A0A2P2HZC9   A0A1L8DXE4   A0A1S4FBT0   A0A084WR60   F4X648   A0A2T7P011   Q178Q5   A0A0L7RIQ3   A0A232FKI0   A0A1L8DX05   A0A182FL31   A0A1B0CAF4   A0A1Q3F338   A0A1Q3F331   A0A2H6NHH5   A0A1L8DWU4   A0A182TQN7   A0A182NG16   S4RPQ6   A0A088ARH5   A0A2M4BI84   A0A2M4BIE9   A0A2M4BIC6   A0A182XHE1   A0A0C9R9B4   A0A182JX08   A0A1Q3F385   Q7QD39   A0A2M3ZGM1   A0A154P6E4   A0A182HU03   U3EQS2   A0A182VGD3   T1PBG3   A0A3M6TXC7   A0A182XWB1   A0A2K6FCU9   A0A1S3JK38   A0A182P6L3   A0A0P4WM13   W5J6U2   A0A2M4A9R7   A0A182QZB6   A0A1S3JIN7   A0A182VYL7   T1E450   A0A250XZ64   R7UXG6  

EC Number

3.5.1.-

Pubmed

19121390    28756777    22118469    26354079    23622113    24845553    + More
23537049    18362917    19820115    22516182    28004739    20075255    20566863    24508170    18563158    30249741    26369729    20798317    12481130    15114417    16519883    24945155    23254933    24438588    21719571    17510324    28648823    12364791    14747013    17210077    23915248    30382153    25244985    20920257    23761445    23758969    28087693   

EMBL

AB194684    BAD74192.1    BABH01019687    ODYU01003502    SOQ42375.1    KZ149949    + More
PZC76699.1    NWSH01000360    PCG76999.1    KY363351    ARS43573.1    AGBW02011359    OWR46787.1    KQ459324    KPJ01463.1    GAIX01006773    JAA85787.1    KQ460045    KPJ18039.1    KK853567    KDR06661.1    FX985733    BBA84471.1    GECU01006971    JAT00736.1    GECU01020351    JAS87355.1    NEVH01026387    PNF14366.1    APGK01028591    KB740694    ENN79433.1    KQ971352    EFA06770.1    BT128565    KI208145    KI210265    AEE63522.1    ERL95803.1    ERL96218.1    GECZ01025918    GECZ01023244    JAS43851.1    JAS46525.1    GEZM01078214    JAV62844.1    JH431265    LJIG01009558    KRT82840.1    GEDC01000897    JAS36401.1    PNF14365.1    KQ976488    KYM83486.1    AAZX01008132    DS235751    EEB16380.1    KK107378    EZA51557.1    GG666577    EEN52847.1    QOIP01000012    RLU16037.1    KZ288282    PBC29567.1    KQ981866    KYN34044.1    KQ983120    KYQ47234.1    JR050108    AEY61180.1    MG321242    AYA73279.1    KQ978530    KYN30279.1    UFQT01001447    SSX30606.1    UFQT01002076    SSX32591.1    GDAI01000274    JAI17329.1    CVRI01000066    CRL06372.1    KQ978501    KYM93515.1    QCYY01001808    ROT75133.1    GL451103    EFN80021.1    BR000200    FAA00231.1    GAPW01001276    JAC12322.1    KB200129    ESP02931.1    PNF14368.1    KQ435726    KOX78237.1    IACF01001407    LAB67109.1    GFDF01003159    JAV10925.1    ATLV01025932    KE525402    KFB52704.1    GL888769    EGI58081.1    PZQS01000008    PVD26760.1    CH477360    EAT42686.1    KQ414584    KOC70616.1    NNAY01000115    OXU30827.1    GFDF01003152    JAV10932.1    AJWK01003746    GFDL01013075    JAV21970.1    GFDL01013081    JAV21964.1    IACI01107984    LAA32571.1    GFDF01003153    JAV10931.1    GGFJ01003624    MBW52765.1    GGFJ01003622    MBW52763.1    GGFJ01003623    MBW52764.1    GBYB01009482    JAG79249.1    GFDL01013034    JAV22011.1    AAAB01008859    EAA07580.5    GGFM01006837    MBW27588.1    KQ434826    KZC07432.1    APCN01000596    GAEP01001518    GBEW01000979    JAB53303.1    JAI09386.1    KA646092    AFP60721.1    RCHS01002740    RMX45954.1    GDRN01030275    JAI67565.1    ADMH02002130    ETN58580.1    GGFK01004037    MBW37358.1    AXCN02000338    GAAZ01002365    JAA95578.1    GFFV01003311    JAV36634.1    AMQN01005776    KB296812    ELU11273.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000027135    + More
UP000235965    UP000019118    UP000007266    UP000030742    UP000192223    UP000078540    UP000002358    UP000009046    UP000053097    UP000001554    UP000279307    UP000242457    UP000078541    UP000075809    UP000078492    UP000075880    UP000183832    UP000078542    UP000283509    UP000008237    UP000008144    UP000030746    UP000053105    UP000007875    UP000030765    UP000007755    UP000245119    UP000008820    UP000053825    UP000215335    UP000069272    UP000092461    UP000075902    UP000075884    UP000245300    UP000005203    UP000076407    UP000075881    UP000007062    UP000076502    UP000075840    UP000075903    UP000275408    UP000076408    UP000233160    UP000085678    UP000075885    UP000000673    UP000075886    UP000075920    UP000014760   

PRIDE

Q5R1T8    H9J6E4   

Pfam

PF02146   SIR2

Interpro

IPR026590   Ssirtuin_cat_dom        + More
IPR003000   Sirtuin       
IPR026591   Sirtuin_cat_small_dom_sf       
IPR029035   DHS-like_NAD/FAD-binding_dom       
IPR017328   Sirtuin_class_I       

SUPFAM

SSF52467   SSF52467       

Gene 3D

3.30.1600.10    

ProteinModelPortal

Q5R1T8   H9J6E4   A0A2H1VNG0   A0A2W1BNR5   A0A2A4JYW2   A0A1X9ZE53   + More
A0A212EZA7   A0A194Q7G2   S4PWH6   A0A194RKT9   A0A067QQH3   A0A347ZJG5   A0A1B6JNI0   A0A1B6IKC6   A0A2J7PDE6   N6TN36   D6WU58   J3JZ84   A0A1B6F187   A0A1Y1KNG4   T1IPY0   A0A0T6B625   A0A1B6EET5   A0A1W4WW89   A0A2J7PDE8   A0A195BH35   K7IUV9   E0VSM4   A0A026W657   C3Z3T3   A0A3L8D6E3   A0A2A3ECV9   A0A195F1S0   A0A151WHD4   V9IJE9   A0A385NHD3   A0A151JSD0   A0A336MJZ4   A0A336MSQ3   A0A0K8TSI2   A0A182J105   A0A1J1J3J6   A0A195BYW4   A0A3R7M8U0   E2BWB7   A0A1W2W011   Q1RL34   A0A023ESR7   V4B5Z2   A0A2J7PDG4   A0A0M9A6I4   H2ZEV4   A0A2P2HZC9   A0A1L8DXE4   A0A1S4FBT0   A0A084WR60   F4X648   A0A2T7P011   Q178Q5   A0A0L7RIQ3   A0A232FKI0   A0A1L8DX05   A0A182FL31   A0A1B0CAF4   A0A1Q3F338   A0A1Q3F331   A0A2H6NHH5   A0A1L8DWU4   A0A182TQN7   A0A182NG16   S4RPQ6   A0A088ARH5   A0A2M4BI84   A0A2M4BIE9   A0A2M4BIC6   A0A182XHE1   A0A0C9R9B4   A0A182JX08   A0A1Q3F385   Q7QD39   A0A2M3ZGM1   A0A154P6E4   A0A182HU03   U3EQS2   A0A182VGD3   T1PBG3   A0A3M6TXC7   A0A182XWB1   A0A2K6FCU9   A0A1S3JK38   A0A182P6L3   A0A0P4WM13   W5J6U2   A0A2M4A9R7   A0A182QZB6   A0A1S3JIN7   A0A182VYL7   T1E450   A0A250XZ64   R7UXG6  

PDB

4R8M     E-value=2.34445e-106,     Score=985

KEGG

692483    K11412 NAD-dependent deacetylase sirtuin 2 [EC:3.5.1.-] | (RefSeq) Sirt2, BmSirt2; NAD-dependent dea

GO

GO:0070403   GO:0008270   GO:0017136   GO:0016787   GO:1900195   GO:0005874   GO:0072686   GO:0045836   GO:0051781   GO:0031641   GO:0044242   GO:0005886   GO:0043204   GO:0008134   GO:2000378   GO:1900226   GO:1900425   GO:0043220   GO:0042826   GO:0048012   GO:0014065   GO:0008285   GO:0022011   GO:0003682   GO:0034983   GO:0035729   GO:0048471   GO:0045944   GO:0005813   GO:0061433   GO:0046970   GO:0045843   GO:1900119   GO:0071219   GO:0033010   GO:0005694   GO:0005739   GO:0030496   GO:0005829   GO:2000777   GO:0051987   GO:0042903   GO:0034599   GO:0005814   GO:0045599   GO:0035035   GO:0010801   GO:0043130   GO:0010507   GO:0070932   GO:0043491   GO:0043388   GO:0043161   GO:0061428   GO:0071872   GO:0042177   GO:0005730   GO:0072687  

Length:

387

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01379

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00512

outside

1  -  387

 

 

Pi

211.887443

Theta

155.87544

Tajima's D

1.172178

CLR

0.251936

CSRT

0.710914454277286

Interpretation

Uncertain