Gene

KWMTBOMO15347

Pre Gene Modal

BGIBMGA005124

Annotation

PREDICTED:_serine/threonine-protein_phosphatase_2A_56_kDa_regulatory_subunit_gamma_isoform_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr25(-):9784606-9836376      View in EpiBrowser

Full name

Serine/threonine protein phosphatase 2A regulatory subunit       + More
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit      
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform      

Alternative Name

PP2A B subunit isoform B'-gamma
PP2A B subunit isoform B56-gamma
PP2A B subunit isoform PR61-gamma
PP2A B subunit isoform R5-gamma
Renal carcinoma antigen NY-REN-29
PP2A B subunit isoform B'-alpha-3

Location in the cell

Mitochondrial   Reliability : 1.422 Nuclear   Reliability : 1.956

CDS

ATGGTTGCGAGGGGACGGCAGAAGACGGCGCGCATGTGCGGCGAGTACGGTGTGCGCAGCGCGTGTCAGTCCAGCCGCCCCGCAGCTCGCACCGGTCCCGGCGCTGCCGGGCTCCCGCTCGGATGCCGCTGCCGGCTACCGCTTGCGATGGTCCACGCCGGGCCGGCCGTGCGCGCGCCCTCTCGCGCGATGTTCGCCGCCGCCGATACTAAACCGCGTCGCGCCGTCTCGCCTCTTGGTATACCGAAATCTCCTTCGTTCCACTCTGGACTTGATCTCGTCGCGAATCAAGCGACAACTAAGCGCTCCGAAAGCGTATCGGACGTCGCCAGAGCCTTTCGGTTTGCGTTGTTCGCCGGCATGGAGGGCCAGGGCCCGCCGCAGAAGGCGCCTTCGCCGCCCGATGCGCGGAGCCCGCCGCCCCCCGTCTCTGCCGCTGTATCACCCGATCGTCCCGTGCTGGTGATACCTAATATTGATAGAGAGAGTCTAATGGAGCAGTTGCCACTGCTGAAAGATGCACCCGCGGCAGAAAAAGAACAGCTCTTCGTGCAGAAGCTGCGGCAGTGCTGTCTGCTGTTCGACTTTGCGGACGAGCCACTGTCTGATCTCAAATGGAAGGAGGTGAAGAGGGCCGCGCTGCTCGAGATGGTCGAATACGTCACGTCGCAGCGAGGCGTCATCACCGACTCTATTTACCCTGAAGCCGTTAATATGTTCGCGATCAATCTATTCCGGACGTTGCCGCCATCGTCGAATCCTAACGGAGCGGAATTCGATCCAGAGGAGGACGAACCCACATTAGAGGCCGCCTGGCCGCATTTACAGCTCGTCTACGAACTGTTCCTGCGGTTACTCGAGTCTCCGGATTTTCAGCCAAACATTGCCAAGAAGTATATAGACCAGAAGTTTGTTTTGCAACTCTTGGAGTTGTTCGATTCTGAGGACCCACGCGAACGAGACTTCCTCAAAACAACTCTCCATAGGATATACGGGAAATTCTTAGTTCTACGCGCTTACATAAGGAAACAGATCAATAACGTATTCTATAGGTTTATTTATGAAACGGAACACCATAATGGCATCGCGGAGCTCCTCGAAATCCTTGGTTCCATCATCAATGGATTCGCGTTGCCTCTCAAAGAGGAACACAAATTATTCTTACTCAGGGTACTACTGCCGCTGCACAAGGCCAAGTCGCTGTCGGTGTACCACCCGCAGCTGGCGTACTGCGTCGTGCAGTTCCTCGAGAAGGACCCCTCCCTCACGCAGCCCGTCGTCAGAGCTCTCTTGAAGTACTGGCCGAAGACTCATTCGCCGAAGGAGGTTATGTTCTTGAACGAGATGGAGGAGATATTGGACGTGGTGGAACCGGCCGAGTTCCAGCGCATCATGGACCCGCTGTTCAAGCAGCTAGCCAAATGTGTCTCCAGTCCGCATTTCCAGGTAGCAGAACGAGCGCTCTACTACTGGAACAACGAATACATAATGTCTTTAATATCGGACAACGCGACCCACATCCTGCCCGTGATGTTTCCGGCGTTGTACCGGAACACAAAGAGCCACTGGAACAAGACGATACACGGGCTCGTGTACAACGCGCTCAAACTGTTCATGGAGATGAATCAGAAACTGTTCGACGAGTGCACGCAGCAGTACAAGCAGGAGAAACAGAAAGAGAGGGAGCGACTTCTGCAGCGAGAGGAGATCTGGCAGCAAATAGAGGAGAGGGCGCAACGAAACGACCGCGGCTCAGAGCCCGCCGAGACACGCAAGCAGACCTATAGTAACGCGAACAAGCCCCTCCTCCGCAAGAAATCGGAGCTGCCCGTGGACAGCAGCGCCGTGCGCGCGCTCGCCGAGCACCGGCGCGCCGACCCCTTCCTGTCCTCGCCGCCCGACATCAACCACTGCTAG

Protein

MVARGRQKTARMCGEYGVRSACQSSRPAARTGPGAAGLPLGCRCRLPLAMVHAGPAVRAPSRAMFAAADTKPRRAVSPLGIPKSPSFHSGLDLVANQATTKRSESVSDVARAFRFALFAGMEGQGPPQKAPSPPDARSPPPPVSAAVSPDRPVLVIPNIDRESLMEQLPLLKDAPAAEKEQLFVQKLRQCCLLFDFADEPLSDLKWKEVKRAALLEMVEYVTSQRGVITDSIYPEAVNMFAINLFRTLPPSSNPNGAEFDPEEDEPTLEAAWPHLQLVYELFLRLLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLVLRAYIRKQINNVFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKLFLLRVLLPLHKAKSLSVYHPQLAYCVVQFLEKDPSLTQPVVRALLKYWPKTHSPKEVMFLNEMEEILDVVEPAEFQRIMDPLFKQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNATHILPVMFPALYRNTKSHWNKTIHGLVYNALKLFMEMNQKLFDECTQQYKQEKQKERERLLQREEIWQQIEERAQRNDRGSEPAETRKQTYSNANKPLLRKKSELPVDSSAVRALAEHRRADPFLSSPPDINHC

Description

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (By similarity).

Subunit

PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with PPP2CA AND PPP2R1A; the interaction is direct. Interacts with SGO1; the interaction is direct. Isoform 1 and isoform 2 interact with TP53 (phosphorylated at Ser-15 by ATM); increased upon DNA damage it drives PP2A-mediated dephosphorylation of TP53 at Thr-55. Interacts with IER3 and/or ERK kinases; regulates ERK dephosphorylation. Interacts with CIP2A; this interaction stabilizes CIP2A (PubMed:28174209).
PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1 (By similarity). Interacts with SGO1; the interaction is direct. May interact with TP53 (By similarity). Interacts with IER3 and/or ERK kinases; regulates ERK dephosphorylation (By similarity). Interacts with CIP2A; this interaction stabilizes CIP2A (By similarity).

Similarity

Belongs to the phosphatase 2A regulatory subunit.
Belongs to the phosphatase 2A regulatory subunit B56 family.

Keywords

3D-structure   Acetylation   Alternative splicing   Centromere   Chromosome   Complete proteome   Nucleus   Phosphoprotein   Polymorphism   Reference proteome  

Feature

chain  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
splice variant  In isoform 4.
sequence variant  In dbSNP:rs3742424.

Uniprot

H9J6I2   A0A2H1WQT3   A0A212EZR8   A0A194Q7H1   A0A3S2NVM3   A0A1X9ZE62   + More
A0A1Y1L9T6   A0A1B6F4U8   A0A2J7PR44   A0A139WEL0   A0A1B6DCD9   A0A1B6BXG3   A0A1Y1L9Q2   E0VIE4   A0A1Y1L7D5   N6U7N6   A0A3B1JZ58   A0A1W5B1D5   A0A3B4E9V4   A0A3B5B7M3   A0A3Q1GZL4   A0A3Q2H408   S4RN43   A0A146YJP5   A0A1W5AW63   Q13362-4   G3R5M9   A0A2R9BMI3   A0A2K6RB64   A0A2J8QLU3   A0A2J8SZU7   F7ANY1   A0A2K5DE82   A0A0P6J6V0   A0A2K5LQB0   U3CGE0   A0A2K6EEH5   A0A3Q2DRM8   A0A3B1JPU2   W5L887   A0A2Y9NFN1   A0A3B4EBK1   A0A2K5SJ37   A0A1W5B3J6   A0A2I2YSJ5   G1LH85   M3WQ21   A0A2K6TKB0   A0A2I3GIU7   A0A3Q7XVL2   A0A3B3R612   A0A3P8Y348   A4QP33   D2HVQ4   A0A383ZUW2   A0A3Q3JGZ5   A0A1S3F380   K9ILB2   A0A3Q1LMZ0   A0A3B4U4E4   A0A3P9A9E3   A0A2Y9TFG5   A0A3B3YIX5   A0A3B3H5W3   A0A3B4U557   A0A3B4UYM4   A0A3N0YYA9   G7PBN1   F1P708   A0A2D0PXZ2   A0A1S3MAW4   A0A1S3MAU2   A0A3Q7UM69   A0A2Y9JTE6   Q6P3P7   A0A3Q0CMP2   A0A3B4UYA3   Q60996-3  

Pubmed

19121390    22118469    26354079    28004739    18362917    19820115    + More
20566863    23537049    25329095    19892987    8617797    8694763    14702039    19054851    12508121    7584044    7592815    8703017    10508479    16580887    16456541    16541025    17245430    17967874    22814378    17174897    17086192    19716788    18618707    28174209    22398555    22722832    25362486    17431167    25319552    25243066    20010809    17975172    29240929    25069045    23594743    19393038    17554307    22002653    16341006    26319212    15489334    12507892    8752144    15051958    21183079   

EMBL

BABH01019765    BABH01019766    BABH01019767    ODYU01010346    SOQ55388.1    AGBW02011239    + More
OWR46988.1    KQ459324    KPJ01487.1    RSAL01000152    RVE45736.1    KY363352    ARS43574.1    GEZM01062592    JAV69601.1    GECZ01024648    GECZ01016200    JAS45121.1    JAS53569.1    NEVH01022633    PNF18810.1    KQ971354    KYB26383.1    GEDC01013996    JAS23302.1    GEDC01031653    JAS05645.1    GEZM01062595    JAV69598.1    DS235199    EEB13150.1    GEZM01062591    JAV69602.1    APGK01036460    APGK01036461    KB740940    KB632083    ENN77685.1    ERL88616.1    GCES01032601    JAR53722.1    U37352    Z69030    AK131391    AK302470    AB451341    AL118558    AL137779    CH471061    D26445    L42375    CABD030094108    CABD030094109    CABD030094110    CABD030094111    CABD030094112    AJFE02020155    AJFE02020156    AJFE02020157    AJFE02020158    AJFE02020159    AJFE02020160    AJFE02020161    AJFE02020162    AJFE02020163    AJFE02020164    NBAG03000028    PNI97255.1    NDHI03003534    PNJ26283.1    JSUE03040466    JSUE03040467    JU335293    AFE79046.1    GEBF01003681    JAN99951.1    GAMT01002688    GAMR01009254    JAB09173.1    JAB24678.1    ACTA01068517    ACTA01076517    ACTA01084517    ACTA01092517    AANG04004659    ADFV01092964    ADFV01092965    ADFV01092966    ADFV01092967    ADFV01092968    ADFV01092969    ADFV01092970    ADFV01092971    ADFV01092972    ADFV01092973    CR381646    BC139635    AAI39636.1    GL193486    EFB22885.1    GABZ01005427    JAA48098.1    RJVU01018862    ROL51286.1    CM001282    EHH63898.1    AAEX03006020    BC063910    CR848574    AAH63910.1    CAJ81484.1    BC003979    AB055635    AB055636    U37353    U59418    AY389498   

Proteomes

UP000005204    UP000007151    UP000053268    UP000283053    UP000235965    UP000007266    + More
UP000009046    UP000019118    UP000030742    UP000018467    UP000192224    UP000261440    UP000261400    UP000265040    UP000002281    UP000245300    UP000005640    UP000001519    UP000240080    UP000233200    UP000006718    UP000233020    UP000233060    UP000008225    UP000233160    UP000265020    UP000248483    UP000233040    UP000008912    UP000011712    UP000233220    UP000001073    UP000286642    UP000261540    UP000265140    UP000000437    UP000261681    UP000261600    UP000081671    UP000009136    UP000261420    UP000261480    UP000001038    UP000009130    UP000002254    UP000221080    UP000087266    UP000286640    UP000248482    UP000189706    UP000000589   

PRIDE

H9J6I2    Q13362    Q60996   

Pfam

PF01603   B56

Interpro

IPR011989   ARM-like        + More
IPR002554   PP2A_B56       
IPR016024   ARM-type_fold       

SUPFAM

SSF48371   SSF48371       

Gene 3D

1.25.10.10    

ProteinModelPortal

H9J6I2   A0A2H1WQT3   A0A212EZR8   A0A194Q7H1   A0A3S2NVM3   A0A1X9ZE62   + More
A0A1Y1L9T6   A0A1B6F4U8   A0A2J7PR44   A0A139WEL0   A0A1B6DCD9   A0A1B6BXG3   A0A1Y1L9Q2   E0VIE4   A0A1Y1L7D5   N6U7N6   A0A3B1JZ58   A0A1W5B1D5   A0A3B4E9V4   A0A3B5B7M3   A0A3Q1GZL4   A0A3Q2H408   S4RN43   A0A146YJP5   A0A1W5AW63   Q13362-4   G3R5M9   A0A2R9BMI3   A0A2K6RB64   A0A2J8QLU3   A0A2J8SZU7   F7ANY1   A0A2K5DE82   A0A0P6J6V0   A0A2K5LQB0   U3CGE0   A0A2K6EEH5   A0A3Q2DRM8   A0A3B1JPU2   W5L887   A0A2Y9NFN1   A0A3B4EBK1   A0A2K5SJ37   A0A1W5B3J6   A0A2I2YSJ5   G1LH85   M3WQ21   A0A2K6TKB0   A0A2I3GIU7   A0A3Q7XVL2   A0A3B3R612   A0A3P8Y348   A4QP33   D2HVQ4   A0A383ZUW2   A0A3Q3JGZ5   A0A1S3F380   K9ILB2   A0A3Q1LMZ0   A0A3B4U4E4   A0A3P9A9E3   A0A2Y9TFG5   A0A3B3YIX5   A0A3B3H5W3   A0A3B4U557   A0A3B4UYM4   A0A3N0YYA9   G7PBN1   F1P708   A0A2D0PXZ2   A0A1S3MAW4   A0A1S3MAU2   A0A3Q7UM69   A0A2Y9JTE6   Q6P3P7   A0A3Q0CMP2   A0A3B4UYA3   Q60996-3  

PDB

2NPP     E-value=0,     Score=1789

KEGG

101740039    K11584 serine/threonine-protein phosphatase 2A regulatory subunit B' | (RefSeq) serine/threonine-pro

PATHWAY

03015    mRNA surveillance pathway - Bombyx mori (domestic silkworm)

GO

GO:0007165   GO:0019888   GO:0000159   GO:0031952   GO:0005829   GO:0005634   GO:0006470   GO:0072542   GO:0016021   GO:0006977   GO:0008285   GO:0042771   GO:0005654   GO:0014066   GO:0005794   GO:0043161   GO:0051898   GO:0000775   GO:0005488   GO:0016020   GO:0006436   GO:0004812   GO:0006418   GO:0004222   GO:0031012   GO:0008233  

PANTHER

PTHR10257  

Subcellular location

Nucleus  
Chromosome  
Centromere  

Length:

638

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05497

Exp number, first 60 AAs:

0.00706

Total prob of N-in:

0.00418

outside

1  -  638

 

 

Pi

246.454836

Theta

178.169649

Tajima's D

1.673809

CLR

0.226227

CSRT

0.817859107044648

Interpretation

Uncertain