Gene

KWMTBOMO15335

Pre Gene Modal

BGIBMGA005070

Annotation

PREDICTED:_dolichyl-phosphate-mannose--protein_mannosyltransferase_4_isoform_X2_[Amyelois_transitella]

Location

Bomo_Chr25(+):9438826-9454659      View in EpiBrowser

Full name

Protein O-mannosyl-transferase 2      

Alternative Name

Dolichyl-phosphate-mannose--protein mannosyltransferase 2
Protein twisted

Location in the cell

PlasmaMembrane   Reliability : 3.962

CDS

ATGGCAAGTTGGTACATAAACAGGACCTTCTTCTTTGATGTACATCCACCACTTGGCAAGATGCTAATAGCATTGTCTGGCAAACTATCAGGGTATGATGGTACATTTCCATTTGAGAAACCTGGAGATAAGTATGATGGTGCGAGGTATCAGGGTATGAGACTATTTTGTACAACGTTAGGTGCTTTGGTTATTCCCCTAACCTTTCTGTCGATATGGGAGATGACTAAATCATTGGAAGCCACGTTCATAGGAACGTTGCTCTTGTTGTGTGATGTTGGCTTTATGACTTTAAACAGATACATCTTATTAGATCCAATCTTGCTGTTCTTCATGAGTTGTTCAATATATGGATGCTTTAAGGTTTCTACTTTAACCAATGACGGCTTACTCCCTTTTTCTCCGAGGATGCTGTCATGGCAAATTTTCTTGGGTACATCATTAGCTTGCACGATGTCCGTCAAGTTTGTGGGATTGTTCGTTGTTCTATTTGTTGGTCTACGGACAGTTGCGGACTTATGGAATATTCTGGGTGATTTATCGAAACCTGTTAAATTCACCATCACACATCTCATTGTCAGAACATTAACCCTCATTGTGTGGCCATTCGTTCTGTACGTGTTCTTCTTTTGGATACATCTCACGGTACTGAGTAAAAGCGGCAACGGTGACGGTTTCTACTCGTCCGGGTTCCAAGCACGTCTCGAAGGGAACAGCCTGCACAACGCCAGCGCGCCACGGGTGCTCGCTTACGGAGCTCTCGTCACTTTGAAGAATCATAGAACTGGCGGGGGGTACTTGCACTCACACCACCACTTGTACCCAGCGGGGGTGGGAGCGAGACAGCAACAGATAACAACATACACTCACAAAGATGAGAATAATCGTTGGCAAATAAAACCGTACAACCGCGAACGAGTCGAGGGGACGGTGGTGGTGCGCAGCGGCGATCTGGTGCGCGTCACGCACGCGCCCACGGGCCGCAACCTGCATTCGCACCGCGAGCGAGCGCCTCTCACCGCCAAGCACCTGCAGGTCACCGGCTACGGGGAGGACGGCGTAGGTGACGCCAACGACGTGTGGAAGATTGTCATATCGGGCGGTAAAGATGGCGAAGAGATCCAAACTGTTCGAAGCAAACTTATGCTTGTTCATTATTTGCAGGCGTGTGTATTGACGACAACAGGGAAGCAACTACCTAAATGGGGCTACGAACAGCAGGAAGTCTCCTGCAATCCCAATTTAAGAGACAAGAACGCGCTGTGGAACATAGAGGATAACGTTTTTGATGATCTGCCTAAAGTGAGTTTCGAATCTTACGCCTCTGGTTTCCTCGAACGTTTCTACGAATCGCACGCCGTCATGTTCCAGGGGAATTCCGGACTCAAACCGAAGGAAGGGGAAGTCACCTCGCAGCCGTGGCAATGGCCCATAAATTACAGGGGTCAATTTTTTTCGGGCAGCACTCACCGCATCTATTTATTAGGAAATCCAGTAGTATGGTGGACGAATCTTGCCTTTCTAATAATATTCTTCTTGGTGTATATCATCAACTCCATAAAAGAAAAGAGGGCAGAAGCTTTTGGTGTTTCTAGACAAGTTGGCGAAGGAAGTTTACTATTGAACGCAGCCGGCTGGACGTTCATAGGATGGGCTCTGCACTACATACCTTTCTGGGCTATGGGCAGAGTTTTGTATTTTCACCATTACTTTCCTGCCCTAGTCTTCAGCTCTATGCTTACAGGTATCTTAACTGAATATCTTCTAAGTAGTGTGCGGAGTTACTTGAGTCCGGAACTGGGAAAGACTGCGTATCATTGCATCATAGGCGTTGTAATATCAACAACAGTGTACAGTTTCTATTTGTTTTCACCACTAGCTTACGGTATGAGCGGACCGTTGGCTAGTGAACCGAATTCGACAATGGCAGGCCTTAAATGGCTTGAATCTTGGGAATTTTAA

Protein

MASWYINRTFFFDVHPPLGKMLIALSGKLSGYDGTFPFEKPGDKYDGARYQGMRLFCTTLGALVIPLTFLSIWEMTKSLEATFIGTLLLLCDVGFMTLNRYILLDPILLFFMSCSIYGCFKVSTLTNDGLLPFSPRMLSWQIFLGTSLACTMSVKFVGLFVVLFVGLRTVADLWNILGDLSKPVKFTITHLIVRTLTLIVWPFVLYVFFFWIHLTVLSKSGNGDGFYSSGFQARLEGNSLHNASAPRVLAYGALVTLKNHRTGGGYLHSHHHLYPAGVGARQQQITTYTHKDENNRWQIKPYNRERVEGTVVVRSGDLVRVTHAPTGRNLHSHRERAPLTAKHLQVTGYGEDGVGDANDVWKIVISGGKDGEEIQTVRSKLMLVHYLQACVLTTTGKQLPKWGYEQQEVSCNPNLRDKNALWNIEDNVFDDLPKVSFESYASGFLERFYESHAVMFQGNSGLKPKEGEVTSQPWQWPINYRGQFFSGSTHRIYLLGNPVVWWTNLAFLIIFFLVYIINSIKEKRAEAFGVSRQVGEGSLLLNAAGWTFIGWALHYIPFWAMGRVLYFHHYFPALVFSSMLTGILTEYLLSSVRSYLSPELGKTAYHCIIGVVISTTVYSFYLFSPLAYGMSGPLASEPNSTMAGLKWLESWEF

Description

Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development.

Catalytic Activity

dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+)
dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+)

Subunit

Interacts with Rt/POMT1.

Similarity

Belongs to the glycosyltransferase 39 family.

Keywords

Complete proteome   Developmental protein   Endoplasmic reticulum   Glycoprotein   Glycosyltransferase   Membrane   Reference proteome   Repeat   Transferase   Transmembrane   Transmembrane helix   Polymorphism  

Feature

chain  Protein O-mannosyl-transferase 2

Uniprot

A0A2A4K8F2   A0A2H1VRD3   A0A3S2MAM0   A0A194Q950   A0A212EZP6   A0A2W1BP81   + More
A0A1B6CJ65   A0A2J7RCJ0   J3JYN2   A0A067QRN3   A0A1Y1KV40   A0A0L0BV96   A0A1B6JB66   N6T575   U4UD25   A0A1B0GJC6   B4JWZ9   A0A1S4FZS8   Q16IB3   B4MT03   K7IQD7   A0A084W6Z5   A0A182QTA3   A0A2S2QAA7   A0A232F425   A0A182HSB3   A0A195C6M6   A0A182JSV5   A0A182XAH3   A0A151XBR6   F4WG18   A0A151JWJ4   A0A0K8VQT0   Q7PGK7   E2AI29   A0A182Y6R6   A0A182VG21   Q29IL2   B4H2N6   B4L836   A0A182IU27   A0A1J1HLJ6   A0A0K8VJP6   M9PG53   Q9W5D4   A0A3L8D7U2   A0A1Y1L2D7   B4M2Y4   B4PX34   B3P9A1   A0A1W4VFF0   A0A3B0JYH9   A0A0A1X547   B4R7H9   A0A158NTG6   W8BFB3   A0A2S2PQ03   B3MR19   A0A195BG62   A0A0L7QTS8   A0A026WBI2   A0A088AB89   A0A0P9A9N4   A0A2A3ERK7   A0A224XCI9   A0A069DVR1   A0A0A9W580   A0A023F4R5   A0A0K8UDX0   T1J5X4   A0A1E1XP87   A0A1Y1KXH3   A0A1D2NH85   A0A336M336   A0A1I8NX85   A0A131XHU0   A0A1E1X910   A0A182G599   A0A2R5LEW3   A0A131YIH4   A0A182LE96   A0A224Y8Z4   A0A0M8ZU82   A0A182FQ56   A0A1B6FFG6   A0A0P5QAM8   A0A182NR86   A0A182VZX6   T1KER1   L7ME23   A0A154P310   L7LTG1   A0A0P6FZX0   A0A0N8D032   A0A0P5DI89   A0A0P6D3K9   A0A0P5NDQ4   A0A0P5YA67   A0A0P6D3L4   A0A0P6EDS0  

EC Number

2.4.1.109

Pubmed

26354079    22118469    28756777    22516182    24845553    28004739    + More
26108605    23537049    17994087    17510324    20075255    24438588    28648823    21719571    12364791    14747013    17210077    20798317    25244985    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    15271988    16219785    10731137    12537569    30249741    17550304    25830018    21347285    24495485    24508170    26334808    25401762    25474469    29209593    27289101    28049606    28503490    26483478    26830274    20966253    28797301    25576852   

EMBL

NWSH01000029    PCG80555.1    ODYU01003989    SOQ43411.1    RSAL01000001    RVE55240.1    + More
KQ459324    KPJ01500.1    AGBW02011239    OWR46968.1    KZ150042    PZC74550.1    GEDC01023762    JAS13536.1    NEVH01005885    PNF38553.1    BT128361    AEE63319.1    KK853897    KDQ71515.1    GEZM01073205    JAV65279.1    JRES01001281    KNC23957.1    GECU01011307    JAS96399.1    APGK01052268    KB741211    ENN72818.1    KB632263    ERL90952.1    AJWK01020147    AJWK01020148    AJWK01020149    CH916376    EDV95275.1    CH478090    EAT34004.1    CH963851    EDW75242.2    ATLV01021070    KE525312    KFB45989.1    AXCN02001468    GGMS01005470    MBY74673.1    NNAY01001084    OXU25203.1    APCN01000260    KQ978205    KYM96514.1    KQ982320    KYQ57789.1    GL888128    EGI66785.1    KQ981639    KYN38691.1    GDHF01011092    JAI41222.1    AAAB01008859    EAA44894.5    GL439621    EFN66937.1    CH379063    EAL32641.1    CH479204    EDW30603.1    CH933814    EDW05611.1    CVRI01000010    CRK88936.1    GDHF01013221    JAI39093.1    AE014298    AGB94948.1    AB176551    AL031583    AY095525    AAF45548.1    AAM12256.1    BAD54755.1    CAA20897.1    QOIP01000012    RLU16152.1    GEZM01073206    JAV65277.1    CH940651    EDW65159.2    CM000162    EDX00820.1    CH954183    EDV45397.1    OUUW01000003    SPP78436.1    GBXI01007843    JAD06449.1    CM000366    EDX16790.1    ADTU01025893    GAMC01006575    JAB99980.1    GGMR01018759    MBY31378.1    CH902622    EDV34224.1    KQ976488    KYM83582.1    KQ414741    KOC61959.1    KK107341    EZA52404.1    KPU75029.1    KZ288194    PBC33846.1    GFTR01007742    JAW08684.1    GBGD01000701    JAC88188.1    GBHO01043580    GBHO01043579    GBHO01032657    GBHO01032655    GBHO01032654    GBHO01032650    JAG00024.1    JAG00025.1    JAG10947.1    JAG10949.1    JAG10950.1    JAG10954.1    GBBI01002743    JAC15969.1    GDHF01027729    JAI24585.1    JH431868    GFAA01002297    JAU01138.1    GEZM01073212    JAV65268.1    LJIJ01000040    ODN04599.1    UFQT01000480    SSX24662.1    GEFH01003360    JAP65221.1    GFAC01003657    JAT95531.1    JXUM01043074    JXUM01043075    JXUM01043076    JXUM01043077    KQ561349    KXJ78868.1    GGLE01003910    MBY08036.1    GEDV01009473    JAP79084.1    GFPF01000893    MAA12039.1    KQ435848    KOX71057.1    GECZ01020828    JAS48941.1    GDIQ01123522    JAL28204.1    CAEY01000028    GACK01002799    JAA62235.1    KQ434809    KZC06223.1    GACK01010137    JAA54897.1    GDIQ01058599    JAN36138.1    GDIP01081991    JAM21724.1    GDIP01157080    JAJ66322.1    GDIQ01083289    JAN11448.1    GDIQ01146776    JAL04950.1    GDIP01254308    GDIP01217924    GDIP01199477    GDIP01097424    GDIP01093285    GDIP01060841    GDIP01060840    GDIP01058659    JAM42874.1    GDIQ01125425    GDIQ01110433    GDIQ01088186    GDIQ01083288    GDIQ01046510    GDIQ01042209    GDIQ01039406    JAN11449.1    GDIQ01064247    GDIQ01064246    JAN30490.1   

Proteomes

UP000218220    UP000283053    UP000053268    UP000007151    UP000235965    UP000027135    + More
UP000037069    UP000019118    UP000030742    UP000092461    UP000001070    UP000008820    UP000007798    UP000002358    UP000030765    UP000075886    UP000215335    UP000075840    UP000078542    UP000075881    UP000076407    UP000075809    UP000007755    UP000078541    UP000007062    UP000000311    UP000076408    UP000075903    UP000001819    UP000008744    UP000009192    UP000075880    UP000183832    UP000000803    UP000279307    UP000008792    UP000002282    UP000008711    UP000192221    UP000268350    UP000000304    UP000005205    UP000007801    UP000078540    UP000053825    UP000053097    UP000005203    UP000242457    UP000094527    UP000095300    UP000069940    UP000249989    UP000075882    UP000053105    UP000069272    UP000075884    UP000075920    UP000015104    UP000076502   

PRIDE

Q29IL2    M9PG53    Q9W5D4   

Pfam

PF02815   MIR        + More
PF02366   PMT
PF16192   PMT_4TMC

Interpro

IPR003342   Glyco_trans_39/83        + More
IPR027005   GlyclTrfase_39-like       
IPR036300   MIR_dom_sf       
IPR032421   PMT_4TMC       
IPR016093   MIR_motif       

SUPFAM

SSF82109   SSF82109       

ProteinModelPortal

A0A2A4K8F2   A0A2H1VRD3   A0A3S2MAM0   A0A194Q950   A0A212EZP6   A0A2W1BP81   + More
A0A1B6CJ65   A0A2J7RCJ0   J3JYN2   A0A067QRN3   A0A1Y1KV40   A0A0L0BV96   A0A1B6JB66   N6T575   U4UD25   A0A1B0GJC6   B4JWZ9   A0A1S4FZS8   Q16IB3   B4MT03   K7IQD7   A0A084W6Z5   A0A182QTA3   A0A2S2QAA7   A0A232F425   A0A182HSB3   A0A195C6M6   A0A182JSV5   A0A182XAH3   A0A151XBR6   F4WG18   A0A151JWJ4   A0A0K8VQT0   Q7PGK7   E2AI29   A0A182Y6R6   A0A182VG21   Q29IL2   B4H2N6   B4L836   A0A182IU27   A0A1J1HLJ6   A0A0K8VJP6   M9PG53   Q9W5D4   A0A3L8D7U2   A0A1Y1L2D7   B4M2Y4   B4PX34   B3P9A1   A0A1W4VFF0   A0A3B0JYH9   A0A0A1X547   B4R7H9   A0A158NTG6   W8BFB3   A0A2S2PQ03   B3MR19   A0A195BG62   A0A0L7QTS8   A0A026WBI2   A0A088AB89   A0A0P9A9N4   A0A2A3ERK7   A0A224XCI9   A0A069DVR1   A0A0A9W580   A0A023F4R5   A0A0K8UDX0   T1J5X4   A0A1E1XP87   A0A1Y1KXH3   A0A1D2NH85   A0A336M336   A0A1I8NX85   A0A131XHU0   A0A1E1X910   A0A182G599   A0A2R5LEW3   A0A131YIH4   A0A182LE96   A0A224Y8Z4   A0A0M8ZU82   A0A182FQ56   A0A1B6FFG6   A0A0P5QAM8   A0A182NR86   A0A182VZX6   T1KER1   L7ME23   A0A154P310   L7LTG1   A0A0P6FZX0   A0A0N8D032   A0A0P5DI89   A0A0P6D3K9   A0A0P5NDQ4   A0A0P5YA67   A0A0P6D3L4   A0A0P6EDS0  

PDB

1T9F     E-value=2.25752e-13,     Score=185

KEGG

101741371    K00728 dolichyl-phosphate-mannose-protein mannosyltransferase [EC:2.4.1.109] | (RefSeq) protein O-ma

PATHWAY

00514    Other types of O-glycan biosynthesis - Bombyx mori (domestic silkworm)
00515    Mannose type O-glycan biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0000030   GO:0006493   GO:0016021   GO:0004169   GO:0016203   GO:0007525   GO:0045214   GO:0030259   GO:0005783   GO:0035269   GO:0005789   GO:0071712   GO:0007517   GO:0016020   GO:0005515   GO:0006357   GO:0006814   GO:0006270   GO:0042555   GO:0015930  

PANTHER

PTHR10050  

Subcellular location

Endoplasmic reticulum membrane  

Length:

653

Number of predicted TMHs:

9

Exp number of AAs in TMHs:

193.98175

Exp number, first 60 AAs:

7.83839

Total prob of N-in:

0.90631

inside

1  -  53

TMhelix

54  -  76

outside

77  -  80

TMhelix

81  -  103

inside

104  -  107

TMhelix

108  -  127

outside

128  -  141

TMhelix

142  -  164

inside

165  -  189

TMhelix

190  -  212

outside

213  -  497

TMhelix

498  -  517

inside

518  -  537

TMhelix

538  -  560

outside

561  -  569

TMhelix

570  -  592

inside

593  -  604

TMhelix

605  -  627

outside

628  -  653

 

 

Pi

177.995606

Theta

151.482762

Tajima's D

1.032922

CLR

0.176536

CSRT

0.670066496675166

Interpretation

Uncertain