Gene

KWMTBOMO15371

Annotation

doublesex_isoform_F_[Bombyx_mori]

Location

Bomo_Chr25(-):10694107-10702125      View in EpiBrowser

Full name

Protein doublesex      

Location in the cell

Extracellular   Reliability : 1.125 Nuclear   Reliability : 1.368

CDS

ATGGTTTCCGTCCCCTCGGAGACGCTTGTGGAGAACTGTCACAGACTCCTCGAGAAGTTCCATTACTCGTGGGAGATGATGCCGCTTGTGCTCGTCATCATGAACTACGCCCGCAGCGACTTGGATGAGGCTTCAAGGAAAATCTACGAAGGGAAGATGATCGTCGACGAGTACGCGAGGAAGCACAACTTGAACGTGTTCGACGGACTAGAACTAAGGAACTCGACACGCCAGAAAATGCTGGAAATTAATAATATAAGTGGTGTACTGTCTTCGTCAATGAAGTTATTTTGCGAATGA

Protein

MVSVPSETLVENCHRLLEKFHYSWEMMPLVLVIMNYARSDLDEASRKIYEGKMIVDEYARKHNLNVFDGLELRNSTRQKMLEINNISGVLSSSMKLFCE

Description

Controls somatic sexual differentiation. Binds directly and specifically to the FBE (fat body enhancer) of the yolk protein 1 and 2 genes (Yp1 and Yp2). This enhancer is sufficient to direct the female-specific transcription characteristic of the Yp genes in adult fat bodies. Involved in regulation of male-specific expression of takeout in brain-associated fat body.

Miscellaneous

Experimentally shown to bind zinc.

Keywords

3D-structure   Alternative splicing   Complete proteome   Differentiation   DNA-binding   Metal-binding   Nucleus   Reference proteome   Sexual differentiation   Transcription   Transcription regulation   Zinc  

Feature

chain  Protein doublesex
splice variant  In isoform Female.

Uniprot

Q9GV03   Q9GR95   A0A0H5BIV2   A0A194QDD2   D9ZD79   D9ZD74   + More
A0A2A4JGA1   I4DQT7   W0IAY8   E3WC93   W0IB68   A0A212FK59   S5TJ17   S5TSE9   A0A2Z5TDL7   T2HTB1   S5TJ21   A0A1Z2RRK5   A0A0H5BJ09   A0A194RPT4   W0IB59   W0IA80   D9ZD80   W0I6F0   D9ZD73   W0I6G3   W0I6C5   W0IAZ6   A0A2Z5TMJ0   S5TSF6   K9M2D0   A0A1L7NS27   K9M474   A0A1L7NS25   A0A0A1WIG0   A0A139WG17   Q06W14   Q8ITN2   Q06W19   O44369   A0A076YFA7   A0A0K8VQ30   Q4KXB9   Q49BC7   Q06W22   Q06W16   Q06W17   Q06W20   Q06W18   Q70TB4   Q06W03   Q06W21   A0A1B0CM75   C7SG52   B4M4Z9   A0A1L8DIF2   Q06W15   B4G2T7   A0A1L8DIS1   P23023-2   A0A0B4LGS9   A0A1L8DIR7   A0A1L8DIJ0   I5AP36   C7SG31   B3M238   A0A3B0KML8   B3NYT7   A0A1W4VXZ0   A0A0Q9X136   A0A0K8TN78   Q6S9V4   D6P3G9   M1VQK8   A0A1I8PWM7   M1VMI7   M1V1Z0   A0A1U7F5R8   A0A2M4AAH5   A0A2M4BYB5   A0A1Y9J029  

Pubmed

11583933    23261436    24244545    24239545    26154510    26354079    + More
20633649    22651552    20728536    28756777    22118469    28605547    23230513    27404087    25830018    18362917    19820115    9723873    25116961    18207077    25348373    16085699    15777677    20976560    17994087    2493994    10731132    12537572    12537569    1907913    8440242    12435630    12537568    12537573    12537574    16110336    17569856    17569867    15632085    26369729    14673649    20876994    12364791    14747013    17210077   

EMBL

AB048543    BAB13471.1    KF255805    KF255810    KF255812    KF255814    + More
KF419163    AB052774    AGS48294.1    AGS48299.1    AGS48301.1    AGS48303.1    AHF81632.1    BAB19780.1    LC033427    BAS02076.1    KQ459324    KPJ01466.1    GU930285    ADL40853.1    GU930280    GU930282    GU930284    ADL40848.1    NWSH01001603    PCG70738.1    AK404783    BAM20277.1    KF419147    KF419153    AHF81640.1    AHF81646.1    AB548679    AB548680    BAJ25851.1    KF419134    KF419140    KZ149949    AHF81652.1    AHF81658.1    PZC76701.1    AGBW02008117    OWR54135.1    KF255806    KF255809    KF419160    KF419162    KF419164    AGS48295.1    AGS48298.1    AHF81629.1    AHF81631.1    AHF81633.1    KF255807    KF255813    AGS48296.1    AGS48302.1    LC329332    BBA83992.1    AB795825    BAN82533.1    KF255811    KF419159    KF419161    AGS48300.1    AHF81628.1    AHF81630.1    KY938836    ASA46477.1    LC054300    BAS02078.1    KQ460045    KPJ18036.1    KF419144    KF419146    KF419148    KF419150    KF419152    KF419154    KF419155    AHF81648.1    KF419143    KF419149    AHF81642.1    GU930286    ADL40854.1    KF419145    KF419151    AHF81644.1    GU930279    GU930281    GU930283    ADL40847.1    KF419133    KF419135    KF419137    KF419139    KF419141    AHF81657.1    AHF81659.1    KF419138    AHF81656.1    KF419132    KF419136    AHF81650.1    AHF81654.1    LC329333    BBA83993.1    KF255817    KF255820    AGS48306.1    AGS48309.1    JQ857100    AFQ62107.1    LC105648    BAW32684.1    JQ857099    AFQ62106.1    LC105649    BAW32685.1    GBXI01015826    JAC98465.1    KQ971352    KYB26747.1    DQ494333    ABF50961.1    AF435087    AAN63598.2    DQ494328    ABF50956.1    AF029675    AAB99947.1    KJ816788    AIK66583.1    GDHF01033041    GDHF01017818    GDHF01014808    GDHF01011320    JAI19273.1    JAI34496.1    JAI37506.1    JAI40994.1    AY669318    GAKP01007049    GAKP01007048    AAV85891.1    JAC51903.1    AY948420    AAY25166.1    DQ494325    ABF50953.1    DQ494331    ABF50959.1    DQ494330    ABF50958.1    DQ494327    ABF50955.1    DQ494329    ABF50957.1    AJ547621    CAD67986.1    DQ494344    ABF50962.1    DQ494326    ABF50954.1    AJWK01018310    AJWK01018311    AJWK01018312    AJWK01018313    AJWK01018314    AJWK01018315    AJWK01018316    AJWK01018317    AJWK01018318    FJ185166    ACN73403.1    CH940652    EDW59710.2    GFDF01007852    JAV06232.1    DQ494332    ABF50960.1    CH479179    EDW24132.1    GFDF01007817    JAV06267.1    M25292    M25293    M25294    AE014297    AY060257    BT029258    AHN57219.1    GFDF01007819    JAV06265.1    GFDF01007818    JAV06266.1    CM000070    EIM52721.1    FJ176944    ACN24617.1    CH902617    EDV43362.1    OUUW01000013    SPP87829.1    CH954181    EDV48200.1    CH933806    KRG01807.1    GDAI01002017    JAI15586.1    AY461853    AAR23812.1    GU784834    ADG37649.1    AB744669    BAM93343.1    AB744667    AB744668    BAM93341.1    BAM93342.1    AB744670    AB744671    AB744672    BAM93344.1    BAM93345.1    BAM93346.1    AY903308    AAAB01008817    AAX48940.1    EGK96311.1    GGFK01004450    MBW37771.1    GGFJ01008861    MBW58002.1   

Proteomes

UP000053268    UP000218220    UP000007151    UP000053240    UP000007266    UP000092461    + More
UP000008792    UP000008744    UP000000803    UP000001819    UP000007801    UP000268350    UP000008711    UP000192221    UP000009192    UP000095300    UP000007062    UP000076407   

PRIDE

Q9GV03    Q9GR95    S5TJ17    S5TSE9    S5TJ21    S5TSF6    + More
P23023   

Pfam

PF00751   DM        + More
PF08828   DSX_dimer

Interpro

IPR001275   DM_DNA-bd        + More
IPR014932   DSX_dimer       
IPR036407   DM_DNA-bd_sf       
IPR026607   DMRT/dsx/mab-3       

SUPFAM

SSF82927   SSF82927       

Gene 3D

4.10.1040.10    

ProteinModelPortal

Q9GV03   Q9GR95   A0A0H5BIV2   A0A194QDD2   D9ZD79   D9ZD74   + More
A0A2A4JGA1   I4DQT7   W0IAY8   E3WC93   W0IB68   A0A212FK59   S5TJ17   S5TSE9   A0A2Z5TDL7   T2HTB1   S5TJ21   A0A1Z2RRK5   A0A0H5BJ09   A0A194RPT4   W0IB59   W0IA80   D9ZD80   W0I6F0   D9ZD73   W0I6G3   W0I6C5   W0IAZ6   A0A2Z5TMJ0   S5TSF6   K9M2D0   A0A1L7NS27   K9M474   A0A1L7NS25   A0A0A1WIG0   A0A139WG17   Q06W14   Q8ITN2   Q06W19   O44369   A0A076YFA7   A0A0K8VQ30   Q4KXB9   Q49BC7   Q06W22   Q06W16   Q06W17   Q06W20   Q06W18   Q70TB4   Q06W03   Q06W21   A0A1B0CM75   C7SG52   B4M4Z9   A0A1L8DIF2   Q06W15   B4G2T7   A0A1L8DIS1   P23023-2   A0A0B4LGS9   A0A1L8DIR7   A0A1L8DIJ0   I5AP36   C7SG31   B3M238   A0A3B0KML8   B3NYT7   A0A1W4VXZ0   A0A0Q9X136   A0A0K8TN78   Q6S9V4   D6P3G9   M1VQK8   A0A1I8PWM7   M1VMI7   M1V1Z0   A0A1U7F5R8   A0A2M4AAH5   A0A2M4BYB5   A0A1Y9J029  

PDB

2JZ1     E-value=8.45537e-20,     Score=232

KEGG

692415    no KO assigned | (RefSeq) Dsx, Bmdsx, dsx-dsr3, dsx-dsr4, dsx-dsr7, dsx1, dsx2, dsx3, dsx4, dsx5, ds

GO

GO:0003700   GO:0043565   GO:0046872   GO:0005634   GO:0045944   GO:0042803   GO:0008049   GO:0006357   GO:0007530   GO:0035215   GO:0007485   GO:0008270   GO:0045498   GO:0045497   GO:0045433   GO:0048071   GO:0001227   GO:0000977   GO:0016199   GO:0046660   GO:0001228   GO:0018993   GO:0007486   GO:0019101   GO:0045893   GO:0045496   GO:0048086   GO:0046661   GO:0045892   GO:0007619  

PANTHER

PTHR12322  

Subcellular location

Nucleus  

Length:

99

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.37151

Exp number, first 60 AAs:

2.37009

Total prob of N-in:

0.09566

outside

1  -  99

 

 

Pi

261.338418

Theta

186.755176

Tajima's D

1.151543

CLR

0.011748

CSRT

0.697965101744913

Interpretation

Uncertain