SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO15336  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA005071
Annotation
PREDICTED:_baculoviral_IAP_repeat-containing_protein_6_[Papilio_machaon]
Full name
Baculoviral IAP repeat-containing protein 6      
Alternative Name
BIR repeat-containing ubiquitin-conjugating enzyme
RING-type E3 ubiquitin transferase BIRC6
Ubiquitin-conjugating BIR domain enzyme apollon
Location in the cell
Cytoplasmic   Reliability : 1.111 Nuclear   Reliability : 1.706 PlasmaMembrane   Reliability : 1.034
 

Sequence

CDS
ATGAACTTTTCTGTAACTTCTCTCACGTACCACAGTAATCTTAATATTATATTGGTGAAGACTGATGTGGGTAGTGTACACGTTTTGGATGTGAATTCGGGTGTGATACTGCAGTCTTCATGTCTGTCAGCGGACGAAGCTGGTACGTTGGGAGTAGAGTACGCTTCCGGAGCGGACCGAGTTTTTGTGTGGGATAGTAGTGGTATTGGTGCACGCACTGATTACAATGGAGTGTTATTACTTCATACAGCTCTGCAACGTCCCCTGCCAATTTCTCATACTGAAAAAAACATAAAGATTGAACTTGTCTTATCTGAGGCTGTGCTCCTGTATCAATGTCTTCAGAGCATAGATGCACATTTTATAGTAGGGCTTTCTGATTTTATCACTGAGTTGAAAAGTGCTATTGATGCTGAACCAGTCCGAAAAGGCGTCAAAGCCCAAAAGTGGAGTACAGTAACAATATGCCTGTCACTATCAACTTTACGACTGGTGGCAGCTAGTGTTGTCCAAGAGCTCAAAGGACAGAGCCGAAGAATTCCGGCCTTAGCTATTGCATCAGCTGTAGGGCAGAGAGCCAATGAACTAGATCCATCATTACGGGATGATGAGAATAGACCCTTGATGAGCTCCGAGGCTGAAAGGAAAGAGACATTCAAAAGATGGCCCCACATGGATTACAAATGGGCTCTCCCAGCTCGTATGGCACAGGCAGGATTCTACCATCAACCATCACCCAGTGGCGATGACCGCGCCATGTGCTTCGCATGTAACGTGTGTCTCGTTTGCTGGGAGAAGAGTGATGAGCCTTGGGTTGAACATGAGCGCCATTCACCTAATTGCTCCTTTGTTAAGGGAGAGTACACACACAACGTCCCCATATCAGTGACAAATGCTACAGCTTGTGCAGTACCATGTCCCAATGTAGCAGTAGTGTCTAAAGGTAACACCGGTGATCTTATCGCTACAGGCACCGTTGAGGGAAAAGTAAACATATGGAGATTCGATTGTGGACTGAAATTAGTCAAATTTGTACATGTTTCACCATATGACTCAATTTTCAGTGGAATTCTCACTACAGATTACAATAAAGTGTGGTCTACAAGCTTAGAGAAAGATTCTTCTACATATAGCATAGAATTGACTGCAATGACTTTTGCTGGAATGACAACTCAATCTGAGAACTACACTCAGGGACAAAATCTAGAAAACATTGAGAAAGATCCAAATATAAACAAGACCAAACCATCACTTATATGTGCTGTCATTATAACGAGAACAAATCTCCCTGAACCCACTTTACCTGTAAAAGATGAAAGTAGCAAAGCCCTCTTCGATTCTGGAGCACTGTCTGAAGAAAAAGTACAAGCAATGAACGATCGAAACGAAGCCGAAAATAGCATGGGACTGACAGAAAAAATACTGTTTTTGCTCACTTATGACATCCACAGTTCCTCAGCAGGGTCCATCACTGCTGTTGTACCAACATCCAATAACAGTGCCAATTCCAAACCAGGTGGTAGCAAGAAAGTTTGCTCAGTAACGAGGACTGACGATGCACATATTTATGACGAAATTTACTTCCAATATTCTGATGATGACACAGAACTACCACAGTGTACTAATACACTGATTGACGAACAAATAAGTAATGTAATAAATTTGAATGCATCATCAAGTAAGGACGACTGTAAAAATTGGGGCGAAACTAAAAAGATTTTTTTAACGAAGCATTTTAAAGTTATGCCACCCCCTCCACCTTCGGCATTGTTGCCTGAACTGCAAGAAGCTGGCCCAGTTAGTATCATAGATATAGTAGGAAAGAAGATGTCCCAAATTAAAAACTGGAAAAGTATGGAGAGTGCTGGTACCAAAATAGTTGATCAAACAGATGCTGTCTTACAAGCTGACCCTTTTGTTCATTATCTGAATATGAGTGGACCTGTTGAAATTCCCGATTTTAAATGGTACGAAAGTGGAGAAAGTACTGAGAAGATCAAGTTTACTACAATTACTGGAAGTAGCAAATTAGGAACTCAAACGGCTGCAACAAATACGAATGACGGGTTTGAAAATGATCCGCCTCAGGAAGAAGCTATCTCTCACGGAGTGGCAGTACAATGTCTGACATTTCCGTCTACGTTAACTCTAAAAGATAATCCCAGAGTGACACATTTGATGCCCACGGAAGATAGAGATCATTTGTTTGTTGTTATATCTCATGTTGATCTTCAAAAACTAAGACTTGAAGACGATACAGACAATGATGGGGATACGAAAATGGAAGTGGATGATGCAGACTTGGAAAAAAAGGCGGATCTAAAAGCTTATTTCATCCTATATAGGCTAAACACTAAAACTTCAATTTACACATTAGAAGATAATCCAATGTCAATTCAAGAGTTACCCTACAATGAAACTCCAATAGATTTATGTTTATTGCCACCGGATAAACATGAACAGTACTCCTTTGCATCTGTTGGTATTGATGGTTGTTTGAGGTTGTACTCTTTGCCAGACTTCAAAATTATATCTGAAAAACGAGTGCCAAAAGGACCTTTCACATCAGTAACATACTGTGCTTCAGTGGAAAGATTGAGTGTGGCAACTAAACATGGGATCATTTATTTCTATGCACTTAATAATGGAGAAAATGATTCAACTGGTGATATTGATGATGACGATTTTGCTAATATTGATTTTGACATGCTTCAACGAGCACCTCGAGATGAAGTTTGTGGACCAACACCTACGCCTATTATAATAGCAAACAAATCTGAACTAGATACTAATGATTTGGAAACTTTGATCAGCGTAACGGGGTTGTATGGTACTAATACGACTGTGCCTTACAGTGCAGTAGTGCCTGGTTTCTGGTGTGAATTATCACCTGCACAAAGACCAACATCGGATCACCAAAATAATAGAACTTGGCGATTACAGAATACGTCTTCAACTTGGGATGAACATGTTCTGGAGTTGACATTACCATACAGTGTCTCGTTAGCTCATATTGAATTTAGCTTCACTTTGCATACGGCATCTACAAGTAGCTTACCAATGATTTTAGTAACACTTTTGAAACAAAACTTACAGGGGATTGGTTACAAAAAAGATGCTTCGTTTGAACCCAAATCTGATTCCCCAGAACAGAATACAACTGAGGAGCCAAATGTCCATAACACAGATATACCTGTAAACAGTGAGGAATATTTACAAGCACAAAATGTTGAAATTTTAGCTGGTCCATTATTACTCTCTACTGGCTTAGATTTGACACAACAGTCTGGAACGTTGATACTGACAAGCCCTAGATTATATAGGGCGAGGGGTAGAACGTTTTTAATCCACATTAAGACTTTATTTGATCCAGCAAAGGATATGAATAAAGCCAATACGAAAACTGGGGAAGGATCTAAAAAATCTGGATTCATTGGATGTGACTGGTTGCATCAGATCTCTTTAACTGTTCGCTCAAGCCCTCATACCAATGTGCCTATGGAACGTCAGCAGAGGATAGCTATGCTCGAATCTAATACATTTTTGAACACATTGTTTGAAATAGCTATAGACAAAAATGATATTAACAAGAGAAAACTCGCACTGGATCTCATAATATGGGTTGTGTCTATTAGACTTCAAAGGATGCGATTAGGATCTAGTGACAAAGTAAAGATCAAAAGTGTCGAAGCTAATCAATTAGAATGTATTAAAATAGTTGAGAAAAACATAAATTCATTAATAAAAACCTGTATTTTATGTGGAAACCGCAGTCTTGCCAAAAAATGTATGAAAATTATACTAGTAACCAGCGAGGGTGACAAACAAGTGCCTAGACCATGGATGTCGACTTTTGACGCGACGCTATCGGGCAGCGTCACGGAGTGCATTCCCTACCTGGGTGCGTGCGAGTCTCCGGGTGCCCTGCGGTGGCTGGTCACTCTGGCACAGCACTGCACGCATCGCTCCACGGCACCCGCCCTGGTCTCCCGGTGCCAAGTTCTACTTGAGAAAACAGCTCGTTGCCTGCGAGAGCGAGCTATCGTCTACCACGACTTGCTAAGAGCCAGATTTGGGCTGTACGGTTTGCCGCTGGAACGCACCCTGTTTGCAACCGAAGTACCGGAGCTTGGCCGGGGTACGCCCGCTCCCGTTACGTACGCCAGCGTACTCTCTGGCGATAATACGACACCACAGCCGCCACCACCACCACCGCCTCCAATACCGAAACTTGATCACCAACTGAAGGATTTACTTAATTTACCATTAGAAATCGATTTAAAAGCGACTCTGTCTCCGTCTGCGTGGTGGGCGCAGAGCAACAGCGTGGCGGTATTCGGCTCGGGGCTGTGCGAGTCCATGCCGCTGCACGTCACGTGTCATATCGCCTCCGACGGCACCAAGCTGGAGTCCACTGGAGGGAGACACTACCCTGCTGTGGTCAGCACCCTGCCTGGACCTGGCTCTGCAGATCCCAATCAGTTGTGGAATGTAATGAAGGAAGGTCAAGCCAAACAAACATCTCAAGATCCTGACTCATTAGAGGATGTGGAAAGTTCAATGATGGATTGCGATTCCCAAGAGAAATTAGAATTTTCGGAAGAAAAGTACTTTAAGGATCAAGAACAGTGCAACATACCTTGGGCCTCTCTGGTTACACGGCCGCCTCAACACACCCTCATTGTGGAAAGAATGCACTCGGGCGCTAGGAGATACATTATATTGGATTTCGGACACACAGTGCGACTTACTGATATCATAATTCCAGCGTGCCCCGATTTAGTAACACTGGGCATTGATATCTGGACCAACTGTGAAGAAACTAACTCGGTCAAACTAGCATATGCCACTGACATAACCAATAAACATCTCGTCCTCACTGATATACAACCTCCGCCTCTTTGCCGATATATGAAGATAACTACAATCGGTCGTTATGGTATGTCTGCCATGAAGTGTAAAATACCACTTGGCTGGTTCTATGGCGAGATAGCTGATATTGCTAATGTTCCAGCGTCCATTAATGCACTCAACGCACTGCACCAAGATTTGACTTGTAGATTCAGGTTGGCGACAGGCAAACTAATGGACCTCCTAAATCCGTATCTGGAACTGTACAATGGTAATGCAGTCCACATGATGTCTTACCTGAATAGTACAATGGATAACGAAGGAAAAGTTATAACAGCTTACCACGAGTGTATAGAGCTCCAGCAACAGATACATACATGTACTAATGTTTTGAAGAAACTGCAGAATAAAACAGATAGCACCCGAAGCATACCAGAGTTGATTGCAAAAGGAAAGGTGACCACTGAAGGTCTCCTTCAGATGTGCTCGACAGATAAACTTAGAGTTATCACAGAGAATATTGTGGATATGTTGCTTTATTTCTATTTCCAAATTGGTGAAATACAATACGAGGAGGTGACTCTGGAATGGTGTCAGAAAGTGACTCCGATGCTATGGGAGTGGAGCGGGCGGAACGCGGGCGCGCTGGCGTCGCTGTTGGCGCGTGCGTGCGGCGCCGCGCCCTGGTGGGGGCCGCACGTCGCCGACACCCTGACCGACGCCTTCGGGGCCTACGACGCACCGCCCATCGCGCTCGACAGGTGTCTGGTGCTGATAATGTACATGTGCCGTAAGAGCGTGCTGTCGGACACCGAGGGAGGCGTGTGCCCGGCGCTCGCGACCCGCACCCTGGAGCTGCTGCAGAGCGGGAGACCACAACCGGCGCTGACGGCTGCACTACTGACTGCCTTGTCAGCTGTTCTAGATGCTGTGTCTGCAGTCACCAATAAACATACCAGATGGGACTGGGTGACGGGCGGGCGGCCCGGCGCCAGCAGCGGCGCCGACACCAGCGCCACGTCGCCGCGCGTGGCCGACTGCCGGCTGCACAGGCGCAAGCTGCACAAGAAACTGCTGCACCAGGTGCGCGAGGTCGAGGCTGCCAAGACCGGCATGCAGGTCGCTTTGGAAGATCAACAGCTATTACAAAGAGCTCGCATGAGTCTTAAAGCTCGACTAGCCGTGGCTGGTAAGCGTGCGCTAAAAGCTGACGTCATAGGCTCGGGCGCTGATTTTCCACCGCCCAGACCTCTGTCTCCCGCGCTGGCCGGGCAACTGGCCCAAGCACTGGTTGCTCACATCCTGGCAGCCGACAGTGCCAGTGACGGAGACGCATTGTTGCTCGCCGCTAAGGTGGTGGGGCGGCTGTGCGCGCTGTCAGGCGGCGACAGTCTGCTGGAGCCCTCGTGCGTGCTGGGGCTGGCGCGCCTCGCCGTCACGCTGCCGCCCTGGCCCAGGCACGCGCTCACCACGCTGCTGCAGGATCTGGTTGAGTACGAAGGTGGCGAAGTGAGTAGCGAAGAGTGGGGCGGCGGCTCGCGCGTCATACACGTGGCGTCTGAGAAGAAGTCTGGGAAAACTCGCAAGAACAAGGGACCGACTGTTGCAGTGTCAATCAAGGACATCGACGTAGAACTAGATTTAAATCAACCAGAGTCCAATGATTCAGACTCTTCGGAAGAGAAACTCGATCAATATTTCTTGGAGGCCGTTAAAAAAGTCACTAGTAGTCTCAAAATCGCTATCGACACAAGCAATAGCAACTTATCTCAGTGCGCGGACGCTCGGCTGGAGAGCGCGGGTGGCGGCGCCGGCGGGCCGGGCGAGGGCTTGGCTCGGCGCGCCCTGCTCACCACGGGACACGCGCTGTCCATCGCCGTGCTCACCGCACCCCTCGCGCCCCGCACGCCGCCCGCCGCGCCGCCCCCCGCGCCTCCCCTGCGACACCATCCCCCGCTTACGCACACGCTCTACGATGTCTTCAGGCATCTCGCACTTGAGTTCCACAATAAGATCGAATGCTCGTTTATGGAGAACGTAGTGTCCCTCTGGTTGACCCTGAACGGCTCGGCGTGGGGCAGCGGCGGCGCCTGGTCGATGGCCACGCTCGCAGTGCCCGTGGACAGGCCGCGAATACGATTGGCGTCTGATACTGTTACGGCCTTGCTTCAGTCTCTGTGCAAATTAGAAAACGTCTCGCTCCGCTGCTGGGTATTATCCATGCAAGCCTTGGCGTGGATCGCGAGCTTGCCCCTGCTGACTGAAGACGGCTGTCAGACTATGGGTCGTGTGATTTTGGAATGTGAACACTTCGTACCCACGTTAGTGAAGTTCGTCACGATGAACGTGAACGCTGACGGCACGGTCGCTTCGTCGGAACCTTACCTCGGCGGAGCGCATATAGGTGCCGGAGCCGGCGCCGCTTCGGCGCTACACTCGGTGATGTCCCGTGTGGTGTGCGGGCGCGGCTCTGCGGGCGCGCTGGCGGCGCTGCGCACCGTGGTCGGCGTGTGGACCCGCCCCTCGCCGCCCGCCCCCGCCTCCGACTTGCACGCCACGTTGTTACGGCTCGCTCATCCCATGCTGCCAGTTCTGTCATCGCATCACCTACATCACGCCTTACCTCTCTTCGAAACAGTCGCGCACGCTTCGTGGTGGTGGGTGTGCGAGACGAGCTGCGGGCGCGGCGAGGGCGGGGCGGAGGCGCGACTGTCGGGTCTGCTGGCGGACGCGTTGGCTGCCGGCGCCGGCCGACGGCCTCCACTGCGCCGCGCTCTCATTGCGCAACTGTTGCACTATTGTCGTAGGATGCTGGCTCTACCTTTGCCGCAGAACGATCAATCTGCCGGATCCTCATCGTCATCCTCTAATGCGGGATCGTCGGGTCCGGAACAGTCTCAGACAGACGAGAGCAAGGCACAAAACAACGCTCGTGAAGCCAACGTCGAAGATGAAAGAAAACAGCAAGCGGCCCGAACTCCGTGCTTTGCCGATACCGTATTACAACAACATCAGATAATGTACAATCTTTATAAAACCCTATCCATATGTGACGGACTCAACATGGCTCTCTTAAATTCAGACAAAAACTTTTCGGACTTGAGCATGAACTCTGAGACTGCTTCAATGAAAGAAGAAATGTATTGGCTGGTGGCACATATCGCCGCCGCTGCTTCGAACCCAAGTCTGATGGTTCCCAGCCTCATCGAATTTATACGTAAAGAAGATTTAGTCAAGTTATCACAATCTATGCAGCTAGTCATGATTCGTTTACTGGACAATCCGGAAGCTCTCGGTGCTTTCATAGATGCCGGAGGTTTTGAACTTGCAGTTGAGAAACTCACTGCTTGTCATCAGGCCGGTCCGAACAGTGGACAAGGGCTCGTGTCTTCTTTGATGAACTACCTTAAGCTTCCTCCTCAAATAATCAACATGTCAACTTCAGCAAACTCTAACAAGAAAAACCAAATGCCAGTTGTCGAGACTTCTAATGGACTGATCAATATCGCTCCGTTTTGCACGGTGACTTGCGGGAACCCGACAGCGCAGGCGGCGGACGTGCTGCTGGACGGCGGCGGCGGCGCCAACGTGCGGGCGGCGTGTGCTGCGCGACGCGTGCGGGCGGCCGCCTGGTCCTACCACTTCTTCAGCGCAGACGACGCTTCTCTCGCGATCACACTCAACCTGCCCTACGCCGTCCAACTGCACGAGGTGCAGCTGCAGCCGCATCTCACGAGCCTCGCCACTTGCCCTGGTGCTGTCGCAGTAGAAGCGGGCTGCGGAGGTACGCTGGCTCCGCTGGGGCCTCCTCAGACTACAGCCGGGACGACCTTCATCCGGCTCGTTATATCGCGGCCTATAGTCTGCAACACAGTACAAGTGCGCCTGTACAAGCCGAGAGACAGCTCTAATATGGGTCTACTGCAGTTGAAGCTACTAGCCATGCCCGCATTCAATACGACGATACCTATCTCAGCGAATACGAATAAGTGGGCGCGCGTGGTGTCGGCGATGAGCGGAGCAGGATCCCGCGTGTCGGATGCCCAATGGGCGGCGCTATGCAGCGGCGGTGCGCTGGCAGCGCTGTGTGCGTGCGTGGCGGCCGGTGGGCCCGCGCAGCACCCCGCTGCCGACGCGCTGCGAGCCGCCGCGCGACACTACCCGCTCGTGCGACCCCATCTAGTGGCAGCGCTCCTCAACATGGACGCGCACGCTCACGCTAACGCCTTCCAAGCGAGCCGCGCAGGTCGCGCGAACAGCAGCATGAGCGCGATATGCGGCTTGGTGCGCGCCGTGTGCGCGGAGAGCGCGGCGCAGTCGGCCGCCACGTACGTGCAGTGGCTGGCGGCCGCCGCCGAGCGCTGGCTGCGCACGCGCACGCCGCCCCCCGCCGCCTTCACGCACACGCTCGCCAACGTTTTATGGACATTGAAAGAAAAACAGCTGCTGGATAATGTAGAAGAATTAATTACGGATGATCTCTTTGACTTGGTCTATACCTGGATCAAAGAAGTGCCAGAAGCAAGTCTGCTGAAGAAATCACTTGACGCAGTTTTATGCTCGATGTGCTACATACGTCCGGAACTATTCAAGATGCTACTTGAGCATATGGATATACCAATGGATCAAGATGAAAGCATGGAAGGCGTGACCGACGACACCAAGGTGCAGGGCTCCAGCAGAGAGGGCGGCGCGGCGGACGGCGGCGTGGCGTGGCGCCTGCGCGGCTGGCAGCTGCGCACCGTGGCCTGCGCCGCCATGTCGCCCGCCGCCACGCTCGCGCTGCTGCACTCGCGCCTGCCCGCCGCCGTCGTCACCGCCATCGCAGAATTCAGCGACGCTAAATTGGAGGCAATAAAACTTCAACGTGATGCTCAAGGAGATGTACCAATGACGGATTCGGATAGAACCACTGGAATGAGTAAAACTGGTTTGACATCAATGAAGAGTGTATGTGAATTAGTGGAATGGGCGCGGCTGGTTTGCACAGAGCGTATACTTAAGGATTGGCTTGGAGGACCAGGTTCTTGTTTCTGGACACCACTATTGCGACTGCTTTGTTACCCGAGACACGCCGAGAGCACCTGGCACGAAGGCGCAGAGTACGCGCAACTGGAGGAAAATACTATACGCCTATTTTCCGAATTAACAGTTTGTCACCCCGCCAATCAGAAACTATTCGCGTCAACGTTGCACAGCATATTGGAGTCCGTGCACTGTACAGGTCCTGAAGGCATCAGCGGGTTCAGTCGCGCGCTGATCCTGCGGCTGGTGCTGTCGGCGGAGCGCGTGCGCGTGGCGGTGCGCTGGGCGAGCGGCGCCACGTGCGTGGTGGGCGGCGCGGGCACGGCGCTGGAGGGCGCGAACCACCCCGCGCTGCACTGCGACGCGCTCTACTCGCTGCCGCTGCACACCTCGCTCAGGACGCTCATCGCAGTGTCTGGCGGATCTGCTATATTTTTCCCTGTGGTGGAGGAGTCGAAGCAGAGCGTGAGCAGCTCCGGCACGGCGTCCGTCCTACGCAGCGCCTCGGATCCCGCGATCGGGGGCGGCGCTGAAATGTGGGAATTGAGTCTGGCTGCGGCTAGCGTGTCCAAAGATAAGCGTGTTAAGGATGTCAAAAACTCTTCCCTCAAGCACCACGCCAGCAAGAAACGGCAGACTAAAGCTGAAACCACCGTCGCGGCAGTGACCGAAGATATGGTCGAAGGCAACGTGCGCATAAAAATAGAAGGCATAGACGCATACGTGGGCGGCAACGTGACGCTCGGACAACTGATATCTTCTGTGCCGCAAGGGTACGGACCTCATCTCACCGTGTCATTGCATTTCGACACCACGGGGGAGGCGGTAGGACCTATGTGGGACAATAACTCGTCTAGCAGCGGGGTAGCGTCGAGCACGCTGGTGCGGGAGTTTGGTGCGTGCGGCGGGCTCGCGCTGGTGGCGGCCCGCCTGCCGCGCCCGCACGCCGCGCCGCCCGACCCGCCGCGCCCCTCGCACCAGCAGGACCTCGACTGGGTCAAACTCGACGACGCCTATGAGGAGGTGGTCGAGCTAGCAGTGACGTCGGGCAGTAACGGTCCCGACGAGTCGACCTGCACCGGGGTGCCGGCTCACGCGCTCATCGCCCTGGGCTTGTTACTGAAGCTCCCTGGATACGCCGACGCGCTGCTGGACGAAGGAGCTCGCGCTGTCCACCTGCTGCGGCTGTTGCTGGGAGTCACGCACGACGAAGAAGGACGTAGCATAGCGGTGAGCGGCGGCGGCGGCAGCGGCGGCGCAGGCTGGTCGCTGGGCACGCTGCCGCTGGTGGTGGTGTCCCGGCTGCTGGAGAGGGCTCCGCGCGGCACGCCGGAGGGCGCGCAGCTGCGGCGCGACCTGATGGCACTCGGGGCGCCGCGCCTGCTGCTCGCCTGTCTCGCTGTGTTTACCCACCACCATCACGCCTCGTCCAACGACAACAGCCAAGCGTCGAACGGGTCGACGGGTAAAACTGAAGAGAAGAACCAACTGTACTGGGCGAAGGGTACCGGCTTCGGCACCGGCTCCACGCAGCAGTCCTGGAACGTGGAGCAGGCGCTCATGCGGCAACGCACCGAGGAGGAGCACGTTACGGCGCTCCTACAAGTATTAGCGTCGTACATAAATCCATGTGAAAAGTGGCCCCCCGAAGAAGGTCAGGAGTCCTCACCGGATACCGAGAGTGAAGCGAACTCTACTGAAGCTCCCAGCGAGGATTGCTCAGACCTGCCTTCAGAGTTTATTGATCTCATAGCCAACAGCTCCCTAGTACCTGCCATCTGTTCGTATCTTAGGAATGATTCAGTGCTGGACATGTCGCGGCACATCCCGCTGTACGTGTGCGTGCTGCGGTGCGCGCGCGGGCTGGCGTCGCTGCGGAGCGCGCGCCTCGCCGCCCCGCTGCGCCCGCTGCCGCGCCTGCTCGCCCAGATGAGCCGCACCACCAACTCCTACGCCACTAAACTCAAAATGAGTAAGAAGACAATATTTGGCAAGATGACCTACAGCCAACGATTCTGTCCAGCCACAAATTCCGAATTATCAGAAGAGGACGAGGGATTAGCTTCACTAATTGCCGACGTACAGGCCACGTCAGCGATGATGTGCAGCGGCAACGTGACCGGCTGGGAGGAGGCGCGCGGCACTCCCAACGCGCCGCCGGCCTCACGCGAGGCTCGGTACATCCAGCTCATGAGAACTATGCAATTCGATACGTACGAGATGATAGCCGAGTGCCCGGAGGCCGGGTTCAAGTTCACCGTGCCGTACCACTTCGAGGGCACCGTGCGCGCGGCCGGCGAGCGCTCGCACCCCGCGCGCGTCAAGCGGCTGGCGCAGGAGGCCGCCACGCTCGCCACCAGCCTGCCGCTCTCCTACTCCTCCTCCGTCTTCGTGCGGTACGACGCCGTCAGGCTCGACGTCATGAAGGTTTTGATAACCGGTCCATCGGATACGCCGTATGCGAACGGCTGCTTTATCTTGGACGTGTACTTCCCTGCCGAGTACCCATCGGTACCGATGCTCATAAACCTGGAGACGACGGGTCGCCACTCGGTCAGATTTAACCCTAACCTCTACAACGATGGCAAGGTCTGCCTCTCCGTACTCAACACCTGGCATGGCAGACCTGAGGAGAAGTGGAACGCTCACACGTCAAGCTTCTTACAGGTATTAGTGTCGATCCAATCACTGATCCTGGTCCCGGAGCCGTACTTCAACGAGCCGGGATACGAGCGCAGCCGGGGCACGCGCGTGGGCAGCACCGCCTCCCTCGAGTACAACTCCAACATATACCAGGCTTGCGTGCGGTGGGCCATGCTGGAACATCTACGGAACCCGGAACCTTGCTTTAAAGAGGTGATTCAGACTCATTTTTGGATAAAACGAAATGAGATAATGCAAACTGTGGCGAATTGGATAACTGAGCTAGAGGGACAGGGCGGAGACGAGCGCACGCAGAGGAGCATACAACTGAACCTCATGGGGCTCAAGCGTCACTACGTTAAGCTGCAAGAGGAGCTCGCGAAGCTGCCGGTGCCGGCTGGCCTCGAGGAGCTGGACGAGCCGTTCCAGCTGCCCGCCGCGCCGCCCCGCCCCGCGCCCCCGCCCGCCGCGCCAGAACCCCGCCCCGCGCCGCCTTCCGACGACGAGATCGATCACGACATGGAGAAGATCGTCGCTTCCTTCCTCGACTGA
Protein
MNFSVTSLTYHSNLNIILVKTDVGSVHVLDVNSGVILQSSCLSADEAGTLGVEYASGADRVFVWDSSGIGARTDYNGVLLLHTALQRPLPISHTEKNIKIELVLSEAVLLYQCLQSIDAHFIVGLSDFITELKSAIDAEPVRKGVKAQKWSTVTICLSLSTLRLVAASVVQELKGQSRRIPALAIASAVGQRANELDPSLRDDENRPLMSSEAERKETFKRWPHMDYKWALPARMAQAGFYHQPSPSGDDRAMCFACNVCLVCWEKSDEPWVEHERHSPNCSFVKGEYTHNVPISVTNATACAVPCPNVAVVSKGNTGDLIATGTVEGKVNIWRFDCGLKLVKFVHVSPYDSIFSGILTTDYNKVWSTSLEKDSSTYSIELTAMTFAGMTTQSENYTQGQNLENIEKDPNINKTKPSLICAVIITRTNLPEPTLPVKDESSKALFDSGALSEEKVQAMNDRNEAENSMGLTEKILFLLTYDIHSSSAGSITAVVPTSNNSANSKPGGSKKVCSVTRTDDAHIYDEIYFQYSDDDTELPQCTNTLIDEQISNVINLNASSSKDDCKNWGETKKIFLTKHFKVMPPPPPSALLPELQEAGPVSIIDIVGKKMSQIKNWKSMESAGTKIVDQTDAVLQADPFVHYLNMSGPVEIPDFKWYESGESTEKIKFTTITGSSKLGTQTAATNTNDGFENDPPQEEAISHGVAVQCLTFPSTLTLKDNPRVTHLMPTEDRDHLFVVISHVDLQKLRLEDDTDNDGDTKMEVDDADLEKKADLKAYFILYRLNTKTSIYTLEDNPMSIQELPYNETPIDLCLLPPDKHEQYSFASVGIDGCLRLYSLPDFKIISEKRVPKGPFTSVTYCASVERLSVATKHGIIYFYALNNGENDSTGDIDDDDFANIDFDMLQRAPRDEVCGPTPTPIIIANKSELDTNDLETLISVTGLYGTNTTVPYSAVVPGFWCELSPAQRPTSDHQNNRTWRLQNTSSTWDEHVLELTLPYSVSLAHIEFSFTLHTASTSSLPMILVTLLKQNLQGIGYKKDASFEPKSDSPEQNTTEEPNVHNTDIPVNSEEYLQAQNVEILAGPLLLSTGLDLTQQSGTLILTSPRLYRARGRTFLIHIKTLFDPAKDMNKANTKTGEGSKKSGFIGCDWLHQISLTVRSSPHTNVPMERQQRIAMLESNTFLNTLFEIAIDKNDINKRKLALDLIIWVVSIRLQRMRLGSSDKVKIKSVEANQLECIKIVEKNINSLIKTCILCGNRSLAKKCMKIILVTSEGDKQVPRPWMSTFDATLSGSVTECIPYLGACESPGALRWLVTLAQHCTHRSTAPALVSRCQVLLEKTARCLRERAIVYHDLLRARFGLYGLPLERTLFATEVPELGRGTPAPVTYASVLSGDNTTPQPPPPPPPPIPKLDHQLKDLLNLPLEIDLKATLSPSAWWAQSNSVAVFGSGLCESMPLHVTCHIASDGTKLESTGGRHYPAVVSTLPGPGSADPNQLWNVMKEGQAKQTSQDPDSLEDVESSMMDCDSQEKLEFSEEKYFKDQEQCNIPWASLVTRPPQHTLIVERMHSGARRYIILDFGHTVRLTDIIIPACPDLVTLGIDIWTNCEETNSVKLAYATDITNKHLVLTDIQPPPLCRYMKITTIGRYGMSAMKCKIPLGWFYGEIADIANVPASINALNALHQDLTCRFRLATGKLMDLLNPYLELYNGNAVHMMSYLNSTMDNEGKVITAYHECIELQQQIHTCTNVLKKLQNKTDSTRSIPELIAKGKVTTEGLLQMCSTDKLRVITENIVDMLLYFYFQIGEIQYEEVTLEWCQKVTPMLWEWSGRNAGALASLLARACGAAPWWGPHVADTLTDAFGAYDAPPIALDRCLVLIMYMCRKSVLSDTEGGVCPALATRTLELLQSGRPQPALTAALLTALSAVLDAVSAVTNKHTRWDWVTGGRPGASSGADTSATSPRVADCRLHRRKLHKKLLHQVREVEAAKTGMQVALEDQQLLQRARMSLKARLAVAGKRALKADVIGSGADFPPPRPLSPALAGQLAQALVAHILAADSASDGDALLLAAKVVGRLCALSGGDSLLEPSCVLGLARLAVTLPPWPRHALTTLLQDLVEYEGGEVSSEEWGGGSRVIHVASEKKSGKTRKNKGPTVAVSIKDIDVELDLNQPESNDSDSSEEKLDQYFLEAVKKVTSSLKIAIDTSNSNLSQCADARLESAGGGAGGPGEGLARRALLTTGHALSIAVLTAPLAPRTPPAAPPPAPPLRHHPPLTHTLYDVFRHLALEFHNKIECSFMENVVSLWLTLNGSAWGSGGAWSMATLAVPVDRPRIRLASDTVTALLQSLCKLENVSLRCWVLSMQALAWIASLPLLTEDGCQTMGRVILECEHFVPTLVKFVTMNVNADGTVASSEPYLGGAHIGAGAGAASALHSVMSRVVCGRGSAGALAALRTVVGVWTRPSPPAPASDLHATLLRLAHPMLPVLSSHHLHHALPLFETVAHASWWWVCETSCGRGEGGAEARLSGLLADALAAGAGRRPPLRRALIAQLLHYCRRMLALPLPQNDQSAGSSSSSSNAGSSGPEQSQTDESKAQNNAREANVEDERKQQAARTPCFADTVLQQHQIMYNLYKTLSICDGLNMALLNSDKNFSDLSMNSETASMKEEMYWLVAHIAAAASNPSLMVPSLIEFIRKEDLVKLSQSMQLVMIRLLDNPEALGAFIDAGGFELAVEKLTACHQAGPNSGQGLVSSLMNYLKLPPQIINMSTSANSNKKNQMPVVETSNGLINIAPFCTVTCGNPTAQAADVLLDGGGGANVRAACAARRVRAAAWSYHFFSADDASLAITLNLPYAVQLHEVQLQPHLTSLATCPGAVAVEAGCGGTLAPLGPPQTTAGTTFIRLVISRPIVCNTVQVRLYKPRDSSNMGLLQLKLLAMPAFNTTIPISANTNKWARVVSAMSGAGSRVSDAQWAALCSGGALAALCACVAAGGPAQHPAADALRAAARHYPLVRPHLVAALLNMDAHAHANAFQASRAGRANSSMSAICGLVRAVCAESAAQSAATYVQWLAAAAERWLRTRTPPPAAFTHTLANVLWTLKEKQLLDNVEELITDDLFDLVYTWIKEVPEASLLKKSLDAVLCSMCYIRPELFKMLLEHMDIPMDQDESMEGVTDDTKVQGSSREGGAADGGVAWRLRGWQLRTVACAAMSPAATLALLHSRLPAAVVTAIAEFSDAKLEAIKLQRDAQGDVPMTDSDRTTGMSKTGLTSMKSVCELVEWARLVCTERILKDWLGGPGSCFWTPLLRLLCYPRHAESTWHEGAEYAQLEENTIRLFSELTVCHPANQKLFASTLHSILESVHCTGPEGISGFSRALILRLVLSAERVRVAVRWASGATCVVGGAGTALEGANHPALHCDALYSLPLHTSLRTLIAVSGGSAIFFPVVEESKQSVSSSGTASVLRSASDPAIGGGAEMWELSLAAASVSKDKRVKDVKNSSLKHHASKKRQTKAETTVAAVTEDMVEGNVRIKIEGIDAYVGGNVTLGQLISSVPQGYGPHLTVSLHFDTTGEAVGPMWDNNSSSSGVASSTLVREFGACGGLALVAARLPRPHAAPPDPPRPSHQQDLDWVKLDDAYEEVVELAVTSGSNGPDESTCTGVPAHALIALGLLLKLPGYADALLDEGARAVHLLRLLLGVTHDEEGRSIAVSGGGGSGGAGWSLGTLPLVVVSRLLERAPRGTPEGAQLRRDLMALGAPRLLLACLAVFTHHHHASSNDNSQASNGSTGKTEEKNQLYWAKGTGFGTGSTQQSWNVEQALMRQRTEEEHVTALLQVLASYINPCEKWPPEEGQESSPDTESEANSTEAPSEDCSDLPSEFIDLIANSSLVPAICSYLRNDSVLDMSRHIPLYVCVLRCARGLASLRSARLAAPLRPLPRLLAQMSRTTNSYATKLKMSKKTIFGKMTYSQRFCPATNSELSEEDEGLASLIADVQATSAMMCSGNVTGWEEARGTPNAPPASREARYIQLMRTMQFDTYEMIAECPEAGFKFTVPYHFEGTVRAAGERSHPARVKRLAQEAATLATSLPLSYSSSVFVRYDAVRLDVMKVLITGPSDTPYANGCFILDVYFPAEYPSVPMLINLETTGRHSVRFNPNLYNDGKVCLSVLNTWHGRPEEKWNAHTSSFLQVLVSIQSLILVPEPYFNEPGYERSRGTRVGSTASLEYNSNIYQACVRWAMLEHLRNPEPCFKEVIQTHFWIKRNEIMQTVANWITELEGQGGDERTQRSIQLNLMGLKRHYVKLQEELAKLPVPAGLEELDEPFQLPAAPPRPAPPPAAPEPRPAPPSDDEIDHDMEKIVASFLD

Summary

Description
Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.
Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Required for normal placenta development.
Catalytic Activity
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
Subunit
Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8.
Homodimer. Binds the activated, processed forms of CASP3, CASP6 and CASP7. Interacts with RNF41, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8 (By similarity). Interacts with CASP9, DIABLO/SMAC and HTRA2.
Similarity
In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.
Keywords
3D-structure   Apoptosis   Cell cycle   Cell division   Complete proteome   Cytoplasm   Cytoskeleton   Endosome   Golgi apparatus   Membrane   Mitosis   Phosphoprotein   Protease inhibitor   Reference proteome   Thiol protease inhibitor   Transferase   Ubl conjugation   Ubl conjugation pathway   Alternative splicing  
Feature
chain  Baculoviral IAP repeat-containing protein 6
splice variant  In isoform 3.
EC Number
2.3.2.27
Pfam
PF00653   BIR        + More
PF00179   UQ_con
PF12356   BIRC6
Interpro
IPR022103   BIRC6        + More
IPR000608   UBQ-conjugat_E2       
IPR016135   UBQ-conjugating_enzyme/RWD       
IPR001370   BIR_rpt       
IPR036322   WD40_repeat_dom_sf       
SUPFAM
SSF54495   SSF54495        + More
SSF50978   SSF50978       
Gene 3D
PDB
3CEG     E-value=9.23429e-106,     Score=990

Ontologies

Topology

Subcellular location
Golgi apparatus   Exhibits cell cycle-dependent localization. Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. On the midbody, localizes to the midbody ring, also called Flemming body (PubMed:18329369). In interphase cells, localizes to the trans-Golgi network membrane and endosomes. During cytokinesis, a fraction moves to the midzone where it specifically arrives at the midbody ring. After abscission completion, travels with the midbody remnant into one daughter cell, and remains bound to it until a new midbody ring is formed during the next cell division (PubMed:18329369).   With evidence from 11 publications.
trans-Golgi network membrane   Exhibits cell cycle-dependent localization. Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. On the midbody, localizes to the midbody ring, also called Flemming body (PubMed:18329369). In interphase cells, localizes to the trans-Golgi network membrane and endosomes. During cytokinesis, a fraction moves to the midzone where it specifically arrives at the midbody ring. After abscission completion, travels with the midbody remnant into one daughter cell, and remains bound to it until a new midbody ring is formed during the next cell division (PubMed:18329369).   With evidence from 11 publications.
Endosome   Exhibits cell cycle-dependent localization. Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. On the midbody, localizes to the midbody ring, also called Flemming body (PubMed:18329369). In interphase cells, localizes to the trans-Golgi network membrane and endosomes. During cytokinesis, a fraction moves to the midzone where it specifically arrives at the midbody ring. After abscission completion, travels with the midbody remnant into one daughter cell, and remains bound to it until a new midbody ring is formed during the next cell division (PubMed:18329369).   With evidence from 11 publications.
Cytoplasm   Exhibits cell cycle-dependent localization. Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. On the midbody, localizes to the midbody ring, also called Flemming body (PubMed:18329369). In interphase cells, localizes to the trans-Golgi network membrane and endosomes. During cytokinesis, a fraction moves to the midzone where it specifically arrives at the midbody ring. After abscission completion, travels with the midbody remnant into one daughter cell, and remains bound to it until a new midbody ring is formed during the next cell division (PubMed:18329369).   With evidence from 11 publications.
Cytoskeleton   Exhibits cell cycle-dependent localization. Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. On the midbody, localizes to the midbody ring, also called Flemming body (PubMed:18329369). In interphase cells, localizes to the trans-Golgi network membrane and endosomes. During cytokinesis, a fraction moves to the midzone where it specifically arrives at the midbody ring. After abscission completion, travels with the midbody remnant into one daughter cell, and remains bound to it until a new midbody ring is formed during the next cell division (PubMed:18329369).   With evidence from 11 publications.
Spindle pole   Exhibits cell cycle-dependent localization. Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. On the midbody, localizes to the midbody ring, also called Flemming body (PubMed:18329369). In interphase cells, localizes to the trans-Golgi network membrane and endosomes. During cytokinesis, a fraction moves to the midzone where it specifically arrives at the midbody ring. After abscission completion, travels with the midbody remnant into one daughter cell, and remains bound to it until a new midbody ring is formed during the next cell division (PubMed:18329369).   With evidence from 11 publications.
Microtubule organizing center   Exhibits cell cycle-dependent localization. Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. On the midbody, localizes to the midbody ring, also called Flemming body (PubMed:18329369). In interphase cells, localizes to the trans-Golgi network membrane and endosomes. During cytokinesis, a fraction moves to the midzone where it specifically arrives at the midbody ring. After abscission completion, travels with the midbody remnant into one daughter cell, and remains bound to it until a new midbody ring is formed during the next cell division (PubMed:18329369).   With evidence from 11 publications.
Centrosome   Exhibits cell cycle-dependent localization. Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. On the midbody, localizes to the midbody ring, also called Flemming body (PubMed:18329369). In interphase cells, localizes to the trans-Golgi network membrane and endosomes. During cytokinesis, a fraction moves to the midzone where it specifically arrives at the midbody ring. After abscission completion, travels with the midbody remnant into one daughter cell, and remains bound to it until a new midbody ring is formed during the next cell division (PubMed:18329369).   With evidence from 11 publications.
Midbody   Exhibits cell cycle-dependent localization. Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. On the midbody, localizes to the midbody ring, also called Flemming body (PubMed:18329369). In interphase cells, localizes to the trans-Golgi network membrane and endosomes. During cytokinesis, a fraction moves to the midzone where it specifically arrives at the midbody ring. After abscission completion, travels with the midbody remnant into one daughter cell, and remains bound to it until a new midbody ring is formed during the next cell division (PubMed:18329369).   With evidence from 11 publications.
Midbody ring   Exhibits cell cycle-dependent localization. Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. On the midbody, localizes to the midbody ring, also called Flemming body (PubMed:18329369). In interphase cells, localizes to the trans-Golgi network membrane and endosomes. During cytokinesis, a fraction moves to the midzone where it specifically arrives at the midbody ring. After abscission completion, travels with the midbody remnant into one daughter cell, and remains bound to it until a new midbody ring is formed during the next cell division (PubMed:18329369).   With evidence from 11 publications.
Length:
4356
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.167300000000001
Exp number, first 60 AAs:
0.00638
Total prob of N-in:
0.00298
outside
1  -  4356
 
 

Population Genetic Test Statistics

Pi
228.770064
Theta
186.207096
Tajima's D
0.637379
CLR
0.610806
CSRT
0.559422028898555
Interpretation
Possibly Positive selection
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