Gene

KWMTBOMO15324

Pre Gene Modal

BGIBMGA005064

Annotation

glutathione_S-transferase_zeta_1_[Bombyx_mori]

Location

Bomo_Chr25(+):9114676-9119572      View in EpiBrowser

Full name

Probable maleylacetoacetate isomerase 2      

Alternative Name

Glutathione S-transferase zeta 2

Location in the cell

Cytoplasmic   Reliability : 2.016

CDS

ATGGGCAAGCAGCCAGTATTATACTCATACTGGCGCAGCTCATGCTCCTGGCGAGTTCGCATAGCACTCAATCTTAAAGAAATACCATACGACATAAAGGCTGTCAGCCTGATTAAGGGAGGCGGAGAACAACACTGCAATGAGTATAGAGAAGTCAACCCTATGGAGCAAGTACCATCTTTATGCATTGATGGGCACACTCTAATTGAATCATTAAACATCATGCATTATTTAGAGGAGACAAGACCACAGAGACCTCTTATGCCGCAAGATTGCTTTAAGAGGGCAAAAGTTCGTGAAATTTGTGAAATGATAGCCTCAGGAATACAGCCATTGCAGAATCTGATTGTGCTAATTTATGTTGGTGAGGAGAAAAAGAAGGAATGGTCCCAACACTGGATCACAAGGGGCTTCAGAGCTATAGAAAAGTTGCTATCGACCACTGCCGGAAAATATTGTGTTGGTGATGAGATTACCCTTGCCGATTGCTGCTTAGTTCCACAAGTGTTCAATGCTAGAAGATTTCATGTTGATCTACGTCCGTTCCCAATCATCCTCCGCATAGACCGTGAACTGGAGAATCATCCCGCATTCCGTGCGGCTCATCCATCTTCTCAGCCAGATTGTCCTCCAGAAGTTGCTAAATGA

Protein

MGKQPVLYSYWRSSCSWRVRIALNLKEIPYDIKAVSLIKGGGEQHCNEYREVNPMEQVPSLCIDGHTLIESLNIMHYLEETRPQRPLMPQDCFKRAKVREICEMIASGIQPLQNLIVLIYVGEEKKKEWSQHWITRGFRAIEKLLSTTAGKYCVGDEITLADCCLVPQVFNARRFHVDLRPFPIILRIDRELENHPAFRAAHPSSQPDCPPEVAK

Description

Catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid in vitro. Has no glutathione thioltransferase activity with 4-hydroxynonenal (4-HNE), adrenochrome, phenethyl isothiocyanate (PEITC), 5-hydroperoxyeicosatetraenoic acid ((5S)-HpETE), prostaglandin A2 (PGA2) or 2-hydroxyethyldisulfide (HED).

Catalytic Activity

4-maleylacetoacetate = 4-fumarylacetoacetate
glutathione + RX = a halide anion + an S-substituted glutathione + H(+)

Cofactor

glutathione

Similarity

Belongs to the GST superfamily.
Belongs to the GST superfamily. Zeta family.

Keywords

Alternative splicing   Complete proteome   Cytoplasm   Isomerase   Phenylalanine catabolism   Reference proteome   Transferase   Tyrosine catabolism  

Feature

chain  Probable maleylacetoacetate isomerase 2
splice variant  In isoform B.

Uniprot

Q2I0J4   A0A1W6I4L4   A0A0K0XRV3   A0A3S2NN74   A0A075X262   A0A2W1BCE4   + More
A0A2H1WXS2   A0A3G1ZLD7   A0A212F981   A0A077D9Z4   A0A0N1IE46   A0A194Q7J6   A0A3G1RJ85   A0A1P8L0U0   S4PY31   H9J6C2   V9Q4A6   Q16NL9   A0A1Y9HA75   A0A182S4L7   A0A1Y9IVM4   A0A182S4L9   A0A182XU91   A0A182PYX6   A0A182S4L8   A0A1Y9IVB2   A0A1C7CZB3   A0A182XU92   Q8MUQ5   A0A182IIW9   A0A1C7CZB2   F5HKG1   A0A1I8JV15   A0A182IIX0   A0A1Y9H2F6   A0A1Y9HAK2   A0A1Y9H1Z0   A0A1Y9IVL2   A0A1Y9H1Z1   A0A1Y9H9G3   A0A1I8JUY9   A0A1C7CZB5   A0A182XU90   F5HKG3   A0A182IIX1   A0A2K6VB26   A0A240PML6   T1DQC5   A0A1Q3FV27   A0A067QP86   A0A1I8JSI6   A0A1B0C8N3   J9Q534   A0A1L8E502   H2DMH8   A0A0K8TKG9   J9Q4H2   F4MI65   E0VJ12   A0A2L1DGA8   A0A336N4Y9   A0A1S3DG01   A0A0A9Y6Q2   A0A1B0GEU2   A0A1A9VIX4   A0A1A9ZM80   A0A1A9WB37   A0A1A9X662   A0A1B0BUL4   A0A0L0C6S8   A0A1I8MLF8   A0A0M4QZA5   A0A023EJH2   T1PEQ1   A0A1I8P5J2   A0A0Q9WMM3   A0A1I8P5N8   A0A170ZKK7   A0A224XJW3   A0A0P4VS84   A0A023FAZ9   A0A069DPN4   R4G8N1   A0A0R3NLD7   A0A1W4W478   A0A3B0JGB1   A0A1W4WK79   A0A077D0C7   A0A1J1I9N5   D6WPZ0   A0A0P8ZXU5   A0A1B6DK24   B4N8U8   A0A223FQX9   A0A0Q9WXI0   A0A0R1E1Z2   Q9VHD2   A0A0A1XRP4   A0A0K8W3C2   A0A0A1XIC1  

EC Number

5.2.1.2

Pubmed

26198868    28756777    30319435    22118469    26354079    29912411    + More
23622113    19121390    17510324    20966253    12364791    12914673    14747013    17210077    20920257    24845553    23457591    22522784    26369729    21276481    20566863    25401762    26823975    26108605    25315136    24945155    17994087    27129103    25474469    26334808    27476595    15632085    18362917    19820115    28767183    17550304    22082028    10731132    12537572    12537569    25830018   

EMBL

DQ355375    DQ443292    ABC79691.1    ABF51381.1    KX500035    ARM39005.1    + More
KP938870    AKS40351.1    RSAL01000001    RVE55252.1    KF482974    AIH07598.1    KZ150138    PZC72959.1    ODYU01011803    SOQ57756.1    MH177612    AYM01184.1    AGBW02009631    OWR50280.1    KM099191    AIL29321.1    KQ460973    KPJ10080.1    KQ459324    KPJ01512.1    MG879014    AWX68894.1    KX229721    APW77582.1    GAIX01003998    JAA88562.1    BABH01019823    KF680501    AHC08063.1    CH477817    EAT35943.2    AXCN02000083    AF515522    AAAB01008859    AAM61889.1    EAA08171.3    APCN01000586    EGK96713.1    EGK96714.1    EGK96715.1    GAMD01001240    JAB00351.1    GFDL01003618    JAV31427.1    KK853897    KDQ71516.1    AJWK01001183    JQ917484    AFJ75819.1    GFDF01000370    JAV13714.1    JN628442    AEY80030.1    GDAI01003012    JAI14591.1    JQ946073    AFJ75820.1    EZ966127    ADK66969.1    DS235219    EEB13368.1    KY773989    AVC68810.1    UFQS01002464    UFQT01002464    SSX14102.1    SSX33518.1    GBHO01016283    GBRD01007745    GDHC01007917    JAG27321.1    JAG58076.1    JAQ10712.1    CCAG010012587    JXJN01020781    JRES01000835    KNC27941.1    KR107241    ALF04576.1    GAPW01004447    JAC09151.1    KA647216    AFP61845.1    CH940650    KRF82753.1    GEMB01002084    JAS01095.1    GFTR01003650    JAW12776.1    GDKW01000622    JAI55973.1    GBBI01000513    JAC18199.1    GBGD01002861    JAC86028.1    ACPB03017618    KX572144    GAHY01000682    ANZ03348.1    JAA76828.1    CM000070    KRS99685.1    OUUW01000005    SPP81185.1    KJ868752    AIL23553.1    CVRI01000040    CRK95145.1    KQ971354    EFA06896.1    CH902617    KPU79514.1    GEDC01011296    JAS26002.1    CH964232    EDW81549.2    MF036034    AST11613.1    CH933806    KRG00751.1    CM000160    KRK03272.1    AE014297    AY060732    BT132880    BT133289    GBXI01000328    JAD13964.1    GDHF01006772    GDHF01005666    JAI45542.1    JAI46648.1    GBXI01006803    GBXI01003566    GBXI01001273    JAD07489.1    JAD10726.1    JAD13019.1   

Proteomes

UP000283053    UP000007151    UP000053240    UP000053268    UP000005204    UP000008820    + More
UP000075886    UP000075900    UP000075920    UP000076407    UP000075885    UP000075882    UP000007062    UP000075840    UP000075902    UP000075884    UP000075880    UP000027135    UP000069272    UP000092461    UP000009046    UP000079169    UP000092444    UP000078200    UP000092445    UP000091820    UP000092443    UP000092460    UP000037069    UP000095301    UP000095300    UP000008792    UP000015103    UP000001819    UP000192221    UP000268350    UP000192223    UP000183832    UP000007266    UP000007801    UP000007798    UP000009192    UP000002282    UP000000803   

PRIDE

Q2I0J4    H9J6C2    Q9VHD2   

Pfam

PF13417   GST_N_3        + More
PF14497   GST_C_3
PF00628   PHD
PF12269   zf-CpG_bind_C
PF02008   zf-CXXC

Interpro

IPR004046   GST_C        + More
IPR036282   Glutathione-S-Trfase_C_sf       
IPR036249   Thioredoxin-like_sf       
IPR004045   Glutathione_S-Trfase_N       
IPR040079   Glutathione_S-Trfase       
IPR010987   Glutathione-S-Trfase_C-like       
IPR034333   GST_Zeta_N       
IPR005955   GST_Zeta       
IPR034330   GST_Zeta_C       
IPR019786   Zinc_finger_PHD-type_CS       
IPR019787   Znf_PHD-finger       
IPR013083   Znf_RING/FYVE/PHD       
IPR037869   Spp1/CFP1       
IPR001965   Znf_PHD       
IPR022056   CpG-bd_C       
IPR011011   Znf_FYVE_PHD       
IPR002857   Znf_CXXC       

SUPFAM

SSF47616   SSF47616        + More
SSF52833   SSF52833       
SSF57903   SSF57903       

Gene 3D

3.30.40.10    

CDD

cd03191  GST_C_Zeta
cd03042  GST_N_Zeta

ProteinModelPortal

Q2I0J4   A0A1W6I4L4   A0A0K0XRV3   A0A3S2NN74   A0A075X262   A0A2W1BCE4   + More
A0A2H1WXS2   A0A3G1ZLD7   A0A212F981   A0A077D9Z4   A0A0N1IE46   A0A194Q7J6   A0A3G1RJ85   A0A1P8L0U0   S4PY31   H9J6C2   V9Q4A6   Q16NL9   A0A1Y9HA75   A0A182S4L7   A0A1Y9IVM4   A0A182S4L9   A0A182XU91   A0A182PYX6   A0A182S4L8   A0A1Y9IVB2   A0A1C7CZB3   A0A182XU92   Q8MUQ5   A0A182IIW9   A0A1C7CZB2   F5HKG1   A0A1I8JV15   A0A182IIX0   A0A1Y9H2F6   A0A1Y9HAK2   A0A1Y9H1Z0   A0A1Y9IVL2   A0A1Y9H1Z1   A0A1Y9H9G3   A0A1I8JUY9   A0A1C7CZB5   A0A182XU90   F5HKG3   A0A182IIX1   A0A2K6VB26   A0A240PML6   T1DQC5   A0A1Q3FV27   A0A067QP86   A0A1I8JSI6   A0A1B0C8N3   J9Q534   A0A1L8E502   H2DMH8   A0A0K8TKG9   J9Q4H2   F4MI65   E0VJ12   A0A2L1DGA8   A0A336N4Y9   A0A1S3DG01   A0A0A9Y6Q2   A0A1B0GEU2   A0A1A9VIX4   A0A1A9ZM80   A0A1A9WB37   A0A1A9X662   A0A1B0BUL4   A0A0L0C6S8   A0A1I8MLF8   A0A0M4QZA5   A0A023EJH2   T1PEQ1   A0A1I8P5J2   A0A0Q9WMM3   A0A1I8P5N8   A0A170ZKK7   A0A224XJW3   A0A0P4VS84   A0A023FAZ9   A0A069DPN4   R4G8N1   A0A0R3NLD7   A0A1W4W478   A0A3B0JGB1   A0A1W4WK79   A0A077D0C7   A0A1J1I9N5   D6WPZ0   A0A0P8ZXU5   A0A1B6DK24   B4N8U8   A0A223FQX9   A0A0Q9WXI0   A0A0R1E1Z2   Q9VHD2   A0A0A1XRP4   A0A0K8W3C2   A0A0A1XIC1  

PDB

2CZ3     E-value=2.02884e-69,     Score=663

KEGG

692997    K01800 maleylacetoacetate isomerase [EC:5.2.1.2] | (RefSeq) GSTz1, GST4; glutathione S-transferase z

PATHWAY

00350    Tyrosine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005737   GO:0009072   GO:0016740   GO:0003824   GO:0004364   GO:0016853   GO:0008270   GO:0045322   GO:0048188   GO:0006749   GO:0016034   GO:0005739   GO:0006559   GO:0006572   GO:0005515   GO:0006357   GO:0006814   GO:0016021   GO:0006270   GO:0042555   GO:0015930  

PANTHER

PTHR46174  

Subcellular location

Cytoplasm  

Length:

215

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02794

Exp number, first 60 AAs:

3e-05

Total prob of N-in:

0.05696

outside

1  -  215

 

 

Pi

195.791104

Theta

138.865409

Tajima's D

1.362785

CLR

0.053339

CSRT

0.75781210939453

Interpretation

Uncertain